Valkion singlet oxygen therapy, links and info

[Guest guest]

Hi, I've put this info together the other day, in case anyone is interested here it is:

Valkion patent page à description:

http://tinyurl.com/5a8thb

ÒÉEven though singlet oxygen quickly returns to oxygen in its ground

state, by studying the effects of the described device, it can be

demonstrated that a medium, liquid or gas, in which singlet oxygen has

been formed, has a certain altered state, at least for a limited

periodÉÓ

shorthand explanation from http://www.breathing.com/articles/oxygen-therapies.htm

Oxidative Response: The cellular defense against Oxidative Stress is

the Oxidative Response. The Oxidative Response System (or cell response

system) protects against, and repairs, Oxidative Stress damage. This is

accomplished mainly through enzyme and coenzyme production. The Oxidative Response is initiated by signal transduction sequences induced by singlet oxygen. Singlet oxygen is an activated oxygen species, but not a free radical. Signaling proteins then trigger the cell response.

Cell response results include, but are not limited to:

Protection against free radical damage

Repair of damage caused by free radicals

Improved Oxygen utilization

Improved cell energy production

Improved cell metabolism

For optimal cell metabolism, a strong Oxidative Response and low Oxidative Stress are essential.

Also:

Singlet Oxygen is also produced in human cells as a by-product of

metabolism. Here, it can be harmful and cause cell damage, as it acts

as a Ôfree radical«. Yet Singlet Oxygen has a very short lifespan, and returns to its ground state within a fraction of a second. In a humid atmosphere, its lifespan comprises only a few hundred thousandths of a second. This means that no Singlet Oxygen can leave the equipment and,

consequently, cannot harm any organismÉ. ÉValkion imitates nature.

They have constructed an activation chamber, where an artificial light

source acts together with a high efficiency heat and light resistant

Ôphotosensitizer«. With an air pump, a stream of activated air is

created. This may then be inhaled, with or without the aid of an

inhalation mask or nasal cannula for research. Applications for

research purposes vary. The findings show that moist air is essential;

that is why every unit is equipped with a humidifier giving the

activated air a humidity level of at least 85%(depending on the

humidity and temperature of the ambient air). From:

http://www.rangeguide.net/valkion.htm

Ukrainian website with links to medical trials in Ukraine:

http://www.tyoma.com.ua/investigation_2_2.html

from them:

Our company, situated in Ukraine, is scientific and selling partner of

Polyvalk AB (Gothenburg, Sweden) à Valkion units producer. In 1997 we

have Registered Valkion unit in Ukraine. Since that time we have sold a

lot of units to Medical Universities, clinics and private people.

We have more than 100 reports from our partners on Pulmonology,

Gastroenterology, Traumatology, Dermatology, Radiology, Nephrology and

urology, Obstetrics and gynaecology, Gerontology, Cardiology,

Hematology, Endocrinology, Neurology, Immunology, Infectology, Surgery.

These researches were done in accordance to international terms of

clinical investigations (2-3 groups with more than 20 patients with

similar disease; one group treated with standard treatment, next à with

Valkion therapy (or combined à Valkion therapy and standard treatment)

and sometimes (when it is possible) à third group à uses placebo) and

published in Ukrainian, European and Asian scientific journals and as

materials of different scientific conferences.

Swedish in vitro and animal studies:

Free Radical Biology and Medicine

Volume 27, Issues 11-12, December 1999, Pages 1203-1207

Harmful singlet oxygen can be helpful

Lillemor Mattsson HultŽna, Marc Holmstršma and Bassam

SoussiCorresponding Author Contact Information, Wallenberg Laboratory

for Cardiovascular Research, University of Gšteborg, Sahlgrenska

University Hospital, Gšteborg, Sweden

Highly reactive harmful singlet oxygen O2(1Î"g)can be helpful while

relaxing to its triplet ground state O2(3Σg-). The energy emitted

during this relaxation from the excited energy state is discernable at

634 nm. We report here on the effect of this energy as photon

illumination and as energy transfer in air on the production of

reactive oxygen species (ROS) by human monocytes, measured as

isoluminol-enhanced chemiluminescence. We demonstrate up to 60%

decrease in the secretion of ROS after 2-min illumination of the

monocytes stimulated with phorbol myristate acatate (PMA). The results provide in vitro documentation of the utility of singlet oxygen energy in modifying cellular behaviour.

Author Keywords: Human monocytes; Singlet oxygen; Reactive oxygen

species; Chemiluminescence; Oxidative stress; Photodynamic therapy;

Free radicals

PMID: 10641712 full text: http://tinyurl.com/6gt4qv

Preservation of rat skeletal muscle energy metabolism by illumination

Ann LindgŒrd, Jonas Lundberg, Olivier Rakotonirainy, Elander and

Bassam Soussi. Department of Surgery and Plastic Surgery,

Bioenergetics Group, Wallenberg Laboratory, Sahlgrenska University

Hospital, Gštenborg University, Gštenborg S-143-45, Sweden

Skeletal muscle viability is crucially dependent on the tissue levels

of its high energy phosphates. In this study we investigated the effect

of the preservation medium Perfadex and illumination with Singlet

Oxygen Energy (SOE). Singlet oxygen can be produced photochemically by

energy transfer from an excited photosensitizer. The energy emitted

from singlet oxygen upon relaxation to its triplet state is captured as

photons at 634 nm and is here referred to as SOE. Rat hind limb rectus

femoris muscles were preserved for five hours at 22 ¡C in Perfadex,

saline, SOE illuminated Perfadex or SOE illuminated saline. Extracts of

the muscles were analysed by 31P NMR. Data were analysed using two-way

analysis of variance and are given as mean values (μmol/g dry weight) ±

SEM. The ATP concentration was higher (p = 0.006) in saline groups

(4.52) compared with Perfadex groups (2.82). There was no statistically

significant difference in PCr between the saline groups (1.25) and

Perfadex groups (0.82). However, there were higher (p = 0.003) ATP in

the SOE illuminated groups (4.61) compared with the non-illuminated

groups (2.73). The PCr was also higher (p < 0.0001) in the SOE

illuminated groups (1.89) compared with the non-illuminated groups

(0.18). In conclusion, Perfadex in this experimental model was

incapable of preserving the high energy phosphates in skeletal muscle

during 5 hours of ischemia. Illumination with SOE at 634 nm improved

the preservation potential, in terms of a positive effect on the energy

status of the muscle cell.

PMID: 12672510 [PubMed - indexed for MEDLINE]

Transplant Proc. 2005 Jan-Feb;37(1):518-20.

Singlet oxygen energy illumination during moderate cold ischemia prolongs the survival of concordant hamster xeno-heart transplants.

Lukes DJ, Skogsberg U, Nilsson A, Lundgren A, Olausson M, Soussi

B. Department of Surgery and Transplantation, Wallenberg Laboratory

for Cardiovascular Research, Gšteborg, Sweden.

INTRODUCTION: Singlet oxygen energy (SOE) is a potent inhibitor of

reactive oxygen species (ROS) in vitro and in vivo in certain dose

ranges and can improve the levels of high-energy phosphates (HEP) in

concordant hamster xeno-heart transplants. Some data indicate that a

certain degree of cold ischemia (CI) might be beneficial to

xenotransplants. We investigated if SOE illumination of hamster

xeno-hearts during moderate cold ischemia (CI) improved graft survival.

MATERIALS AND METHODS: Eighteen hearts from Golden Syrian hamsters (70

to 80 g) were subjected to 8 hours of CI in cold (+4 degrees C) saline

solution (NaCL, 0.9%) before heterotopic cervical transplantation to

rats (220 g). Among the treatment group (n = 8), SOE was produced

by illuminating the hearts for 10 minutes every 30 minutes with photons

at lambda 634 nm with the Oxylight equipment. Graft function was

evaluated every 6 hours after transplantation with digital exam until

cessation of heart beats. RESULTS: The graft survival of

SOE-illuminated ischemic hamster xenografts was 2.34 +/- 0.56 versus

1.15 +/- 0.37 days in the control group (P < .05). All hearts

displayed immediate graft function versus 70% in the controls (NS).

CONCLUSIONS: SOE illumination at lambda 634 nm during moderate cold

ischemia (+4 degrees C) can improve the survival of concordant hamster

xeno-heart transplants. The exact mechanism(s) are currently unknown,

but the effect might in part be exerted by a combination of reduced

production of ROS and increased oxidative phosphorylation.

Publication Types: * Research Support, Non-U.S. Gov't

PMID: 15808696 [PubMed - indexed for MEDLINE]

Non-published research (study in Spanish):

Therapy Valkion, its effect on non-traumatic joint pain.

Dra. Flora Mar'a Hern‡ndez Pedraza, Dr. Orlando S‡nchez Freire .

Orlando Freire. Especialista de 1er Grado en Medicina F'sica y

Rehabilitaci—n.Diplomado en Fitoterapia Cl'nicaÉ.Clinic Natural and

Traditional Medicine. Santa Clara. Santa Clara. Villa Clara. Villa

Clara.

We studied a total of 300 patients with non-traumatic joint pain from

the clinic of traditional medicine and natural Santa Clara in the first

period from February 2000 until February 1, 2001. 3 groups were formed

with 100 patients each: a control group with acupuncture and two tanks,

one with phototherapy and another with VALKION therapy. The average

number of days of treatment was 16 days, ending two months of treatment

patients treated with VALKION had no relapses and decreased consumption

of drugs and therefore believe that this therapy should be used in

patients with this condition because it is odourless and harmless to

the patient as well as by its high therapeutic effectiveness.

Therapy centres using valkion:

http://www.hartcenter.com/webLOxygenTherapy.htm

http://www.comprehensivenaturopathy.com/

natasa