Controlled clinical evaluations of chlorine dioxide, chlorite and chlorate

[Guest guest]

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569027/

To assess the relative safety of chronically administered chlorine water

disinfectants in man, a controlled study was undertaken. The clinical evaluation

was conducted in the three phases common to investigational drug studies. Phase

I, a rising dose tolerance investigation, examined the acute effects of

progressively increasing single doses of chlorine disinfectants to normal

healthy adult male volunteers. Phase II considered the impact on normal subjects

of daily ingestion of the disinfectants at a concentration of 5 mg/l. for twelve

consecutive weeks. Persons with a low level of glucose-6-phosphate dehydrogenase

may be expected to be especially susceptible to oxidative stress; therefore, in

Phase III, chlorite at a concentration of 5 mg/l. was administered daily for

twelve consecutive weeks to a small group of potentially at-risk

glucose-6-phosphate dehydrogenase-deficient subjects. Physiological impact was

assessed by evaluation of a battery of qualitative and quantitative tests. The

three phases of this controlled double-blind clinical evaluation of chlorine

dioxide and its potential metabolites in human male volunteer subjects were

completed uneventfully. There were no obvious undesirable clinical sequellae

noted by any of the participating subjects or by the observing medical team. In

several cases, statistically significant trends in certain biochemical or

physiological parameters were associated with treatment; however, none of these

trends was judged to have physiological consequence. One cannot rule out the

possibility that, over a longer treatment period, these trends might indeed

achieve proportions of clinical importance. However, by the absence of

detrimental physiological responses within the limits of the study, the relative

safety of oral ingestion of chlorine dioxide and its metabolites, chlorite and

chlorate, was demonstrated.

[Guest guest]

Hello Healinghope,

That is a great study.

It shows that 1/2 drop of MMS in 1 liter of water, an amount that produces a

concentration of 5 PPM, is safe.

Now, how does that relate to the MMS protocol?

Tom

--- In , " healinghope " <mfrreman@...>

wrote:

>

> http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569027/

> To assess the relative safety of chronically administered chlorine water

disinfectants in man, a controlled study was undertaken. The clinical evaluation

was conducted in the three phases common to investigational drug studies. Phase

I, a rising dose tolerance investigation, examined the acute effects of

progressively increasing single doses of chlorine disinfectants to normal

healthy adult male volunteers. Phase II considered the impact on normal subjects

of daily ingestion of the disinfectants at a concentration of 5 mg/l. for twelve

consecutive weeks. Persons with a low level of glucose-6-phosphate dehydrogenase

may be expected to be especially susceptible to oxidative stress; therefore, in

Phase III, chlorite at a concentration of 5 mg/l. was administered daily for

twelve consecutive weeks to a small group of potentially at-risk

glucose-6-phosphate dehydrogenase-deficient subjects. Physiological impact was

assessed by evaluation of a battery of qualitative and quantitative tests. The

three phases of this controlled double-blind clinical evaluation of chlorine

dioxide and its potential metabolites in human male volunteer subjects were

completed uneventfully. There were no obvious undesirable clinical sequellae

noted by any of the participating subjects or by the observing medical team. In

several cases, statistically significant trends in certain biochemical or

physiological parameters were associated with treatment; however, none of these

trends was judged to have physiological consequence. One cannot rule out the

possibility that, over a longer treatment period, these trends might indeed

achieve proportions of clinical importance. However, by the absence of

detrimental physiological responses within the limits of the study, the relative

safety of oral ingestion of chlorine dioxide and its metabolites, chlorite and

chlorate, was demonstrated.

>

[Guest guest]

Hello Healinghope,

That is a great study.

It shows that 1/2 drop of MMS in 1 liter of water, an amount that produces a

concentration of 5 PPM, is safe.

Now, how does that relate to the MMS protocol?

Tom

>>>>>>>>>>>>>>>>>>

Blasphemy *wink*

[Guest guest]

Tom Perhaps the way this relates to mms is a study with man. Also if you look at

the entire study on day 16 the concentration was much higher. Day 16 was 24.0

not 5.0

ORAL INTAKE OF CHLORINE DISINFECTANTS IN MAN

Table 1. Concentration of disinfectants in phase I: acute rising dose

tolerance.a

Disinfectant concentration, mg/l.

Water disinfectant Day 1 Day 4 Day 7 Day 10 Day 13 Day 16

Chlorate 0.01 0.1 0.5 1.0 1.8 2.4

Water control 0 0 0 0 0 0

Chlorine dioxide 0.1 1.0 5.0 10.0 18.0 24.0

Chlorite 0.01 0.1 0.5 1.0 1.8 2.4

Chlorine 0.1 1.0 5.0 10.0 18.0 24.0

Chloramine 0.01 1.0 8.0 18.0 24.0

aFor each dose, two portions of 500 ml each were administered at 4-hr intervals.

Table

>

>

> Hello Healinghope,

>

> That is a great study.

>

> It shows that 1/2 drop of MMS in 1 liter of water, an amount that produces a

concentration of 5 PPM, is safe.

>

> Now, how does that relate to the MMS protocol?

>

> Tom

>

>

> --- In , " healinghope " <mfrreman@>

wrote:

> >

> > http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569027/

> > To assess the relative safety of chronically administered chlorine water

disinfectants in man, a controlled study was undertaken. The clinical evaluation

was conducted in the three phases common to investigational drug studies. Phase

I, a rising dose tolerance investigation, examined the acute effects of

progressively increasing single doses of chlorine disinfectants to normal

healthy adult male volunteers. Phase II considered the impact on normal subjects

of daily ingestion of the disinfectants at a concentration of 5 mg/l. for twelve

consecutive weeks. Persons with a low level of glucose-6-phosphate dehydrogenase

may be expected to be especially susceptible to oxidative stress; therefore, in

Phase III, chlorite at a concentration of 5 mg/l. was administered daily for

twelve consecutive weeks to a small group of potentially at-risk

glucose-6-phosphate dehydrogenase-deficient subjects. Physiological impact was

assessed by evaluation of a battery of qualitative and quantitative tests. The

three phases of this controlled double-blind clinical evaluation of chlorine

dioxide and its potential metabolites in human male volunteer subjects were

completed uneventfully. There were no obvious undesirable clinical sequellae

noted by any of the participating subjects or by the observing medical team. In

several cases, statistically significant trends in certain biochemical or

physiological parameters were associated with treatment; however, none of these

trends was judged to have physiological consequence. One cannot rule out the

possibility that, over a longer treatment period, these trends might indeed

achieve proportions of clinical importance. However, by the absence of

detrimental physiological responses within the limits of the study, the relative

safety of oral ingestion of chlorine dioxide and its metabolites, chlorite and

chlorate, was demonstrated.

> >

>

[Guest guest]

Hello Mfrreman,

On Day 1 they drank 1 liter of water that had 0.1 PPM chlorine dioxide. They

took no chlorine dioxide for the next 2 days, then on Day 4 drank 1 liter of

water that had 1 PPM chlorine dioxide. Next they skipped a few days and on Day

7 took a liter of water that had 5 PPM. Skip a few more days with nothing and

on Day 10 drink a liter of 10 PPM chlorine dioxide water. Skip a few more days

and on Day 13 drink a liter with a concentration of 18 PPM. Skip a few more

days and end up on Day 16 drinking a liter of water that has a concentration of

24 PPM chlorine dioxide.

24 PPM in 1 liter of water is 3 drops of MMS.

Over 16 days the study found that it was safe to consume the equivalent of a

total of a little over 7 drops of MMS.

I might also point out that these concentrations were made using chlorine

dioxide technology, and did not involve drinking acidified sodium chlorite.

Now, how does this relate to the MMS protocol?

The MMS protocol at 3 drops has you drinking a solution with about 190 PPM

chlorine dioxide every couple of hours.

If it is " safe " to drink a solution that has a concentration of 24 PPM once in

16 days, does that mean that it is also safe to drink a solution that has a

concentration of 190 PPM every 2 hours over a period of several days?

I might also add that water purification is done at a concentration around 2

PPM.

Tom

--- In , " mfrreman " <mfrreman@...>

wrote:

>

> Tom Perhaps the way this relates to mms is a study with man. Also if you look

at the entire study on day 16 the concentration was much higher. Day 16 was 24.0

not 5.0

> ORAL INTAKE OF CHLORINE DISINFECTANTS IN MAN

> Table 1. Concentration of disinfectants in phase I: acute rising dose

tolerance.a

> Disinfectant concentration, mg/l.

> Water disinfectant Day 1 Day 4 Day 7 Day 10 Day 13 Day 16

> Chlorate 0.01 0.1 0.5 1.0 1.8 2.4

> Water control 0 0 0 0 0 0

> Chlorine dioxide 0.1 1.0 5.0 10.0 18.0 24.0

> Chlorite 0.01 0.1 0.5 1.0 1.8 2.4

> Chlorine 0.1 1.0 5.0 10.0 18.0 24.0

> Chloramine 0.01 1.0 8.0 18.0 24.0

> aFor each dose, two portions of 500 ml each were administered at 4-hr

intervals.

> Table

>

[Guest guest]

At least you read the study this time. Tom you are insistent on being right even

when wrong. Chlorine dioxide is the study Tom, that is MMS.

>

>

> Hello Mfrreman,

>

> On Day 1 they drank 1 liter of water that had 0.1 PPM chlorine dioxide. They

took no chlorine dioxide for the next 2 days, then on Day 4 drank 1 liter of

water that had 1 PPM chlorine dioxide. Next they skipped a few days and on Day

7 took a liter of water that had 5 PPM. Skip a few more days with nothing and

on Day 10 drink a liter of 10 PPM chlorine dioxide water. Skip a few more days

and on Day 13 drink a liter with a concentration of 18 PPM. Skip a few more

days and end up on Day 16 drinking a liter of water that has a concentration of

24 PPM chlorine dioxide.

>

> 24 PPM in 1 liter of water is 3 drops of MMS.

>

> Over 16 days the study found that it was safe to consume the equivalent of a

total of a little over 7 drops of MMS.

>

> I might also point out that these concentrations were made using chlorine

dioxide technology, and did not involve drinking acidified sodium chlorite.

>

> Now, how does this relate to the MMS protocol?

>

> The MMS protocol at 3 drops has you drinking a solution with about 190 PPM

chlorine dioxide every couple of hours.

>

> If it is " safe " to drink a solution that has a concentration of 24 PPM once in

16 days, does that mean that it is also safe to drink a solution that has a

concentration of 190 PPM every 2 hours over a period of several days?

>

> I might also add that water purification is done at a concentration around 2

PPM.

>

> Tom

>

>

> --- In , " mfrreman " <mfrreman@>

wrote:

> >

> > Tom Perhaps the way this relates to mms is a study with man. Also if you

look at the entire study on day 16 the concentration was much higher. Day 16 was

24.0 not 5.0

> > ORAL INTAKE OF CHLORINE DISINFECTANTS IN MAN

> > Table 1. Concentration of disinfectants in phase I: acute rising dose

tolerance.a

> > Disinfectant concentration, mg/l.

> > Water disinfectant Day 1 Day 4 Day 7 Day 10 Day 13 Day 16

> > Chlorate 0.01 0.1 0.5 1.0 1.8 2.4

> > Water control 0 0 0 0 0 0

> > Chlorine dioxide 0.1 1.0 5.0 10.0 18.0 24.0

> > Chlorite 0.01 0.1 0.5 1.0 1.8 2.4

> > Chlorine 0.1 1.0 5.0 10.0 18.0 24.0

> > Chloramine 0.01 1.0 8.0 18.0 24.0

> > aFor each dose, two portions of 500 ml each were administered at 4-hr

intervals.

> > Table

> >

>

[Guest guest]

Cleary this company is using acidified sodium chlorite (MMS) to get the " active

ingredient " chlorine dioxide. They clearly say their system produces a chlorous

acid/chlorine dioxide complex, which increases its efficacy. And " numerous

studies " show no adverse health effects by skin contact or ingestion. Ole Tom

says this is exactly what MMS does, but he keeps claiming it is not proven safe.

Who is wrong, Tom or this pharma company?

2. What is the " DioxiCare® System " ?

The DioxiCare® System is Frontier Pharmaceutical's proprietary method of

generating chlorine dioxide for small-scale application. The gas is captured in

a liquid or gel at specific concentrations. The activated product is immediately

available for use. Frontier's inventive 2-part system enables the user to

produce the active ingredient on demand, and at an acidity that is suitable for

use on the body. This is in contrast to other chlorine dioxide systems which

require lower, more irritating acidity levels, and long reaction times to

achieve usable concentrations. The DioxiCare System actually produces a chlorous

acid/chlorine dioxide complex, which increases its efficacy. Frontier's

versatile products are available in liquid, gel and paste dosage forms.

3. Is chlorine dioxide safe?

The Niagara Falls New York water treatment plant first used chlorine dioxide for

drinking water disinfection in 1944. Currently, there are approximately 400 -

500 water treatment plants in the United States and over 1000 in Europe

utilizing ClO2 to purify municipal drinking water systems. Numerous studies have

shown chlorine dioxide, when used at the appropriate concentrations, has no

adverse health effects, either by skin contact or ingestion.

http://www.frontierpharm.com/faqs.php?osCsid=69b1e680949060ba4dacef3829413a2d#ac\

tive

> >

> >

> > Hello Mfrreman,

> >

> > On Day 1 they drank 1 liter of water that had 0.1 PPM chlorine dioxide.

They took no chlorine dioxide for the next 2 days, then on Day 4 drank 1 liter

of water that had 1 PPM chlorine dioxide. Next they skipped a few days and on

Day 7 took a liter of water that had 5 PPM. Skip a few more days with nothing

and on Day 10 drink a liter of 10 PPM chlorine dioxide water. Skip a few more

days and on Day 13 drink a liter with a concentration of 18 PPM. Skip a few

more days and end up on Day 16 drinking a liter of water that has a

concentration of 24 PPM chlorine dioxide.

> >

> > 24 PPM in 1 liter of water is 3 drops of MMS.

> >

> > Over 16 days the study found that it was safe to consume the equivalent of a

total of a little over 7 drops of MMS.

> >

> > I might also point out that these concentrations were made using chlorine

dioxide technology, and did not involve drinking acidified sodium chlorite.

> >

> > Now, how does this relate to the MMS protocol?

> >

> > The MMS protocol at 3 drops has you drinking a solution with about 190 PPM

chlorine dioxide every couple of hours.

> >

> > If it is " safe " to drink a solution that has a concentration of 24 PPM once

in 16 days, does that mean that it is also safe to drink a solution that has a

concentration of 190 PPM every 2 hours over a period of several days?

> >

> > I might also add that water purification is done at a concentration around 2

PPM.

> >

> > Tom

> >

> >

> > --- In , " mfrreman " <mfrreman@>

wrote:

> > >

> > > Tom Perhaps the way this relates to mms is a study with man. Also if you

look at the entire study on day 16 the concentration was much higher. Day 16 was

24.0 not 5.0

> > > ORAL INTAKE OF CHLORINE DISINFECTANTS IN MAN

> > > Table 1. Concentration of disinfectants in phase I: acute rising dose

tolerance.a

> > > Disinfectant concentration, mg/l.

> > > Water disinfectant Day 1 Day 4 Day 7 Day 10 Day 13 Day 16

> > > Chlorate 0.01 0.1 0.5 1.0 1.8 2.4

> > > Water control 0 0 0 0 0 0

> > > Chlorine dioxide 0.1 1.0 5.0 10.0 18.0 24.0

> > > Chlorite 0.01 0.1 0.5 1.0 1.8 2.4

> > > Chlorine 0.1 1.0 5.0 10.0 18.0 24.0

> > > Chloramine 0.01 1.0 8.0 18.0 24.0

> > > aFor each dose, two portions of 500 ml each were administered at 4-hr

intervals.

> > > Table

> > >

> >

>

[Guest guest]

Actually I should point out this company is probably not using chlorine dioxide

at the concentrations recommended by Jim. The big problem with Tom's PPM

mentality is that is a description of what happens OUTSIDE the body in a

non-living situation. Jim has always ignored PPM because you mix your dose of

mms with as much water/juice as you want, the PPM is irrelevant. This is

because inside the body is a living, intelligent system. The immune system

cells can grab the chlorine dioxide molecules and take them to where they are

needed--this is an intelligent system--not a dead, outside the body system. So

the body does not need PPM concentrations floating in the blood to kill off

pathogens, it only needs to get the chlorine dioxide molecules in the dose into

the hands of the intelligent immune system components. This is what Jim has

always said. The chlorine dioxide molecules are super powerful weapons placed

right into the hands of the immune system, not just floating around in the blood

randomly as in an outside the body situation. If you understand this, then only

small amounts of chlorine dioxide are needed to get great effects. It explains

why the chemistry outside the body is not very relevant, and yet Tom keeps

stressing it.

> > >

> > >

> > > Hello Mfrreman,

> > >

> > > On Day 1 they drank 1 liter of water that had 0.1 PPM chlorine dioxide.

They took no chlorine dioxide for the next 2 days, then on Day 4 drank 1 liter

of water that had 1 PPM chlorine dioxide. Next they skipped a few days and on

Day 7 took a liter of water that had 5 PPM. Skip a few more days with nothing

and on Day 10 drink a liter of 10 PPM chlorine dioxide water. Skip a few more

days and on Day 13 drink a liter with a concentration of 18 PPM. Skip a few

more days and end up on Day 16 drinking a liter of water that has a

concentration of 24 PPM chlorine dioxide.

> > >

> > > 24 PPM in 1 liter of water is 3 drops of MMS.

> > >

> > > Over 16 days the study found that it was safe to consume the equivalent of

a total of a little over 7 drops of MMS.

> > >

> > > I might also point out that these concentrations were made using chlorine

dioxide technology, and did not involve drinking acidified sodium chlorite.

> > >

> > > Now, how does this relate to the MMS protocol?

> > >

> > > The MMS protocol at 3 drops has you drinking a solution with about 190 PPM

chlorine dioxide every couple of hours.

> > >

> > > If it is " safe " to drink a solution that has a concentration of 24 PPM

once in 16 days, does that mean that it is also safe to drink a solution that

has a concentration of 190 PPM every 2 hours over a period of several days?

> > >

> > > I might also add that water purification is done at a concentration around

2 PPM.

> > >

> > > Tom

> > >

> > >

> > > --- In , " mfrreman " <mfrreman@>

wrote:

> > > >

> > > > Tom Perhaps the way this relates to mms is a study with man. Also if you

look at the entire study on day 16 the concentration was much higher. Day 16 was

24.0 not 5.0

> > > > ORAL INTAKE OF CHLORINE DISINFECTANTS IN MAN

> > > > Table 1. Concentration of disinfectants in phase I: acute rising dose

tolerance.a

> > > > Disinfectant concentration, mg/l.

> > > > Water disinfectant Day 1 Day 4 Day 7 Day 10 Day 13 Day 16

> > > > Chlorate 0.01 0.1 0.5 1.0 1.8 2.4

> > > > Water control 0 0 0 0 0 0

> > > > Chlorine dioxide 0.1 1.0 5.0 10.0 18.0 24.0

> > > > Chlorite 0.01 0.1 0.5 1.0 1.8 2.4

> > > > Chlorine 0.1 1.0 5.0 10.0 18.0 24.0

> > > > Chloramine 0.01 1.0 8.0 18.0 24.0

> > > > aFor each dose, two portions of 500 ml each were administered at 4-hr

intervals.

> > > > Table

> > > >

> > >

> >

>

[Guest guest]

Jim has always ignored PPM because you mix your dose of mms with as much

water/juice as you want, the PPM is irrelevant. This is because inside the

body is a living, intelligent system. The immune system cells can grab the

chlorine dioxide molecules and take them to where they are needed--this is

an intelligent system--not a dead, outside the body system.

>>>>>>>>>>>>>>>>>>>>

Okay, now I get it...finally. all the ppl that it doesn't work on have

stupid systems.

Sheesh...thanks for clearing that up

[Guest guest]

Hello Healinghope,

Actually MMS is all about acidified sodium chlorite...

Chlorine dioxide technology is different.

I might point out that after spending 16 days increasing the dose and ending

with a MMS equivalent amount of a little over 7 drops, they went on to study

what happens when people drink 5 PPM over 12 weeks. That is like putting 1/2

drop of MMS into 1 liter of water and drinking that liter in a day. That is the

long term study with humans that Jim Humble claims that proves that MMS is safe

to consume.

Tom

--- In , " healinghope " <mfrreman@...>

wrote:

>

> At least you read the study this time. Tom you are insistent on being right

even when wrong. Chlorine dioxide is the study Tom, that is MMS.

>

[Guest guest]

Hello Healinghope,

Frontier Pharmaceutical makes products for topical use on animals. They are

using concentrations in the 5 - 20 PPM range. They make some great products.

Yes, chlorine dioxide technology is used to disinfect water at concentrations in

the 2 PPM range. They don't use acidified sodium chlorite to treat water.

When properly used at the correct concentrations, chlorine dioxide is very safe

to use and has no adverse effects. The studies have shown this with rising

concentrations up to 24 PPM and over long term studies at 5 PPM.

Keep in mind that a 3 drop dose of MMS is about 190 PPM, and the protocol calls

for taking that amount every couple of hours.

Tom

--- In , " healinghope " <mfrreman@...>

wrote:

>

> Cleary this company is using acidified sodium chlorite (MMS) to get the

" active ingredient " chlorine dioxide. They clearly say their system produces a

chlorous acid/chlorine dioxide complex, which increases its efficacy. And

" numerous studies " show no adverse health effects by skin contact or ingestion.

Ole Tom says this is exactly what MMS does, but he keeps claiming it is not

proven safe. Who is wrong, Tom or this pharma company?

> 2. What is the " DioxiCare® System " ?

>

> The DioxiCare® System is Frontier Pharmaceutical's proprietary method of

generating chlorine dioxide for small-scale application. The gas is captured in

a liquid or gel at specific concentrations. The activated product is immediately

available for use. Frontier's inventive 2-part system enables the user to

produce the active ingredient on demand, and at an acidity that is suitable for

use on the body. This is in contrast to other chlorine dioxide systems which

require lower, more irritating acidity levels, and long reaction times to

achieve usable concentrations. The DioxiCare System actually produces a chlorous

acid/chlorine dioxide complex, which increases its efficacy. Frontier's

versatile products are available in liquid, gel and paste dosage forms.

>

> 3. Is chlorine dioxide safe?

>

> The Niagara Falls New York water treatment plant first used chlorine dioxide

for drinking water disinfection in 1944. Currently, there are approximately 400

- 500 water treatment plants in the United States and over 1000 in Europe

utilizing ClO2 to purify municipal drinking water systems. Numerous studies have

shown chlorine dioxide, when used at the appropriate concentrations, has no

adverse health effects, either by skin contact or ingestion.

>

http://www.frontierpharm.com/faqs.php?osCsid=69b1e680949060ba4dacef3829413a2d#ac\

tive

>

[Guest guest]

Hello Healinghope,

Sorry, but all oxidative therapies involve having a concentration of the oxidant

in contact with the pathogen for a specific amount of time.

You, and Jim, can dream up some magic method of the immune system using chlorine

dioxide, but chlorine dioxide is a killer. By killing things off the immune

system may be stimulated, but the immune system doesn't use chlorine dioxide.

The reason so many people have poor results when using MMS is that they don't

have the proper concentration in contact with the pathogen and it doesn't get

killed off.

Jim has mentioned PPM several times. He ignores the science behind it because

he doesn't understand how these chemicals work.

Tom

--- In , " healinghope " <mfrreman@...>

wrote:

>

> Actually I should point out this company is probably not using chlorine

dioxide at the concentrations recommended by Jim. The big problem with Tom's

PPM mentality is that is a description of what happens OUTSIDE the body in a

non-living situation. Jim has always ignored PPM because you mix your dose of

mms with as much water/juice as you want, the PPM is irrelevant. This is

because inside the body is a living, intelligent system. The immune system

cells can grab the chlorine dioxide molecules and take them to where they are

needed--this is an intelligent system--not a dead, outside the body system. So

the body does not need PPM concentrations floating in the blood to kill off

pathogens, it only needs to get the chlorine dioxide molecules in the dose into

the hands of the intelligent immune system components. This is what Jim has

always said. The chlorine dioxide molecules are super powerful weapons placed

right into the hands of the immune system, not just floating around in the blood

randomly as in an outside the body situation. If you understand this, then only

small amounts of chlorine dioxide are needed to get great effects. It explains

why the chemistry outside the body is not very relevant, and yet Tom keeps

stressing it.

>