Re: Danazol Increases Platelet Counts in Thrombocytopenia Patients w

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In case anyone else was confused about yet another new illness/symptom/word was, here is what Thrombocytopenia is..Butch Thrombocytopenia Contents of this page: Definition Causes Symptoms Exams and Tests Outlook (Prognosis) Possible Complications When to Contact a Medical Professional Prevention Definition Thrombocytopenia is any disorder in which there are not enough platelets. Platelets are cells in the blood that help blood to clot. This condition is sometimes associated with abnormal bleeding. Causes Thrombocytopenia is often divided into

three major causes of low platelets: Low production of platelets in the bone marrow Increased breakdown of platelets in the bloodstream (called intravascular) Increased breakdown of platelets in the spleen or liver (called extravascular) Disorders that involve low production in the bone marrow include: Aplastic anemia Cancer in the bone marrow Infections in the bone marrow (rare) Drugs (very rare) Disorders that involve the breakdown of platelets include: Immune thrombocytopenic purpura (ITP) Drug-induced immune thrombocytopenia Drug-induced nonimmune thrombocytopenia Thrombotic thrombocytopenic purpura Disseminated intravascular coagulation (DIC) Hypersplenism Symptoms Bruising Nosebleeds or bleeding in the mouth Rash (pinpoint red spots) Other symptoms may be present as well, depending on the cause of the condition. Mild thrombocytopenia can occur without symptoms. Exams and Tests

CBC shows low platelets Bone marrow aspiration or biopsy may be normal or may show low megakaryocytes (platelet precursors) or an infiltrating disease. PTT clotting study is normal PT clotting study is normal Platelet associated antibodies may be present Treatment Treatment depends on the cause of the condition. In some cases, a transfusion

of platelets may be required to stop or prevent bleeding. Outlook (Prognosis) The outcome depends on the disorder causing the low platelet counts. Possible Complications Hemorrhage Gastrointestinal bleeding (vomiting blood or blood in the stools) Bleeding in the brain (intracranial hemorrhage) When to Contact a Medical

Professional Call your healthcare provider if you experience unexplained bleeding or bruising. Prevention Prevention depends on the specific cause. Update Date: 9/20/2006

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How does Danazol effect tx? Does it alter the treatment in any way? Can it be used while you are on tx or must you wait until you've stopped? My platlete count is low but not dangerous. It would be good to know that there is a treatment other than platelete or whole blood infusion. Steve...

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