Re: Rapamycin Reverse Autism's Effects

[Guest guest]

Where did you get this? TSC is a specific disease that causes brain tumors which results in autism. I don't know if this is supposed to work on mercury-induced autism.

Subject: Rapamycin Reverse Autism's EffectsTo: mb12 valtrex Date: Monday, July 28, 2008, 3:37 PM

I just recived this artical...could this be true??UCLA researchers have discovered that an FDA-approved drug reverses the brain dysfunction caused by tuberous sclerosis complex (TSC); because half of TSC patients also suffer from autism, the researchers are hopeful the treatment can address associated learning disorders. The journal Nature Medicine published the findings in its June 22 online edition.The scientists used the drug rapamycin on mice models of TSC; rapamycin is well-known for targeting an enzyme involved in creating proteins needed for memory. The same enzyme is also regulated by TSC proteins."This is the first study to demonstrate that the drug rapamycin can repair learning deficits related to a genetic mutation that causes autism in humans. The same mutation in animals produces learning disorders, which we were able to eliminate in adult mice," said lead

investigator Alcino Silva, professor of neurobiology and psychiatry at the Geffen School of Medicine at UCLA. "Our work and other recent studies suggest that some forms of mental retardation can be reversed, even in the adult brain."The researchers studied mice bred with tuberous sclerosis complex and confirmed that the animals suffered from the same severe learning disabilities as human patients. The learning problems were tied to biochemical changes and abnormal functioning of the hippocampus, a brain structure that plays a vital role in memory."After only three days of treatment, the TSC mice learned as quickly as the healthy mice," said first author Dan Ehninger, postgraduate researcher in neurobiology. "The rapamycin corrected the biochemistry, reversed the learning deficits and restored normal hippocampal function, allowing the mice's brains to store memories

properly."

[Guest guest]

This does make sense. Rapamycin is an immunosuppressant, which slows down an overactive immune system. This is what happened to most kids that were hyper vax'd with all those 5 in 1 shots. Their immune system went into overdrive, and they will later present with some autoimmune disorder (more than likely hypothyroidisim).

Curious to see if there's more information on this. If anyone has it I'd be curious to see .

Amy

From: tiffrutherf <tiffrutherf@ yahoo.com>Subject: Rapamycin Reverse Autism's EffectsTo: mb12 valtrex@ yahoogroups. comDate: Monday, July 28, 2008, 3:37 PM

I just recived this artical...could this be true??UCLA researchers have discovered that an FDA-approved drug reverses the brain dysfunction caused by tuberous sclerosis complex (TSC); because half of TSC patients also suffer from autism, the researchers are hopeful the treatment can address associated learning disorders. The journal Nature Medicine published the findings in its June 22 online edition.The scientists used the drug rapamycin on mice models of TSC; rapamycin is well-known for targeting an enzyme involved in creating proteins needed for memory. The same enzyme is also regulated by TSC proteins."This is the first study to demonstrate that the drug rapamycin can repair learning deficits related to a genetic mutation that causes autism in humans. The same mutation in animals produces learning disorders, which we were able to eliminate in adult mice," said lead

investigator Alcino Silva, professor of neurobiology and psychiatry at the Geffen School of Medicine at UCLA. "Our work and other recent studies suggest that some forms of mental retardation can be reversed, even in the adult brain."The researchers studied mice bred with tuberous sclerosis complex and confirmed that the animals suffered from the same severe learning disabilities as human patients. The learning problems were tied to biochemical changes and abnormal functioning of the hippocampus, a brain structure that plays a vital role in memory."After only three days of treatment, the TSC mice learned as quickly as the healthy mice," said first author Dan Ehninger, postgraduate researcher in neurobiology. "The rapamycin corrected the biochemistry, reversed the learning deficits and restored normal hippocampal function, allowing the mice's brains to store memories

properly."

[Guest guest]

Rapamycin Reverse Autism's EffectsTo: mb12 valtrex@ yahoogroups. comDate: Monday, July 28, 2008, 3:37 PM

I just recived this artical...could this be true??UCLA researchers have discovered that an FDA-approved drug reverses the brain dysfunction caused by tuberous sclerosis complex (TSC); because half of TSC patients also suffer from autism, the researchers are hopeful the treatment can address associated learning disorders. The journal Nature Medicine published the findings in its June 22 online edition.The scientists used the drug rapamycin on mice models of TSC; rapamycin is well-known for targeting an enzyme involved in creating proteins needed for memory. The same enzyme is also regulated by TSC proteins."This is the first study to demonstrate that the drug rapamycin can repair learning deficits related to a genetic mutation that causes autism in humans. The same mutation in animals produces learning disorders, which we were able to eliminate in adult mice," said lead investigator Alcino Silva, professor of neurobiology and psychiatry at the Geffen School of Medicine at UCLA. "Our work and other recent studies suggest that some forms of mental retardation can be reversed, even in the adult brain."The researchers studied mice bred with tuberous sclerosis complex and confirmed that the animals suffered from the same severe learning disabilities as human patients. The learning problems were tied to biochemical changes and abnormal functioning of the hippocampus, a brain structure that plays a vital role in memory."After only three days of treatment, the TSC mice learned as quickly as the healthy mice," said first author Dan Ehninger, postgraduate researcher in neurobiology. "The rapamycin corrected the biochemistry, reversed the learning deficits and restored normal hippocampal function, allowing the mice's brains to store memories properly."

[Guest guest]

Does it have anti-inflammatory effects?

From: tiffrutherf <tiffrutherf@ yahoo.com>Subject: Rapamycin Reverse Autism's EffectsTo: mb12 valtrex@ yahoogroups. comDate: Monday, July 28, 2008, 3:37 PM

I just recived this artical...could this be true??UCLA researchers have discovered that an FDA-approved drug reverses the brain dysfunction caused by tuberous sclerosis complex (TSC); because half of TSC patients also suffer from autism, the researchers are hopeful the treatment can address associated learning disorders. The journal Nature Medicine published the findings in its June 22 online edition.The scientists used the drug rapamycin on mice models of TSC; rapamycin is well-known for targeting an enzyme involved in creating proteins needed for memory. The same enzyme is also regulated by TSC proteins."This is the first study to demonstrate that the drug rapamycin can repair learning deficits related to a genetic mutation that causes autism in humans. The same mutation in animals produces learning disorders, which we were able to eliminate in adult mice," said lead

investigator Alcino Silva, professor of neurobiology and psychiatry at the Geffen School of Medicine at UCLA. "Our work and other recent studies suggest that some forms of mental retardation can be reversed, even in the adult brain."The researchers studied mice bred with tuberous sclerosis complex and confirmed that the animals suffered from the same severe learning disabilities as human patients. The learning problems were tied to biochemical changes and abnormal functioning of the hippocampus, a brain structure that plays a vital role in memory."After only three days of treatment, the TSC mice learned as quickly as the healthy mice," said first author Dan Ehninger, postgraduate researcher in neurobiology. "The rapamycin corrected the biochemistry, reversed the learning deficits and restored normal hippocampal function, allowing the mice's brains to store memories

properly."

[Guest guest]

I know lots of parents are scared of antibiotics b/c they feel they were part of their childs initial problem. It is possible that they were. However, it is equally possible that your child was put on anitiobitcs over and over again b/c there was an obvious underlying bacterial infection, however, they were never treated with the correct antibiotic or treated long enough to erradicate the bugs. Instead, they were treated just long enough for the body to produce more antibodies against the pathogen and they regressed each time you stopped treating them!

It is interesting if you look at the fact that my son tested negative for Lymes the first time he was tested. I felf that he had it, so I took him to a Lyme specialist. In order for the dr to get a positive test, he first had to treat my son on antibiotics for 3 months, take him off for 4 days (my son fell into a fog) and suddenly his body was making antibodies against Lyme. It was there all the time, but his body did not make antibiodies until he was initially treated. This may be the reason that antibiotic treatment has led to the onset of autism for many children. The antibiotics (and possibly vaccines) actually ACTIVATE THE IMMUNE SYSTEM AGAINT LYME (or other intracellular infection that is difficult to erradicate) and it is the antibodies that cause the inflammation. At the surface, it appears that antibiotics are the villain, when in fact, when the right ones are used long term, they are the

cure!!!!!!!!!!!!!!!!!!!

Caryn Reid

[Guest guest]

Hugs, .

It's the autoimmune response to this that *should* be of interest.

The higher functioning autistics tend to have outstanding rote memory, so it's not memory that we want to improve.

When these kids go into hyper-immune state, the body begins attacking itself, usually starting in the gut then moving to the brain, liver, thyroid, etc. If we can stop the hyper immunity, and the body's immune response is again normal, function in all areas should return or begin.

I saw a previous post that mentioned when children were removed from the trial drug that gains were not lost, but there was regression. Why has this not been followed up on? Anyone have any nmore information?I'm going to give this to the lead ped neuro here where I am. I'm sure it will be ignored but I'm curious on thoughts on this....

Great to *see* you, .

Amy

From: tiffrutherf <tiffrutherf@ yahoo.com>Subject: Rapamycin Reverse Autism's EffectsTo: mb12 valtrex@ yahoogroups. comDate: Monday, July 28, 2008, 3:37 PM

I just recived this artical...could this be true??UCLA researchers have discovered that an FDA-approved drug reverses the brain dysfunction caused by tuberous sclerosis complex (TSC); because half of TSC patients also suffer from autism, the researchers are hopeful the treatment can address associated learning disorders. The journal Nature Medicine published the findings in its June 22 online edition.The scientists used the drug rapamycin on mice models of TSC; rapamycin is well-known for targeting an enzyme involved in creating proteins needed for memory. The same enzyme is also regulated by TSC proteins."This is the first study to demonstrate that the drug rapamycin can repair learning deficits related to a genetic mutation that causes autism in humans. The same mutation in animals produces learning disorders, which we were able to eliminate in adult mice," said lead

investigator Alcino Silva, professor of neurobiology and psychiatry at the Geffen School of Medicine at UCLA. "Our work and other recent studies suggest that some forms of mental retardation can be reversed, even in the adult brain."The researchers studied mice bred with tuberous sclerosis complex and confirmed that the animals suffered from the same severe learning disabilities as human patients. The learning problems were tied to biochemical changes and abnormal functioning of the hippocampus, a brain structure that plays a vital role in memory."After only three days of treatment, the TSC mice learned as quickly as the healthy mice," said first author Dan Ehninger, postgraduate researcher in neurobiology. "The rapamycin corrected the biochemistry, reversed the learning deficits and restored normal hippocampal function, allowing the mice's brains to store memories

properly."

[Guest guest]

Hi Nikki, In the first 3 months of antibiotics (just omnicef) my son regained all receptive language and now never zones out or ignores us. He has since been diagnosed with Babesia, a protozoan which is a coinfection to Lymes. After 4 days on Nepron, in addition to the omincef, he has a runny nose and difficult moody/crying dye-off behaviors. However, his excessive thirst (used to drink as much as 3-4 times a day what a child his age should be drinking) is completely gone, he is no longer oversensitive to bouncing, he is playing with his own image in the mirror, splashing and playing in the bath tub for the first time, and playing with cars and trucks for the first time. I am pretty sure that we have Bartonella as well. He has not tested positive for this, but I have all of the symptoms and have done great in the past

while taking rifampin, which is the drug of choice to treat this. We will probably need to treat this one too. I am very optimistic that treating Lymes will be a major part of my son's recovery.

Caryn Reid

[Guest guest]

Thanks Caryn!

What are some obvious symptoms that can be related to lyme?I am currently using Cat's claw and not antibiotics for my son.Everything we have done until now has helped somewhat but he is still clearly affected by autism.I would say he is moderate and has severe language delay although receptive language appears to be good.My next step is to research more on lyme and try to find a doctor that will help.

Thanks again!

"To accomplish great things, we must not only act, wemust dream; not only plan but also believe."

Subject: Re: Rapamycin Reverse Autism's EffectsTo: mb12 valtrex Received: Tuesday, July 29, 2008, 1:55 PM

Hi Nikki, In the first 3 months of antibiotics (just omnicef) my son regained all receptive language and now never zones out or ignores us. He has since been diagnosed with Babesia, a protozoan which is a coinfection to Lymes. After 4 days on Nepron, in addition to the omincef, he has a runny nose and difficult moody/crying dye-off behaviors. However, his excessive thirst (used to drink as much as 3-4 times a day what a child his age should be drinking) is completely gone, he is no longer oversensitive to bouncing, he is playing with his own image in the mirror, splashing and playing in the bath tub for the first time, and playing with cars and trucks for the first time. I am pretty sure that we have Bartonella as well. He has not tested positive for this, but I have all of the symptoms and have done great in the past while taking rifampin, which is the drug of choice to treat this. We will

probably need to treat this one too. I am very optimistic that treating Lymes will be a major part of my son's recovery.

Caryn Reid

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[Guest guest]

My don't know if my son's symptoms of autism from Lyme is significantly different than other kids with autism. He was not very happy, had lots of digestive problems, poor eye contact, no receptive language, low tone, hyperlexic, mercury toxic despite not being vaccinated. I guess I knew my son had Lymes because I am sick too. I have had recurrent throat or bladder infections on and off for 10 years. I have had some vertigo, arthritis, chronic fatigue, a couple miscarriages and I was miserable during my pregnancy. I vomitted about every day while I was pregnant with my son and many days could barely get out of bed.

Caryn Reid