Guest guest Posted March 21, 1999 Report Share Posted March 21, 1999 When I first got sick, I had a rash on my leg which looked something like a bulls-eye rash. Dr wasn't sure if it was and put me on tetracycline for 14 days. After I finished the tetracycline, I was still having symptoms. The dr felt if I had lyme, he cured me with 14 days of tetracycline and told me I had CFIDS. But 18 months later I tested positive for lyme and was treated with IV antibiotics and oral antibiotics. I felt better while on the antiobiotics and my joint pain improved a lot. But once off antibiotics for a while, I got worse. Drs then said I no longer had lyme disease but that I now had autoimmune problems. Some drs say that I never had lyme (that tests were false positive) and that I had autoimmune problems/connective tissue disease all along. Others believe that lyme may have triggered autoimmune/connective tissue disease problems. I still wonder if I have chronic lyme disease, still active, which also caused autoimmune problems. I am going to have lyme test repeated again. I am on doxycycline and think it is helping whether for lyme or connective tissue disease, although with lyme I think the dosage is higher. I wish the tests for lyme were 100% reliable. I think too many drs, at least here in the US, dismiss lyme as a diagnosis or feel that it is easily curable which I don't think is always the case. Carol E from NY Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 14, 1999 Report Share Posted May 14, 1999 Can someone more knowledgable than me please help this gentleman? Sure would appreciate it!!! His e-mail is mikeyookie@... > > Hi, > my name is and I attend Glen Waverley Secondary College in > Melbourne Australia. I am currently in year 11. I was wondering if you > would be kind enough to send me some information on Lyme disease. This > could include: - > -damage caused to the host organism > -characteristics of the pathogen > -techniques used by the host to survive > > If you are unable to send me this information, I will understand. If > you do send it to me, I would be most grateful. > Sincerely yours, > Ng Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 14, 1999 Report Share Posted May 14, 1999 I sent him to Georgia. She is finder (and keeper) of Lyme medical texts on the Lyme NG. > >From: " " <jeand@...> > >Can someone more knowledgable than me please help this gentleman? Sure > >would appreciate it!!! His e-mail is mikeyookie@... > >> Hi, > >> my name is and I attend Glen Waverley Secondary College in > >> Melbourne Australia. I am currently in year 11. I was wondering if you > >> would be kind enough to send me some information on Lyme disease. This > >> could include: - > >> -damage caused to the host organism > >> -characteristics of the pathogen > >> -techniques used by the host to survive > >> > >> If you are unable to send me this information, I will understand. If > >> you do send it to me, I would be most grateful. > >> Sincerely yours, > >> Ng Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 14, 1999 Report Share Posted May 14, 1999 I wish I could help this guy, but I really don't know all that much about anything. Have you tried posting this to the Lyme newsgroup, or is that where you got it from? In the meantime I will send him Tom Grier's essay on " The Complexities of Lyme. " Marta - >From: " " <jeand@...> > >Can someone more knowledgable than me please help this gentleman? Sure >would appreciate it!!! > >His e-mail is mikeyookie@... > >> >> Hi, >> my name is and I attend Glen Waverley Secondary College in >> Melbourne Australia. I am currently in year 11. I was wondering if you >> would be kind enough to send me some information on Lyme disease. This >> could include: - >> -damage caused to the host organism >> -characteristics of the pathogen >> -techniques used by the host to survive >> >> If you are unable to send me this information, I will understand. If >> you do send it to me, I would be most grateful. >> Sincerely yours, >> Ng > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 14, 1999 Report Share Posted May 14, 1999 Thanks ... appreciate that. Jean Re: [Lyme-aid] Fw: Lyme Disease > From: FIG4159@... > > I sent him to Georgia. She is finder (and keeper) of Lyme medical texts on > the Lyme NG. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 15, 1999 Report Share Posted May 15, 1999 Now why didn't I think of that! Good thinking, she has the most information of anyone I know in the Lyme community! >From: FIG4159@... > >I sent him to Georgia. She is finder (and keeper) of Lyme medical texts on >the Lyme NG. > > > >> >From: " " <jeand@...> >> >Can someone more knowledgable than me please help this gentleman? Sure >> >would appreciate it!!! His e-mail is mikeyookie@... >> >> Hi, >> >> my name is and I attend Glen Waverley Secondary College in >> >> Melbourne Australia. I am currently in year 11. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 18, 1999 Report Share Posted June 18, 1999 : The physician at the Emergency Room diagnosed me as having Lyme Disease based on my symptoms - arthritis like pain in every joint in my body, slight fever, nausea. Then when the test came back, it was negative. I know there is a test for it but I am not sure what the test is called. If you feel you need the test, I would insist your doctor follow up. It is just a blood test so there shouldn't be any reason for your doctor to refuse. Good luck. Kaye (AIH) in Ohio CRBDJB@... wrote: > From: CRBDJB@... > > I think last comment from me today-- > > For those of you misdiagnosed with Lyme Disease, why did that happen? And for > all others have you been tested for Lyme Disease? > > I was just wondering, since this is one test I have not had and plan to ask > for it. > > Any comments? > > in Georgia > crbdjb@... > > ------------------------------------------------------------------------ > Congratulations to " PAFind, " our latest ONElist of the Week. > > How is ONElist changing YOUR life? Visit our homepage and let us know! > ------------------------------------------------------------------------ > Please support the American Liver Foundation! > > 1.) To subscribe send e-mail to -subscribeonelist > 2.) To UNsubscribe send to -unsubscribeonelist > 3.) Digest e-mail format send to -digestonelist > 4.) Normal e-mail format send to -normalonelist Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 19, 1999 Report Share Posted June 19, 1999 , Thanks for that warning about the test, I had thought it would be a simple blood test for Lyme disease. I will definitely clarify what kind of test with the doctors. So you have been diagnosed with Lyme, Lupus and AIH? How can the differentiate the AIH from the other two? How long have you been sick? In a message dated 6/18/99 4:25:12 PM Pacific Daylight Time, kslink@... writes: << , I've just been diagnosed. with Lyme disease and Lupus, been through every test I think. Started on IV Antibiotics yesterday. There is a constant battle between all of my Doctors. I've been taken off immuran while being tested and treated for the Lyme and increased the prednisone, which I had been off since March. Currently I'm feeling worse than I did prior to being diagnosed. with AIH. From what I understand there are a lot of cross over symptoms with all of these illnesses. Be careful what test you ask for. I didn't ask for it, and ended up having a spinal tap in the hospital with contrast die, just like a mylagram only shorter. What ever they did taking the fluid, my lower left side is so sore I'm having trouble walking, sitting , just about everything. mary(AIH) >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 19, 1999 Report Share Posted June 19, 1999 , I've just been diagnosed. with Lyme disease and Lupus, been through every test I think. Started on IV Antibiotics yesterday. There is a constant battle between all of my Doctors. I've been taken off immuran while being tested and treated for the Lyme and increased the prednisone, which I had been off since March. Currently I'm feeling worse than I did prior to being diagnosed. with AIH. From what I understand there are a lot of cross over symptoms with all of these illnesses. Be careful what test you ask for. I didn't ask for it, and ended up having a spinal tap in the hospital with contrast die, just like a mylagram only shorter. What ever they did taking the fluid, my lower left side is so sore I'm having trouble walking, sitting , just about everything. mary(AIH) [ ] Lyme Disease From: CRBDJB@... I think last comment from me today-- For those of you misdiagnosed with Lyme Disease, why did that happen? And for all others have you been tested for Lyme Disease? I was just wondering, since this is one test I have not had and plan to ask for it. Any comments? in Georgia crbdjb@... ------------------------------------------------------------------------ Congratulations to " PAFind, " our latest ONElist of the Week. How is ONElist changing YOUR life? Visit our homepage and let us know! ------------------------------------------------------------------------ Please support the American Liver Foundation! 1.) To subscribe send e-mail to -subscribeonelist 2.) To UNsubscribe send to -unsubscribeonelist 3.) Digest e-mail format send to -digestonelist 4.) Normal e-mail format send to -normalonelist Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 20, 1999 Report Share Posted June 20, 1999 , The AIH was diagnosed in July 1998 with Smooth Muscle Antibodies, and a liver biopsy. Thing were typical AIH treated with prednisone & immuran; tired, achy, irritable, sleeplessness, fat etc. I tapered off prednisone and stooped on Christmas day what a present. I had all the aches and pains of withdraw of prednisone, then the first week of Feb got really sick, chills fever, aches in my hands that I couldn't use them, leg aches. My GI diagnosed a viral infection that flared my AIH. I went back on prednisone for a month along whit a week of antibiotics. Felt the best I had felt in 6 years, but that was short lived. I've been having really bad bouts whit aches in my hands and legs and URQ pain since. In May went to a neurologist for the pain in my hands, and she ran the ELISA test for Lyme with the western bloc. ELISA was neg. but the western was positive for Lyme, and my ANA was 1:640. Went thru another round of test and now an infectious disease doctor and a rheumatologist. The later two were conflicting with the neurologist who thinks the diagnose Lyme disease too quickly without finds others such as lupus or cancer. I guess I glad that the neurologist was as thorough as she was. Currently I not feeling too bad except my liver counts are rising a little. I can't wait for the day that I can wake up in the morning and say I feel great and really mean It. Re: [ ] Lyme Disease From: CRBDJB@... , Thanks for that warning about the test, I had thought it would be a simple blood test for Lyme disease. I will definitely clarify what kind of test with the doctors. So you have been diagnosed with Lyme, Lupus and AIH? How can the differentiate the AIH from the other two? How long have you been sick? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 21, 1999 Report Share Posted June 21, 1999 I think my doc said there were some type of antibodies on it or something like that. I'm not for sure. I should ask him about it. >From: CRBDJB@... >Reply- onelist > onelist >Subject: Re: [ ] Lyme Disease >Date: Mon, 21 Jun 1999 11:14:04 EDT > >From: CRBDJB@... > >In a message dated 6/20/99 2:13:28 AM Pacific Daylight Time, >kslink@... >writes: > >So do they still believe you have AIH? Also to the group, so many of you >keep saying your AIH was confirmed by your biopsy, well I like some further >explanation of that, since my research tells me the biopsy only tells the >condition of the liver, it can not specifically say that any damage was >caused by AIH. > ><< , > The AIH was diagnosed in July 1998 with Smooth Muscle Antibodies, and a > liver biopsy. > Thing were typical AIH treated with prednisone & immuran; tired, achy, > irritable, sleeplessness, fat etc. > I tapered off prednisone and stooped on Christmas day what a present. I >had > all the aches and pains of withdraw of prednisone, then the first week of > Feb got really sick, chills fever, aches in my hands that I couldn't use > them, leg aches. My GI diagnosed a viral infection that flared my AIH. I > went back on prednisone for a month along whit a week of antibiotics. >Felt > the best I had felt in 6 years, but that was short lived. I've been >having > really bad bouts whit aches in my hands and legs and URQ pain since. In >May > went to a neurologist for the pain in my hands, and she ran the ELISA >test > for Lyme with the western bloc. ELISA was neg. but the western was >positive > for Lyme, and my ANA was 1:640. Went thru another round of test and now >an > infectious disease doctor and a rheumatologist. The later two were > conflicting with the neurologist who thinks the diagnose Lyme disease too > quickly without finds others such as lupus or cancer. I guess I glad >that > the neurologist was as thorough as she was. Currently I not feeling too >bad > except my liver counts are rising a little. I can't wait for the day >that I > can wake up in the morning and say I feel great and really mean It. > > ----- >> > >------------------------------------------------------------------------ >Last chance to earn $5000 for your charity of choice! > >Deadline for " GROW TO GIVE " is June 19. See homepage for details. >------------------------------------------------------------------------ >Please support the American Liver Foundation! > >1.) To subscribe send e-mail to -subscribeonelist >2.) To UNsubscribe send to -unsubscribeonelist >3.) Digest e-mail format send to -digestonelist >4.) Normal e-mail format send to -normalonelist _______________________________________________________________ Get Free Email and Do More On The Web. Visit http://www.msn.com Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 21, 1999 Report Share Posted June 21, 1999 In a message dated 6/20/99 2:13:28 AM Pacific Daylight Time, kslink@... writes: So do they still believe you have AIH? Also to the group, so many of you keep saying your AIH was confirmed by your biopsy, well I like some further explanation of that, since my research tells me the biopsy only tells the condition of the liver, it can not specifically say that any damage was caused by AIH. << , The AIH was diagnosed in July 1998 with Smooth Muscle Antibodies, and a liver biopsy. Thing were typical AIH treated with prednisone & immuran; tired, achy, irritable, sleeplessness, fat etc. I tapered off prednisone and stooped on Christmas day what a present. I had all the aches and pains of withdraw of prednisone, then the first week of Feb got really sick, chills fever, aches in my hands that I couldn't use them, leg aches. My GI diagnosed a viral infection that flared my AIH. I went back on prednisone for a month along whit a week of antibiotics. Felt the best I had felt in 6 years, but that was short lived. I've been having really bad bouts whit aches in my hands and legs and URQ pain since. In May went to a neurologist for the pain in my hands, and she ran the ELISA test for Lyme with the western bloc. ELISA was neg. but the western was positive for Lyme, and my ANA was 1:640. Went thru another round of test and now an infectious disease doctor and a rheumatologist. The later two were conflicting with the neurologist who thinks the diagnose Lyme disease too quickly without finds others such as lupus or cancer. I guess I glad that the neurologist was as thorough as she was. Currently I not feeling too bad except my liver counts are rising a little. I can't wait for the day that I can wake up in the morning and say I feel great and really mean It. ----- >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 21, 1999 Report Share Posted June 21, 1999 , Yes my hepatologist insists that I had AIH first then Lyme. I've begun to not believe all that they say. Between all of my doctors the only two that agree are the infectious disease and rheumatologist. As far as being confirmed by biopsy, the hepatologist refused to diagnose AIH until he received the biopsy results and I never questioned what the biopsy showed. Re: [ ] Lyme Disease From: CRBDJB@... In a message dated 6/20/99 2:13:28 AM Pacific Daylight Time, kslink@... writes: So do they still believe you have AIH? Also to the group, so many of you keep saying your AIH was confirmed by your biopsy, well I like some further explanation of that, since my research tells me the biopsy only tells the condition of the liver, it can not specifically say that any damage was caused by AIH. << , The AIH was diagnosed in July 1998 with Smooth Muscle Antibodies, and a liver biopsy. Thing were typical AIH treated with prednisone & immuran; tired, achy, irritable, sleeplessness, fat etc. I tapered off prednisone and stooped on Christmas day what a present. I had all the aches and pains of withdraw of prednisone, then the first week of Feb got really sick, chills fever, aches in my hands that I couldn't use them, leg aches. My GI diagnosed a viral infection that flared my AIH. I went back on prednisone for a month along whit a week of antibiotics. Felt the best I had felt in 6 years, but that was short lived. I've been having really bad bouts whit aches in my hands and legs and URQ pain since. In May went to a neurologist for the pain in my hands, and she ran the ELISA test for Lyme with the western bloc. ELISA was neg. but the western was positive for Lyme, and my ANA was 1:640. Went thru another round of test and now an infectious disease doctor and a rheumatologist. The later two were conflicting with the neurologist who thinks the diagnose Lyme disease too quickly without finds others such as lupus or cancer. I guess I glad that the neurologist was as thorough as she was. Currently I not feeling too bad except my liver counts are rising a little. I can't wait for the day that I can wake up in the morning and say I feel great and really mean It. ----- >> ------------------------------------------------------------------------ Last chance to earn $5000 for your charity of choice! Deadline for " GROW TO GIVE " is June 19. See homepage for details. ------------------------------------------------------------------------ Please support the American Liver Foundation! 1.) To subscribe send e-mail to -subscribeonelist 2.) To UNsubscribe send to -unsubscribeonelist 3.) Digest e-mail format send to -digestonelist 4.) Normal e-mail format send to -normalonelist Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 22, 1999 Report Share Posted June 22, 1999 I believe that the radiologist can determine the most likely cause of damage by the pattern of damage. When combined with autoantibody findings from bloodwork, and of course, our liver panels, it can confirm the suspicion of AIH. Unfortunately, confirm is perhaps too strong of a word, since there is no test that can say with certainty whether one has AIH or not. Don Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 24, 1999 Report Share Posted September 24, 1999 In a message dated 9/23/1999 3:30:10 PM Eastern Daylight Time, krhess@... writes: << My question for the group is: Who has been tested, treated, or researched Lyme? >> Tested and treated for lyme. When I first got sick I had a rash on my leg. 18 months later I tested positive and was treated for late-stage lyme. I had IV and oral antibiotics for about 6 months. Do believe that I got better from antibiotic tx--esp with joint pain. But then I was off antiobiotics for a while and developed many autoimmune problems. Drs feel I no longer have lyme but have undifferentiated connective tissue disease and secondary Sjogren's Syndrome. I still have a positive IgM for lyme but drs say this is false positive seen with UCTD. I'm not so sure I believe them. I think lyme triggered my autoimmune problems and also wonder if lyme disease is still an active, persistent infection with me. I am glad that I've found a dr who is willing to give me antiobiotic tx again, even though he thinks I have UCTD. So I have been on doxycycline--100 mgs every other day for about 19 months and see some improvement. I cannot tolerate higher dosages of doxy--gives me GI trouble and yeast. As far as researching lyme--I've done some of that but I think bottom line is to say that there is much controversy on this topic and that more research is needed. If anyone wants a packet of information from AmericaOnLyme, let me know and I can e-mail it. Carol E from NY Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 31, 2000 Report Share Posted January 31, 2000 In a message dated 01/31/2000 8:45:09 PM Eastern Standard Time, goingnutz@... writes: << Did any of your doctors think it was Lyme's disease. I looked up the symptoms but it doesn't seem to be it. Can arthritis come from Lyme's disease? I know you are not doctors but seem to have a great knowledge of this. >> yes, my dh was tested for Lyme disease....Lyme disease does cause arthritic symptoms....and I believe JRA kids usually do not have elevated red and white counts. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 1, 2000 Report Share Posted February 1, 2000 Did any of your doctors think it was Lyme's disease. I looked > up the symptoms but it doesn't seem to be it. Can arthritis come from Lyme's > disease? I know you are not doctors but seem to have a great knowledge of this. > > Thanks again, > Ree Ree, I don't remember them ever test or mentioning Lyme disease in my daughter's case. Amy Mother to 3 1/2 years old (poly-jra) Mother to Andy 2 years old Mother to Madeline 8 months old Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 1, 2000 Report Share Posted February 1, 2000 hello, when my son first came down with jra symptoms the first thing they did was check for lyme disease and rule that out.. jane Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 1, 2000 Report Share Posted February 1, 2000 Hello, Red blood cell counts usually go down in cases of anemia, which often accompanies chronic illness, such as JRA. White blood cell count, however, often appears elevated in cases of systemic JRA. My son's WBC at the onset of his JRA was among the highest ever seen by our pediatrician. Still, after nearly 5 years, it has never gotten down to the normal range. Close, since he started taking the injections vs. pills of MTX, but never yet to the normal range. Take care, Georgina Poos1pal@... wrote: > yes, my dh was tested for Lyme disease....Lyme disease does cause arthritic > symptoms....and I believe JRA kids usually do not have elevated red and white > counts. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 1, 2000 Report Share Posted February 1, 2000 Hi Ree, I just checked in my bookmarks file and came across a page I saved that discusses Lyme Disease misdiagnosed as JRA. I'll copy and paste some of what I've found. Hope this helps a little Take care, Georgina Lyme disease misdiagnosed as juvenile rheumatoid arthritis (JRA) ************************************************************************ as of 26 October 1999 [Note: Lyme disease was " discovered " in Lyme, Connecticut in 1975 because of the perseverance of Polly Murray, a homemaker who thought that too much juvenile rheumatoid arthritis was being diagnosed in her community.] Introduction to Lyme disease and juvenile rheumatoid arthritis (JRA): JRA is also know as: systemic JRA Still's Disease (systemic-onset JRA, adult onset JRA) juvenile chronic arthritis (JCA) juvenile arthritis (JA) monarticular juvenile arthritis polyarticular juvenile arthritis Lyme disease is also known as: Lyme arthritis Lyme borreliosis Lyme encephalopathy Lyme meningitis Tick-borne borreliosis Neuroborreliosis Borreliosis Lyme disease is a serious bacterial infection caused by a tick bite and affects humans and animals. Symptoms of Lyme disease http://www.geocities.com/HotSprings/Spa/6772/symptoms.txt [Editorial note: The purpose of this compilation of material related to Lyme disease and JRA is to present information that could be considered prior to diagnosis and treatment. Putting aside the issue of whether Lyme disease does or does not " cause " some cases of JRA, the two diseases share so many symptoms that Lyme disease, as documented below, is often mistaken for JRA. In any case, Lyme disease should be a differential diagnosis for all JRA patients.] ----- Nine reasons for false negative Lyme disease tests results: The Lyme Disease Foundation (LDF), in their brochure entitled " LDF Frequently Asked Questions About Lyme Disease " lists the following nine reasons for false negative Lyme disease tests results: [brackets contain my words] a. Antibodies against Bb are present, but the laboratory is unable to detect them. [borrelia burgdorferi (Bb) is the Lyme disease bacteria.] b. Antibodies against Bb may not be present in detectable levels in patients with Lyme disease. Reasons are listed below. 1. The patient is currently on, or has recently taken, antibiotics. The antibacterial effect of antibiotics can reduce the body's production of antibodies. 2. The patient is currently on or has previously taken anti-inflammatory steroidal drugs (such as those taken to treat rheumatoid arthritis) or certain anticancer drugs. These can suppress a person's immune system, thus reducing or preventing an antibody response. 3. The patient's antibodies may be bound with the bacteria with not enough free antibodies available for testing. [i think this reason is very important and prevalent. For this reason, some of the worst cases of Lyme disease test negative - too much bacteria for the immune system to handle.] 4. The patient could be immunosuppressed for a number of other reasons and the immune system is not reacting to the bacterium. 5. The bacterium has changed its makeup (antigenic shift) limiting recognition by the patient's immune system. 6. The patient's immune response has not been stimulated to produce antibodies, i.e., the blood test is taken too soon after the tick-bite (2-6 weeks). Please do not interpret this statement as implying that you should wait for a positive test to begin treatment. 7. The laboratory has raised its cutoff so high that a patient's previously positive test is now borderline or negative. 8. The patient is reacting to the Lyme bacterium, but is not producing the " right " bands to be considered positive. Lyme Disease Foundation 1 Financial Plaza Hartford, CT 06103 (860)525-2000 fax (860)525-TICK Lyme Disease National Hotline (800)886-LYME email: mailto:lymefnd@... web page: http://www.lyme.org/index2.html For more on false negative/positive Lyme disease test results see: Lyme disease and false negative or false positive blood test results http://www.geocities.com/HotSprings/Spa/6772/false-neg-pos-index.html --------------- Medical and scientific abstracts on Lyme disease and JRA: Sources: National Library of Medicine: Internet Grateful Med Search Screen http://igm.nlm.nih.gov/cgi-bin/doler?account=++ & password=++ Welcome to PubMed http://www.ncbi.nlm.nih.gov/PubMed/ The Lyme Disease Network of NJ, Inc. Lyme Disease Network Medical / Scientific Literature Database Search Form http://www2.lymenet.org/domino/abstract.nsf/$$Search Abstracts: Contents -------- - Abstracts supportive of a connection between JRA and Lyme disease. - Abstracts not supportive of a connection between JRA and Lyme disease. - Other abstracts pertaining to JRA and Lyme disease. --------------- Abstracts supportive of a connection between JRA and Lyme disease: TITLE: [synovial cellular immune response to bacterial pathogens in patients with chronic juvenile arthritis] VERNACULAR TITLE: Synoviale zellulare Immunantwort auf bakterielle Erreger bei Patienten mit juveniler chronischer Arthritis. AUTHORS: Braun J; Doring E; Wu P; Heesemann J; Treharne J; Eggens U; Sieper J AUTHOR AFFILIATION: Abteilung fur Allgemeine Innere Medizin und Nephrologie, Klinikum Steglitz, Freien Universitat Berlin. SOURCE: Z Rheumatol 1993 Jul-Aug;52(4):201-9 CITATION IDS: PMID: 7692686 UI: 94026003 ABSTRACT: Juvenile chronic arthritis is a heterogenous disease with an ill-defined pathogenesis. In our study, synovial fluid (SF) and peripheral blood (PB) of 70 children with oligoarthritis were investigated; bacteria-specific lymphocyte proliferation and antibodies to arthritogenic bacteria were determined. Specific cellular immune responses in SF but not in PB were found in 4/7 patients with either Lyme- or reactive arthritis (60%). In comparison, in subgroup JCA II (n = 45) encompassing mainly elder HLA B27 positive boys, a specific response in SF but again not in PB was detected in 10 children to Yersinia enterocolitica (YE), in four children either to Borrelia burgdorferi (BB) and Chlamydia trachomatis (CT), and in one child to Campylobacter jejuni (CJ). In contrast, in subgroup JCA I (n = 17) encompassing mainly young ANA-positive girls with chronic iridocyclitis, no specific response was found. The correlation of the synovial cellular and the humoral immune responses was 100% in the case of BB and 50% for YE; no antibodies against CT or CJ were detectable. Neither specific cellular nor humoral immune responses were detected against Salmonella or Shigella. We conclude that, in the pathogenesis of some patients with JCA, bacterial microbes have a triggering role. Mainly YE, but also BB and CT are responsible for cases of JCA in which no symptomatic infection preceded. http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7692686 & form=6 & db=m & Dopt\ =b ----- TITLE: Prevalence of antibody to Borrelia burgdorferi in children with juvenile rheumatoid arthritis. AUTHORS: Saulsbury FT; Katzmann JA AUTHOR AFFILIATION: Department of Pediatrics, University of Virginia Health Sciences Center, Charlottesville. SOURCE: J Rheumatol 1990 Sep;17(9):1193-4 CITATION IDS: PMID: 2290160 UI: 91148060 ABSTRACT: Lyme arthritis and juvenile rheumatoid arthritis (JRA) share a number of clinical features. Our study was performed in order to determine the prevalence of antibody to Borrelia burgdorferi in 50 children with JRA who reside in a nonendemic area. Three patients were weakly reactive and one patient was reactive when tested using an enzyme immunoassay to detect serum antibody to B. burgdorferi. No patient, however, had definitive serologic evidence of B. burgdorferi infection by Western blot analysis. We conclude that the prevalence of antibody to B. burgdorferi is very low in children with JRA who reside in a nonendemic area. (More in next post) Ree Whitman wrote: > > From: Ree Whitman <goingnutz@...> > > Hi there, > Yep it's me again. Boy it's a good thing you don't charge me for my > consultations or I would really be in trouble. ) > > I just wanted to run by you what happened today. We went in to see Mikie's > pediatrician. Mikie's knee is still swollen and so is his right shoulder. He is > still limping but not in as much pain. I don't know whether it's the Naproxen > doing it or Mikie saying it so that he does not make another trip to the > doctor. Anyway, the Lyme part of the blood work was not back. His white blood > cells were elevated as well as his red. His red were 70. Anyway, he said he > would try and get in touch with Dr's Goldmont and Dr. White to see if we could > get an earlier appt. We left the office and came home to a message from the ped > to call him on his cell phone or ofc phone. He wanted us to go over to an > Pediatric Orthopedic Surgeon to have him take some fluid from his knee to check > for bacteria. This is what Dr. White the Rhuemy suggested. Well the Orthopedic > Surgeon took x-rays and opted not to take fluid because Mikie was really upset > and that he feels that Mikie most likely has Lyme Disease. Now I have never > noticed a bull's eye bite, or unusual rash. The doctor said he could bet money > on it. If the Lyme test comes back positive then we will continue on that > track. If not we will have the fluid taken from his knee. Thursday we see the > Rhuematologist. Did any of your doctors think it was Lyme's disease. I looked > up the symptoms but it doesn't seem to be it. Can arthritis come from Lyme's > disease? I know you are not doctors but seem to have a great knowledge of this. > > Thanks again, > Ree Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 2, 2000 Report Share Posted February 2, 2000 s white blood cell count is down to 1300 first time in 1year 1/2 her sed rat is 54 and her hemaglobin is 11 ever sense she started the metho shot she has just done wonderful no fever no fash she is still toe walking but only when she does not have shoes on> we are starting to tapper her pred again she is on it one time a day and down to 4 mg this is the first time in a year that she does not need spilt doeses >I give the credit to the methotrexate I hope that it works as well for josh >From: Georgina <gmckin@...> >Reply- onelist > onelist >Subject: Re: Lyme Disease >Date: Tue, 01 Feb 2000 10:14:37 -1000 >MIME-Version: 1.0 >Received: from [208.48.218.16] by hotmail.com (3.2) with ESMTP id >MHotMailBA60897C0097D820F3E0D030DA109637161; Tue Feb 01 12:19:57 2000 >Received: from [10.1.10.36] by fj. with NNFMP; 01 Feb 2000 >20:15:10 -0000 >Received: (qmail 1034 invoked from network); 1 Feb 2000 20:14:57 -0000 >Received: from unknown (10.1.10.26) by 10.1.10.36 with QMQP; 1 Feb 2000 >20:14:57 -0000 >Received: from unknown (HELO smtppop2.gte.net) (207.115.153.21) by >mta1.onelist.com with SMTP; 1 Feb 2000 20:14:57 -0000 >Received: from gte.net (1Cust113.tnt1.wailuku.hi.da.uu.net [63.21.75.113]) >by smtppop2.gte.net with ESMTP for < onelist>; id OAA22330841 >Tue, 1 Feb 2000 14:14:55 -0600 (CST) >From sentto-80038-2982-shancna Tue Feb 01 12:22:46 2000 >X-eGroups-Return: sentto-80038-2982-shancna=hotmail.comreturns (DOT) onelist.com >Message-ID: <38973EAD.594447E0@...> >X-Mailer: Mozilla 4.61 [en] (Win95; I) >X-Accept-Language: en >References: <60.c3a387.25c7b420@...> >Mailing-List: list onelist; contact -owneronelist >Delivered-mailing list onelist >Precedence: bulk >List-Unsubscribe: <mailto: -unsubscribeONElist> > >From: Georgina <gmckin@...> > >Hello, > >Red blood cell counts usually go down in cases of anemia, which often >accompanies chronic illness, such as JRA. White blood cell count, >however, often appears elevated in cases of systemic JRA. My son's WBC >at the onset of his JRA was among the highest ever seen by our >pediatrician. Still, after nearly 5 years, it has never gotten down to >the normal range. Close, since he started taking the injections vs. >pills of MTX, but never yet to the normal range. > >Take care, >Georgina > >Poos1pal@... wrote: > > > yes, my dh was tested for Lyme disease....Lyme disease does cause >arthritic > > symptoms....and I believe JRA kids usually do not have elevated red and >white > > counts. > >--------------------------- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 3, 2000 Report Share Posted February 3, 2000 Well to whomever posted Dr. Uthman's Website, here is his response to me. Needless to say he has Horns also. Pepi Subject: Re: Lyme Disease > > I shall try and make this very quick. My name is I live in > > Donie, Tx am 33 and have Lyme,Monocytic Ehrlichiosis and Babesiosis, my LD > > went unDx since '84 until this last July. Since I have the HME we know that > > I was reinfected here in TX. I am being treated by a great Neurologist for > > my LD, HME and B. My problem is this, I have C-5,6+7 Disc damage w/ > > protrusion into spinal chord and will need surgery. I have a Cardiologist > > there in Houston at St Lukes of whom I have lost all faith in, very long > > story. Since my disc damage is from LD I need a Neurosurgeon that understand > > the disease, do you know of one? > > Hi, , > > This all sounds rather outlandish to me. I hope you have seen a > Board-certified subspecialist in infectious diseases who made all these > diagnoses. If not, and since you have access to Houston, I would recommend > Drs Vardian or Septimus, both of whom are excellent. > > For one thing, Lyme disease does not cause disc damage. Lyme is mentioned in > reference to the disc, because the damage Lyme causes to the nerves can > cause a pain that mimics disc damage clinically, as the abstract given below > describes: > > ------------- > > Acta Neurochir (Wien) 1989;98(1-2):42-6 > > Meningoradiculoneuritis mimicking vertebral disc herniation. A > " neurosurgical " complication of Lyme-borreliosis. > > Meier C, Reulen HJ, Huber P, Mumenthaler M > > University Department of Neurology, Inselspital, Bern, Switzerland. > > We report on 3 patients with meningoradiculoneuritis (MRN) due to > Lyme-borreliosis (LB), which presented clinically as vertebral disc > herniation. In 2 cases the underlying infection was discovered only after > unsuccessful neurosurgical treatment. In the differential diagnosis between > MRN and disc herniation the following criteria are suggestive of MRN and > should raise suspicion of a non-discogenic aetiology: History of tick bite > or erythema chronicum migrans, fever or general malaise, mono- or > oligoradiculopathy with absent or insignificant lumbar pain and complaints > of a burning character of the radiating pain. In suspicious cases we > recommend blood investigations including antibody determination against > borrelia burgdorferi and CSF investigations including cell count and > cytology, protein and glucose determination, nephelometry and isoelectric > focusing to exclude MRN and other conditions that may mimic disc herniation. > > ------------- > > Best regards, > > Ed > > -------------- > Ed Uthman, MD <uthman@...> " Nemo liber est qui > Pathologist, Houston/Richmond, Texas, USA corpori servit " > <http://www.neosoft.com/~uthman> -Seneca > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 9, 2000 Report Share Posted February 9, 2000 You GO Girl!!!!!! go kick his butt! Pepi > > Dear Senator Lack: You have got to be kidding!!! What sort of > outrageous monster are you to have thrown our lobbyist out of your > office and swear and scream at her in an unprofessional manner?? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 11, 2000 Report Share Posted February 11, 2000 , That is terrific news! I am so happy for ! Her SED rate is still high but hopefully that will soon start to improve, as well. I'm really glad that she is handling the decreased prednisone dose. I assume you cut out the evening one? Sleep can be disturbed by taking steroids in the PM hours, so I wonder if you have noticed any change in her sleeping habits now, since she only gets one dose a day? I'm so glad things are getting better. Josh had his MTX shot yesterday and for whatever reasons, his wrists were so sore afterwards. This morning he woke up with lots of visible swelling on his right wrist. He's not feeling so good so instead of going to school, he came downstairs and is sleeping on the couch. I'll see if he's ready to go in a little later. The day after MTX is still usually rough for him, especially in the morning. Kind of sad but last night Josh was asking about when he'll be seeing the rheumatologist next. We haven't gotten the call about when they'll be flying over yet so I'm not sure, but Josh says he doesn't think he can lower his prednisone again yet because he's been having more pain. I think a part of it was because he had a cold for a couple days and while it didn't cause a flare up, it did cause a slight setback. Still, he's taking 20mgs/17.5mgs on alternate days. Plus all the other stuff. I guess only time will tell. Take care, Georgina SHANNON MARTINO wrote: > > s white blood cell count is down to 1300 first time in 1year 1/2 her > sed rat is 54 and her hemaglobin is 11 ever sense she started the metho shot > she has just done wonderful no fever no fash she is still toe walking but > only when she does not have shoes on> we are starting to taper her pred > again she is on it one time a day and down to 4 mg this is the first time in > a year that she does not need spilt doeses >I give the credit to the > methotrexate I hope that it works as well for josh > > >From: Georgina <gmckin@...> > >Hello, > > > >Red blood cell counts usually go down in cases of anemia, which often > >accompanies chronic illness, such as JRA. White blood cell count, > >however, often appears elevated in cases of systemic JRA. My son's WBC > >at the onset of his JRA was among the highest ever seen by our > >pediatrician. Still, after nearly 5 years, it has never gotten down to > >the normal range. Close, since he started taking the injections vs. > >pills of MTX, but never yet to the normal range. > > > >Take care, > >Georgina Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 12, 2000 Report Share Posted February 12, 2000 Hi PatB -- PA was absolutely the _last_ thing they got around to for me. Before my final diagnosis they tested me for everything from Lyme disease to schizophrenia! I don't have Lyme and neither me or my buddy here has schizophrenia -- though I am positive we both have PA! and Friend North Jersey Highlands raharris@... __________________________________________________ Quote Link to comment Share on other sites More sharing options...
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