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CML drug resistance

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Dear Group,

I am always interested in learning more about patients who are resistant to all

CML drugs. I found this at the My CML website, and a few other things that

every newcomer should know. It does not give you much hope for any drugs that

are emerging in the marketplace, but we are not alone with this dilema.

Sometimes you make such small steps towards CCR, but never achieve it. I did

for a short while and lost it - old story, but it does not freak me out, because

I have managed to survive for nearly 15 years. My shelf life seems to coincide

with the rest, I just have not earned the graduate status of PCRU that we all

strive for. So to all of you out there who are worrying frantically, our day

may never come, but we can have our own, silent yipees and s when we learn

that our longevity is the same as everyone else's.

" ....in some people, leukemia cells may resist the effects of medication. When

this happens, the medication is unable to slow down or stop the growth of cancer

cells. This is called resistance, and it can happen to people who just started

taking medication for chronic myeloid leukemia (CML) or who have been treated

with the same medication for a while. Resistance in chronic myeloid leukemia

(CML) treatment is not your fault and cannot be prevented. The causes are

complicated and are not fully understood, but resistance can be detected through

test results, which is why it is so important to make sure you undergo the right

laboratory tests at the right time, as recommended by your doctor.

***************

From My CML website:

" When resistance happens, the recommended treatment milestones may not be met

with your current treatment. If you have not met your treatment milestones, your

doctor may discuss other tests and treatment options with you. (My suggestions

are as follows: 1) I would highly recommend that you learn to understand your

test results. 2) Record your side effects with your doctor and with the group.

3)Keep building on the foundation of what you already know - there is always

more to learn. 4) Don't pass up the opportunity to learn from each other, it

can be more valuable than a textbook, it's from an actual CML patient, just like

you and a lot more personal than a booklet that does not cover all the questions

you want to know to your own satisfaction.)

Learn these basic terms, they will be your new vocabulary, ad infinitium.

http://www.mycmlcare.com/patients/glossary/default.aspx

FYI,

Lottie Duthu

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