Recapitulation Of The Entire Hepatitis C Virus Life In Engineered Mouse Cell Lines

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Recapitulation Of The Entire Hepatitis C Virus Life In

Engineered Mouse Cell Lines

20 Apr 2012

A US study presentedat The International Liver CongressTM 2012

demonstrates that the entire HCV lifecycle can be recapitulated in

murine cells, implying that HCV permissive mouse models could soon

be developed.(1)

The data suggests that HCV replication in the murine environment is

limited by innate immune responses. Inactivating these pathways and

the expression of the appropriate entry factors and miR-122 creates

murine fibroblasts that can be infected and support replication.

The study also corroborates previous data that the expression of

apoE promotes production of infectious virus.

Although mouse orthologs of MAVS and TRIF could be cleaved by the

HCV NS3/4A protease, this was not enough to establish robust HCV

replication.

In contrast, impairment of type I and type III IFN signaling

enhanced the permissiveness of murine fibroblasts for persistent HCV

replication.

The in-depth study of hepatitis C pathogenesis and immune responses

is currently hampered by the lack of suitable small animal models.

This study is a positive step to addressing this issue.

References:

1. Vogt A, Recapitulation of the entire Hepatitis C virus life in

engineered mouse cell lines. Abstract presented at the

International Liver CongressTM 2012

European Association

for the Study of the Liver

Citations:

Please use one of the following formats to cite this article in your

essay, paper or report:

MLA

European Association for the Study of

the Liver. "Recapitulation Of The Entire Hepatitis C Virus Life

In Engineered Mouse Cell Lines." Medical News Today.

MediLexicon, Intl., 20 Apr. 2012. Web.

20 Apr. 2012.

<http://www.medicalnewstoday.com/releases/244329.php>

APA

European Association for the Study of

the Liver. (2012, April 20). "Recapitulation Of The Entire

Hepatitis C Virus Life In Engineered Mouse Cell Lines." Medical

News Today. Retrieved from

http://www.medicalnewstoday.com/releases/244329.php.

Please note: If no author information is provided, the source is

cited instead.

--

Bill Eastman

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