FW: Brain glutathione levels in patients with epilepsy

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Brain glutathione levels in patients with epilepsy measured by

in vivo ^1 H-MRS

* S. G. Mueller, MD, A. H. Trabesinger, PhD, P. Boesiger, PhD and H.

G.

Wieser, MD

*/Neurology/ 2001;57:1422-1427

http://www.neurology.org/cgi/content/full/57/8/1422

//

Objective:/ /--- Glutathione in its reduced form (GSH) is^ the most

important free radical scavenging compound in the mammalian^ nervous

system that prevents membrane lipid peroxidation. It^ is suspected

that

epileptic seizures are accompanied by a massive^ production of

reactive

oxygen species, i.e., oxidative stress.^

//Methods://--- Using an ^1 H MRS technique developed at the

authors'^

site, the authors measured glutathione levels in a volume of^

interest

(VOI) of 25 x 25 x 25 mm placed in structurally normal-appearing^

tissue

in the parietooccipital region of each hemispheres in^ patients with

and

without active epilepsy, and in a age-matched^ control group.^

//Results://--- The GSH/water ratio in patients with epilepsy^ was

significantly reduced in the parietooccipital region of^ both

hemispheres (1.6 ± 1.0 x 10^- ^5 ) compared to the GSH/water^ ratio

in

healthy controls (2.4 ± 1.1 x 10^- ^5 ). There was^ no significant

difference between the hemisphere with epileptogenic^ focus and the

hemisphere without epileptogenic focus. The GSH/water^ ratios of the

patients without active epilepsy were not different^ from the

GSH/water

ratios of patients with active epilepsy.^

//Conclusion://--- The authors found evidence for a widespread^

impairment of the glutathione system in patients with epilepsy^

independent from seizure activity.

http://www.neurology.org/cgi/content/full/57/8/1422

..

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