Re: Alcohol reducing symptoms of autism in some individuals

[Guest guest]

Hi Natasa,

This is something we're interested in.

Tim is MUCH better with alcohol though it is very bad for yeast.

I think I first read about it in letters in past issues of The Autism

File. I thought at first it was the normal effect of alcohol that made

Tim better but it is actually a much more pronounced effect than this.

Best wishes,

Sandy

[Guest guest]

--- natasa778 wrote:

Sam is 12 and actively " clocks " a glass of wine and

will go to great lengths to get it! At christmas he

slugged 1/2 glass of champagne and sat there calmly

watching a film with us! this is unheard of, usually

he would sit for a few minutes and then start whirling

around the room so yes we noticed a benefit and

sometimes I let him have a small amount which I think

is very continental and hope nobody on here reports me

to social services! Have to be careful though as he

has no concept of the idea of " a sip " he will just

down it in one! and then laughs!!

Di x

> forwarding this from another list - are there any

> people on this list

> with adult ASD kids? I was wondering if any tended

> to drank wine (or

> other alcohol), and if noticed any changes in

> 'autism'?

>

> ....I was very intrigued by something posted on

> another

> board. In this link a woman is saying her child

> (adult Aspie) seems more

> typical after

> drinking alcohol and that he doesn't seem drunk at

> all. If this was

> across the board with all ASD kids/adults or even

> very common it might

> point to something in that is worth looking into.

>

> Indeed one comment left on board confirmed the

> effects in another ASD

> individual. http://youtube.com/watch?v=MWXLiTcq4y0

> <http://youtube.com/watch?v=MWXLiTcq4y0>

>

> I have had a quick look through literature and it

> turns up alcohol, esp.

> some types of drinks, decrease inflammatory

> responses. Sometimes

> dramatically. It is well know that chronic long-term

> consumption/intoxification messes up the immune

> system…

>

> I have copied some most interesting abstracts here,

> wonder if anyone

> would have any thoughts on this, or maybe some other

> mechanisms that

> could be at work…

>

> Natasa

>

>

> Atherosclerosis. 2007 Jun;192(2):335-41. Epub 2006

> Sep 12.

>

> Ethanol beverages containing polyphenols decrease

> nuclear factor kappa-B

> activation in mononuclear cells and circulating

> MCP-1 concentrations in

> healthy volunteers during a fat-enriched diet.

>

> Blanco-Colio LM..

>

> AIMS: Different epidemiological studies have

> demonstrated that some

> ethanol containing beverages intake could be

> associated with a reduction

> of cardiovascular mortality, effect attributed in

> part to its

> antioxidant properties. Nuclear factor-kappa B

> (NF-kappaB) is a redox

> sensitive transcription factor implicated in the

> pathogenesis of

> atherosclerosis. We have examined the effect of four

> different ethanol

> containing beverages on the activation of NF-kappaB

> in peripheral blood

> mononuclear cells (PBMC) and circulating

> concentrations of monocyte

> chemoattractant protein-1 (MCP-1) in healthy

> volunteers receiving a

> fat-enriched diet. METHODS AND RESULTS: Sixteen

> volunteers received 16

> g/m(2) of ethanol in form of red wine, spirits

> (vodka, rum, and brandy)

> or no ethanol intake along with a fat-enriched diet

> during 5 days and

> all of them took all alcohols at different periods.

> NF-kappaB activation

> (electrophoretic mobility shift assay) and

> circulating MCP-1 levels

> (ELISA) were examined in blood samples taken before

> and after 5 days of

> ethanol intake. Subjects receiving a fat-enriched

> diet had increased

> NF-kappaB activation in PBMC at day 5. Furthermore,

> MCP-1 levels were

> increased in plasma at day 5. Red wine intake and

> some ethanol beverages

> containing polyphenols (brandy and rum) prevented

> NF-kappaB activation

> and decreased MCP-1 release. CONCLUSION: Consumption

> of moderate amounts

> of alcoholic drinks containing polyphenols decreases

> NF-kappaB

> activation in PBMCs and MCP-1 plasma levels during a

> fat-enriched diet.

> Our results provide additional evidence of the

> anti-inflammatory effects

> of some ethanol containing beverages, further

> supporting the idea that

> its moderate consumption may help to reduce overall

> cardiovascular

> mortality.

>

> Publication Types: * Research Support, Non-U.S.

> Gov't

> PMID: 16970955 [PubMed - indexed for MEDLINE]

>

>

>

> 2: Alcohol Clin Exp Res. 2005 Jul;29(7):1198-205.

>

> Effects of systemic and local CXC chemokine

> administration on the

> ethanol-induced suppression of pulmonary neutrophil

> recruitment.

>

> Quinton LJ, S, Zhang P, Happel KI, Gamble L,

> Bagby GJ.

> Department of Physiology, Louisiana State University

> Health Sciences

> Center, New Orleans, Louisiana 70112, USA.

>

> BACKGROUND: Acute alcohol intoxication impairs the

> neutrophil

> response to intrapulmonary infection, resulting in

> impaired host defense

> and increased patient morbidity and mortality. We

> recently showed that

> intratracheal (IT) chemokine administration promotes

> pulmonary

> neutrophil migration in rats and that this process

> is enhanced by

> systemic administration of the Glu-Leu-Arg (ELR+)

> and CXC chemokine

> cytokine-induced neutrophil chemoattractant (CINC).

> Here we hypothesized

> that exogenous chemokine administration would

> mitigate the suppressive

> effect of alcohol on neutrophil recruitment into the

> lung. METHODS:

> Macrophage inflammatory protein-2 (MIP-2), a rat

> ELR+ CXC chemokine, or

> live Klebsiella pneumoniae (K. pneumoniae) was

> administered it to induce

> alveolar neutrophil migration in the absence or

> presence of acute

> ethanol intoxication. Depending on the experimental

> protocol, rats

> received either intravenous (IV) CINC or IT

> chemokines (CINC and MIP-2)

> 20 min after it MIP-2 or K. pneumoniae. Rats were

> euthanized 90 min or

> four hr after the first IT injection for sample

> collection. RESULTS:

> Neutrophil counts were significantly elevated in

> bronchoalveolar lavage

> fluid (BALF) of rats receiving IT MIP-2 compared

> with vehicle-treated

> rats, and this response was significantly decreased

> in animals

> pretreated with ethanol. CINC IV enhanced the

> neutrophil response to IT

> MIP-2 in both the absence and presence of acute

> ethanol intoxication. In

> rats challenged with K. pneumoniae, ethanol

> pretreatment significantly

> reduced BALF levels of CINC and MIP-2, suppressed

> alveolar neutrophil

> recruitment, and decreased whole-lung

> myeloperoxidase activity. CINC IV

> did not alter BALF neutrophil counts in the absence

> or presence of

> ethanol administration 4 hr after IT K. pneumoniae.

> Alternatively, IT

> chemokine instillation partially restored BALF

> neutrophil recruitment

> but not whole-lung myeloperoxidase activity in

> ethanol-treated rats.

> CONCLUSIONS: Ethanol significantly inhibits the

> pulmonary inflammatory

> responses to both MIP-2 and K. pneumoniae. Exogenous

> chemokine

> administration may be a useful means to enhance host

> defenses in the

> ethanol-intoxicated host, although the results of

> this study also

> indicate that ethanol intoxication can impair

> neutrophil recruitment,

> independent of its effects on local chemotactic

> gradients.

>

> Publication Types: PMID: 16046875 [PubMed - indexed

> for MEDLINE]

>

>

>

> 3: Am J Physiol Heart Circ Physiol. 2005

> Oct;289(4):H1669-75. Epub 2005

> May 20.

>

> Ethanol inhibits monocyte chemotactic protein-1

> expression

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