Re: Stanford Ds Research Supports Possible Treatment to Improve Cognition

September 27, 2008

Thank you for posting this Christy! I was wondering how the presentation went. This is all very exciting news and I really hope that every single person sends in their $15!!! Carol in ILMom to , 8 DS My problem is not how I look. It's how you see me.VOTE NOBAMA '08Join our Down Syndrome information group - http://health. groups.yahoo. com/group/ DownSyndromeInfo Exchange/ Listen to oldest dd's music http://www.myspace. com/vennamusic [DownSyndromeInfoExchange] Stanford Ds Research Supports Possible Treatment to Improve Cognition

My name is Christy and I have a 12 month old son with Ds. I want to share the following information with your group. Last weekend I flew to New York City and watched the premiere of the documentary, "Changing a Mind." Let me say, my reaction to the film was "WOW!" The potential of the research being done at Garner Lab at Stanford is absolutely amazing. If you have not looked at Garner Lab's website lately - you need to! Dr. Garner just posted A LOT of new information last week. Be sure to read through every page, every link - it is quite interesting.

Please read the excerpt (from Garner Lab's website) I've pasted at the end of this email. It discusses how learning is impaired for individuals with Ds. In a nutshell, he has demonstrated in the Ds mouse model that the inhibitory communication in the brains of Ds mice is acting like a "parking brake" by being overactive and inhibiting learning. By turning it down (they are using a drug called PTZ in the lab - currently not available in the US) learning can better occur. It is based on this research that people are now giving their kids Ginkgo Biloba. It is the Bilobalide in the Ginkgo Biloba that works to "release the parking brake" ever so slightly. Dr. Garner is hopeful that the PTZ will have a much BETTER effect than the Ginkgo Biloba on the inhibitory pathways. Dr. Cody Cashion formulated the CMP treatment featured in the documentary. It is important to note

that the BEST RESULTS occurred in the film when the Ginkgo Biloba was used IN CONJUNCTION with Prozac. According to the research referenced on the changingmindsfounda tion.com Research section, Prozac has been proven to have a neurogenesis effect on the brain (produce new neurons). This is an important component of the Protocol since it has been shown by autopsy that by six months of age, babies with Down syndrome have ONLY HALF of the number of neurons in the brain as a typical child. In the lab, when Prozac was given to mice their neuron count DOUBLED in 24 days (this article is also posted in the Research section on changingmindsfounda tion.com ). So basically, by increasing the neuron count AND "releasing the parking brake" on the inhibitory pathway - the kids in the film made tremendous progress.

I was able to meet with Dr. Garner and discuss his current research for over an hour after the film. He truly has a passion to find an effective treatment to improve cognition in individuals with Down syndrome. I'm sure that many of you have the same questions I did, but here is the main one - WHAT IS IT GOING TO TAKE TO GET THIS NEW DRUG THROUGH CLINICAL TRIAL AND TO MARKET? The answer is very simple - Money - approximately $3 - $5 million. This may sound like a lot, but really - it's not! There are 350,000 people with Ds living in the US. If each family of each person with Ds gave just $15 DIRECTLY to Dr. Garner's Ds Lab fund that would be over $5 million!! He could go forward with the process of conducting a proper clinical trial without having to jump through time consuming hoops to raise the money through alternate sources.

The Changing Minds Foundation is also raising money to go toward Dr. Garner's research. Don't take my word for how impressive this research is - I'm not a scientist, I'm just a mom like you. Read all of the information for yourself at http://garnerlab. stanford. edu/ . Watch the 3 minute preview on www.changingmindsfo undation. org . Read the research posted on www.changingmindsfo undation. com . Buy the DVD directly from their website for $35. Host a showing of the DVD at a local church or school as a fund raiser for this vital research!

I would like to encourage each of you to do your part right now and write a check for at least $15 and send it to: Attn: Deborah Stinchfield, Stanford University, Office of Medical Development, 2700 Sand Hill Road, Menlo Park, CA 94025. Make your check payable to Stanford University and BE SURE TO INCLUDE THE FOLLOWING CODE in the memo section (DHAYQ) - this designates your gift for the Garner Down Syndrome Fund.

"Studies in the Garner lab have confirmed that in this mouse model of Down syndrome communication between two types of brain cells—excitatory and inhibitory neurons—is out of balance. There is too much inhibitory communication, which prevents learning from properly taking place. It's as if somebody forgot to release the parking break—the car just won't go.The Garner lab further investigated whether inhibitory communication between neurons could somehow be reduced in this mouse model. For this purpose, Down syndrome mice and normal mice were tested on two tasks that were designed to assess learning and memory. As expected, the Down syndrome mice performed significantly worse than the normal mice.

The Down syndrome mice were then treated for several weeks with different drugs, which are known to reduce inhibitory communication. These drugs work by partially blocking a receptor located on the neurons called GABA A receptor. Blocking these receptors should reduce inhibitory communication, thereby increasing excitatory communication. When tested on the learning and memory tasks, the Down syndrome mice now performed almost as well as the normal mice. Even several weeks after drug treatment had been terminated, these mice still performed better.

These results confirm that too much inhibitory communication between neurons indeed prevents learning from taking place in this mouse model of Down syndrome. Reducing this inhibition with specific drugs restores the balance between inhibitory and excitatory neurons so that learning can take place."

September 27, 2008

Christy,

May I forward this email to my local group?

Thank you,

Caroline

Carol in IL wrote:

> Thank you for posting this Christy! I was wondering how the

> presentation went. This is all very exciting news and I really hope

> that every single person sends in their $15!!!

> Carol in IL

> Mom to , 8 DS

>

> My problem is not how I look. It's how you see me.

> VOTE NOBAMA '08

>

> Join our Down Syndrome information group -

> http://health. groups.yahoo. com/group/ DownSyndromeInfo Exchange/

>

> Listen to oldest dd's music http://www.myspace. com/vennamusic

>

> [DownSyndromeInfoExchange] Stanford Ds Research Supports

> Possible Treatment to Improve Cognition

>

> My name is Christy and I have a 12 month old son with Ds. I want to

> share the following information with your group. Last weekend I flew

> to New York City and watched the premiere of the documentary,

> " Changing a Mind. " Let me say, my reaction to the film was " WOW! " The

> potential of the research being done at Garner Lab at Stanford is

> absolutely amazing. If you have not looked at Garner Lab's website

> lately - you need to! Dr. Garner just posted A LOT of new information

> last week. Be sure to read through every page, every link - it is

> quite interesting.

>

> Please read the excerpt (from Garner Lab's website) I've pasted at the

> end of this email. It discusses how learning is impaired for

> individuals with Ds. In a nutshell, he has demonstrated in the Ds

> mouse model that the _inhibitory communication _in the brains of Ds

> mice is acting like a " parking brake " by being overactive and

> inhibiting learning. By turning it down (they are using a drug called

> PTZ in the lab - currently not available in the US) learning can

> better occur. It is based on this research that people are now giving

> their kids Ginkgo Biloba. It is the Bilobalide in the Ginkgo Biloba

> that works to " release the parking brake " ever so slightly. Dr. Garner

> is hopeful that the PTZ will have a much BETTER effect than the Ginkgo

> Biloba on the inhibitory pathways. Dr. Cody Cashion formulated

> the CMP treatment featured in the documentary. It is important to note

> that the BEST RESULTS occurred in the film when the Ginkgo Biloba was

> used IN CONJUNCTION with Prozac. According to the research referenced

> on the changingmindsfounda tion.com <http://tion.com> Research

> section, Prozac has been proven to have a neurogenesis effect on the

> brain (produce new neurons). This is an important component of the

> Protocol since it has been shown by autopsy that by six months of age,

> babies with Down syndrome have ONLY HALF of the number of neurons in

> the brain as a typical child. In the lab, when Prozac was given to

> mice their neuron count DOUBLED in 24 days (this article is also

> posted in the Research section on changingmindsfounda tion.com ). So

> basically, by increasing the neuron count AND " releasing the parking

> brake " on the inhibitory pathway - the kids in the film made

> tremendous progress.

>

> I was able to meet with Dr. Garner and discuss his current research

> for over an hour after the film. He truly has a passion to find an

> effective treatment to improve cognition in individuals with Down

> syndrome. I'm sure that many of you have the same questions I did, but

> here is the main one - WHAT IS IT GOING TO TAKE TO GET THIS NEW DRUG

> THROUGH CLINICAL TRIAL AND TO MARKET? The answer is very simple -

> Money - approximately $3 - $5 million. This may sound like a lot, but

> really - it's not! There are 350,000 people with Ds living in the US.

> If each family of each person with Ds gave just $15 DIRECTLY to Dr.

> Garner's Ds Lab fund that would be over $5 million!! He could go

> forward with the process of conducting a proper clinical trial without

> having to jump through time consuming hoops to raise the money through

> alternate sources.

>

> The Changing Minds Foundation is also raising money to go toward Dr.

> Garner's research. Don't take my word for how impressive this research

> is - I'm not a scientist, I'm just a mom like you. Read all of the

> information for yourself at http://garnerlab. stanford. edu/

> <http://garnerlab.stanford.edu/>_ _ . Watch the 3 minute preview on

> www.changingmindsfo undation. org

> <http://www.changingmindsfoundation.org/> . Read the research posted

> on www.changingmindsfo undation. com

> <http://www.changingmindsfoundation.com/> . Buy the DVD directly from

> their website for $35. Host a showing of the DVD at a local church or

> school as a fund raiser for this vital research!

>

> I would like to encourage each of you to do your part right now and

> write a check for *at least $15* and send it to: /Attn: Deborah

> Stinchfield, Stanford University, Office of Medical Development, 2700

> Sand Hill Road, Menlo Park, CA 94025/. Make your check payable to

> _Stanford University_ and BE SURE TO INCLUDE THE FOLLOWING CODE in the

> memo section (DHAYQ) - this designates your gift for the Garner Down

> Syndrome Fund.

>

> * " **/Studies in the Garner lab have confirmed that in this mouse model

> of Down syndrome communication between two types of brain

> cells—excitatory and inhibitory neurons—is out of balance. There is

> too much inhibitory communication, which prevents learning from

> properly taking place. It's as if somebody forgot to release the

> parking break—the car just won't go.

> The Garner lab further investigated whether inhibitory communication

> between neurons could somehow be reduced in this mouse model. For this

> purpose, Down syndrome mice and normal mice were tested on two tasks

> that were designed to assess learning and memory. As expected, the

> Down syndrome mice performed significantly worse than the normal mice. /*

>

> /

> /*/The Down syndrome mice were then treated for several weeks with

> different drugs, which are known to reduce inhibitory communication.

> These drugs work by partially blocking a receptor located on the

> neurons called GABA A receptor. Blocking these receptors should reduce

> inhibitory communication, thereby increasing excitatory communication.

> When tested on the learning and memory tasks, the Down syndrome mice

> now performed almost as well as the normal mice. Even several weeks

> after drug treatment had been terminated, these mice still performed

> better./*

>

> /

> /*/These results confirm that too much inhibitory communication

> between neurons indeed prevents learning from taking place in this

> mouse model of Down syndrome. Reducing this inhibition with specific

> drugs restores the balance between inhibitory and excitatory neurons

> so that learning can take place. " /*

>

> **

>

September 27, 2008

We are starting our son, Reece on this program. We're going to add each item one at a time to see the individual benefits. We're starting Gingko tomorrow and then on to Prozac next week. I'll be sure to let everyone know how Reece is progressing. Our Pedi strongly feels that Dr. Garner is on to something huge and he is so excited about it!

Judy

[DownSyndromeInfoExchange] Stanford Ds Research Supports Possible Treatment to Improve Cognition

My name is Christy and I have a 12 month old son with Ds. I want to share the following information with your group. Last weekend I flew to New York City and watched the premiere of the documentary, "Changing a Mind." Let me say, my reaction to the film was "WOW!" The potential of the research being done at Garner Lab at Stanford is absolutely amazing. If you have not looked at Garner Lab's website lately - you need to! Dr. Garner just posted A LOT of new information last week. Be sure to read through every page, every link - it is quite interesting.

Please read the excerpt (from Garner Lab's website) I've pasted at the end of this email. It discusses how learning is impaired for individuals with Ds. In a nutshell, he has demonstrated in the Ds mouse model that the inhibitory communication in the brains of Ds mice is acting like a "parking brake" by being overactive and inhibiting learning. By turning it down (they are using a drug called PTZ in the lab - currently not available in the US) learning can better occur. It is based on this research that people are now giving their kids Ginkgo Biloba. It is the Bilobalide in the Ginkgo Biloba that works to "release the parking brake" ever so slightly. Dr. Garner is hopeful that the PTZ will have a much BETTER effect than the Ginkgo Biloba on the inhibitory pathways. Dr. Cody Cashion formulated the CMP treatment featured in the documentary. It is important to note that

the BEST RESULTS occurred in the film when the Ginkgo Biloba was used IN CONJUNCTION with Prozac. According to the research referenced on the changingmindsfounda tion.com Research section, Prozac has been proven to have a neurogenesis effect on the brain (produce new neurons). This is an important component of the Protocol since it has been shown by autopsy that by six months of age, babies with Down syndrome have ONLY HALF of the number of neurons in the brain as a typical child. In the lab, when Prozac was given to mice their neuron count DOUBLED in 24 days (this article is also posted in the Research section on changingmindsfounda tion.com ). So basically, by increasing the neuron count AND "releasing the parking brake" on the inhibitory pathway - the kids in the film made tremendous progress.

I was able to meet with Dr. Garner and discuss his current research for over an hour after the film. He truly has a passion to find an effective treatment to improve cognition in individuals with Down syndrome. I'm sure that many of you have the same questions I did, but here is the main one - WHAT IS IT GOING TO TAKE TO GET THIS NEW DRUG THROUGH CLINICAL TRIAL AND TO MARKET? The answer is very simple - Money - approximately $3 - $5 million. This may sound like a lot, but really - it's not! There are 350,000 people with Ds living in the US. If each family of each person with Ds gave just $15 DIRECTLY to Dr. Garner's Ds Lab fund that would be over $5 million!! He could go forward with the process of conducting a proper clinical trial without having to jump through time consuming hoops to raise the money through alternate sources.

The Changing Minds Foundation is also raising money to go toward Dr. Garner's research. Don't take my word for how impressive this research is - I'm not a scientist, I'm just a mom like you. Read all of the information for yourself at http://garnerlab. stanford. edu/ . Watch the 3 minute preview on www.changingmindsfo undation. org . Read the research posted on www.changingmindsfo undation. com

.. Buy the DVD directly from their website for $35. Host a showing of the DVD at a local church or school as a fund raiser for this vital research!

I would like to encourage each of you to do your part right now and write a check for at least $15 and send it to: Attn: Deborah Stinchfield, Stanford University, Office of Medical Development, 2700 Sand Hill Road, Menlo Park, CA 94025. Make your check payable to Stanford University and BE SURE TO INCLUDE THE FOLLOWING CODE in the memo section (DHAYQ) - this designates your gift for the Garner Down Syndrome Fund.

"Studies in the Garner lab have confirmed that in this mouse model of Down syndrome communication between two types of brain cells—excitatory and inhibitory neurons—is out of balance. There is too much inhibitory communication, which prevents learning from properly taking place. It's as if somebody forgot to release the parking break—the car just won't go.The Garner lab further investigated whether inhibitory communication between neurons could somehow be reduced in this mouse model. For this purpose, Down syndrome mice and normal mice were tested on two tasks that were designed to assess learning and memory. As expected, the Down syndrome mice performed significantly worse than the normal mice.

The Down syndrome mice were then treated for several weeks with different drugs, which are known to reduce inhibitory communication. These drugs work by partially blocking a receptor located on the neurons called GABA A receptor. Blocking these receptors should reduce inhibitory communication, thereby increasing excitatory communication. When tested on the learning and memory tasks, the Down syndrome mice now performed almost as well as the normal mice. Even several weeks after drug treatment had been terminated, these mice still performed better.

These results confirm that too much inhibitory communication between neurons indeed prevents learning from taking place in this mouse model of Down syndrome. Reducing this inhibition with specific drugs restores the balance between inhibitory and excitatory neurons so that learning can take place."

September 27, 2008

My doctor read all the information but is very apprehensive about the Prozac. I was a little disappointed, although it scares me too.

Shari

We are starting our son, Reece on this program. We're going to add each item one at a time to see the individual benefits. We're starting Gingko tomorrow and then on to Prozac next week. I'll be sure to let everyone know how Reece is progressing. Our Pedi strongly feels that Dr. Garner is on to something huge and he is so excited about it!

Judy

[DownSyndromeInfoExchange] Stanford Ds Research Supports Possible Treatment to Improve Cognition

My name is Christy and I have a 12 month old son with Ds. I want to share the following information with your group. Last weekend I flew to New York City and watched the premiere of the documentary, " Changing a Mind. " Let me say, my reaction to the film was " WOW! " The potential of the research being done at Garner Lab at Stanford is absolutely amazing. If you have not looked at Garner Lab's website lately - you need to! Dr. Garner just posted A LOT of new information last week. Be sure to read through every page, every link - it is quite interesting.

Please read the excerpt (from Garner Lab's website) I've pasted at the end of this email. It discusses how learning is impaired for individuals with Ds. In a nutshell, he has demonstrated in the Ds mouse model that the inhibitory communication in the brains of Ds mice is acting like a " parking brake " by being overactive and inhibiting learning. By turning it down (they are using a drug called PTZ in the lab - currently not available in the US) learning can better occur. It is based on this research that people are now giving their kids Ginkgo Biloba. It is the Bilobalide in the Ginkgo Biloba that works to " release the parking brake " ever so slightly. Dr. Garner is hopeful that the PTZ will have a much BETTER effect than the Ginkgo Biloba on the inhibitory pathways. Dr. Cody Cashion formulated the CMP treatment featured in the documentary. It is important to note that

the BEST RESULTS occurred in the film when the Ginkgo Biloba was used IN CONJUNCTION with Prozac. According to the research referenced on the changingmindsfounda tion.com Research section, Prozac has been proven to have a neurogenesis effect on the brain (produce new neurons). This is an important component of the Protocol since it has been shown by autopsy that by six months of age, babies with Down syndrome have ONLY HALF of the number of neurons in the brain as a typical child. In the lab, when Prozac was given to mice their neuron count DOUBLED in 24 days (this article is also posted in the Research section on changingmindsfounda tion.com ). So basically, by increasing the neuron count AND " releasing the parking brake " on the inhibitory pathway - the kids in the film made tremendous progress.

I was able to meet with Dr. Garner and discuss his current research for over an hour after the film. He truly has a passion to find an effective treatment to improve cognition in individuals with Down syndrome. I'm sure that many of you have the same questions I did, but here is the main one - WHAT IS IT GOING TO TAKE TO GET THIS NEW DRUG THROUGH CLINICAL TRIAL AND TO MARKET? The answer is very simple - Money - approximately $3 - $5 million. This may sound like a lot, but really - it's not! There are 350,000 people with Ds living in the US. If each family of each person with Ds gave just $15 DIRECTLY to Dr. Garner's Ds Lab fund that would be over $5 million!! He could go forward with the process of conducting a proper clinical trial without having to jump through time consuming hoops to raise the money through alternate sources.

The Changing Minds Foundation is also raising money to go toward Dr. Garner's research. Don't take my word for how impressive this research is - I'm not a scientist, I'm just a mom like you. Read all of the information for yourself at http://garnerlab. stanford. edu/ . Watch the 3 minute preview on www.changingmindsfo undation. org . Read the research posted on www.changingmindsfo undation. com

.. Buy the DVD directly from their website for $35. Host a showing of the DVD at a local church or school as a fund raiser for this vital research!

I would like to encourage each of you to do your part right now and write a check for at least $15 and send it to: Attn: Deborah Stinchfield, Stanford University, Office of Medical Development, 2700 Sand Hill Road, Menlo Park, CA 94025. Make your check payable to Stanford University and BE SURE TO INCLUDE THE FOLLOWING CODE in the memo section (DHAYQ) - this designates your gift for the Garner Down Syndrome Fund.

" Studies in the Garner lab have confirmed that in this mouse model of Down syndrome communication between two types of brain cells—excitatory and inhibitory neurons—is out of balance. There is too much inhibitory communication, which prevents learning from properly taking place. It's as if somebody forgot to release the parking break—the car just won't go.

The Garner lab further investigated whether inhibitory communication between neurons could somehow be reduced in this mouse model. For this purpose, Down syndrome mice and normal mice were tested on two tasks that were designed to assess learning and memory. As expected, the Down syndrome mice performed significantly worse than the normal mice.

The Down syndrome mice were then treated for several weeks with different drugs, which are known to reduce inhibitory communication. These drugs work by partially blocking a receptor located on the neurons called GABA A receptor. Blocking these receptors should reduce inhibitory communication, thereby increasing excitatory communication. When tested on the learning and memory tasks, the Down syndrome mice now performed almost as well as the normal mice. Even several weeks after drug treatment had been terminated, these mice still performed better.

These results confirm that too much inhibitory communication between neurons indeed prevents learning from taking place in this mouse model of Down syndrome. Reducing this inhibition with specific drugs restores the balance between inhibitory and excitatory neurons so that learning can take place. "

September 27, 2008

Judy

how old is Reece?

I'm beginning to think this might something for our son as well, but

he's only turning 4 this December. I can see the face of our

paediatrician when we suggest Prozac - he'll kill us!

/ Switzerland

--

with Saskia, Nora-Jane*2001, *2004/DS

(Lemon flavored Codliver Oil, highly dosed CoenzymeQ10, Vit. A, buffered Vit. C + natural Vit. E, Raspberry flavored Folic Acid + B12, Selenium, Zinc, Probiotic, Ginkgo Biloba, Prilosec, Thyroxine)

Judy schrieb:

We are starting our son, Reece on this program. We're going to

add each item one at a time to see the individual benefits. We're

starting Gingko tomorrow and then on to Prozac next week. I'll be sure

to let everyone know how Reece is progressing.

Our Pedi strongly feels that Dr. Garner is on to something huge and he

is so excited about it!

Judy

September 27, 2008

Reece is 3 1/2. I had my reservations about Prozac as well but our Pediatrician said that it is safe. Maybe it would help if you sent the Changing minds website and the Stanford site to your doctor.

Judy

Re: [DownSyndromeInfoExchange] Stanford Ds Research Supports Possible Treatment to Improve Cognition

Judyhow old is Reece?I'm beginning to think this might something for our son as well, but he's only turning 4 this December. I can see the face of our paediatrician when we suggest Prozac - he'll kill us!/ Switzerland

--

with Saskia, Nora-Jane*2001, *2004/DS

(Lemon flavored Codliver Oil, highly dosed CoenzymeQ10, Vit. A, buffered Vit. C + natural Vit. E, Raspberry flavored Folic Acid + B12, Selenium, Zinc, Probiotic, Ginkgo Biloba, Prilosec, Thyroxine)

Judy schrieb:

We are starting our son, Reece on this program. We're going to add each item one at a time to see the individual benefits. We're starting Gingko tomorrow and then on to Prozac next week. I'll be sure to let everyone know how Reece is progressing. Our Pedi strongly feels that Dr. Garner is on to something huge and he is so excited about it!

Judy

September 27, 2008

One more thing...I also sent the website to our Developmental Pediatrician. I haven't gotten her response yet but I'll let you know.

Judy

Re: [DownSyndromeInfoExchange] Stanford Ds Research Supports Possible Treatment to Improve Cognition

Judyhow old is Reece?I'm beginning to think this might something for our son as well, but he's only turning 4 this December. I can see the face of our paediatrician when we suggest Prozac - he'll kill us!/ Switzerland

--

with Saskia, Nora-Jane*2001, *2004/DS

(Lemon flavored Codliver Oil, highly dosed CoenzymeQ10, Vit. A, buffered Vit. C + natural Vit. E, Raspberry flavored Folic Acid + B12, Selenium, Zinc, Probiotic, Ginkgo Biloba, Prilosec, Thyroxine)

Judy schrieb:

We are starting our son, Reece on this program. We're going to add each item one at a time to see the individual benefits. We're starting Gingko tomorrow and then on to Prozac next week. I'll be sure to let everyone know how Reece is progressing. Our Pedi strongly feels that Dr. Garner is on to something huge and he is so excited about it!

Judy

September 27, 2008

Fyi..I am sure that you have considered this carefully, but just

wanted to mention the possible side effects of Prozac.

What side effects may occur?

Return

to top

Side

effects cannot be anticipated. If any develop or change in intensity, inform

your doctor as soon as possible. Only your doctor can determine if it is safe

for you to continue taking Prozac.

Side effects may include:

Abnormal dreams, abnormal ejaculation, abnormal vision, anxiety, diarrhea,

diminished sex drive, dizziness, dry mouth, flu-like symptoms, flushing,

gas, headache, impotence, insomnia, itching, loss of appetite, nausea,

nervousness, rash, sex-drive changes, sinusitis, sleepiness, sore throat,

sweating, tremors, upset stomach, vomiting, weakness, yawning

Why should Prozac not be

prescribed?

Return

to top

If

you are sensitive to or have ever had an allergic reaction to Prozac or similar

drugs, you should not take this medication. Make sure that your doctor is aware

of any drug reactions that you have experienced.

Do

not take this drug while using an MAO inhibitor (see " Most important fact

about this drug " ). You should also not use Prozac if you are taking

thioridazine. Likewise, do not start taking thioridazine within 5 weeks of

stopping Prozac.

Special warnings about Prozac

Return

to top

In

clinical studies, antidepressants increased the risk of suicidal thinking and

behavior in children and adolescents with depression and other psychiatric

disorders. Anyone considering the use of Prozac or any other antidepressant in

a child or adolescent must balance this risk with the clinical need. Prozac is

approved for treating major depression in children 8 years and older and for treating

obsessive-compulsive disorder in children 7 years and older.

Additionally,

the progression of major depression is associated with a worsening of symptoms

and/or the emergence of suicidal thinking or behavior in both adults and

children, whether or not they are taking antidepressants. Individuals being

treated with Prozac and their caregivers should watch for any change in

symptoms or any new symptoms that appear suddenly—especially agitation,

anxiety, hostility, panic, restlessness, extreme hyperactivity, and suicidal

thinking or behavior—and report them to the doctor immediately. Be especially

observant at the beginning of treatment or whenever there is a change in dose.

Unless

you are directed to do so by your doctor, do not take this medication if you

are recovering from a heart attack or if you have liver disease or diabetes.

Prozac

may cause you to become drowsy or less alert and may affect your judgment.

Therefore, driving or operating dangerous machinery or participating in any

hazardous activity that requires full mental alertness is not recommended.

While

taking this medication, you may feel dizzy or light-headed or actually faint

when getting up from a lying or sitting position. If getting up slowly doesn't

help or if this problem continues, notify your doctor.

If

you develop a skin rash or hives while taking Prozac, discontinue use of the

medication and notify your doctor immediately.

Prozac

should be used with caution if you have a history of mania or seizures. You

should discuss all of your medical conditions with your doctor before taking

this medication.

Prozac

can occasionally cause decreased appetite and weight loss, especially in

depressed people who are already underweight and in those with bulimia. If you

notice changes in your weight or appetite, tell your doctor.

Antidepressants

such as Prozac could potentially cause stomach bleeding, especially when

combined with nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin,

ibuprofen, naproxen, and ketoprofen. Consult your doctor before combining

Prozac with NSAIDs or blood-thinning medications.

There

have been rare reports of prolonged seizures in people who received

electroconvulsive therapy (ECT) while taking Prozac. To date, there are no

clinical studies establishing the benefit of combined treatment with Prozac and

ECT.

As

with other SSRIs, Prozac therapy should be slowly tapered instead of abruptly

stopped. If abruptly discontinued, drowsiness, irritability, agitation,

anxiety, headache, and insomnia may occur.

Possible food and drug

interactions when taking Prozac

Return

to top

Never

take Prozac with MAO inhibitors or thioridazine (see " Most important fact

about this drug " ).

Do

not drink alcohol while taking this medication.

If

Prozac is taken with certain other drugs, the effects of either could be

increased, decreased, or altered. It is especially important to check with your

doctor before combining Prozac with the following:

AlprazolamAny other

antidepressantsAspirinCarbamazepineClozapineepamDigitoxinDrugs that impair

brain function, such as sleep aids and narcotic

painkillersFlecainideHaloperidolLithiumNonsteroidal anti-inflammatory drugs

(NSAIDs) such as aspirin, ibuprofen, naproxen, and

ketoprofenPhenytoinPimozideSumatriptanTryptophanVinblastineWarfarin

From: DownSyndromeInfoExchange

[mailto:DownSyndromeInfoExchange ] On Behalf Of

Müller

Sent: Saturday, September 27, 2008 4:53 PM

To: DownSyndromeInfoExchange

Subject: Re: [DownSyndromeInfoExchange] Stanford Ds Research Supports

Possible Treatment to Improve Cognition

Judy

how old is Reece?

I'm beginning to think this might something for our son as well, but he's only

turning 4 this December. I can see the face of our paediatrician when we

suggest Prozac - he'll kill us!

/ Switzerland

-- with Saskia, Nora-Jane*2001, *2004/DS(Lemon flavored Codliver Oil, highly dosed CoenzymeQ10, Vit. A, buffered Vit. C + natural Vit. E, Raspberry flavored Folic Acid + B12, Selenium, Zinc, Probiotic, Ginkgo Biloba, Prilosec, Thyroxine)

Judy schrieb:

We are starting our son, Reece on this program. We're

going to add each item one at a time to see the individual

benefits. We're starting Gingko tomorrow and then on to Prozac

next week. I'll be sure to let everyone know how Reece is

progressing. Our Pedi strongly feels that Dr.

Garner is on to something huge and he is so excited about it!

Judy

September 27, 2008

This is why everyone needs to send MONEY so they can do trials and then we can all use it if proves to be safe. Carol in ILMom to , 8 DS My problem is not how I look. It's how you see me.VOTE NOBAMA '08Join our Down Syndrome information group - http://health. groups.yahoo. com/group/ DownSyndromeInfo Exchange/ Listen to oldest dd's music http://www.myspace. com/vennamusic [DownSyndromeInfoEx change] Stanford Ds Research Supports Possible Treatment to Improve Cognition

My name is Christy and I have a 12 month old son with Ds. I want to share the following information with your group. Last weekend I flew to New York City and watched the premiere of the documentary, "Changing a Mind." Let me say, my reaction to the film was "WOW!" The potential of the research being done at Garner Lab at Stanford is absolutely amazing. If you have not looked at Garner Lab's website lately - you need to! Dr. Garner just posted A LOT of new information last week. Be sure to read through every page, every link - it is quite interesting.

Please read the excerpt (from Garner Lab's website) I've pasted at the end of this email. It discusses how learning is impaired for individuals with Ds. In a nutshell, he has demonstrated in the Ds mouse model that the inhibitory communication in the brains of Ds mice is acting like a "parking brake" by being overactive and inhibiting learning. By turning it down (they are using a drug called PTZ in the lab - currently not available in the US) learning can better occur. It is based on this research that people are now giving their kids Ginkgo Biloba. It is the Bilobalide in the Ginkgo Biloba that works to "release the parking brake" ever so slightly. Dr. Garner is hopeful that the PTZ will have a much BETTER effect than the Ginkgo Biloba on the inhibitory pathways. Dr. Cody Cashion formulated the CMP treatment featured in the documentary.

It is important to note that

the BEST RESULTS occurred in the film when the Ginkgo Biloba was used IN CONJUNCTION with Prozac. According to the research referenced on the changingmindsfounda tion.com Research section, Prozac has been proven to have a neurogenesis effect on the brain (produce new neurons). This is an important component of the Protocol since it has been shown by autopsy that by six months of age, babies with Down syndrome have ONLY HALF of the number of neurons in the brain as a typical child. In the lab, when Prozac was given to mice their neuron count DOUBLED in 24 days (this article is also posted in the Research section on changingmindsfounda tion.com ). So basically, by increasing the neuron count AND "releasing the parking brake" on the inhibitory pathway - the kids in the film made tremendous progress.

I was able to meet with Dr. Garner and discuss his current research for over an hour after the film. He truly has a passion to find an effective treatment to improve cognition in individuals with Down syndrome. I'm sure that many of you have the same questions I did, but here is the main one - WHAT IS IT GOING TO TAKE TO GET THIS NEW DRUG THROUGH CLINICAL TRIAL AND TO MARKET? The answer is very simple - Money - approximately $3 - $5 million. This may sound like a lot, but really - it's not! There are 350,000 people with Ds living in the US. If each family of each person with Ds gave just $15 DIRECTLY to Dr. Garner's Ds Lab fund that would be over $5 million!! He could go forward with the process of conducting a proper clinical trial without having to jump through time consuming hoops to raise the money through alternate sources.

The Changing Minds Foundation is also raising money to go toward Dr. Garner's research. Don't take my word for how impressive this research is - I'm not a scientist, I'm just a mom like you. Read all of the information for yourself at http://garnerlab. stanford. edu/ . Watch the 3 minute preview on www.changingmindsfo undation. org . Read the research posted on www.changingmindsfo undation. com

.. Buy the DVD directly from their website for $35. Host a showing of the DVD at a local church or school as a fund raiser for this vital research!

I would like to encourage each of you to do your part right now and write a check for at least $15 and send it to: Attn: Deborah Stinchfield, Stanford University, Office of Medical Development, 2700 Sand Hill Road, Menlo Park, CA 94025. Make your check payable to Stanford University and BE SURE TO INCLUDE THE FOLLOWING CODE in the memo section (DHAYQ) - this designates your gift for the Garner Down Syndrome Fund.

"Studies in the Garner lab have confirmed that in this mouse model of Down syndrome communication between two types of brain cells—excitatory and inhibitory neurons—is out of balance. There is too much inhibitory communication, which prevents learning from properly taking place. It's as if somebody forgot to release the parking break—the car just won't go.

The Garner lab further investigated whether inhibitory communication between neurons could somehow be reduced in this mouse model. For this purpose, Down syndrome mice and normal mice were tested on two tasks that were designed to assess learning and memory. As expected, the Down syndrome mice performed significantly worse than the normal mice.

The Down syndrome mice were then treated for several weeks with different drugs, which are known to reduce inhibitory communication. These drugs work by partially blocking a receptor located on the neurons called GABA A receptor. Blocking these receptors should reduce inhibitory communication, thereby increasing excitatory communication. When tested on the learning and memory tasks, the Down syndrome mice now performed almost as well as the normal mice. Even several weeks after drug treatment had been terminated, these mice still performed better.

These results confirm that too much inhibitory communication between neurons indeed prevents learning from taking place in this mouse model of Down syndrome. Reducing this inhibition with specific drugs restores the balance between inhibitory and excitatory neurons so that learning can take place."

September 27, 2008

I will definitely be sending $15.00 for this testing. I'm so glad I joined this list. This is amazing information!

Thank you,

Carolyn

http://stores.ebay.com/ck-antiques_W0QQsspagenameZL2222QQtZkm

We've gone co-op! Come and see our newest location at Black Diamond Antiques in the Schuylkill Mall, Frackville, PA!

'Don't worry about the world coming to an end today.It's already tomorrow in Australia ' ( Schultz)

-- Re: [DownSyndromeInfoExchange] Stanford Ds Research Supports Possible Treatment to Improve Cognition

This is why everyone needs to send MONEY so they can do trials and then we can all use it if proves to be safe.

Carol in ILMom to , 8 DS My problem is not how I look. It's how you see me.VOTE NOBAMA '08Join our Down Syndrome information group - http://health. groups.yahoo. com/group/ DownSyndromeInfo Exchange/Listen to oldest dd's music http://www.myspace. com/vennamusic

[DownSyndromeInfoEx change] Stanford Ds Research Supports Possible Treatment to Improve Cognition

My name is Christy and I have a 12 month old son with Ds. I want to share the following information with your group. Last weekend I flew to New York City and watched the premiere of the documentary, "Changing a Mind." Let me say, my reaction to the film was "WOW!" The potential of the research being done at Garner Lab at Stanford is absolutely amazing. If you have not looked at Garner Lab's website lately - you need to! Dr. Garner just posted A LOT of new information last week. Be sure to read through every page, every link - it is quite interesting.

Please read the excerpt (from Garner Lab's website) I've pasted at the end of this email. It discusses how learning is impaired for individuals with Ds. In a nutshell, he has demonstrated in the Ds mouse model that the inhibitory communication in the brains of Ds mice is acting like a "parking brake" by being overactive and inhibiting learning. By turning it down (they are using a drug called PTZ in the lab - currently not available in the US) learning can better occur. It is based on this research that people are now giving their kids Ginkgo Biloba. It is the Bilobalide in the Ginkgo Biloba that works to "release the parking brake" ever so slightly. Dr. Garner is hopeful that the PTZ will have a much BETTER effect than the Ginkgo Biloba on the inhibitory pathways. Dr. Cody Cashion formulated the CMP treatment featured in the documentary. It is important to note that the BEST RESULTS occurred in the film when the Ginkgo Biloba was used IN CONJUNCTION with Prozac. According to the research referenced on the changingmindsfounda tion.com Research section, Prozac has been proven to have a neurogenesis effect on the brain (produce new neurons). This is an important component of the Protocol since it has been shown by autopsy that by six months of age, babies with Down syndrome have ONLY HALF of the number of neurons in the brain as a typical child. In the lab, when Prozac was given to mice their neuron count DOUBLED in 24 days (this article is also posted in the Research section on changingmindsfounda tion.com ). So basically, by increasing the neuron count AND "releasing the parking brake" on the inhibitory pathway - the kids in the film made tremendous progress.

I was able to meet with Dr. Garner and discuss his current research for over an hour after the film. He truly has a passion to find an effective treatment to improve cognition in individuals with Down syndrome. I'm sure that many of you have the same questions I did, but here is the main one - WHAT IS IT GOING TO TAKE TO GET THIS NEW DRUG THROUGH CLINICAL TRIAL AND TO MARKET? The answer is very simple - Money - approximately $3 - $5 million. This may sound like a lot, but really - it's not! There are 350,000 people with Ds living in the US. If each family of each person with Ds gave just $15 DIRECTLY to Dr. Garner's Ds Lab fund that would be over $5 million!! He could go forward with the process of conducting a proper clinical trial without having to jump through time consuming hoops to raise the money through alternate sources.

The Changing Minds Foundation is also raising money to go toward Dr. Garner's research. Don't take my word for how impressive this research is - I'm not a scientist, I'm just a mom like you. Read all of the information for yourself at http://garnerlab. stanford. edu/ . Watch the 3 minute preview on www.changingmindsfo undation. org . Read the research posted on www.changingmindsfo undation. com . Buy the DVD directly from their website for $35. Host a showing of the DVD at a local church or school as a fund raiser for this vital research!

I would like to encourage each of you to do your part right now and write a check for at least $15 and send it to: Attn: Deborah Stinchfield, Stanford University, Office of Medical Development, 2700 Sand Hill Road, Menlo Park, CA 94025. Make your check payable to Stanford University and BE SURE TO INCLUDE THE FOLLOWING CODE in the memo section (DHAYQ) - this designates your gift for the Garner Down Syndrome Fund.

"Studies in the Garner lab have confirmed that in this mouse model of Down syndrome communication between two types of brain cells—excitatory and inhibitory neurons—is out of balance. There is too much inhibitory communication, which prevents learning from properly taking place. It's as if somebody forgot to release the parking break—the car just won't go.The Garner lab further investigated whether inhibitory communication between neurons could somehow be reduced in this mouse model. For this purpose, Down syndrome mice and normal mice were tested on two tasks that were designed to assess learning and memory. As expected, the Down syndrome mice performed significantly worse than the normal mice.

The Down syndrome mice were then treated for several weeks with different drugs, which are known to reduce inhibitory communication. These drugs work by partially blocking a receptor located on the neurons called GABA A receptor. Blocking these receptors should reduce inhibitory communication, thereby increasing excitatory communication. When tested on the learning and memory tasks, the Down syndrome mice now performed almost as well as the normal mice. Even several weeks after drug treatment had been terminated, these mice still performed better.

These results confirm that too much inhibitory communication between neurons indeed prevents learning from taking place in this mouse model of Down syndrome. Reducing this inhibition with specific drugs restores the balance between inhibitory and excitatory neurons so that learning can take place."

September 27, 2008

I agree…I am chicken enough that I won’t use it for Danny yet,

but I will send money for the trial, because it does sound promising.

KathyR

From:

DownSyndromeInfoExchange

[mailto:DownSyndromeInfoExchange ] On Behalf Of Carol in

IL

Sent: Saturday, September 27, 2008 5:14 PM

To: DownSyndromeInfoExchange

Subject: Re: [DownSyndromeInfoExchange] Stanford Ds Research Supports

Possible Treatment to Improve Cognition

This

is why everyone needs to send MONEY so they can do trials and then we can all

use it if proves to be safe.

Carol

in IL

Mom to , 8 DS

My problem is not how I look. It's how you see me.

VOTE NOBAMA '08

Join our Down Syndrome information group -

http://health. groups.yahoo. com/group/ DownSyndromeInfo Exchange/

Listen to oldest dd's music http://www.myspace. com/vennamusic

[DownSyndromeInfoEx change] Stanford Ds Research Supports Possible Treatment

to Improve Cognition

My name is Christy and I

have a 12 month old son with Ds. I want to share the following

information with your group. Last weekend I flew to New York City and

watched the premiere of the documentary, " Changing a Mind. " Let

me say, my reaction to the film was " WOW! " The potential of the

research being done at Garner Lab at Stanford is absolutely amazing. If

you have not looked at Garner Lab's website lately - you need to! Dr.

Garner just posted A LOT of new information last week. Be sure to read

through every page, every link - it is quite interesting.

Please read the excerpt

(from Garner Lab's website) I've pasted at the end of this email. It

discusses how learning is impaired for individuals with Ds. In a nutshell, he has

demonstrated in the Ds mouse model that the inhibitory communication in

the brains of Ds mice is acting like a " parking brake " by being

overactive and inhibiting learning. By turning it down (they are

using a drug called PTZ in the lab - currently not available in the US)

learning can better occur. It is based on this research that people are

now giving their kids Ginkgo Biloba. It is the Bilobalide in the Ginkgo

Biloba that works to " release the parking brake " ever so slightly.

Dr. Garner is hopeful that the PTZ will have a much BETTER effect than the

Ginkgo Biloba on the inhibitory pathways. Dr. Cody Cashion

formulated the CMP treatment featured in the documentary. It is important

to note that the BEST RESULTS occurred in the film when the Ginkgo Biloba was

used IN CONJUNCTION with Prozac. According to the research referenced on

the changingmindsfounda tion.com

Research section, Prozac has been proven to have a neurogenesis effect on the

brain (produce new neurons). This is an important component of the

Protocol since it has been shown by autopsy that by six months of age, babies

with Down syndrome have ONLY HALF of the number of neurons in the brain as a

typical child. In the lab, when Prozac was given to mice their neuron

count DOUBLED in 24 days (this article is also posted in the Research section

on changingmindsfounda tion.com

). So basically, by increasing the neuron count AND " releasing the

parking brake " on the inhibitory pathway - the kids in the film made

tremendous progress.

I was able to meet with

Dr. Garner and discuss his current research for over an hour after the

film. He truly has a passion to find an effective treatment to improve cognition

in individuals with Down syndrome. I'm sure that many of you have the

same questions I did, but here is the main one - WHAT IS IT GOING TO TAKE TO

GET THIS NEW DRUG THROUGH CLINICAL TRIAL AND TO MARKET? The answer is

very simple - Money - approximately $3 - $5 million. This may sound like

a lot, but really - it's not! There are 350,000 people with Ds living in

the US. If each family of each person with

Ds gave just $15 DIRECTLY to Dr. Garner's Ds Lab fund that would be

over $5 million!! He could go forward

with the process of conducting a proper clinical trial without having to jump

through time consuming hoops to raise the money through alternate sources.

The Changing Minds

Foundation is also raising money to go toward Dr. Garner's research. Don't

take my word for how impressive this research is - I'm not a scientist, I'm

just a mom like you. Read all of the information for yourself at http://garnerlab. stanford. edu/ . Watch the 3

minute preview on www.changingmindsfo undation. org . Read the research

posted on www.changingmindsfo

undation. com . Buy the DVD directly from their

website for $35. Host a showing of the DVD at a local church or school as

a fund raiser for this vital research!

I would like to encourage

each of you to do your part right now and write a check for at least $15

and send it to: Attn:

Deborah Stinchfield, Stanford University, Office of Medical Development, 2700

Sand Hill Road, Menlo Park, CA 94025.

Make your check payable to Stanford University and BE SURE TO INCLUDE

THE FOLLOWING CODE in the memo section (DHAYQ) - this designates

your gift for the Garner Down Syndrome Fund.

" Studies

in the Garner lab have confirmed that in this mouse model of Down syndrome

communication between two types of brain cells—excitatory and inhibitory

neurons—is out of balance. There is too much inhibitory communication, which

prevents learning from properly taking place. It's as if somebody forgot to

release the parking break—the car just won't go.

The Garner lab further investigated whether inhibitory communication between

neurons could somehow be reduced in this mouse model. For this purpose, Down

syndrome mice and normal mice were tested on two tasks that were designed to

assess learning and memory. As expected, the Down syndrome mice performed

significantly worse than the normal mice.

The Down syndrome mice were then treated for several weeks with different

drugs, which are known to reduce inhibitory communication. These drugs work by

partially blocking a receptor located on the neurons called GABA A receptor.

Blocking these receptors should reduce inhibitory communication, thereby

increasing excitatory communication. When tested on the learning and memory

tasks, the Down syndrome mice now performed almost as well as the normal mice.

Even several weeks after drug treatment had been terminated, these mice still

performed better.

These results confirm that too much inhibitory communication between neurons

indeed prevents learning from taking place in this mouse model of Down

syndrome. Reducing this inhibition with specific drugs restores the balance

between inhibitory and excitatory neurons so that learning can take

place. "

September 27, 2008

I did consider it carefully....I don't even like giving Reece Tylenol. I appreciate the information though! By starting each medication individually, we'll be able to determine which ones (if any) are causing any side affects.

Re: [DownSyndromeInfoEx change] Stanford Ds Research Supports Possible Treatment to Improve Cognition

Judyhow old is Reece?I'm beginning to think this might something for our son as well, but he's only turning 4 this December. I can see the face of our paediatrician when we suggest Prozac - he'll kill us!/ Switzerland

-- with Saskia, Nora-Jane*2001, *2004/DS(Lemon flavored Codliver Oil, highly dosed CoenzymeQ10, Vit. A, buffered Vit. C + natural Vit. E, Raspberry flavored Folic Acid + B12, Selenium, Zinc, Probiotic, Ginkgo Biloba, Prilosec, Thyroxine)

Judy schrieb:

We are starting our son, Reece on this program. We're going to add each item one at a time to see the individual benefits. We're starting Gingko tomorrow and then on to Prozac next week. I'll be sure to let everyone know how Reece is progressing. Our Pedi strongly feels that Dr. Garner is on to something huge and he is so excited about it!

Judy

September 27, 2008

Do they recommend starting the different things so close

together? From what I read today, sometimes it takes 4 weeks to see improvement

in depression after starting Prozac..are the changes quicker in kids w/Ds? I

saw improvement in Danny within a couple of weeks after starting him on Gingko.

From:

DownSyndromeInfoExchange

[mailto:DownSyndromeInfoExchange ] On Behalf Of Judy

Sent: Saturday, September 27, 2008 7:39 PM

To: DownSyndromeInfoExchange

Subject: Re: [DownSyndromeInfoExchange] Stanford Ds Research Supports

Possible Treatment to Improve Cognition

I

did consider it carefully....I don't even like giving Reece Tylenol. I

appreciate the information though! By starting each medication

individually, we'll be able to determine which ones (if any) are causing any

side affects.

Re: [DownSyndromeInfoEx change] Stanford Ds Research Supports

Possible Treatment to Improve Cognition

Judy

how old is Reece?

I'm beginning to think this might something for our son as well, but he's only

turning 4 this December. I can see the face of our paediatrician when we

suggest Prozac - he'll kill us!

/ Switzerland

-- with Saskia, Nora-Jane*2001, *2004/DS(Lemon flavored Codliver Oil, highly dosed CoenzymeQ10, Vit. A, buffered Vit. C + natural Vit. E, Raspberry flavored Folic Acid + B12, Selenium, Zinc, Probiotic, Ginkgo Biloba, Prilosec, Thyroxine)

Judy schrieb:

We

are starting our son, Reece on this program. We're going to add

each item one at a time to see the individual benefits. We're

starting Gingko tomorrow and then on to Prozac next week. I'll be

sure to let everyone know how Reece is progressing.

Our Pedi strongly feels that Dr. Garner is on to

something huge and he is so excited about it!

Judy

September 27, 2008

My understanding of Prozac for down syndrome is to to make more neurons since people with DS are born with 1/2 of what typical people are born with. I'm not sure how soon we would know more neurons have developed. On the Changing Minds sight they said that most people start all of the medicines at once. If Reece is having a side affect then it seems it would be hard to determine which of the ingredients is causing it. After reading about it again, maybe it would be better to give it a few weeks before adding a new item. As far as Prozac side affects, our doctor was telling us that the most common side affect is diarrhea. Reece is usually constipated so maybe it'll work out for him. I am putting a lot of trust in my doctor as he said all of the items in the protocol are safe. The next item on the list after Prozac is the body bio

balanced oil. My dr doesn't know what that is and what's it's for so he's going to put in a call at Stanford. I feel pretty good knowing that our dr is going to be working with us closely on this.

Listed below is what was sent to my husband.

Changing Minds Protocol TM Frequently Asked Questions

· How do I get started on the CMPTM

Protocol Order of Importance Ginkgo Biloba Prozac Body Bio Balanced Oil Phosphatidyl Choline Focalin XR Folic acid/B12 Each part of the protocol is helpful, even by itself. However, the best results will not be received by just participating in one or two. We have found that the protocol works exponentially well together, given consistently and over a period of time. Therefore, all parts are integral to the total success and helping the body to work as effectively as possible. · Should I start everything at once? Most participants have started everything at once; however, you may find it better to start one at a time. This way you will see the independent results and it is easier to determine appropriate dosing if adding one substance at a time and allowing a few weeks before adding another.

Re: [DownSyndromeInfoEx change] Stanford Ds Research Supports Possible Treatment to Improve Cognition

Judyhow old is Reece?I'm beginning to think this might something for our son as well, but he's only turning 4 this December. I can see the face of our paediatrician when we suggest Prozac - he'll kill us!/ Switzerland

-- with Saskia, Nora-Jane*2001, *2004/DS(Lemon flavored Codliver Oil, highly dosed CoenzymeQ10, Vit. A, buffered Vit. C + natural Vit. E, Raspberry flavored Folic Acid + B12, Selenium, Zinc, Probiotic, Ginkgo Biloba, Prilosec, Thyroxine)

Judy schrieb:

We are starting our son, Reece on this program. We're going to add each item one at a time to see the individual benefits. We're starting Gingko tomorrow and then on to Prozac next week. I'll be sure to let everyone know how Reece is progressing. Our Pedi strongly feels that Dr. Garner is on to something huge and he is so excited about it!

Judy

September 27, 2008

Let us know what they say about the body bio balanced oil!Shari

My understanding of Prozac for down syndrome is to to make more neurons since people with DS are born with 1/2 of what typical people are born with. I'm not sure how soon we would know more neurons have developed. On the Changing Minds sight they said that most people start all of the medicines at once. If Reece is having a side affect then it seems it would be hard to determine which of the ingredients is causing it. After reading about it again, maybe it would be better to give it a few weeks before adding a new item. As far as Prozac side affects, our doctor was telling us that the most common side affect is diarrhea. Reece is usually constipated so maybe it'll work out for him. I am putting a lot of trust in my doctor as he said all of the items in the protocol are safe. The next item on the list after Prozac is the body bio

balanced oil. My dr doesn't know what that is and what's it's for so he's going to put in a call at Stanford. I feel pretty good knowing that our dr is going to be working with us closely on this.

Listed below is what was sent to my husband.

Changing Minds Protocol TM Frequently Asked Questions

· How do I get started on the CMPTM

Protocol Order of Importance Ginkgo Biloba Prozac Body Bio Balanced Oil Phosphatidyl Choline Focalin XR Folic acid/B12 Each part of the protocol is helpful, even by itself. However, the best results will not be received by just participating in one or two. We have found that the protocol works exponentially well together, given consistently and over a period of time. Therefore, all parts are integral to the total success and helping the body to work as effectively as possible. · Should I start everything at once? Most participants have started everything at once; however, you may find it better to start one at a time. This way you will see the independent results and it is easier to determine appropriate dosing if adding one substance at a time and allowing a few weeks before adding another.

Re: [DownSyndromeInfoEx change] Stanford Ds Research Supports Possible Treatment to Improve Cognition

Judyhow old is Reece?I'm beginning to think this might something for our son as well, but he's only turning 4 this December. I can see the face of our paediatrician when we suggest Prozac - he'll kill us!

/ Switzerland

-- with Saskia, Nora-Jane*2001, *2004/DS(Lemon flavored Codliver Oil, highly dosed CoenzymeQ10, Vit. A, buffered Vit. C + natural Vit. E, Raspberry flavored Folic Acid + B12, Selenium, Zinc, Probiotic, Ginkgo Biloba, Prilosec, Thyroxine)

Judy schrieb:

We are starting our son, Reece on this program. We're going to add each item one at a time to see the individual benefits. We're starting Gingko tomorrow and then on to Prozac next week. I'll be sure to let everyone know how Reece is progressing. Our Pedi strongly feels that Dr. Garner is on to something huge and he is so excited about it!

Judy

September 27, 2008

Yeah, I think it is a good idea to start slow and see how each

component is affecting him before adding another thing. Reece had had his

thyroid checked, right? Danny was very constipated as a baby, but once we

started him on thyroid meds (and digestive enzymes) he started having normal

bms.

From:

DownSyndromeInfoExchange

[mailto:DownSyndromeInfoExchange ] On Behalf Of Judy

Sent: Saturday, September 27, 2008 11:56 PM

To: DownSyndromeInfoExchange

Subject: Re: [DownSyndromeInfoExchange] Stanford Ds Research Supports

Possible Treatment to Improve Cognition

My

understanding of Prozac for down syndrome is to to make more neurons

since people with DS are born with 1/2 of what typical people are born

with. I'm not sure how soon we would know more neurons have

developed. On the Changing Minds sight they said that most people

start all of the medicines at once. If Reece is having a side

affect then it seems it would be hard to determine which of

the ingredients is causing it. After reading about it again, maybe

it would be better to give it a few weeks before adding a new item. As

far as Prozac side affects, our doctor was telling us that the most common

side affect is diarrhea. Reece is usually constipated so maybe it'll

work out for him. I am putting a lot of trust in my doctor as

he said all of the items in the protocol are safe. The

next item on the list after Prozac is the body bio balanced

oil. My dr doesn't know what that is and what's it's for so he's going to

put in a call at Stanford. I feel pretty good knowing that our dr is

going to be working with us closely on this.

Listed

below is what was sent to my husband.

Changing Minds

Protocol

TM Frequently

Asked Questions

· How do I get

started on the

CMPTM

Protocol

Order of Importance

Ginkgo

Biloba

Prozac

Body

Bio Balanced Oil

Phosphatidyl

Choline

Focalin

XR

Folic

acid/B12

Each

part of the protocol is helpful, even by itself. However, the best results will

not be received by just participating in one or two. We have found that the

protocol works exponentially well together, given consistently and over a

period of time. Therefore, all parts are integral to the total success and

helping the body to work as effectively as possible.

· Should I start

everything at once?

Most

participants have started everything at once; however, you may find it better

to start one at a time. This way you will see the independent results and it is

easier to determine appropriate dosing if adding one substance at a time and

allowing a few weeks before adding another.

Re: [DownSyndromeInfoEx change] Stanford Ds Research Supports

Possible Treatment to Improve Cognition

Judy

how old is Reece?

I'm beginning to think this might something for our son as well, but he's only

turning 4 this December. I can see the face of our paediatrician when we

suggest Prozac - he'll kill us!

/ Switzerland

-- with Saskia, Nora-Jane*2001, *2004/DS(Lemon flavored Codliver Oil, highly dosed CoenzymeQ10, Vit. A, buffered Vit. C + natural Vit. E, Raspberry flavored Folic Acid + B12, Selenium, Zinc, Probiotic, Ginkgo Biloba, Prilosec, Thyroxine)

Judy schrieb:

We

are starting our son, Reece on this program. We're going to add

each item one at a time to see the individual benefits. We're

starting Gingko tomorrow and then on to Prozac next week. I'll be

sure to let everyone know how Reece is progressing.

Our Pedi strongly feels that Dr. Garner is on to

something huge and he is so excited about it!

Judy

September 27, 2008

Yep, Reece is taking Synthroid. He's been non ambulatory up until a couple months ago so I'm sure that will change now that he's using a walker to get around. Oh, and he just learned to crawl 2 days ago....wooohooo! I'm really hoping that this treatment helps Reece. It seems like the gap between Reece and typical children is getting wider as he gets older. I'd sure like to to see it get closer.

Re: [DownSyndromeInfoEx change] Stanford Ds Research Supports Possible Treatment to Improve Cognition

Judyhow old is Reece?I'm beginning to think this might something for our son as well, but he's only turning 4 this December. I can see the face of our paediatrician when we suggest Prozac - he'll kill us!/ Switzerland

-- with Saskia, Nora-Jane*2001, *2004/DS(Lemon flavored Codliver Oil, highly dosed CoenzymeQ10, Vit. A, buffered Vit. C + natural Vit. E, Raspberry flavored Folic Acid + B12, Selenium, Zinc, Probiotic, Ginkgo Biloba, Prilosec, Thyroxine)

Judy schrieb:

We are starting our son, Reece on this program. We're going to add each item one at a time to see the individual benefits. We're starting Gingko tomorrow and then on to Prozac next week. I'll be sure to let everyone know how Reece is progressing. Our Pedi strongly feels that Dr. Garner is on to something huge and he is so excited about it!

Judy

September 27, 2008

Yep, Reece is taking Synthroid. He's been non ambulatory up until a couple months ago so I'm sure that will change now that he's using a walker to get around. Oh, and he just learned to crawl 2 days ago....wooohooo! I'm really hoping that this treatment helps Reece. It seems like the gap between Reece and typical children is getting wider as he gets older. I'd sure like to to see it get closer.

Re: [DownSyndromeInfoEx change] Stanford Ds Research Supports Possible Treatment to Improve Cognition

Judyhow old is Reece?I'm beginning to think this might something for our son as well, but he's only turning 4 this December. I can see the face of our paediatrician when we suggest Prozac - he'll kill us!/ Switzerland

-- with Saskia, Nora-Jane*2001, *2004/DS(Lemon flavored Codliver Oil, highly dosed CoenzymeQ10, Vit. A, buffered Vit. C + natural Vit. E, Raspberry flavored Folic Acid + B12, Selenium, Zinc, Probiotic, Ginkgo Biloba, Prilosec, Thyroxine)

Judy schrieb:

We are starting our son, Reece on this program. We're going to add each item one at a time to see the individual benefits. We're starting Gingko tomorrow and then on to Prozac next week. I'll be sure to let everyone know how Reece is progressing. Our Pedi strongly feels that Dr. Garner is on to something huge and he is so excited about it!

Judy

September 27, 2008

Hey, good for him!!

We noticed a huge change in Danny(speechwise…longer sentences,

etc) after he started the gingko…hope that the same thing happens for Reece.

From:

DownSyndromeInfoExchange

[mailto:DownSyndromeInfoExchange ] On Behalf Of Judy

Sent: Sunday, September 28, 2008 12:35 AM

To: DownSyndromeInfoExchange

Subject: Re: [DownSyndromeInfoExchange] Stanford Ds Research Supports

Possible Treatment to Improve Cognition

Yep,

Reece is taking Synthroid. He's been non ambulatory up until a couple

months ago so I'm sure that will change now that he's using a walker to get

around. Oh, and he just learned to crawl 2 days

ago....wooohooo! I'm really hoping that this treatment

helps Reece. It seems like the gap between Reece and typical

children is getting wider as he gets older. I'd sure

like to to see it get closer.

Re: [DownSyndromeInfoEx change] Stanford Ds Research Supports

Possible Treatment to Improve Cognition

Judy

how old is Reece?

I'm beginning to think this might something for our son as well, but he's only

turning 4 this December. I can see the face of our paediatrician when we

suggest Prozac - he'll kill us!

/ Switzerland

-- with Saskia, Nora-Jane*2001, *2004/DS(Lemon flavored Codliver Oil, highly dosed CoenzymeQ10, Vit. A, buffered Vit. C + natural Vit. E, Raspberry flavored Folic Acid + B12, Selenium, Zinc, Probiotic, Ginkgo Biloba, Prilosec, Thyroxine)

Judy schrieb:

We

are starting our son, Reece on this program. We're going to add

each item one at a time to see the individual benefits. We're

starting Gingko tomorrow and then on to Prozac next week. I'll be

sure to let everyone know how Reece is progressing. Our Pedi strongly feels that Dr.

Garner is on to something huge and he is so excited about it!

Judy

September 27, 2008

Hey, good for him!!

We noticed a huge change in Danny(speechwise…longer sentences,

etc) after he started the gingko…hope that the same thing happens for Reece.

From:

DownSyndromeInfoExchange

[mailto:DownSyndromeInfoExchange ] On Behalf Of Judy

Sent: Sunday, September 28, 2008 12:35 AM

To: DownSyndromeInfoExchange

Subject: Re: [DownSyndromeInfoExchange] Stanford Ds Research Supports

Possible Treatment to Improve Cognition

Yep,

Reece is taking Synthroid. He's been non ambulatory up until a couple

months ago so I'm sure that will change now that he's using a walker to get

around. Oh, and he just learned to crawl 2 days

ago....wooohooo! I'm really hoping that this treatment

helps Reece. It seems like the gap between Reece and typical

children is getting wider as he gets older. I'd sure

like to to see it get closer.

Re: [DownSyndromeInfoEx change] Stanford Ds Research Supports

Possible Treatment to Improve Cognition

Judy

how old is Reece?

I'm beginning to think this might something for our son as well, but he's only

turning 4 this December. I can see the face of our paediatrician when we

suggest Prozac - he'll kill us!

/ Switzerland

-- with Saskia, Nora-Jane*2001, *2004/DS(Lemon flavored Codliver Oil, highly dosed CoenzymeQ10, Vit. A, buffered Vit. C + natural Vit. E, Raspberry flavored Folic Acid + B12, Selenium, Zinc, Probiotic, Ginkgo Biloba, Prilosec, Thyroxine)

Judy schrieb:

We

are starting our son, Reece on this program. We're going to add

each item one at a time to see the individual benefits. We're

starting Gingko tomorrow and then on to Prozac next week. I'll be

sure to let everyone know how Reece is progressing. Our Pedi strongly feels that Dr.

Garner is on to something huge and he is so excited about it!

Judy

September 27, 2008

Thanks, Kathy! I'll keep you posted!

Re: [DownSyndromeInfoEx change] Stanford Ds Research Supports Possible Treatment to Improve Cognition

Judyhow old is Reece?I'm beginning to think this might something for our son as well, but he's only turning 4 this December. I can see the face of our paediatrician when we suggest Prozac - he'll kill us!/ Switzerland

-- with Saskia, Nora-Jane*2001, *2004/DS(Lemon flavored Codliver Oil, highly dosed CoenzymeQ10, Vit. A, buffered Vit. C + natural Vit. E, Raspberry flavored Folic Acid + B12, Selenium, Zinc, Probiotic, Ginkgo Biloba, Prilosec, Thyroxine)

Judy schrieb:

We are starting our son, Reece on this program. We're going to add each item one at a time to see the individual benefits. We're starting Gingko tomorrow and then on to Prozac next week. I'll be sure to let everyone know how Reece is progressing. Our Pedi strongly feels that Dr. Garner is on to something huge and he is so excited about it!

Judy

September 27, 2008

Thanks, Kathy! I'll keep you posted!

Re: [DownSyndromeInfoEx change] Stanford Ds Research Supports Possible Treatment to Improve Cognition

Judyhow old is Reece?I'm beginning to think this might something for our son as well, but he's only turning 4 this December. I can see the face of our paediatrician when we suggest Prozac - he'll kill us!/ Switzerland

-- with Saskia, Nora-Jane*2001, *2004/DS(Lemon flavored Codliver Oil, highly dosed CoenzymeQ10, Vit. A, buffered Vit. C + natural Vit. E, Raspberry flavored Folic Acid + B12, Selenium, Zinc, Probiotic, Ginkgo Biloba, Prilosec, Thyroxine)

Judy schrieb:

We are starting our son, Reece on this program. We're going to add each item one at a time to see the individual benefits. We're starting Gingko tomorrow and then on to Prozac next week. I'll be sure to let everyone know how Reece is progressing. Our Pedi strongly feels that Dr. Garner is on to something huge and he is so excited about it!

Judy

September 28, 2008

Judy,

Prozac - most of the children are taking 10 mg. Results have been

obtained with 5 mg. For a child only 3 1/2 years old, I would start

with 5 mg. Since your son is so young, it may be advisable to wait

a little longer with the prozac. But, you have to live in your own

skin, and I know that it would be hard to wait if you have a doctor

who is excited and ready to implement the protocol.

Ginkgo - we are giving our son, , 300 mg of Ginkgold (2.85

mg/lb). suggests a minimum of 2.5 mg/lb. I'm thinking of

raising it to 360 mg (3.3 mg/lb) but will wait for awhile.

Focalin-XR - frankly, this one scares me the most. This is for

attention, each child is different. I would not rush with the

Focalin-XR.

As far as the " order of importance " , you may wish to put the B6/B12

ahead of the Focalin-XR.

All the best to you and your son,

Marsha

>

> My understanding of Prozac for down syndrome is to to make

more neurons since people with DS are born with 1/2 of what typical

people are born with. I'm not sure how soon we would know more

neurons have developed. On the Changing Minds sight they said that

most people start all of the medicines at once. If Reece is having

a side affect then it seems it would be hard to determine which of

the ingredients is causing it. After reading about it again, maybe

it would be better to give it a few weeks before adding a new item.

As far as Prozac side affects, our doctor was telling us that the

most common side affect is diarrhea. Reece is usually constipated

so maybe it'll work out for him. I am putting a lot of trust in my

doctor as he said all of the items in the protocol are safe. The

next item on the list after Prozac is the body bio balanced oil. My

dr doesn't know what that is and what's it's for so he's going to

put in a

> call at Stanford. I feel pretty good knowing that our dr is going

to be working with us closely on this.

>

> Listed below is what was sent to my husband.

>

> Changing Minds Protocol TM Frequently Asked Questions

> · How do I get started on theCMPTM

> Protocol Order of Importance

> Ginkgo Biloba

> Prozac

> Body Bio Balanced Oil

> Phosphatidyl Choline

> Focalin XR

> Folic acid/B12

>

> Each part of the protocol is helpful, even by itself. However, the

best results will not be received by just participating in one or

two. We have found that the protocol works exponentially well

together, given consistently and over a period of time. Therefore,

all parts are integral to the total success and helping the body to

work as effectively as possible.

>

> · Should I start everything at once?

> Most participants have started everything at once; however, you

may find it better to start one at a time. This way you will see the

independent results and it is easier to determine appropriate dosing

if adding one substance at a time and allowing a few weeks before

adding another.

>

> Re: [DownSyndromeInfoEx change] Stanford Ds Research

Supports Possible Treatment to Improve Cognition

>

> Judy

> how old is Reece?

> I'm beginning to think this might something for our son as well,

but he's only turning 4 this December. I can see the face of our

paediatrician when we suggest Prozac - he'll kill us!

> / Switzerland

>

> --

>

> with Saskia, Nora-Jane*2001, *2004/DS

> (Lemon flavored Codliver Oil, highly dosed CoenzymeQ10, Vit. A,

buffered Vit. C + natural Vit. E, Raspberry flavored Folic Acid +

B12, Selenium, Zinc, Probiotic, Ginkgo Biloba, Prilosec, Thyroxine)

>

> Judy schrieb:

> We are starting our son, Reece on this program. We're going to

add each item one at a time to see the individual benefits. We're

starting Gingko tomorrow and then on to Prozac next week. I'll be

sure to let everyone know how Reece is progressing.

Our Pedi strongly feels that Dr. Garner is on to something huge and

he is so excited about it!

>

> Judy

>

September 28, 2008

Judy,

I'm glad that your doctor is willing to work closely with you on this!

How exciting. I know that just seeing the word Prozac listed as

something to give our kids scares a lot of parents. But I think that

you and I have the right idea by taking it straight to our doctors

first. And may I suggest to others that if your own doctor isn't

familiar with or willing to work with you on this protocol to seek a

second (or third) opinion. I didn't realize until investigating this

recently that Prozac is sometimes prescribed for constipation! It seems

that not only is most of our immune system in our gut, but it also has

serotonin which when brought back into balance can help regulate bowel

movements. I would also like to say that I was quite concerned about

the " increased suicidal thoughts " side effect listed for Prozac. I

asked a doctor about that also and he said that you have to keep in mind

that this side effect was noticed in persons who already had suicidal or

depression tendencies. My child doesn't have a depressed bone in his

body right now. . . so I believe that the risk of this incidence would

be minutely small. Good luck and let us how this works for your son.

Christy

>

> My understanding of Prozac for down syndrome is to to make more

neurons since people with DS are born with 1/2 of what typical people

are born with. I'm not sure how soon we would know more neurons have

developed. On the Changing Minds sight they said that most people start

all of the medicines at once. If Reece is having a side affect then it

seems it would be hard to determine which of the ingredients is causing

it. After reading about it again, maybe it would be better to give it a

few weeks before adding a new item. As far as Prozac side affects, our

doctor was telling us that the most common side affect is diarrhea.

Reece is usually constipated so maybe it'll work out for him. I am

putting a lot of trust in my doctor as he said all of the items in the

protocol are safe. The next item on the list after Prozac is the body

bio balanced oil. My dr doesn't know what that is and what's it's for

so he's going to put in a

> call at Stanford. I feel pretty good knowing that our dr is going to

be working with us closely on this.

>

> Listed below is what was sent to my husband.

>

> Changing Minds Protocol TM Frequently Asked Questions

> · How do I get started on theCMPTM

> Protocol Order of Importance

> Ginkgo Biloba

> Prozac

> Body Bio Balanced Oil

> Phosphatidyl Choline

> Focalin XR

> Folic acid/B12

>

> Each part of the protocol is helpful, even by itself. However, the

best results will not be received by just participating in one or two.

We have found that the protocol works exponentially well together, given

consistently and over a period of time. Therefore, all parts are

integral to the total success and helping the body to work as

effectively as possible.

>

> · Should I start everything at once?

> Most participants have started everything at once; however, you may

find it better to start one at a time. This way you will see the

independent results and it is easier to determine appropriate dosing if

adding one substance at a time and allowing a few weeks before adding

another.

>

> Re: [DownSyndromeInfoEx change] Stanford Ds Research Supports

Possible Treatment to Improve Cognition

>

> Judy

> how old is Reece?

> I'm beginning to think this might something for our son as well, but

he's only turning 4 this December. I can see the face of our

paediatrician when we suggest Prozac - he'll kill us!

> / Switzerland

>

> --

>

> with Saskia, Nora-Jane*2001, *2004/DS

> (Lemon flavored Codliver Oil, highly dosed CoenzymeQ10, Vit. A,

buffered Vit. C + natural Vit. E, Raspberry flavored Folic Acid + B12,

Selenium, Zinc, Probiotic, Ginkgo Biloba, Prilosec, Thyroxine)

>

> Judy schrieb:

> We are starting our son, Reece on this program. We're going to add

each item one at a time to see the individual benefits. We're starting

Gingko tomorrow and then on to Prozac next week. I'll be sure to let

everyone know how Reece is progressing. Our Pedi strongly feels that

Dr. Garner is on to something huge and he is so excited about it!

>

> Judy

>

September 28, 2008

This has been a great thread, enjoy reading it and will be anxiously awaiting the results of the trials and the resulting recommendations. I like to listen to the medical podcasts and they all say the same thing regarding the suicide risk of prozac- the stats are because of the population that typicaly takes it, not a side effect of the drug it's self.Also wanted to point out the SCD helps guts to work efficiently and there by improves immunity and serotonin levels. One of the big surprises of the diet was her huge increase in skills across the board. Exercise has been shown to increase serotonin and exposing your child to as many new experiences as possible, also helps to build neuronal connections. That's the route I have been taking and it's working very well.

If this proves safe, we would use if for , but until then I will send money and wait. :-) Carol in ILMom to , 8 DS My problem is not how I look. It's how you see me.VOTE NOBAMA '08Join our Down Syndrome information group - http://health. groups.yahoo. com/group/ DownSyndromeInfo Exchange/ Listen to oldest dd's music http://www.myspace. com/vennamusic [DownSyndromeInfoExchange] Re: Stanford Ds Research

Supports Possible Treatment to Improve Cognition Judy, I'm glad that your doctor is willing to work closely with you on this! How exciting. I know that just seeing the word Prozac listed as something to give our kids scares a lot of parents. But I think that you and I have the right idea by taking it straight to our doctors first. And may I suggest to others that if your own doctor isn't familiar with or willing to work with you on this protocol to seek a second (or third) opinion. I didn't realize until investigating this recently that Prozac is sometimes prescribed for constipation! It seems that not only is most of our immune system in our

gut, but it also has serotonin which when brought back into balance can help regulate bowel movements. I would also like to say that I was quite concerned about the "increased suicidal thoughts" side effect listed for Prozac. I asked a doctor about that also and he said that you have to keep in mind that this side effect was noticed in persons who already had suicidal or depression tendencies. My child doesn't have a depressed bone in his body right now. . . so I believe that the risk of this incidence would be minutely small. Good luck and let us how this works for your son. Christy --

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