Re: Glutathione patches combined with transdermal or oral glutathion

[Guest guest]

..Hi Natasa and ,

A word of caution....There would be no need to also use NAC...as that

purportedly only "modestly" increases GSH levels...

And may have TOXIC side effects... as per the info I'm quoting below..

The actually study near the bottom below

comes from the University of Virgina Health System:

(But the beginning section is from another source on the net.)

Hope that helps,

Sue

PS.. the "Other means below" would include LW Yage GSH booster patches..

since they boost the bodies OWN GSH levels..a natural source./.your own body.

" Glutathione levels cannot be increased to a clinically beneficial extent by orally ingesting a single dose of glutathione. (1) This is because glutathione is manufactured inside the cell, from its precursor (or building blocks) amino acids, glycine, glutamate and cysteine.

What this means is that in order to increase glutathione you must either provide the precursors of glutathione, or enhance its production by some Other means.

( The manufacture of glutathione inside your cells is limited by the levels of its sulphur-containing precursor amino acid, cysteine.

Some common drugs, dietary supplements and food sources that help boost glutathione levels:

One of the commonly used enhancers is N Acetyl L-Cysteine (NAC) which is an antioxidant DRUG. It is the ALTERED form of the amino acid Cysteine, which is commonly found in food and later synthesized by the body to create glutathione. NAC has been demonstrated to facilitate the SHORT TERM cellular detoxification of alcohol, tobacco smoke, acetaminophen [Tylenol®] poisoning and environmental pollutants in several in vitro studies.

Recent studies show NAC supplementation MAY BE HARMFUL over long periods and have been associated with ONLY MODEST increases in serum glutathione. NAC has NOT PROVEN particularly USEFUL in the treatment of chronic, long-term intracellular glutathione deficiencies. Furthermore, therapeutic levels of NAC are relatively TOXIC and have been associated with significant side effects. At therapeutic doses, oral NAC supplementation has been associated with cerebral symptoms (dizziness), nausea, blurred vision, skin rashes and vomiting.

University of Virginia Health System

Contact:Abena Foreman-Trice

A Type of Antioxidant May Not be as Safe as Once Thought

CHARLOTTESVILLE, Va., September 4, 2007 - Certain preparations taken to enhance athletic performance or stave off disease contain an antioxidant that could cause harm. According to new research at the University of Virginia Health System, N-acetylcysteine (NAC), an antioxidant commonly used in nutritional and body-building supplements, can form a red blood cell-derived molecule that makes blood vessels think they are not getting enough oxygen. This leads to pulmonary arterial hypertension (PAH), a serious condition characterized by high blood pressure in the arteries that carry blood to the lungs. The results appear in the September issue of the Journal of Clinical Investigation.

"NAC fools the body into thinking that it has an oxygen shortage," said Dr. Ben Gaston, UVa Children's Hospital pediatrician and researcher who led the study. "We found that an NAC product formed by red blood cells, know as a nitrosothiol, bypasses the normal regulation of oxygen sensing. It tells the arteries in the lung to ‘remodel'; they become narrow, increasing the blood pressure in the lungs and causing the right side of the heart to swell."

Gaston notes that this is an entirely new understanding of the way oxygen is sensed by the body. The body responds to nitrosothiols, which are made when a decreased amount of oxygen is being carried by red blood cells; the response is not to the amount of oxygen dissolved in blood. He says that this pathway was designed much more elegantly than anyone had previously imagined. "We were really surprised", he said.

The research team administered both NAC and nitrosothiols to mice for three weeks. The NAC was converted by red blood cells into the nitrosothiol, S-nitroso-N-acetylcysteine (SNOAC). The normal mice that received NAC and SNOAC developed PAH. Mice missing an enzyme known as endothelial nitric oxide synthase did not convert NAC to SNOAC, and were protected from the adverse effects of NAC, but not SNOAC. This suggests that NAC must be converted to SNOAC to cause PAH.

Could regular use of NAC produce the same effects in humans? The next step is to determine a threshold past which antioxidant use becomes detrimental to heart or lung function, according to Dr. Palmer, co-researcher of the study.

"The more we understand about complexities in humans, the more we need to be aware of chemical reactions in the body," said Palmer.

According to Gaston and Palmer, NAC is being tested in clinical trials for patients with cystic fibrosis as well as other conditions; and clinical trials with nitrosothiols are being planned. These results, Palmer says, should motivate researchers to check their patients for PAH.

The results also open up a range of possibilities in treating PAH. Palmer added that the signaling process could be restorative and healing if they figured out how to keep NAC from fooling the body.

"From here we could devise new ways for sensing hypoxia or we could in theory modify signaling to treat PAH," Palmer said.

Re: Glutathione patches combined with transdermal or oral glutathion

Posted by: "jackben14" rfc012@... jackben14

Wed Jun 25, 2008 5:27 pm (PDT)

Hi Natasa, i started my son on oral glutathione at the end of March 2008, and saw some improvement in him.. then started the lifewave glutathione patches just under 3 weeks ago.. at the moment i'm using both until his tablets run out.. although i have cut back the dosage and frequency of the pills greatly. He has 1/2 a tablet left to take then he will just be on the patches.The patches are supposed to boost your body stores of glutathione.. and i suspected my son to be deficient in this.. so tried to get the oral to replenish it.But oral can only absorbs about 10% of the tablet(sometimes zero).. as stomach acids can dissolve most of it.. and i have read that oral glutathione can flare yeast too.Perhaps taking the pre-cursers to glutathione.. as well as the patches could be more effective..which are ..NAC, cystine and lipoic acid.ALWAYS start low on oral.. it can effect behaviour.Since reducing his oral.. and wearing the patches.. he has continued to improve in his focus and alertness.. also babbling more.(and sleeping slightly longer!).>> Hi, wondering if anyone on this list is doing Lifewave patches at the> same time as lotion or oral glutathione?> > or if used these at different times, how would you compare effects in> your kids?> > tia> Natasa