Precautions if you take Sprycel

[Guest guest]

We are always wondering what drugs could be counterproductive if we take the

newer TKI's. Even doctors who prescribe it are not always aware of all of it.

I found this website with some useful information for patients who are on

Sprycel. I was on it at

one time and I didn't have all of this information, so some of you may benefit

from it.

If you already know it, pass it on to someone else or just let it stay in

cyberspace. LOL

For instance, I took Nexium for years and was never told that it could have a

counterindication with Sprycel. Better to be informed than sorry.

Tell your healthcare provider about all the medicines you take, including

prescription and non-prescription medicines, vitamins, antacids, and herbal

supplements.

Especially tell your healthcare provider if you take:

a.. medicines that increase the amount of SPRYCEL in your bloodstream, such

as:

a.. Nizoral® (ketoconazole)

b.. Sporanox® (itraconazole)

c.. Norvir® (ritonavir)

d.. Reyataz® (atazanavir sulfate)

e.. Crixivan® (indinavir)

f.. Viracept® (nelfinavir)

a.. Nefazodone® (serzone, nefadar)

b.. Invirase® (saquinavir)

c.. Ketek® (telithromycin)

d.. E-mycin® (erythromycin)

e.. Biaxin® (clarithromycin)

b.. medicines that decrease the amount of SPRYCEL in your bloodstream, such

as:

a.. Decadron® (dexamethasone)

b.. Dilantin® (phenytoin)

c.. Tegretol® (carbamazepine)

a.. Rimactane® (rifampin)

b.. Luminal® (phenobarbital)

c.. medicines whose blood levels might change by taking SPRYCEL, such as:

a.. Sandimmune® (cyclosporine)

b.. Alfenta® (alfentanil)

c.. Fentanyl® (fentanyl)

d.. Orap® (pimozide)

a.. Rapamune® (sirolimus)

b.. Prograf® (tacrolimus)

c.. Ergomar® (ergotamine)

SPRYCEL is best absorbed from your stomach into your bloodstream in the presence

of stomach acid. You should avoid taking medicines that reduce stomach acid,

such as:

a.. Tagamet® (cimetidine)

b.. Pepcid® (famotidine)

c.. Zantac® (ranitidine)

d.. Prilosec® (omeprazole)

a.. Protonix® (pantoprazole sodium)

b.. Nexium® (esomeprazole)

c.. AcipHex® (rabeprazole)

d.. Prevacid® (lansoprazole)

Medicines that neutralize stomach acid, such as

Maalox® (aluminum hydroxide/magnesium hydroxide),

Tums® (calcium carbonate), or Rolaids® (calcium carbonate and magnesia) may be

taken up to 2 hours before or 2 hours after SPRYCEL.

Since SPRYCEL therapy may cause bleeding, tell your healthcare provider if you

are using blood thinner medicine, such as Coumadin® (warfarin sodium) or

aspirin.

Know the medicines you take. Keep a list of your medicines and show it to your

healthcare provider and pharmacist when you get a new medicine.

Take SPRYCEL exactly as prescribed by your healthcare provider.

**********************************

http://tinyurl.com/4l7hmxp (The original had 154 characters)

FYI,

Lottie Duthu

[Guest guest]

Lottie,

I'm glad you have brought this to everyones attention because it's the same

thing with allopurinol and GLeevec. THe allopurinol increases the amount of

gleevec in your blood stream.  The oncologist never warned us of this we had to

find this out  through our rheumatologist!

 ~Karine~

________________________________

From: Lottie Duthu <lotajam@...>

CML < >

Sent: Thu, January 20, 2011 2:27:46 PM

Subject: [ ] Precautions if you take Sprycel

We are always wondering what drugs could be counterproductive if we take the

newer TKI's.  Even doctors who prescribe it are not always aware of all of it. 

I found this website with some useful information for patients who are on

Sprycel.  I was on it at

one time and I didn't have all of this information, so some of you may benefit

from it.

If you already know it, pass it on to someone else or just let it stay in

cyberspace.  LOL

For instance, I took Nexium for years and was never told that it could have a

counterindication with Sprycel.  Better to be informed than sorry.

Tell your healthcare provider about all the medicines you take, including

prescription and non-prescription medicines, vitamins, antacids, and herbal

supplements.

Especially tell your healthcare provider if you take:

  a.. medicines that increase the amount of SPRYCEL in your bloodstream, such

as:

    a.. Nizoral® (ketoconazole)

    b.. Sporanox® (itraconazole)

    c.. Norvir® (ritonavir)

    d.. Reyataz® (atazanavir sulfate)

    e.. Crixivan® (indinavir)

    f.. Viracept® (nelfinavir)

    a.. Nefazodone® (serzone, nefadar)

    b.. Invirase® (saquinavir)

    c.. Ketek® (telithromycin)

    d.. E-mycin® (erythromycin)

    e.. Biaxin® (clarithromycin)

  b.. medicines that decrease the amount of SPRYCEL in your bloodstream, such

as:

    a.. Decadron® (dexamethasone)

    b.. Dilantin® (phenytoin)

    c.. Tegretol® (carbamazepine)

    a.. Rimactane® (rifampin)

    b.. Luminal® (phenobarbital)

  c.. medicines whose blood levels might change by taking SPRYCEL, such as:

    a.. Sandimmune® (cyclosporine)

    b.. Alfenta® (alfentanil)

    c.. Fentanyl® (fentanyl)

    d.. Orap® (pimozide)

    a.. Rapamune® (sirolimus)

    b.. Prograf® (tacrolimus)

    c.. Ergomar® (ergotamine)

SPRYCEL is best absorbed from your stomach into your bloodstream in the presence

of stomach acid. You should avoid taking medicines that reduce stomach acid,

such as:

  a.. Tagamet® (cimetidine)

  b.. Pepcid® (famotidine)

  c.. Zantac® (ranitidine)

  d.. Prilosec® (omeprazole)

  a.. Protonix® (pantoprazole sodium)

  b.. Nexium® (esomeprazole)

  c.. AcipHex® (rabeprazole)

  d.. Prevacid® (lansoprazole)

Medicines that neutralize stomach acid, such as

Maalox® (aluminum hydroxide/magnesium hydroxide),

Tums® (calcium carbonate), or Rolaids® (calcium carbonate and magnesia) may be

taken up to 2 hours before or 2 hours after SPRYCEL.

Since SPRYCEL therapy may cause bleeding, tell your healthcare provider if you

are using blood thinner medicine, such as Coumadin® (warfarin sodium) or

aspirin.

Know the medicines you take. Keep a list of your medicines and show it to your

healthcare provider and pharmacist when you get a new medicine.

Take SPRYCEL exactly as prescribed by your healthcare provider.

**********************************

http://tinyurl.com/4l7hmxp  (The original had 154 characters)

FYI,

Lottie Duthu

[Guest guest]

Thanks Lottie.

Another good place to look is the CML Society's drug interaction list. This also

includes additional drug and herbal interactions, and is organizaed by side

effect type as well as drug type.

The link is:

http://www.cmlsociety.org/files/documents/CMLDrugInteraction2%20August%202010.pd\

f

Best to all,

Leah

>

> We are always wondering what drugs could be counterproductive if we take the

newer TKI's. Even doctors who prescribe it are not always aware of all of it.

I found this website with some useful information for patients who are on

Sprycel. I was on it at

> one time and I didn't have all of this information, so some of you may benefit

from it.

> If you already know it, pass it on to someone else or just let it stay in

cyberspace. LOL

> For instance, I took Nexium for years and was never told that it could have a

counterindication with Sprycel. Better to be informed than sorry.

>

> Tell your healthcare provider about all the medicines you take, including

prescription and non-prescription medicines, vitamins, antacids, and herbal

supplements.

>

> Especially tell your healthcare provider if you take:

> a.. medicines that increase the amount of SPRYCEL in your bloodstream, such

as:

> a.. Nizoral® (ketoconazole)

> b.. Sporanox® (itraconazole)

> c.. Norvir® (ritonavir)

> d.. Reyataz® (atazanavir sulfate)

> e.. Crixivan® (indinavir)

> f.. Viracept® (nelfinavir)

> a.. Nefazodone® (serzone, nefadar)

> b.. Invirase® (saquinavir)

> c.. Ketek® (telithromycin)

> d.. E-mycin® (erythromycin)

> e.. Biaxin® (clarithromycin)

> b.. medicines that decrease the amount of SPRYCEL in your bloodstream, such

as:

> a.. Decadron® (dexamethasone)

> b.. Dilantin® (phenytoin)

> c.. Tegretol® (carbamazepine)

> a.. Rimactane® (rifampin)

> b.. Luminal® (phenobarbital)

> c.. medicines whose blood levels might change by taking SPRYCEL, such as:

> a.. Sandimmune® (cyclosporine)

> b.. Alfenta® (alfentanil)

> c.. Fentanyl® (fentanyl)

> d.. Orap® (pimozide)

> a.. Rapamune® (sirolimus)

> b.. Prograf® (tacrolimus)

> c.. Ergomar® (ergotamine)

> SPRYCEL is best absorbed from your stomach into your bloodstream in the

presence of stomach acid. You should avoid taking medicines that reduce stomach

acid, such as:

>

> a.. Tagamet® (cimetidine)

> b.. Pepcid® (famotidine)

> c.. Zantac® (ranitidine)

> d.. Prilosec® (omeprazole)

> a.. Protonix® (pantoprazole sodium)

> b.. Nexium® (esomeprazole)

> c.. AcipHex® (rabeprazole)

> d.. Prevacid® (lansoprazole)

>

> Medicines that neutralize stomach acid, such as

> Maalox® (aluminum hydroxide/magnesium hydroxide),

> Tums® (calcium carbonate), or Rolaids® (calcium carbonate and magnesia) may be

taken up to 2 hours before or 2 hours after SPRYCEL.

>

> Since SPRYCEL therapy may cause bleeding, tell your healthcare provider if you

are using blood thinner medicine, such as Coumadin® (warfarin sodium) or

aspirin.

>

> Know the medicines you take. Keep a list of your medicines and show it to your

healthcare provider and pharmacist when you get a new medicine.

>

> Take SPRYCEL exactly as prescribed by your healthcare provider.

> **********************************

> http://tinyurl.com/4l7hmxp (The original had 154 characters)

>

> FYI,

> Lottie Duthu

>

>

>

>

>

[Guest guest]

Thanks for the link. I've been looking for something like that.

I didn't know that Nexium interacted until my last refill, which stated on

the bottle not to take within 2 hours of Sprycel.

[ ] Re: Precautions if you take Sprycel

Thanks Lottie.

Another good place to look is the CML Society's drug interaction list. This

also includes additional drug and herbal interactions, and is organizaed by

side effect type as well as drug type.

The link is:

http://www.cmlsociety.org/files/documents/CMLDrugInteraction2%20August%20201

0.pdf

Best to all,

Leah