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Pertussis infection has been suspected to be a potential causal factor in the development of atopic disease because of the effect of pertussis immunization on specific IgE antibodies. Although several studies found a positive association between pertussis infection and atopic disorders, this relationship has not yet been studied in a population stratified by vaccination status. Atopy is the tendency to develop an allergy. Allergic conditions include eczema and hay fever as well as asthmaTo assess the association between pertussis infection and atopic disorders in pertussis-unvaccinated children and in pertussis-vaccinated children. Using data from a previously conducted study on the relationship between the diphtheria-tetanus-pertussis-(inactivated) poliomyelitis vaccination in the first year of life and atopic disorders, the study population of 1,872 children who were between 8 and 12yrs of age was divided into children pertussis-unvaccinated and children pertussis-vaccinated in the first year of life. Within each group, the association between pertussis infection and atopic disorders (both as reported by the parents) was assessed. In the unvaccinated group, there were no significant associations between pertussis infection and atopic disorders. In the vaccinated group, all associations between pertussis infection and atopic disorders were positive, the associations with asthma [odds ratio (OR) & #8201;= & #8201;2.24, 95% confidence interval (CI95%): 1.36-3.70], hay fever (OR & #8201;= & #8201;2.35, CI95%: 1.46-3.77) and food allergy (OR & #8201;= & #8201;2.68, CI95%: 1.48-4.85) being significant. There was a positive association between pertussis infection and atopic disorders in the pertussis vaccinated group only. From the present study, it cannot be concluded whether this association is causal or due to reverse causation. FROM: Pediatric Allergy and Immunology, Volume 19, Number 1, February 2008 , pp. 46-52(7)

Pertussis infection has been suspected to be a potential causal

factor in the development of atopic disease because of the effect of

pertussis immunization on specific IgE antibodies. Although several

studies found a positive association between pertussis infection and

atopic disorders, this relationship has not yet been studied in a

population stratified by vaccination status. Atopy is the tendency to

develop an allergy. Allergic conditions include eczema and hay fever

as well as asthma

To assess the association between pertussis infection and atopic

disorders in pertussis-unvaccinated children and in pertussis-

vaccinated children. Using data from a previously conducted study on

the relationship between the diphtheria-tetanus-pertussis-

(inactivated) poliomyelitis vaccination in the first year of life and

atopic disorders, the study population of 1,872 children who were

between 8 and 12yrs of age was divided into children pertussis-

unvaccinated and children pertussis-vaccinated in the first year of

life. Within each group, the association between pertussis infection

and atopic disorders (both as reported by the parents) was assessed.

In the unvaccinated group, there were no significant associations

between pertussis infection and atopic disorders.

In the vaccinated group, all associations between pertussis infection

and atopic disorders were positive, the associations with asthma

[odds ratio (OR) & #8201;= & #8201;2.24, 95% confidence interval (CI95%): 1.36-3.70],

hay fever (OR & #8201;= & #8201;2.35, CI95%: 1.46-3.77) and food allergy (OR & #8201;= & #8201;2.68,

CI95%: 1.48-4.85) being significant.

There was a positive association between pertussis infection and

atopic disorders in the pertussis vaccinated group only. From the

present study, it cannot be concluded whether this association is

causal or due to reverse causation.

FROM: Pediatric Allergy and Immunology, Volume 19, Number 1, February

2008 , pp. 46-52(7)