1. HISTORY of CFS/ EBV, HHV6/ and LOW GLUTATHIONE & sulfur

[Guest guest]

Hi from Sue,

I found this history interesting of CFS..and included a few paragraphs of interest of how

low GSH and sulfur depletion are related to EBV and HHV6 ...from the same report.

The 3rd paragraph notes the relationship to low levels of glutathione (GSH) and diarrhea, and cognitive ability.

This article also focused on Fluoride damage..

It also reminds me how important it is to have topical sulfur like Epsom salts baths or sulfur ointment with GSH..

due to the ozone layer depleting sulfur.

THE CHRONIC FATIGUE SYNDROME REPORT

Final Diagnosis: Environmental Toxic Pathway Analysis and Immune System Cytokine Modality Provide Key Insight into Chronic Fatigue Syndrome Mechanism and Etiology of Varied Pathogen Driven Illnesses.

By: J. E. Phelps Copyright 2005 Abstract:

"The term "CFS" (or CFIDS) made its national appearance in the mid 1980's with the investigations of Dr. Cheney concerning sick persons in the area of Lake Tahoe, on the California and Nevada border. Most of these CFS persons were fine one day and came down with mononucleosis like illness the next, with flu like symptoms persisting. In 1999, Cheney described the illness as one that depleted glutathione, used much ATP, and showed a very significant up regulation in an enzymatic pathway known as the 2-5A RNase L.[3] Looking for toxic exposure factors, the waters of Lake Tahoe are pristine, but the area is of volcanic origin that contaminate some wells and soils with volcanic materials. Well waters are often contaminated with higher levels of arsenic, manganese, radium, radon, and fluoride than surface waters. South Lake Tahoe has public water supplies from wells that have metal contamination, often associated with volcanic zones or mining. South Lake Tahoe water reports have specific caution for immune compromised persons because of these pollutants.[4] Cheney's CFS Tahoe cluster diagnosis was made possible by detection of new chemical bio-markers, but CFS is not new as it appears to be symptomatically reported in 1750 and in other terms in earlier periods.[5] It is also speculated that the biblical story of Jesus healing the person by the well is even earlier evidence of the illness. The Cheney / Tahoe mononucleosis like illness is associated with swollen lymph node from activation of EBV, HHV-6, and other viral pathogens that are associated with follow on disease factors, like MS.[6, 7] Glutathione (GSH) depletion is associated with the cellular oxidant repair process and detoxification of tissues and it is lowered by chemical and pathogen damage to mitochondria of cells that manufacture ATP.[8, 9] Lowered GSH can hasten cell apoptosis and is an indicator in chronic disease, cancer, arthritis, and rapid aging.[10, 11, 12, 13, 14, 15] Glutathione is important in liver detoxification and in maintaining the mucosa cells that line the intestine.[16, 17] Selenium associated Glutathion depletion drives shifts in cytokine mode from Th1 to Th2.[18] "

One of the prime CFS symptoms is that of frequent diarrhea and this again is associated with the levels of GSH and SOD in the cells of the gut walls. Persons with CFS and GWI generally have impaired levels of GSH and SOD enzymes. This effect is made much worse in the local area of the gut when these persons drink excessive levels of sugar-laden colas or other sugary foods. Processed sugar is a GSH and SOD antagonist and this promotes high levels of free radical damage to the cells of the gut wall. The high rates of free radical damage causes the gut cells to sluff-off with lots of water much as a blister type effect from a burn. The same type effect occurs from the radiation intestinal death effects for acute radiation doses that make the same levels of ROS damage to the cells. The extreme damage from the high levels of ROS damage also cause damage to the blood vessels in the colon and cause bleeding hemorrhoid problems and loss of blood and essential trace metals. The high levels of ROS damage in these local cells also damages the Mn dependent 2-5A RNase L enzyme resulting in lots of local cells having active viral infection problems that involve the local lymph system. The problems of reduction in the cell production of GSH and SOD well define the mechanism of problems like persistent diarrhea and even the issue of loss of cognitive abilities from similar problems in the brain.

These intestinal effects are even spoken of in the Biblical Narrative with recognition of guts like stinking sulfur bogs. The Biblical Narratives also speak to the use of the plant called "Aloe Vera" as a type of medicine. Aloe Vera has very high levels of both the enzymes GSH and SOD. The high levels of SOD in the plant is why it is often used so effectively to treat burns, as it corrects for the free radical damage effects to cells. Persons seeking to correct for the free radical damage of their intestinal tract often consume Aloe Vera juice.

The UV and Ozone Hole problem has severely upset the global sulfur cycle upon which the Se-GSH system depends for adequate sulfur. The ocean plankton levels have been reduced which causes an increase in the global CO-2 levels and a loss of DMS that is formed from the process that regulates cloud formation. The loss of cloud seeding by the DMS causes the bulk of the global warming problem via loss of reflective clouds for the IR radiation reflection. Plankton are the world's largest CO-2 sink and the largest system that places sulfur into the human and animal food chain. When the DMS is impacted by UV radiation, it lowers the DMS, DMSO, and MSM pathway into the human chain to supply the levels of sulfur needed by GSH in the liver and cells to remove toxic metals from the body. This systemic loss of sulfur stores causes a metabolic ACIDOSIS and HYPERTHYROID shift in the population that results in CFS and many other immune illnesses.

Sue comments = while this article was ALSO noting the damaging effects of fluoride,

HERE the last sentence in it's conclusion:

"The depletion of GSH will lead to discovery of problems with the global sulfur cycle from ozone hole effects damaging the DMS levels needed to support hepatic clearance of toxic metals and prevent hyperthyroid type shifts and metabolic acidosis leading to CFS and other immune system illnesses. This report is a comprehensive and broad based discussion illustrated with practical examples and referenced to peer reviewed scientific journals to show the key effect in CFS and human immune health."