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Biology of Liquid Tumors

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By inhibiting the protein with a drug, researchers can reduce the growth of the

liquid tumor in test tubes by about 50 percent.

The direction that the researchers aim toward is looking at these blood-born

cancers for the expression of various proteins that are related to a subject

called angiogenesis - growth of new blood vessels.

" Now we are ready to take it to the next step and begin looking at certain

treatment options that are directed against these growth factors as well as the

process of angiogenesis, " said Dr. Edgar Bellamy, the lead researcher in the

study. " It may give us another tool to fight these particular types of cancer. "

Beginning May 1, UA assistant professor of medicine Dr. Alison Stopeck will

oversee the testing of VEGF inhibitors on cancer patients who have non-Hodgkin's

lymphoma. She will check whether the patients get well and whether the

anti-angiogenic treatment is non-toxic.

The discovery, which was published in the scientific journal Blood this month,

was the result of two years of work studying angiogenesis.

The work has involved three different labs and eight researchers, one of whom is

a medical student who battled a potential cancer himself while he worked on the

project. Angiogenesis - the creation of new blood vessels that tumors rely on to

grow and spread - has been a widely-studied subject in cancer over the past

decade.

" Almost every tumor imaginable has this process turned on, so there is a

tremendous excitement in this area right now in terms of therapeutic

potentials, " Bellamy said.

Sorry, I lost this URL, too.

FYI,

Lottie Duthu

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