Guest guest Posted January 9, 2011 Report Share Posted January 9, 2011 My CML specialist is four hours away, so for routine issues I go to my primary care physician and email my Oncologist if I need anything. Well for the past four weeks I have battling pneumonia and I am currently on my second round of antibiotics and breathing inhalers. When I let my oncologist know, he said that of did not clear up this time, he wanted a CT Scan on the chest because Sprycel is known to cause a condition called pneumonitis.. Since I am not familiar with this condition, I was hoping someone who has had pneumonitus could tell me about it. Thank you and Happy New Year to All. Sincerely, Matt Maynor Sent from my iPhone On Jan 8, 2011, at 9:19 PM, " Lottie Duthu " <lotajam@...> wrote: > I was interested in the article I reported yesterday about this subject and did > some more digging to see what I could find that would add to the report. This is some of what I found. > > " There's a particular concentration at which you have optimal results, so below that you don't have enough of the drug to get a good response, and above that it might be even more toxic. " The new invention could allow doctors to control the amount of drug released at a time, and to release the drug only in the tumor region, thereby protecting healthy cells from damage caused by the drug. This is where the gold lining comes in. > Drugs Coated in Gold > " A property of gold is that it can convert near infrared light into heat, " said Kachur. " By putting gold on the surface of these liposomes, we can then put in a stimulus such as near-infrared light. The gold converts the light into heat, the heat causes the liposome to become leaky, and then whatever's really concentrated inside can diffuse out through the leaky liposome. " > The theory goes that the amount of infrared light can be varied to control the amount of drug that is released from the gold-coated liposomes. > > Despite increased blood-flow to tumor cells and the key-in-lock action of the ligands, some liposomes may still end up inside healthy cells. In that case, the gold-coating could potentially act to prevent release of the toxic drug to the healthy cells. By selectively shining the infrared light only in the tumor region, doctors could make sure only liposomes in the tumor region are able to release the drug. > > The invention has another bonus: " The gold-coated liposome is biodegradable, which is one of the best parts of our system, " said Leung. Currently there are no approved chemotherapeutic treatments that allow the gold nanostructures to be eliminated from the body by the body's own mechanisms, said Leung. > > Kidneys, the organs that normally filter waste molecules out of the blood, have a limit as to the size of molecule they can filter. " Because of the size it degrades into, our system should be clearable via the kidney, which is really unique, " said Leung. > > http://www.laboratory-journal.com/news/scientific-news/chemotherapeutic-drug-del\ ivery-improved > > FYI, > > Lottie Duthu > > Quote Link to comment Share on other sites More sharing options...
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