Guest guest Posted January 26, 2011 Report Share Posted January 26, 2011 " ...needs to get off the Nexium....it is a proton pump inhibitor and it is interferring with her cml drug. This has been determined now. " I'm curious, , who/what is your source of the statement that proton pump inhibitors interfere with CML drugs. I've never heard this and I've been taking Nexium and Gleevec for years. B from California Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 26, 2011 Report Share Posted January 26, 2011 B- It is documented. Someone on here has it in an article and I am sure will post it, but I have heard it said as well not to take those meds. There is around 5-6 of them. Someone post the info for B...... RN Wife and mother of 3 (14,11,9) CML 5/13/05 Gleevec 800mg until 8/07 Sprycel 100mg since In a message dated 1/25/2011 9:47:55 P.M. Central Standard Time, nancybelcher@... writes: " ...needs to get off the Nexium....it is a proton pump inhibitor and it is interferring with her cml drug. This has been determined now. " I'm curious, , who/what is your source of the statement that proton pump inhibitors interfere with CML drugs. I've never heard this and I've been taking Nexium and Gleevec for years. B from California Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 26, 2011 Report Share Posted January 26, 2011 What about H2 blockers like zantac? Â ~Karine~ ________________________________ From: " vegasrnjen@... " <vegasrnjen@...> Sent: Tue, January 25, 2011 7:59:15 PM Subject: Re: [ ] Re: Relapse for C Â B- It is documented. Someone on here has it in an article and I am sure will post it, but I have heard it said as well not to take those meds. There is around 5-6 of them. Someone post the info for B...... RN Wife and mother of 3 (14,11,9) CML 5/13/05 Gleevec 800mg until 8/07 Sprycel 100mg since In a message dated 1/25/2011 9:47:55 P.M. Central Standard Time, nancybelcher@... writes: " ...needs to get off the Nexium....it is a proton pump inhibitor and it is interferring with her cml drug. This has been determined now. " I'm curious, , who/what is your source of the statement that proton pump inhibitors interfere with CML drugs. I've never heard this and I've been taking Nexium and Gleevec for years. B from California Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 26, 2011 Report Share Posted January 26, 2011 I agree. I take Pantaprazole (Somac) as I developed a stomach ulcer and that was no joy. It is worse with Tasigna as it absolutely needs an acid anvironment and no food or meds can be taken 2 hours before and at least 1 hour after. It has been well documented that proton pump inhibitors (PPI), need to be taken at least 2 hours prior to or after taking our TKI's to prevent absorption issues. My pharmacist writes on my packet of Tasigna: Do NOT take dairy products, antacids, iron or calcium supplements within 2 hours of this medication. I am not strict with the dairy as I am in withdrawals for my cup of tea with milk once the fasting is over, but usually wait out the 2 hours to have my cereal with yoghurt and skim milk. Cheers From: jedhall <nancybelcher@...> Cc: Sent: Wednesday, 26 January 2011 2:47 PM Subject: [ ] Re: Relapse for C  " ...needs to get off the Nexium....it is a proton pump inhibitor and it is interferring with her cml drug. This has been determined now. " I'm curious, , who/what is your source of the statement that proton pump inhibitors interfere with CML drugs. I've never heard this and I've been taking Nexium and Gleevec for years. B from California Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 26, 2011 Report Share Posted January 26, 2011 I have been on Nexium for 7 years and still remain PCRU. In fact, there is an article, if I can find it, that says proton pump inhibitors are no problem. Lynn F. Re: [ ] Re: Relapse for C B- It is documented. Someone on here has it in an article and I am sure will post it, but I have heard it said as well not to take those meds. There is around 5-6 of them. Someone post the info for B...... RN Wife and mother of 3 (14,11,9) CML 5/13/05 Gleevec 800mg until 8/07 Sprycel 100mg since In a message dated 1/25/2011 9:47:55 P.M. Central Standard Time, nancybelcher@... writes: " ...needs to get off the Nexium....it is a proton pump inhibitor and it is interferring with her cml drug. This has been determined now. " I'm curious, , who/what is your source of the statement that proton pump inhibitors interfere with CML drugs. I've never heard this and I've been taking Nexium and Gleevec for years. B from California Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 26, 2011 Report Share Posted January 26, 2011 It is a problem with dasatinib. Lynn F. Re: [ ] Re: Relapse for C B- It is documented. Someone on here has it in an article and I am sure will post it, but I have heard it said as well not to take those meds. There is around 5-6 of them. Someone post the info for B...... RN Wife and mother of 3 (14,11,9) CML 5/13/05 Gleevec 800mg until 8/07 Sprycel 100mg since In a message dated 1/25/2011 9:47:55 P.M. Central Standard Time, nancybelcher@... writes: " ...needs to get off the Nexium....it is a proton pump inhibitor and it is interferring with her cml drug. This has been determined now. " I'm curious, , who/what is your source of the statement that proton pump inhibitors interfere with CML drugs. I've never heard this and I've been taking Nexium and Gleevec for years. B from California Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 26, 2011 Report Share Posted January 26, 2011 > It has been well documented that proton pump inhibitors (PPI), need to be taken at least 2 hours prior to or after taking our TKI's to prevent absorption issues. My pharmacist writes on my packet of Tasigna: Do NOT take dairy products, antacids, iron or calcium supplements within 2 hours of this medication. I am not strict with the dairy as I am in withdrawals for my cup of tea with milk once the fasting is over, but usually wait out the 2 hours to have my cereal with yoghurt and skim milk. > > Cheers _______________________________ Hi all interested in this topic, You want to stay away from the proton pump inhibitors period....don't use them at all (because they are in your system 24/7).........you can use antacids 2 hrs before or after the drug, but they are different (Tums, etc). B. there has been a lot of discussion about this topic on Jerry's website and he gives some references I believe....I think you can do a search on that site and find it. Our drugs need an acid environment for absorption and the proton pump inhibitors are eliminating that around the clock. There are other ways to deal with acid reflux, etc. IF you are doing great and using this type of medication, then you are probably really sensitive to the drug anyway? but I think the recommendation now is to not use PPIs. Jerry himself recently posted a very strong statement about this....and his source among others is Dr. Talpaz. C. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 26, 2011 Report Share Posted January 26, 2011 I was trying to find the original message about Nexium, and as I am reading responses I can only tell you my experience. I have been on Nexium since 2001 due to horrible heartburn after I started Gleevec. I was only on Gleevec a short time when I started to suffer. I had a EGD done, and they saw some erosion going on already from the Gleevec. After only a few weeks of Nexium the heartburn stopped and having another EGD showed the healing of my esophagus. I have not had any problems with Nexium and Gleevec together for the past 9 years. I think I would be more afraid of Esophageal Cancer which is deadly. Everyone absorbs things differently, and everyone is different. I do have to say the price is outrageous, but so far I have managed to refill it when needed. > > > > > > > " ...needs to get off the Nexium....it is a proton pump inhibitor and it is interferring with her cml drug. This has been determined now. " > > I'm curious, , who/what is your source of the statement that proton pump inhibitors interfere with CML drugs. I've never heard this and I've been taking Nexium and Gleevec for years. > > B from California > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 27, 2011 Report Share Posted January 27, 2011 Hi , Thanks for the information! As always these groups have the " power' through knowledge. I will look at the research and discuss with my haemtologist when I see him in Feb. Unfortunately I have just seen my enterologist. I must say that when I stopped Glivec, I stopped the Somac, so after 6 months on Tasigna, I started to feel really ill and that is when I was dx with the stomach ulcer after a gastroscopy. A follow up gastroscopy 3 months later showed it had healed and I have been on Somac since. I also have crohns disease and take mesalazine for this, so between the 2 they are keeping my sensitive gut on track. I've been PCRU for 2 years, so luckily for me it has not interferred with the action of Tasigna. Cheers From: hey00nanc <ncogan@...> Cc: Sent: Thursday, 27 January 2011 5:02 AM Subject: [ ] Re: Relapse for C  > It has been well documented that proton pump inhibitors (PPI), need to be taken at least 2 hours prior to or after taking our TKI's to prevent absorption issues. My pharmacist writes on my packet of Tasigna: Do NOT take dairy products, antacids, iron or calcium supplements within 2 hours of this medication. I am not strict with the dairy as I am in withdrawals for my cup of tea with milk once the fasting is over, but usually wait out the 2 hours to have my cereal with yoghurt and skim milk. > > Cheers _______________________________ Hi all interested in this topic, You want to stay away from the proton pump inhibitors period....don't use them at all (because they are in your system 24/7).........you can use antacids 2 hrs before or after the drug, but they are different (Tums, etc). B. there has been a lot of discussion about this topic on Jerry's website and he gives some references I believe....I think you can do a search on that site and find it. Our drugs need an acid environment for absorption and the proton pump inhibitors are eliminating that around the clock. There are other ways to deal with acid reflux, etc. IF you are doing great and using this type of medication, then you are probably really sensitive to the drug anyway? but I think the recommendation now is to not use PPIs. Jerry himself recently posted a very strong statement about this....and his source among others is Dr. Talpaz. C. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 27, 2011 Report Share Posted January 27, 2011 Can someone please tell me if they know. Can Zantac a H2 blocker have the same effects on Gleevec as proton inhibitors? Thanks,~Karine~ ________________________________ From: Malseed <rodorbal@...> " " < > Sent: Wed, January 26, 2011 9:26:33 PM Subject: Re: [ ] Re: Relapse for C  Hi , Thanks for the information! As always these groups have the " power' through knowledge. I will look at the research and discuss with my haemtologist when I see him in Feb. Unfortunately I have just seen my enterologist. I must say that when I stopped Glivec, I stopped the Somac, so after 6 months on Tasigna, I started to feel really ill and that is when I was dx with the stomach ulcer after a gastroscopy. A follow up gastroscopy 3 months later showed it had healed and I have been on Somac since. I also have crohns disease and take mesalazine for this, so between the 2 they are keeping my sensitive gut on track. I've been PCRU for 2 years, so luckily for me it has not interferred with the action of Tasigna. Cheers From: hey00nanc <ncogan@...> Cc: Sent: Thursday, 27 January 2011 5:02 AM Subject: [ ] Re: Relapse for C  > It has been well documented that proton pump inhibitors (PPI), need to be taken >at least 2 hours prior to or after taking our TKI's to prevent absorption >issues. My pharmacist writes on my packet of Tasigna: Do NOT take dairy >products, antacids, iron or calcium supplements within 2 hours of this >medication. I am not strict with the dairy as I am in withdrawals for my cup >of tea with milk once the fasting is over, but usually wait out the 2 hours to >have my cereal with yoghurt and skim milk. > > Cheers _______________________________ Hi all interested in this topic, You want to stay away from the proton pump inhibitors period....don't use them at all (because they are in your system 24/7).........you can use antacids 2 hrs before or after the drug, but they are different (Tums, etc). B. there has been a lot of discussion about this topic on Jerry's website and he gives some references I believe....I think you can do a search on that site and find it. Our drugs need an acid environment for absorption and the proton pump inhibitors are eliminating that around the clock. There are other ways to deal with acid reflux, etc. IF you are doing great and using this type of medication, then you are probably really sensitive to the drug anyway? but I think the recommendation now is to not use PPIs. Jerry himself recently posted a very strong statement about this....and his source among others is Dr. Talpaz. C. Quote Link to comment Share on other sites More sharing options...
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