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Busulfan (Myleran)

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Skip and I discussed Busulfan many times, so we are going to collaborate on this

post. Several people think it saved his life, else why would he still be

walking around, but be aware that it is extremely potent. He said he felt well

enough to continue working and never had to have a transfusion. Now he is

transfustion dependent. When I spoke to my oncologist about him, he seems to

agree that Busulfan saved his hide. LOL. I'm sure the doctor who prescribed it

knew it and told Skip about it, but there was no other alternative 34 years ago.

We also talked about posting something on it, but since no one else had taken

it, some may not be interested. I think it is part of the history of medical

facts concerning CML and the group sometimes discuss that, so I thought, what

the heck, so if you are interested, these are 2 websites you can go to that Skip

is providing from his own research. Skip by the way, is quite a buff, he does

research on many things and reads a lot. When he speaks, everyone should

listen, he's been around longer than anyone else, so he speaks about his

experience with CML. If you get to know him, you will find out how well rounded

he is about other subjects as well.

Skip said he wondered why doctors didn't still use Busulfan for patients who

couldn't afford the other expensive drugs that we pay $4000 to $7500 a month

for. This drug also crosses the blood brain barrier, so pregnant women would not

be able to use it as a substitute, either - only INF. It is relatively cheap,

so he has a point if you compare costs. Hydrea sells for about $50 a month,

too. Hydrea is used for other things, but because of the nature of the compound

in Busulfan is only used on CML patients under the close supervision of a doctor

and I think that it is sometimes used for transplant patients. These are not

drugs we will ever see selling over the counter (maybe in Mexico, you don't need

a prescription for anything). BTW, Skip, I just realized that I had been

mispelling Myleran all these years. LOL. I think it is not in common use

simply because the drug companies make it available at little to no costs for

those who are financially unable to pay the higher costs of the TKIs.

http://www.drugs.com/pro/myleran.html

http://us.gsk.com/products/assets/us_myleran.pdf

FYI,

Lottie Duthu & Skip Duffie

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