uridine therapy for autism

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Prog Neuropsychopharmacol Biol Psychiatry. 2002 Feb;26(2):397-400. Links

Metabolic treatment of hyperuricosuric autism.

Page T, department of Neurosciences, University of California, San Diego, La Jolla 92093-0624, USA.

A

single male subject with hyperuricosuric autism was treated for a

period of 2 years with an oral dose of uridine, which increased from 50

to 500 mg/kg/day. This patient experienced dramatic social, cognitive,

language, and motor improvements. These improvement decreased within 72

h of the discontinuation of uridine, but reappeared when uridine

supplementation was resumed. Thus, it appears that patients with

hyperuricosuric autism benefit from metabolic therapy with oral uridine

therapy in a manner similar to that seen in other disorders of purine

metabolism in which there is autistic symptomatology.

PMID: 11817520 [PubMed - indexed for MEDLINE]

Biochim Biophys Acta. 2000 Mar 17;1500(3):291-6.