Eating High-Fat Meal Raises Blood's Proinflammatory Factors; Vitamins E, C Counter Response

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Source:   University At Buffalo (http://www.buffalo.edu/)

Date:   Posted 6/17/2002

Eating High-Fat Meal Raises Blood's Proinflammatory Factors; Vitamins E, C

Counter Response

SAN FRANCISCO -- In a series of studies designed to define the role of

dietary macronutrients in the initiation of arterial inflammation that

predisposes a person to atherosclerosis, University at Buffalo researchers

have found that a high intake of glucose, or eating a high-fat, high-calorie

fast-food meal causes an increase in the blood's inflammatory components.

However, they also have shown that the antioxidant vitamins E and C can

nullify this inflammatory response.

Results of the research were presented here today (June 16, 2002) at the

annual meeting of the American Diabetes Association.

" A meal high in calories and fat caused an increase in inflammatory markers

that lasted three to four hours, " said Paresh Dandona, M.D., professor of

medicine, head of the UB School of Medicine and Biomedical Sciences'

Division of Endocrinology, and senior author on the studies.

" We think the influx of macronutrients may alter cell behavior and that

genes are activated to produce more powerful enzymes and mediators that are

potentially more damaging to the lining of blood vessels. Obese persons may

have an ongoing abnormality of the white blood cells and the lining of blood

vessels. " (Calories, fat, protein, carbohydrates and water, the major

components of any food, are considered macronutrients.)

" On the other hand, we found that one way to render an 'unsafe' meal 'safe'

is to include antioxidant vitamins, " Dandona said. " The proinflammatory

effect of glucose is stopped if right at the outset you give vitamins E and

C. "

The " meal " study was conducted with nine normal subjects who ate a

900-calorie breakfast -- an egg-and-ham sandwich and hash browns from a

fast-food restaurant -- after an overnight fast. Blood samples were taken

before eating and at one, two and three hours after eating to determine the

concentration of oxygen free radicals, which can begin the inflammation

cascade by injuring blood vessel linings, and of several blood mediators of

inflammation.

Results showed a mean increase of free radicals over baseline of 129

percent, 175 percent and 138 percent at the three sampling times,

respectively. Levels of several proinflammatory indicators also increased

significantly, while the level of a factor that inhibits inflammation was

reduced.

Four additional studies further defined the proinflammatory cascade

initiated by an influx of glucose alone and of an infusion of fatty acids.

These studies also showed that both sugar and fat caused a reduction in the

ability of vessels to expand and contract in response to changes in blood

flow, actions crucial for maintaining healthy blood pressure and blood flow

to vital organs.

In yet another study, eight subjects took 1,200 I.U. of vitamin E and 500

mg. of vitamin C before a glucose challenge, and on a subsequent occasion,

took only glucose. Blood samples were taken before the challenges and at

one, two and three hours after.

Results showed that levels of oxygen free radicals and two proinflammatory

markers increased when glucose was taken alone, but did not increase when

accompanied by the two antioxidant vitamins.

Additional researchers on these studies, all from the UB Department of

Medicine, were Ahmad Alijada, Ph.D.; Husam Ghanim, a graduate student; Priya

Mohanty, M.D.; Deborah Hofmeyer; Devjit Tripathy, M.D.; Tufail Syed, M.D.;

Toufic Abdo, M.D., and Ajay Chaudhuri, M.D.