Resveratrol Fights Flu Viruses

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substance (resveratrol) in red wine that is slowing down the aging process in mice. Will it someday lengthen the lives of humans, too?

Resveratrol is produced naturally by several plants as a defense when under attack by pathogens such as bacteria or fungal infection brought on by environmental stresses.

Our beautiful human bodies are subject to the same onslaught brought on by the food we eat and the environment we live in. Resveratrol has been found in a variety of plants and foods such as the skin of red grapes, red wine, blue berries, peanuts and Japanese Knotweed. Up until this point, red wine has been one of the best sources of resveratrol and has been herald for millenniums for its health benefits. Science is looking intently at what is called the “French Paradox†which refers to the observation that the French who consume a great deal of red wine suffer a relatively low incidence of coronary heart disease despite having a diet rich in saturated fats. (Heart disease is the leading cause of death for men and women in the U.S.)

Studies have shown that Resveratrol has shown several health benefits such as anti-cancer, antiviral, antioxidant that protect cells from free radical damage, anti-inflammatory and anti-aging to name a few. Resveratrol’s neuroprotectiveness is attributed to its ability to affect amyloid plaque in brain tissue that is associated with Alzheimer’s disease. Resveratrol has been effective against heart disease, type 2 Diabetes and insulin resistance and shown to promote mitochondria activation which is the “power plant†of our cells.

resveratrol and science

Through scientific research, resveratrol has shown to have a remarkable effect on the longevity on a variety of life forms. When fed resveratrol, Yeast cell’s life span increased by an astounding 60%, Fruit flies 29%, Round Worms by 15%, Killfish by 59% and Lab mice by 31%.

Not only did resveratrol dramatically increase the life span of these organisms but the quality of existence improved. Killfish that where fed resveratrol where able to navigate through tests with remarkable success compared to fish not fed resvertrol. Middle aged mice showed astounding balance and increased endurance compared to the mice that where not feed resveratrol and when examining their organs shown to be much healthier.

Resveratrol’s key is its ability to activate the SIRT1 gene which closely mimics caloric restriction (CR) which is a diet with 30% less calories but with proper nutrients. CR studies have shown up to a 40% increase in maximum life span and also provides numerous secondary health benefits, such as a greatly lowered risk for most degenerative conditions of aging. Caloric restriction is a biological stressor like natural food scarcity that induces a defensive response to boost an organism’s chances of survival.

According to the OSU College of Pharmacy; “In trying to determine the molecular basis for this genetic link to longevity, the new study found that SIRT1 increases the use of fat and reduces the formation of new fat cells - apparently it represses one or more fat-regulating proteins and other genes that drive fat storage following calorie restriction. This may have been an evolutionary adaptation for the body to sense short-term famine and counter it by increasing the burning of stored body fat.â€

Resveratrol has shown to mimic the longevity and health benefits of a caloric restrictive diet with out actually restricting caloric intake.

Resveratrol can easily degrade from its active form of Trans-Resveratrol to its inactive form, cis-resveratrol. Resveratrol degrades easily from exposure to light, heat and oxygen much like a bottle of fine wine when not cellared properly.

is a unique formula of Trans-Resveratrol made from pure Polygonum Cuspidatum (Japanese Knotweed) that is manufactured in a climate controlled, oxygen-free and nitrogen rich environment by Capsugel®, a division of Pfizer. is encapsulated in air tight liquid-filled capsules that are dark green (chlorophyll) much like a bottle of wine, and sealed in air tight blister packs. Red wines globally offer from about .30mg to 1.07mg of resveratrol in a 5oz glass. If you do the math you can see that one 100mg capsule of REZILIENCETM can equal from 93 to 333 glasses of wine with out the side effects of

alcohol, calories or preservatives.Order Online

To Life!

From the May 31, 2005 article published on www.cidrap.umn.eduRead the full article here.

“In an initial cell-culture experiment, treatment with resveratrol at 20 mcg/mL reduced flu virus replication 90%, and treatment with 40 mcg/mL blocked replication completely.â€

The researchers also tested the effects of starting resveratrol treatment at different intervals after infecting cells with the virus. Treatment was most effective—reducing viral growth 87.5%—when treatment began 3 hours after virus exposure. Effects were lower but still significant when treatment began 6 hours after infection, and treatment had no significant benefit if delayed until 9 hours after infection.

Given these and other findings, the researchers concluded that resveratrol interferes with the manufacture of proteins made late in the viral replication process, such as hemagglutinin, and limits the transport of viral ribonucleoproteins from the cell nucleus to the cytoplasm. The authors also determined that the molecular mechanism for resveratrol’s effects has to do with the inhibition of protein kinase C activity and its dependent pathways.

In the tests on mice, the researchers found that resveratrol treatment increased survival by 40% in treated mice, compared with mice that received a placebo. The level of virus found in the lungs 6 days after infection was 98% lower in treated mice than in the placebo group.

“We have shown that RV [resveratrol], a natural polyphenol whose concentration in red wine is 1.5-3.0 mg/L, can inhibit the in vitro and in vivo replication of influenza A virus without producing any significant toxicity,†the article states.

The apparent ability of resveratrol to block host-cell functions that flu viruses rely on offers important advantages, the researchers say. Compared with existing anti-flu drugs, resveratrol would be less likely to induce resistance by flu viruses, and it would probably be effective for all types and strains of flu virus.

Rezilience is 100mg of trans-resveratrol manufactured under strict conditions for the highest potency by Capsugel®, a subsidiary of Pfizer® and produced in an oxygen free, nitrogen rich environment and sealed in opaque capsules made of chlorophyll.

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