Is it ok to chelate while on antibiotics?

[Guest guest]

I am wondering about chelating while on antibiotics. My 5 1/2 year old

son has been on antibiotics (amoxycillin and zithromax) the last 2 weeks

for lymes disease. We have seen nice initial changes in hyperactivity.

I saw the articles below posted on the abmd list (thanks cara) about

reduced excretion rates of mercury in mice given antibiotics. I have

been chelating my son for 9 months (3 months DMSA then 6 months

DMSA/LA). Can anyone advise me whether I should stop chelating while my

son is on antibiotics? The antibiotics may be long term as one doctor

has diagnosed my son with late stage lyme which typically needs long

term antibiotics to cure. I am giving probiotics (20 billion cells

twice per day) 3 hours away from the antibiotics to try to keep the

beneficial bacteria up. Is getting a reduced rate of mercury out better

than not chelating?

Dave

Methyl mercury decomposition in mice treated with antibiotics.

Seko Y, Miura T, Takahashi M, Koyama T

Acta Pharmacol Toxicol (Copenh) 1981 Oct, 49:4259-65

[Related MEDLINE Records]

Abstract

The role of intestinal flora in the decomposition and faecal excretion

of

methyl mercury was studied in mice treated with antibiotics. The

antibiotics, neomycin sulfate and chloramphenicol, were given to mice in

drinking water for six days before intraperitoneal administration of

methyl

mercuric chloride (MMC), and intestinal microorganisms were thereby

reduced.

Inorganic and organic mercury were determined separately for faeces,

intestinal contents and organs. On the fourth day after the mercury

administration, the percentage ratios of inorganic mercury to total

mercury

in the contents of the caecum and large intestine were less in the mice

treated with antibiotics, at 37% and 39%, respectively, than in the

control

mice (66% and 65%, respectively). Administration of the antibiotics

reduced

the excretion of inorganic mercury in the faeces to 26% of that of

control

mice and also reduced the excretion of total mercury to 60%. Reduction

of

intestinal microorganisms by the antibiotics was assumed to have caused

the

reduced decomposition of methyl mercury in the caecal contents and the

reduced excretion of total mercury in the faeces.

Effects of diet on mercury metabolism and excretion in mice given

methylmercury: role of gut flora.

Rowland IR, RD, Doherty RA

Arch Environ Health 1984 Nov-Dec, 39:6401-8

[Related MEDLINE Records]

Abstract

Mice fed either (1) a pelleted rodent diet, (2) evaporated milk, or (3)

a

synthetic diet (high protein, low fat) exhibited different rates of

whole

body mercury elimination and fecal mercury excretion after exposure (per

os)

to methylmercuric chloride. The percentage of the total mercury body

burden

present as mercuric mercury was highest (35.3%) in mice fed the

synthetic

diet (which had the highest rate of mercury elimination) and lowest

(6.6%)

in the animals having the lowest mercury elimination rate (milk-fed

mice).

Mice fed the synthetic diet had lower mercury concentrations and had a

higher proportion of mercuric mercury in their tissues than the mice

from

the other dietary groups. Treatment of the mice with antibiotics

throughout

the experimental period to suppress the gut flora reduced fecal mercury

excretion and the dietary differences in whole body retention of

mercury.

Tissue mercury concentrations and proportion of organic mercury in

feces,

cecal contents, liver, and kidneys were increased by antibiotic

treatment of

mice fed the pelleted or synthetic diets. These results are consistent

with

the theory that demethylation of methylmercury by intestinal microflora

is a

major factor determining the excretion rate of mercury.

[Guest guest]

Dave, I am not sure where I found the article but I thought I read

while searching alpha lipoic acid that the ALA helps the body utilize

the antibiotic more efficiently. Aiding the processing in the

liver. But I also read that adults should take 50-100mg a day as an

antioxidant. nne

> I am wondering about chelating while on antibiotics. My 5 1/2 year

old

> son has been on antibiotics (amoxycillin and zithromax) the last 2

weeks

> for lymes disease. We have seen nice initial changes in

hyperactivity.

> I saw the articles below posted on the abmd list (thanks cara) about

> reduced excretion rates of mercury in mice given antibiotics. I

have

> been chelating my son for 9 months (3 months DMSA then 6 months

> DMSA/LA). Can anyone advise me whether I should stop chelating

while my

> son is on antibiotics? The antibiotics may be long term as one

doctor

> has diagnosed my son with late stage lyme which typically needs long

> term antibiotics to cure. I am giving probiotics (20 billion cells

> twice per day) 3 hours away from the antibiotics to try to keep the

> beneficial bacteria up. Is getting a reduced rate of mercury out

better

> than not chelating?

>

> Dave

>

>

>

>

>

> Methyl mercury decomposition in mice treated with antibiotics.

> Seko Y, Miura T, Takahashi M, Koyama T

> Acta Pharmacol Toxicol (Copenh) 1981 Oct, 49:4259-65

> [Related MEDLINE Records]

>

> Abstract

> The role of intestinal flora in the decomposition and faecal

excretion

> of

> methyl mercury was studied in mice treated with antibiotics. The

> antibiotics, neomycin sulfate and chloramphenicol, were given to

mice in

> drinking water for six days before intraperitoneal administration of

> methyl

> mercuric chloride (MMC), and intestinal microorganisms were thereby

> reduced.

> Inorganic and organic mercury were determined separately for faeces,

> intestinal contents and organs. On the fourth day after the mercury

> administration, the percentage ratios of inorganic mercury to total

> mercury

> in the contents of the caecum and large intestine were less in the

mice

> treated with antibiotics, at 37% and 39%, respectively, than in the

> control

> mice (66% and 65%, respectively). Administration of the antibiotics

> reduced

> the excretion of inorganic mercury in the faeces to 26% of that of

> control

> mice and also reduced the excretion of total mercury to 60%.

Reduction

> of

> intestinal microorganisms by the antibiotics was assumed to have

caused

> the

> reduced decomposition of methyl mercury in the caecal contents and

the

> reduced excretion of total mercury in the faeces.

>

> Effects of diet on mercury metabolism and excretion in mice given

> methylmercury: role of gut flora.

> Rowland IR, RD, Doherty RA

> Arch Environ Health 1984 Nov-Dec, 39:6401-8

> [Related MEDLINE Records]

>

> Abstract

> Mice fed either (1) a pelleted rodent diet, (2) evaporated milk, or

(3)

> a

> synthetic diet (high protein, low fat) exhibited different rates of

> whole

> body mercury elimination and fecal mercury excretion after exposure

(per

> os)

> to methylmercuric chloride. The percentage of the total mercury body

> burden

> present as mercuric mercury was highest (35.3%) in mice fed the

> synthetic

> diet (which had the highest rate of mercury elimination) and lowest

> (6.6%)

> in the animals having the lowest mercury elimination rate (milk-fed

> mice).

> Mice fed the synthetic diet had lower mercury concentrations and

had a

> higher proportion of mercuric mercury in their tissues than the mice

> from

> the other dietary groups. Treatment of the mice with antibiotics

> throughout

> the experimental period to suppress the gut flora reduced fecal

mercury

> excretion and the dietary differences in whole body retention of

> mercury.

> Tissue mercury concentrations and proportion of organic mercury in

> feces,

> cecal contents, liver, and kidneys were increased by antibiotic

> treatment of

> mice fed the pelleted or synthetic diets. These results are

consistent

> with

> the theory that demethylation of methylmercury by intestinal

microflora

> is a

> major factor determining the excretion rate of mercury.