Resveratrol and D3

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Resveratrol Linked to Healthy Aging

By Dr. S. phs Co-Founder & Chairman, Vitacost.com

12/12/2008

There are some studies that are so meaningful that they're worth mentioning again and again. Back in 2006, researchers from Harvard Medical School and the National Institute of Aging discovered a compound called Sir2 that appeared to increase the life span of obese mice1. When researchers looked into this further, they found that a certain nutrient called resveratrol activated Sir2. Harvard researchers studied three groups of mice, the first group was placed on a standard diet, the second group was placed on a high caloric diet with 60% calories from fat and the third group was placed on the same high caloric diet that was supplemented with resveratrol. The diets were started around 52 weeks of life for the mice, which would be the equivalent of middle age. At 60 weeks, the mice that were on the high caloric diet began to die and develop disease. At 114 weeks, 58% of the mice fed this high caloric diet had died, compared to only 42% of the mice that were either on the standard diet or on the high caloric diet supplemented with resveratrol. Additionally, it was found that those mice fed the resveratrol on the high fat diet had a much higher quality of life, outperforming the other mice on motor skills. They were living better, more active lives.It appeared that the resveratrol would activate the Sir2 compound. Previously, researchers found that resveratrol was able to extend the life span of worms and flies by nearly 30% and fish by almost 60%. There are no guarantees this will apply to humans, but I am very excited about this nutrient and accompanying research. Studies with red wine in humans have indicated health benefits with moderate consumption. The human equivalent dosages would be around 250–500 mg per day. The reason that I bring this up is that this research was just discussed in the November 29, 2008 edition of the scientific journal The Daily Galaxy2.I was pleased to see a recent position statement3 released by the American Academy of Dermatology regarding vitamin D3. Dr. Hanke, President of the American Academy of Dermatology, indicated "vitamin D3 is essential for optimal health, and the medical literature supports safe ways to get it–a healthy diet which incorporates foods rich in vitamin D3, vitamin fortified foods and beverages and vitamin D3 supplements." There are other institutions that have also been calling for increased intake of vitamin D3.Last month, the American Academy of Pediatrics issued a statement4 indicating that children should double the usual recommended level of vitamin D3 consumption up to 400 IU daily compared to the 200 IU previously recommended by the AAP. Also, within the last several weeks, a group of 18 scientists from the University of California stated that the recommended daily intake of vitamin D3 should be raised to 2,000 IU for vitamin D35. The benefits for vitamin D3 are far reaching. Aside from helping to optimize healthy bone structure and function, it also appears vitamin D3 plays a role in promoting healthy muscles, cellular growth, immune systems and cardiovascular function along with healthy blood sugar.Also in a recent study6 published in the journal Biology of Reproduction regarding vitamin D3, the authors noted that supplementing the diet of pregnant women with vitamin D3 may improve immunity within the placenta.Nutraceutical Sciences Institute® (NSI®) has always prided itself on keeping our pulse on the medical literature in regard to nutrition. We have approximately a 13-year history of reformulating products based on the medical literature and releasing new products when something meaningful comes on the market. Our Synergy Multi-Vitamin called Synergy 3000 is up to version 11. We always try to stay ahead of the pack. In 1997, The New England Journal of Medicine published a study7 showing that elderly men and women given 700 IU of vitamin D and 500 mg of calcium citrate daily reduced fracture rates by about 60% over three years. Shortly after that point, we raised the daily dose of vitamin D from 400 IU to 700 IU, well ahead of the competition. In more recent years, we have raised the dose of vitamin D3 to 2,000 IU in our Synergy daily multi-vitamins based on the increasing favorable literature. Two years ago when the Harvard Study on resveratrol hit the news, we reviewed the study and felt that it was so significant that literally later that day we were able to secure a large quantity of resveratrol and have it available on our website in a matter of weeks. This is the way that we have always operated and will continue to do so. You can rest assured that as the medical literature changes, both favorably and unfavorably for certain nutrients, we will make the changes accordingly in our products. As we approach 2009 and many of you begin to think about your New Year's resolutions, I strongly urge all of you to consider the Synergy line of multi-vitamins along with NSI fish oil (Mega EFA®) and, of course, resveratrol. If you have any doubts about the benefits or quality of NSI products, visit each product and read the consumer reviews. Tens of thousands of our customers have rated them with a typical rating of 4.5–5 out of 5 stars for quality, value, effectiveness and satisfaction. In fact, 98% of our customers have said they would recommend Synergy 3000 Version 11 to a friend.To review all NSI Synergy choices click here.1. Baur JA, Pearson KJ, Price2 NL, et al, Resveratrol improves health and survival of mice on a high-calorie diet, Nature, pp. 337-342, November 16, 2006, published online November 1, 2006. 2. Kazan C, Harvard Team Unlocks Clues to Genes that Control Longevity, The Daily Galaxy, November 29, 2008. 3. Position Statement on Vitamin D, American Academy of Dermatology, approved by the Board of Directors on November 01, 2008.4. Wagner CL and Greer FR, et al, Prevention of Rickets and Vitamin D Deficiency in Infants, Children, and Adolescents, AAP Policy, Pediatrics, Volume 122, No. 5, November 2008, pp. 1142-1152.5. Statement reported in Vitamin D Expert at UC Riverside Leads UC Scientists' Call Recommending Increase in Daily Vitamin D Intake, UC Riverside Newsroom Online, November 13, 2008.6. Liu N, Kaplan AT, Low J, et al, Vitamin D Induces Innate Antibacterial Responses in Human Trophoblasts via an Intracrine Pathway, Biology of Reproduction, published online November 12, 2008.7. Dawson- B, SS, Krall EA, et al, Effect of Calcium and Vitamin D Supplementation on Bone Density in Men and Women 65 Years of Age or Older, The New England Journal of Medicine, Volume 337, Number 10, September 4, 1997, pp. 670–676.