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Health Benefits DMSO: Dimethyl Sulfoxide

Dimethyl Sulfoxide

Also known as: DMSO; Dimethylsulphoxide; RIMSO

Description

Dimethyl Sulfoxide is a Sulfuric Compound originally used as an industrial

solvent that since the 1960's has been recognized for various therapeutic

benefits - its usage has been highly controversial.

Health Benefits of DMSO

Detoxification

DMSO (administered intravenously) facilitates the excretion of excessive

accumulated Amyloid (amyloidosis).

DMSO (applied topically) protects the body against the toxic effects of X-Rays

[scientific research - animals].

Excretory System

DMSO (50% solution applied topically to the Feet) alleviates Foot Odour

(Bromidrosis) [observations to date indicate that the longer that the DMSO

solution is allowed to remain in contact with the feet, the longer thereafter

the Foot Odour subsides].

DMSO has been approved by the FDA in the treatment of Interstitial Cystitis (IC)

[scientific research - double blind human studies: DMSO markedly improves the

condition of 93% of IC patients]:

DMSO treatment for IC should be administered by a suitably qualified medical

practitioner - the usual treatment protocol involves the administration of a 50%

solution of DMSO intravesically (i.e. instilled into the Urinary Tract) every 2

weeks for 2 sessions of 4 treatments each.

Immune System

DMSO helps to alleviate Allergies (by " unfolding " Cell Membranes, DMSO permits

more Antigens to attach to Cell Membranes, where they are more effectively

neutralized by Antibodies).

DMSO significantly lessens Inflammation and swelling by reducing inflammatory

exudate and enhancing the development of granulation tissue. DMSO facilitates

the movement of Macrophages around and through the body's tissues (by increasing

the body's production of Migration Inhibitory Factor [MIF]).

Metabolism

DMSO deactivates Hydroxyl Free Radicals (DMSO combines with Hydroxyl Free

Radicals to form Dimethyl Sulfone and Water which are then readily excreted from

the body).

Musculoskeletal System

DMSO (either applied topically or consumed orally) minimizes the damage caused

by crushing injuries such as Bruises and pulled or wrenched Muscles :

- DMSO is a powerful scavenger of Hydroxyl Free Radicals which are responsible

for much of the damage caused in these injuries.

- If DMSO is applied quickly to an injury it is possible to eliminate entirely

any Bruising.

DMSO alleviates Rheumatoid Arthritis (by deactivating Hydroxyl Free Radicals

which are one of the principal causes of the Inflammation and Pain associated

with Rheumatoid Arthritis).

Nervous System

DMSO (DMSO/Amino Acid Combination) therapy partially reverses some of the

abnormalities that occur in Down's Syndrome [scientific research - humans:

DMSO/Amino Acid therapy causes a tendency towards accelerated maturity in Down's

Syndrome children treated, with marked progress in language integration. In some

cases, this therapy causes the physical appearance of Down's Syndrome children

to more closely resemble that of normal children].

DMSO markedly reduces the formation of the abnormal Antibodies that are

characteristic of Myasthenia Gravis [scientific research - animals: note that

this finding has not yet been confirmed for humans]:

- As a secondary means of alleviating Myasthenia Gravis, DMSO also inhibits the

actions of Cholinesterases (similarly to the Anticholinesterase Pharmaceutical

Drugs employed by orthodox medicine in the treatment of Myasthenia Gravis).

DMSO alleviates Pain by impeding the conduction of Nerve Impulses relating to

the Pain sensation in the smaller Nerve Fibers.

DMSO (1 gram per kg of body weight administered intravenously in a 40% solution

within 1 hour of the occurrence of quadriplegia) helps to prevent Paralysis

following injuries to the Brain or Spinal Cord (by inhibiting the Free Radical

damage that causes Paralysis) [scientific research].

DMSO (1 gram per kg of body weight administered intravenously into the Spinal

Cord in a 40% solution within 1 hour of the occurrence of quadriplegia) helps to

prevent Paralysis following injuries to the Spinal Cord that would otherwise

cause Quadriplegia [scientific research - animals & humans: this treatment often

results in total avoidance and reversal of paralysis/quadriplegia].

DMSO (administered intravenously within 4 hours, and preferably within 90

minutes of its occurrence) helps to prevent the after-effects (including

Paralysis) following (the Embolic and Hemorrhagic forms of) Stroke [scientific

research - animals].

Respiratory System

DMSO (placed directly into the nostrils) can open the blocked Sinuses that are

associated with Sinusitis [scientific observation -

humans: relief occurs within minutes].

Skin

DMSO (applied topically) alleviates the lesions that occur as a result of Herpes

Zoster (Shingles).

DMSO (applied topically) helps to dissolve the (skin) tissues involved in

Scarring [scientific research - humans: a concentration of 50-80% DMSO applied

topically 3 times per day flattens raised external scars after several months -

microscopic examination of the skin will reveal loosening of Collagen bundles].

DMSO (applied topically) potently alleviates Scleroderma (where Scleroderma

affects the Skin).

DMSO Enhances the Function of these Substances

DMSO enhances the bioavailability of many substances (it has the capability to

transport many therapeutic substances across the body's Cell Membranes without

altering the integrity of Cell Membranes). By increasing their bioavailability,

DMSO permits a lower dosage of some drugs than would otherwise be required.

Enzymes

DMSO inhibits the release of Cholinesterases (i.e. it possesses similar

properties to Pharmaceutical Anticholinesterases).

Hormones

When exogenous forms of endogenous Steroids (including Testosterone and the

Hydrocortisone form of Cortisone) are dissolved in DMSO prior to topical

application, their topical bioavailability increases by 300% [scientific

research - humans].

Immune System Chemicals

DMSO can enter Cells to prime or activate the sub-cellular mechanisms involved

in the production and release of Migration Inhibitory Factor (MIF) and in

addition, produces a cofactor that enhances MIF or has MIF-like activity.

Neurotransmitters

DMSO facilitates the transport of (supplemental) Gamma Aminobutyric Acid (GABA)

across the Blood-Brain Barrier (without DMSO as a carrier-vehicle, GABA poorly

crosses the Blood-Brain Barrier).

Pharmaceutical Drugs

DMSO enhances the bioavailability and effectiveness of many Anti-Viral

Pharmaceutical Drugs (DMSO facilitates their transport directly across Cell

Membranes into Cells where they are most potent against Viruses).

DMSO facilitates the absorption of Penicillins - i.e. Penicillins can be

dissolved in DMSO and applied topically where they are efficiently transported

across the Skin.

These Substances Enhance the Function of DMSO

Antioxidants

Antioxidants counteract DMSO's tendency to convert to Sulfoxide Free Radicals.

Side Effects of DMSO Therapy

Excretory System

DMSO (temporarily) causes Halitosis in the form of a garlic-like odor of the

breath (this odor is very unpleasant and appears to be the major practical

drawback in the usage of DMSO).

Free Radicals

After chemically reacting with Hydroxyl Free Radicals, DMSO is converted to a

Sulfoxide Free Radical.

Skin

Itching is a common side effect of topical DMSO therapy - this side effect can

usually be avoided by diluting the concentration of DMSO. Skin Rashes are a

common side effect of topical DMSO therapy - this side effect can usually be

avoided by diluting the concentration of DMSO.

Myths Dispelled

Eyes/Eyesight

DMSO is often avoided by orthodox medical practitioners due to UNFOUNDED fears

that it can cause Cataracts and other changes within the human Eye:

- This aspect of DMSO toxicology has been extensively tested in both animals and

humans: the results clearly show that DMSO does NOT cause Cataracts in humans

even at extremely high dosages for periods up to two years. No adverse changes

were found in human or monkey eyes after prolonged, high levels (up to 30 times

the usual dosage) of DMSO treatment.

- The myth regarding DMSO's toxicity to human Eyes arises from toxicology

studies that show that DMSO DOES cause Cataracts and other changes in the Eyes

of both dogs and rabbits, however the toxicity of DMSO to the eyes of these

animals definitely differs from that of humans.

Bioavailability

DMSO has the ability to pass through every tissue and Cell Membrane of the body

except the Enamel of Teeth, fingernails and Hair without destroying the

integrity of these tissues and Cell Membranes (i.e. it is a membrane penetrate).

DMSO also permits the passage of a number of compounds across the barriers of

Cell Membranes.

DMSO is readily absorbed when administered topically onto human Skin - peak

levels occur after 4-8 hours. Topical administered DMSO is slightly less

bioavailable than orally ingested DMSO.

Orally ingested DMSO is also rapidly absorbed and reaches a blood serum peak in

4 hours and becomes undetectable after 120 hours.

DMSO readily crosses the Blood-Brain Barrier (this property of DMSO allows its

utilization as an effective vehicle for transporting other substances that may

not normally cross the Blood-Brain Barrier).

DMSO is excreted from the body partly in an unchanged state and partly as its

metabolite - Dimethyl Sulfoxone (DMSO2).

DMSO as part of the Global Sulfur Cycle

DMSO is an intermediate product of the methyl-S-methane global Sulfur cycle

which distributes bioavailable Sulfur for all animal and plant life.

Approximately 85% of Sulfur (for life) is derived from the pathway:

- Sulfonium Salts > Dimethylsulfide > Dimethyl Sulfoxide (DMSO) >

Methylsulfonylmethane (MSM)

- Sulfonium Salts (produced by phytoplankton in Water) yield the volatile

thioether named Dimethylsulfide which is released into the upper atmosphere.

- Sunlight catalyzes the oxidation of Dimethylsufide to DMSO.

- DMSO is further oxidized in the upper atmosphere (by Sunlight) to form MSM.

- This MSM is then concentrated into raindrops which return to the surface of

the earth.

- Plants absorb and accumulate this MSM (and use some of this MSM for bulding

Sulfuric compounds).

Forms of DMSO

DMSO is manufactured in liquid and gel forms.

Dosage Recommendations

Long Term Dosage Reduction

Less DMSO is required to achieve therapeutic results as time passes (i.e. the

cumulative effects of DMSO appear to increase with the passage of time).

Topical Therapeutic Dosage Protocol

The liquid form of DMSO is the most effective form of topical DMSO application,

although most people prefer the gel form.

Topically applied DMSO is not rubbed onto the Skin but painted or patted on with

a thin coating.

The concentration of DMSO used in topical treatments should ideally be

individualized on a cases by case basis - the optimal concentration varies from

50-80% DMSO.

The Face and Neck are more sensitive to topical DMSO than other parts of the

body - the maximum concentration of DMSO for application to the Face or Neck

should be no greater than 50%.

Topical applications of DMSO should not exceed 70% in areas of the skin affected

by poor circulation. It is desirable to commence topical DMSO treatment at low

concentrations until Skin tolerance builds up.

The Skin must be clean, dry and unbroken before topical application of DMSO.

Aloe Vera gel is an excellent remedy for the temporary Skin irritation that

sometimes occurs as a result of topical DMSO therapy.

Oral DMSO Dosage Protocol

The usual oral dosage of DMSO is 1 - 2 teaspoons (5 - 10 ml) per day.

Oral DMSO is normally mixed with Tomato juice or Grape juice to mask its " foul "

taste.

Intravenous Injections of DMSO Dosage Protocol

Up to 20 cc DMSO that has been diluted to a 25% concentration with sterile water

is often administered via intravenous injection by suitably trained physicians

for the treatment of the more serious degenerative diseases.

Injected DMSO is not administered by infusion or by the drip technique but is

administered by the " slow push " method which involves a slow push into the

bloodstream all at once.

Intravenous Drip DMSO Dosage Protocol

The slow intravenous drip method is applied over a 2-3 hour period. It involves

the addition of 50-100 cc DMSO to a 500 cc glucose or saline solution, dripped

into a vein in the patient's arm. This method should only be administered by a

suitably qualified physician.

Commercial Availability of DMSO

Industrial Grade DMSO

Caution: many of the industrial grade DMSO solutions intended for use as

solvents have an acid or Acetone contamination of several percent. Acetone

contamination can lead to serious medical consequences - because of its small

molecular weight, Acetone is readily carried into the blood by

Acetone-contaminated DMSO.

Source of Commercial DMSO

In the USA, commercially manufactured DMSO is derived from Lignin.

DMSO/Water Combinations

Brand Composition Description

RIMSO-50: 50% DMSO

50% Water Pure pharmaceutical grade DMSO manufactured by Terra Pharmaceuticals

Inc. of Buena Park, California.

Supplied in 50 cc vials.

Domosa: 90% DMSO

10% Water Pharmaceutical grade DMSO suitable for injection or for further

dilution with water for topical or oral ingestion.

Supplied in pint bottles and in gallon bottles for veterinary use.

Dimexide: Brand name for DMSO in Russia.

DMSO/Amino Acid Combinations

Brand Country Available Description

Akron:

Merinex: Argentina

Chile DMSO combined with Amino Acids (Gamma-Aminobutyric Acid [GABA],

Gamma-Amino-Beta-Hydroxybutyric Acid [GABOB] and Acetylglutamine).5 ml ampoules

(for intramuscular injection) and capsules (for oral administration).The dosage

protocol for DMSO/Amino Acid combinations involves one intramuscular injection

every 2nd day and 2 or 3 capsules orally each day. Injections are suspended

every 40 days for a rest period of 1 month during which capsules are still used.

This program of treatment normally lasts for 1 year.Akron and Merinex are not

approved by the FDA for use in the USA.

Vasoactive DMSO Combinations

Ipran is the trade name of a vasoactive DMSO product, however this product has

not been approved for use in the USA.

DMSO's Chemical Structure

The DMSO molecule is ten-sided with a center occupied by a Sulfur atom. It

contains two methyl groups - an oxygen atom and a nonbinding electron pair -

located at the points of the tetrahydron.

Molecular weight: 78.15

Freezing point: 68 degrees Fahrenheit

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