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Good morning,

I've been on plaquinel for RA since mid-April and recently

re-started brand-name sulfasalazine after the generic version

gave me horrid side-effects. My doc says that the brand name -

can't remember what it is called - shouldn't produce as much

gastric upset. Anyway, I am not taking a " full-dose " yet cause I

just don't want to experience that nasty feeling again. I am taking

500 mg twice daily and am supposed to work up to 1000 mg

twice a day.

My question is, w/ sulfasalazine what is the therapeutic dose? Is

is 2000 mg per day regardless of one's weight and the severity

of one's symptoms, or does the dose vary?

And, how long before I can know for sure if these drugs (both the

sulfa and the plaquenil) are working? I continue to have joint

swelling, but the pain has been moderately reduced.

Best to all and thank you

Charlotte

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