Very concerned about something on son's urine test (fatty acid metabolites)

[Guest guest]

3-hydroxybutyric

Normal range is 0 - 10 ... my son's result is 1847.29!

acetoacetic

Normal range is 0 - 10 ... my son's result is 4775.92!

Our DAN said he doesn't even know what this is ... can anyone else help me with

this?

Thanks.

gfcfmom

[Guest guest]

I'm no expert - but ...The first one relates to fatty acid metabolism

http://cancerweb.ncl.ac.uk/cgi-bin/omd?3-hydroxybutyric+acid

You can get practitioner interpretation guides for some test

results. For example, IWDl have got there's on-line (I've found them

quite helpful in the past)

http://www.iwdl.net/Practitioners.htm

but a quick scan of the fatty acid test doesn't match anything. The

organix perhaps?

Best wishes,

Sandy

>

> 3-hydroxybutyric

> Normal range is 0 - 10 ... my son's result is 1847.29!

>

> acetoacetic

> Normal range is 0 - 10 ... my son's result is 4775.92!

>

> Our DAN said he doesn't even know what this is ... can anyone else

help me with this?

>

> Thanks.

>

> gfcfmom

>

[Guest guest]

Hi

I am no expert but when something is very high on a metabolic cycle

or pathway it might mean that there is a blockage in the step

afterwards so you are accumulating the precursor, maybe a faulty

enzyme could be responsible.

It could also be due to contamination of the sample or degardation of

the sample. I would think your DAN should be doing some rooting

around for you to check this out. If they suspect some contamination

sometimes the lab will repeat something just to check it out.

Was the pH wildly out too, both of those things are acidic so I would

think that would be the case too.

They are both short chain fatty acids and often when these are out it

indicates poor gut health, like malabsorption, poor digestion,

inflammation. Did you also do a CDSA at the same time, maybe there is

some other indicators of this with bacterial biomarkers or fungal

dysbiosis or raised Calprotectin or Eosinophilic X Protein?

There are good interpretations on the websites of most Labs. I would

contact them directly too and find out their take on it.

Good Luck

Caroline

x

[Guest guest]

There is a journal paper that covers urinary organic acid markers.

Alain Kumps, Pierre Duez, Yves Mardens, Clinical Chemistry, 48:5,

2002, pages 708 - 717.

It provides a table which outlines the possible medical causes of

non-standard urinary levels of organic acids.

Both of the markers you list indicate the same thing (I presume the

second one is acetoacetate).

Environmental causes:

Ketosis, B12 deficiency, Reye or Reye like syndromes, pulmonary

infections, viral gastroenteritis, von Gierke disease,

hyprethyroidism, pregnancy (unlikely to be the case here!), heat

stroke, ethanol, protein malnutrition, high fat diet.

There are also a number of inherent metabolic disorders that can

cause this. These inborn errors of metabolism include:

Gluconeogenesis, PHD complex deficiency, respiratory chain defects,

IVA, PA, MMA, multiple carboxylase deficiency, 3-methylcrotonyl-CoA

carboxylase deficiency, glyceroluria, MSUD, GA I, MAD deficiency,

Beta-ketothiolase deficiencies,2-amino/2ketoadipic acidemia,

mitochondrial SCHAD, fatty acids oxidation deficiency (inappropriate

ketosis).

Take that to your DAN doc and get them thinking. And remember -

Finding something weird is a good thing. Once you have that tracked

down, you can target an intervention to that medical condition.

Hope this helps.

Liam

PS, if you need a copy of the paper, I can photocopy it and pop it

in the post.

>

> 3-hydroxybutyric

> Normal range is 0 - 10 ... my son's result is 1847.29!

>

> acetoacetic

> Normal range is 0 - 10 ... my son's result is 4775.92!

>

> Our DAN said he doesn't even know what this is ... can anyone else

help me with this?

>

> Thanks.

>

> gfcfmom

>