Re: Question re Crohn's/PG for Jeff, [our Expert]

[Guest guest]

rebecca,

that is pretty observent on your part. this particular bacteria will

exploit tissue breakdown on a human, could be internal or external.

people that are immunosuppressed or have an immunodlogical situation

where the bodies defenses are not fighting off this bateria can be

effected.

" Pseudomonas aeruginosa is an opportunistic pathogen, meaning that it

exploits some break in the host defenses to initiate an infection. "

i don't believe pg or crohns and there is a host of other " at risk "

diseases such as cancer, cystic fibrosis, and burns, are caused by

this. likely this is more like a secondary infection. There is

little to associate between pg and pseudomonas, but i suppose you

could end up with both at the same time.

remember, just like we don't know the exact mechanism of pg, we also

know that for some strange reason, pg tends to resist infection.

jeff

>

> Hi Jeff,

> Just noticed this and wanted to run it past you:

>

> http://www.mediscene.com/patient/topic.php?topic=skin

>

> << (Crohn's)

> My son has crohns and recently developed a sore on his leg. The first

> physican I took him to said it is pyoderma gangrenosum. I have found

> pictures on the web but not an explaination as to what causes this,

> the physican said it was related to crohns, but his gastro. dr. said

> that is not so?? Any information would be welcomed.

>

> Pyoderma gangrenosum is a disease of the skin which is associated

> with but not necessarily caused by infection with pseudomonas germs.

> It is not clear how it arises and exactly how it is connected to the

> germs. It is not clear whether the germs cause the infection or simply

> take up housekeeping once the sore is there. The reason you don't find

> much about it is because we don't knwo much about it. Fortunately it

> does often respond to medication.>>

> *******

> I never heard of the psuedomonas germs causing or being associated

> with PG. Maybe this is what Wayne was referring to when he said

> Crohn's was possibly caused by imparied immunity and might be helped

> by antibiotics? Your thoughts?

>

> Love,

>

>

[Guest guest]

Hi Jeff,

I did a search using some key words from your statement <<remember,

just like we don't know the exact mechanism of pg, we also know that

for some strange reason, pg tends to resist infection.>>

I hoped to find other conditons that behaved like PG with respect to

resisting infection. No luck, however I did get this link illustrating

debridement, that you have so often mentioned:

http://healthgate.partners.org/browsing/LearningCenter.asp?fileName=14803.xml & ti\

tle=Debridement%20of%20a%20Wound,%20Infection,%20or%20Burn

Hope the link doesn't get cut off. I'll add it to our Wound Care and

PG links.

Love,