Re: Stanford Ds Research Supports Possible Treatment to Improve Cognition

September 28, 2008

Hi everyone,

I too went to the premiere of the documentary "Changing a Mind".. This is an exciting time for down syndrome research. They are having another showing in Houston next week.

If you can't make it I believe you can buy the DVD for $35 check the website www.changingmindsfoundation.com

I was able to speak to Dr. Cody after the movie... I love that she is "just a mom" An amazing one at that.

She told me she is hoping to have a physicians packet by the end of this week.

I am very interested in the protocol, however not sure our pediatrician will love the prozac so I am waiting for the physicans packet.

Alison

[DownSyndromeInfoExchange] Stanford Ds Research Supports Possible Treatment to Improve CognitionTo: DownSyndromeInfoExchange > > My name is Christy and I have a 12 month old son with Ds. I > want to> share the following information with your group. Last weekend I > flew to> New York City and watched the premiere of the documentary, > "Changing a> Mind." Let me say, my reaction to the film was "WOW!" The > potential of> the research being done at Garner Lab at Stanford is absolutely > amazing.If you have not looked at Garner Lab's website lately - > you need to! > Dr. Garner just posted A LOT of new information last week. Be > sure to> read through every page, every link - it is quite interesting.> > Please read the excerpt (from Garner Lab's website) I've pasted > at the> end of this email. It discusses how learning is impaired for > individualswith Ds. In a nutshell, he has demonstrated in the Ds > mouse model that> the inhibitory communication in the brains of Ds mice is acting > like a> "parking brake" by being overactive and inhibiting learning. By > turningit down (they are using a drug called PTZ in the lab - > currently not> available in the US) learning can better occur. It is based on this> research that people are now giving their kids Ginkgo Biloba. > It is the> Bilobalide in the Ginkgo Biloba that works to "release the parking> brake" ever so slightly. Dr. Garner is hopeful that the PTZ > will have a> much BETTER effect than the Ginkgo Biloba on the inhibitory > pathways. > Dr. Cody Cashion formulated the CMP treatment featured in the> documentary. It is important to note that the BEST RESULTS > occurred in> the film when the Ginkgo Biloba was used IN CONJUNCTION with > Prozac. > According to the research referenced on the > changingmindsfoundation.comResearch section, Prozac has been > proven to have a neurogenesis effect> on the brain (produce new neurons). This is an important > component of> the Protocol since it has been shown by autopsy that by six > months of> age, babies with Down syndrome have ONLY HALF of the number of neurons> in the brain as a typical child. In the lab, when Prozac was > given to> mice their neuron count DOUBLED in 24 days (this article is also > postedin the Research section on changingmindsfoundation.com ). > So basically,> by increasing the neuron count AND "releasing the parking brake" > on the> inhibitory pathway - the kids in the film made tremendous progress.> > I was able to meet with Dr. Garner and discuss his current > research for> over an hour after the film. He truly has a passion to find an> effective treatment to improve cognition in individuals with Down> syndrome. I'm sure that many of you have the same questions I > did, but> here is the main one - WHAT IS IT GOING TO TAKE TO GET THIS NEW DRUG> THROUGH CLINICAL TRIAL AND TO MARKET? The answer is very simple > - Money> - approximately $3 - $5 million. This may sound like a lot, but > really- it's not! There are 350,000 people with Ds living in > the US. If each> family of each person with Ds gave just $15 DIRECTLY to Dr. > Garner's Ds> Lab fund that would be over $5 million!! He could go forward > with the> process of conducting a proper clinical trial without having to jump> through time consuming hoops to raise the money through alternate> sources.> > The Changing Minds Foundation is also raising money to go > toward Dr.> Garner's research. Don't take my word for how impressive this > researchis - I'm not a scientist, I'm just a mom like you. Read > all of the> information for yourself at http://garnerlab.stanford.edu/> . Watch the 3 minute > preview on> www.changingmindsfoundation.org> . Read the research posted> on www.changingmindsfoundation.com> . Buy the DVD > directly from> their website for $35. Host a showing of the DVD at a local > church or> school as a fund raiser for this vital research!> > I would like to encourage each of you to do your part right now and> write a check for at least $15 and send it to: Attn: Deborah> Stinchfield, Stanford University, Office of Medical Development, 2700> Sand Hill Road, Menlo Park, CA 94025. Make your check payable to> Stanford University and BE SURE TO INCLUDE THE FOLLOWING CODE > in the> memo section (DHAYQ) - this designates your gift for the Garner Down> Syndrome Fund.> > "Studies in the Garner lab have confirmed that in this mouse model> of Down syndrome communication between two types of brain> cells—excitatory and inhibitory neurons—is out of balance. There> is too much inhibitory communication, which prevents learning from> properly taking place. It's as if somebody forgot to release the> parking break—the car just won't go.> The Garner lab further investigated whether inhibitory communication> between neurons could somehow be reduced in this mouse model. > For this> purpose, Down syndrome mice and normal mice were tested on two tasks> that were designed to assess learning and memory. As expected, > the Down> syndrome mice performed significantly worse than the normal mice.> > > The Down syndrome mice were then treated for several weeks with> different drugs, which are known to reduce inhibitory communication.> These drugs work by partially blocking a receptor located on the > neuronscalled GABA A receptor. Blocking these receptors should reduce> inhibitory communication, thereby increasing excitatory communication.> When tested on the learning and memory tasks, the Down syndrome > mice now> performed almost as well as the normal mice. Even several weeks after> drug treatment had been terminated, these mice still performed better.> > > These results confirm that too much inhibitory communication between> neurons indeed prevents learning from taking place in this mouse model> of Down syndrome. Reducing this inhibition with specific drugs > restoresthe balance between inhibitory and excitatory neurons so > that learning> can take place."> > > > > > >

September 28, 2008

Alison,

How can we sign up for the physician's packet?

Thank you,

Carolyn

http://stores.ebay.com/ck-antiques_W0QQsspagenameZL2222QQtZkm

We've gone co-op! Come and see our newest location at Black Diamond Antiques in the Schuylkill Mall, Frackville, PA!

'Don't worry about the world coming to an end today.It's already tomorrow in Australia ' ( Schultz)

-- Re: [DownSyndromeInfoExchange] Stanford Ds Research Supports Possible Treatment to Improve Cognition

Hi everyone,

I too went to the premiere of the documentary "Changing a Mind".. This is an exciting time for down syndrome research. They are having another showing in Houston next week.

If you can't make it I believe you can buy the DVD for $35 check the website www.changingmindsfoundation.com

I was able to speak to Dr. Cody after the movie... I love that she is "just a mom" An amazing one at that.

She told me she is hoping to have a physicians packet by the end of this week.

I am very interested in the protocol, however not sure our pediatrician will love the prozac so I am waiting for the physicans packet.

Alison

[DownSyndromeInfoExchange] Stanford Ds Research Supports Possible Treatment to Improve CognitionTo: DownSyndromeInfoExchange > > My name is Christy and I have a 12 month old son with Ds. I > want to> share the following information with your group. Last weekend I > flew to> New York City and watched the premiere of the documentary, > "Changing a> Mind." Let me say, my reaction to the film was "WOW!" The > potential of> the research being done at Garner Lab at Stanford is absolutely > amazing.If you have not looked at Garner Lab's website lately - > you need to! > Dr. Garner just posted A LOT of new information last week. Be > sure to> read through every page, every link - it is quite interesting.> > Please read the excerpt (from Garner Lab's website) I've pasted > at the> end of this email. It discusses how learning is impaired for > individualswith Ds. In a nutshell, he has demonstrated in the Ds > mouse model that> the inhibitory communication in the brains of Ds mice is acting > like a> "parking brake" by being overactive and inhibiting learning. By > turningit down (they are using a drug called PTZ in the lab - > currently not> available in the US) learning can better occur. It is based on this> research that people are now giving their kids Ginkgo Biloba. > It is the> Bilobalide in the Ginkgo Biloba that works to "release the parking> brake" ever so slightly. Dr. Garner is hopeful that the PTZ > will have a> much BETTER effect than the Ginkgo Biloba on the inhibitory > pathways. > Dr. Cody Cashion formulated the CMP treatment featured in the> documentary. It is important to note that the BEST RESULTS > occurred in> the film when the Ginkgo Biloba was used IN CONJUNCTION with > Prozac. > According to the research referenced on the > changingmindsfoundation.comResearch section, Prozac has been > proven to have a neurogenesis effect> on the brain (produce new neurons). This is an important > component of> the Protocol since it has been shown by autopsy that by six > months of> age, babies with Down syndrome have ONLY HALF of the number of neurons> in the brain as a typical child. In the lab, when Prozac was > given to> mice their neuron count DOUBLED in 24 days (this article is also > postedin the Research section on changingmindsfoundation.com ). > So basically,> by increasing the neuron count AND "releasing the parking brake" > on the> inhibitory pathway - the kids in the film made tremendous progress.> > I was able to meet with Dr. Garner and discuss his current > research for> over an hour after the film. He truly has a passion to find an> effective treatment to improve cognition in individuals with Down> syndrome. I'm sure that many of you have the same questions I > did, but> here is the main one - WHAT IS IT GOING TO TAKE TO GET THIS NEW DRUG> THROUGH CLINICAL TRIAL AND TO MARKET? The answer is very simple > - Money> - approximately $3 - $5 million. This may sound like a lot, but > really- it's not! There are 350,000 people with Ds living in > the US. If each> family of each person with Ds gave just $15 DIRECTLY to Dr. > Garner's Ds> Lab fund that would be over $5 million!! He could go forward > with the> process of conducting a proper clinical trial without having to jump> through time consuming hoops to raise the money through alternate> sources.> > The Changing Minds Foundation is also raising money to go > toward Dr.> Garner's research. Don't take my word for how impressive this > researchis - I'm not a scientist, I'm just a mom like you. Read > all of the> information for yourself at http://garnerlab.stanford.edu/> . Watch the 3 minute > preview on> www.changingmindsfoundation.org> . Read the research posted> on www.changingmindsfoundation.com> . Buy the DVD > directly from> their website for $35. Host a showing of the DVD at a local > church or> school as a fund raiser for this vital research!> > I would like to encourage each of you to do your part right now and> write a check for at least $15 and send it to: Attn: Deborah> Stinchfield, Stanford University, Office of Medical Development, 2700> Sand Hill Road, Menlo Park, CA 94025. Make your check payable to> Stanford University and BE SURE TO INCLUDE THE FOLLOWING CODE > in the> memo section (DHAYQ) - this designates your gift for the Garner Down> Syndrome Fund.> > "Studies in the Garner lab have confirmed that in this mouse model> of Down syndrome communication between two types of brain> cells—excitatory and inhibitory neurons—is out of balance. There> is too much inhibitory communication, which prevents learning from> properly taking place. It's as if somebody forgot to release the> parking break—the car just won't go.> The Garner lab further investigated whether inhibitory communication> between neurons could somehow be reduced in this mouse model. > For this> purpose, Down syndrome mice and normal mice were tested on two tasks> that were designed to assess learning and memory. As expected, > the Down> syndrome mice performed significantly worse than the normal mice.> > > The Down syndrome mice were then treated for several weeks with> different drugs, which are known to reduce inhibitory communication.> These drugs work by partially blocking a receptor located on the > neuronscalled GABA A receptor. Blocking these receptors should reduce> inhibitory communication, thereby increasing excitatory communication.> When tested on the learning and memory tasks, the Down syndrome > mice now> performed almost as well as the normal mice. Even several weeks after> drug treatment had been terminated, these mice still performed better.> > > These results confirm that too much inhibitory communication between> neurons indeed prevents learning from taking place in this mouse model> of Down syndrome. Reducing this inhibition with specific drugs > restoresthe balance between inhibitory and excitatory neurons so > that learning> can take place."> > > > > > >

September 28, 2008

Not sure yet. I am waiting to hear from Dr. Cody bythe end of the week or beginning of next. As soon as I know I will let EVERYONE know.

[DownSyndromeInfoExchange] Stanford Ds Research > Supports Possible> Treatment to Improve Cognition> > To: DownSyndromeInfoExchange > > > > > > > > My name is Christy and I have a 12 month old son with Ds. I > > > want to> > > share the following information with your group. Last weekend > I > > > flew to> > > New York City and watched the premiere of the documentary, > > > "Changing a> > > Mind." Let me say, my reaction to the film was "WOW!" The > > > potential of> > > the research being done at Garner Lab at Stanford is > absolutely > > > amazing.If you have not looked at Garner Lab's website lately -> > > > you need to! > > > Dr. Garner just posted A LOT of new information last week. Be > > > sure to> > > read through every page, every link - it is quite interesting.> > > > > > Please read the excerpt (from Garner Lab's website) I've > pasted > > > at the> > > end of this email. It discusses how learning is impaired for > > > individualswith Ds. In a nutshell, he has demonstrated in the > Ds > > > mouse model that> > > the inhibitory communication in the brains of Ds mice is > acting > > > like a> > > "parking brake" by being overactive and inhibiting learning. > By > > > turningit down (they are using a drug called PTZ in the lab - > > > currently not> > > available in the US) learning can better occur. It is based on this> > > research that people are now giving their kids Ginkgo Biloba. > > > It is the> > > Bilobalide in the Ginkgo Biloba that works to "release the parking> > > brake" ever so slightly. Dr. Garner is hopeful that the PTZ > > > will have a> > > much BETTER effect than the Ginkgo Biloba on the inhibitory > > > pathways. > > > Dr. Cody Cashion formulated the CMP treatment featured > in the> > > documentary. It is important to note that the BEST RESULTS > > > occurred in> > > the film when the Ginkgo Biloba was used IN CONJUNCTION with > > > Prozac. > > > According to the research referenced on the > > > changingmindsfoundation.comResearch section, Prozac has been > > > proven to have a neurogenesis effect> > > on the brain (produce new neurons). This is an important > > > component of> > > the Protocol since it has been shown by autopsy that by six > > > months of> > > age, babies with Down syndrome have ONLY HALF of the number of > neurons> > in the brain as a typical child. In the lab, when Prozac was > > > given to> > > mice their neuron count DOUBLED in 24 days (this article is > also > > > postedin the Research section on changingmindsfoundation.com > ). > > > So basically,> > > by increasing the neuron count AND "releasing the parking > brake" > > > on the> > > inhibitory pathway - the kids in the film made tremendous progress.> > > > > > I was able to meet with Dr. Garner and discuss his current > > > research for> > > over an hour after the film. He truly has a passion to find an> > > effective treatment to improve cognition in individuals with Down> > > syndrome. I'm sure that many of you have the same questions I > > > did, but> > > here is the main one - WHAT IS IT GOING TO TAKE TO GET THIS > NEW DRUG> > > THROUGH CLINICAL TRIAL AND TO MARKET? The answer is very > simple > > > - Money> > > - approximately $3 - $5 million. This may sound like a lot, > but > > > really- it's not! There are 350,000 people with Ds living in > > > the US. If each> > > family of each person with Ds gave just $15 DIRECTLY to Dr. > > > Garner's Ds> > > Lab fund that would be over $5 million!! He could go forward > > > with the> > > process of conducting a proper clinical trial without having > to jump> > > through time consuming hoops to raise the money through alternate> > > sources.> > > > > > The Changing Minds Foundation is also raising money to go > > > toward Dr.> > > Garner's research. Don't take my word for how impressive this > > > researchis - I'm not a scientist, I'm just a mom like you. > Read > > > all of the> > > information for yourself at http://garnerlab.stanford.edu/> > > . Watch the 3 minute > > > preview on> > > www.changingmindsfoundation.org> > > . Read the research posted> > > on www.changingmindsfoundation.com> > > . Buy the DVD > > > directly from> > > their website for $35. Host a showing of the DVD at a local > > > church or> > > school as a fund raiser for this vital research!> > > > > > I would like to encourage each of you to do your part right > now and> > > write a check for at least $15 and send it to: Attn: Deborah> > > Stinchfield, Stanford University, Office of Medical > Development, 2700> > > Sand Hill Road, Menlo Park, CA 94025. Make your check payable to> > > Stanford University and BE SURE TO INCLUDE THE FOLLOWING CODE > > > in the> > > memo section (DHAYQ) - this designates your gift for the > Garner Down> > > Syndrome Fund.> > > > > > "Studies in the Garner lab have confirmed that in this mouse model> > > of Down syndrome communication between two types of brain> > > cells—excitatory and inhibitory neurons—is out of balance. There> > > is too much inhibitory communication, which prevents learning from> > > properly taking place. It's as if somebody forgot to release the> > > parking break—the car just won't go.> > > The Garner lab further investigated whether inhibitory communication> > > between neurons could somehow be reduced in this mouse model. > > > For this> > > purpose, Down syndrome mice and normal mice were tested on two tasks> > > that were designed to assess learning and memory. As expected, > > > the Down> > > syndrome mice performed significantly worse than the normal mice.> > > > > > > > > The Down syndrome mice were then treated for several weeks with> > > different drugs, which are known to reduce inhibitory communication.> > > These drugs work by partially blocking a receptor located on > the > > > neuronscalled GABA A receptor. Blocking these receptors should > reduce> > inhibitory communication, thereby increasing excitatory > communication.> > When tested on the learning and memory tasks, the Down > syndrome > > > mice now> > > performed almost as well as the normal mice. Even several > weeks after> > > drug treatment had been terminated, these mice still performed > better.> > > > > > > > These results confirm that too much inhibitory communication between> > > neurons indeed prevents learning from taking place in this > mouse model> > > of Down syndrome. Reducing this inhibition with specific drugs > > > restoresthe balance between inhibitory and excitatory neurons > so > > > that learning> > > can take place."> > > > > > > > > > > > > > > > > > > > > > > > >

September 28, 2008

Not sure yet. I am waiting to hear from Dr. Cody bythe end of the week or beginning of next. As soon as I know I will let EVERYONE know.

[DownSyndromeInfoExchange] Stanford Ds Research > Supports Possible> Treatment to Improve Cognition> > To: DownSyndromeInfoExchange > > > > > > > > My name is Christy and I have a 12 month old son with Ds. I > > > want to> > > share the following information with your group. Last weekend > I > > > flew to> > > New York City and watched the premiere of the documentary, > > > "Changing a> > > Mind." Let me say, my reaction to the film was "WOW!" The > > > potential of> > > the research being done at Garner Lab at Stanford is > absolutely > > > amazing.If you have not looked at Garner Lab's website lately -> > > > you need to! > > > Dr. Garner just posted A LOT of new information last week. Be > > > sure to> > > read through every page, every link - it is quite interesting.> > > > > > Please read the excerpt (from Garner Lab's website) I've > pasted > > > at the> > > end of this email. It discusses how learning is impaired for > > > individualswith Ds. In a nutshell, he has demonstrated in the > Ds > > > mouse model that> > > the inhibitory communication in the brains of Ds mice is > acting > > > like a> > > "parking brake" by being overactive and inhibiting learning. > By > > > turningit down (they are using a drug called PTZ in the lab - > > > currently not> > > available in the US) learning can better occur. It is based on this> > > research that people are now giving their kids Ginkgo Biloba. > > > It is the> > > Bilobalide in the Ginkgo Biloba that works to "release the parking> > > brake" ever so slightly. Dr. Garner is hopeful that the PTZ > > > will have a> > > much BETTER effect than the Ginkgo Biloba on the inhibitory > > > pathways. > > > Dr. Cody Cashion formulated the CMP treatment featured > in the> > > documentary. It is important to note that the BEST RESULTS > > > occurred in> > > the film when the Ginkgo Biloba was used IN CONJUNCTION with > > > Prozac. > > > According to the research referenced on the > > > changingmindsfoundation.comResearch section, Prozac has been > > > proven to have a neurogenesis effect> > > on the brain (produce new neurons). This is an important > > > component of> > > the Protocol since it has been shown by autopsy that by six > > > months of> > > age, babies with Down syndrome have ONLY HALF of the number of > neurons> > in the brain as a typical child. In the lab, when Prozac was > > > given to> > > mice their neuron count DOUBLED in 24 days (this article is > also > > > postedin the Research section on changingmindsfoundation.com > ). > > > So basically,> > > by increasing the neuron count AND "releasing the parking > brake" > > > on the> > > inhibitory pathway - the kids in the film made tremendous progress.> > > > > > I was able to meet with Dr. Garner and discuss his current > > > research for> > > over an hour after the film. He truly has a passion to find an> > > effective treatment to improve cognition in individuals with Down> > > syndrome. I'm sure that many of you have the same questions I > > > did, but> > > here is the main one - WHAT IS IT GOING TO TAKE TO GET THIS > NEW DRUG> > > THROUGH CLINICAL TRIAL AND TO MARKET? The answer is very > simple > > > - Money> > > - approximately $3 - $5 million. This may sound like a lot, > but > > > really- it's not! There are 350,000 people with Ds living in > > > the US. If each> > > family of each person with Ds gave just $15 DIRECTLY to Dr. > > > Garner's Ds> > > Lab fund that would be over $5 million!! He could go forward > > > with the> > > process of conducting a proper clinical trial without having > to jump> > > through time consuming hoops to raise the money through alternate> > > sources.> > > > > > The Changing Minds Foundation is also raising money to go > > > toward Dr.> > > Garner's research. Don't take my word for how impressive this > > > researchis - I'm not a scientist, I'm just a mom like you. > Read > > > all of the> > > information for yourself at http://garnerlab.stanford.edu/> > > . Watch the 3 minute > > > preview on> > > www.changingmindsfoundation.org> > > . Read the research posted> > > on www.changingmindsfoundation.com> > > . Buy the DVD > > > directly from> > > their website for $35. Host a showing of the DVD at a local > > > church or> > > school as a fund raiser for this vital research!> > > > > > I would like to encourage each of you to do your part right > now and> > > write a check for at least $15 and send it to: Attn: Deborah> > > Stinchfield, Stanford University, Office of Medical > Development, 2700> > > Sand Hill Road, Menlo Park, CA 94025. Make your check payable to> > > Stanford University and BE SURE TO INCLUDE THE FOLLOWING CODE > > > in the> > > memo section (DHAYQ) - this designates your gift for the > Garner Down> > > Syndrome Fund.> > > > > > "Studies in the Garner lab have confirmed that in this mouse model> > > of Down syndrome communication between two types of brain> > > cells—excitatory and inhibitory neurons—is out of balance. There> > > is too much inhibitory communication, which prevents learning from> > > properly taking place. It's as if somebody forgot to release the> > > parking break—the car just won't go.> > > The Garner lab further investigated whether inhibitory communication> > > between neurons could somehow be reduced in this mouse model. > > > For this> > > purpose, Down syndrome mice and normal mice were tested on two tasks> > > that were designed to assess learning and memory. As expected, > > > the Down> > > syndrome mice performed significantly worse than the normal mice.> > > > > > > > > The Down syndrome mice were then treated for several weeks with> > > different drugs, which are known to reduce inhibitory communication.> > > These drugs work by partially blocking a receptor located on > the > > > neuronscalled GABA A receptor. Blocking these receptors should > reduce> > inhibitory communication, thereby increasing excitatory > communication.> > When tested on the learning and memory tasks, the Down > syndrome > > > mice now> > > performed almost as well as the normal mice. Even several > weeks after> > > drug treatment had been terminated, these mice still performed > better.> > > > > > > > These results confirm that too much inhibitory communication between> > > neurons indeed prevents learning from taking place in this > mouse model> > > of Down syndrome. Reducing this inhibition with specific drugs > > > restoresthe balance between inhibitory and excitatory neurons > so > > > that learning> > > can take place."> > > > > > > > > > > > > > > > > > > > > > > > >

September 28, 2008

That is so great of you! Thank you so much! I want to have all of Olivia's specialists and ped read it over. She has so many health issues.

Thanks again,

Carolyn

http://stores.ebay.com/ck-antiques_W0QQsspagenameZL2222QQtZkm

We've gone co-op! Come and see our newest location at Black Diamond Antiques in the Schuylkill Mall, Frackville, PA!

'Don't worry about the world coming to an end today.It's already tomorrow in Australia ' ( Schultz)

-- Re: [DownSyndromeInfoExchange] Stanford Ds Research Supports Possible Treatment to Improve Cognition

Not sure yet. I am waiting to hear from Dr. Cody bythe end of the week or beginning of next. As soon as I know I will let EVERYONE know.

[DownSyndromeInfoExchange] Stanford Ds Research > Supports Possible> Treatment to Improve Cognition> > To: DownSyndromeInfoExchange > > > > > > > > My name is Christy and I have a 12 month old son with Ds. I > > > want to> > > share the following information with your group. Last weekend > I > > > flew to> > > New York City and watched the premiere of the documentary, > > > "Changing a> > > Mind." Let me say, my reaction to the film was "WOW!" The > > > potential of> > > the research being done at Garner Lab at Stanford is > absolutely > > > amazing.If you have not looked at Garner Lab's website lately -> > > > you need to! > > > Dr. Garner just posted A LOT of new information last week. Be > > > sure to> > > read through every page, every link - it is quite interesting.> > > > > > Please read the excerpt (from Garner Lab's website) I've > pasted > > > at the> > > end of this email. It discusses how learning is impaired for > > > individualswith Ds. In a nutshell, he has demonstrated in the > Ds > > > mouse model that> > > the inhibitory communication in the brains of Ds mice is > acting > > > like a> > > "parking brake" by being overactive and inhibiting learning. > By > > > turningit down (they are using a drug called PTZ in the lab - > > > currently not> > > available in the US) learning can better occur. It is based on this> > > research that people are now giving their kids Ginkgo Biloba. > > > It is the> > > Bilobalide in the Ginkgo Biloba that works to "release the parking> > > brake" ever so slightly. Dr. Garner is hopeful that the PTZ > > > will have a> > > much BETTER effect than the Ginkgo Biloba on the inhibitory > > > pathways. > > > Dr. Cody Cashion formulated the CMP treatment featured > in the> > > documentary. It is important to note that the BEST RESULTS > > > occurred in> > > the film when the Ginkgo Biloba was used IN CONJUNCTION with > > > Prozac. > > > According to the research referenced on the > > > changingmindsfoundation.comResearch section, Prozac has been > > > proven to have a neurogenesis effect> > > on the brain (produce new neurons). This is an important > > > component of> > > the Protocol since it has been shown by autopsy that by six > > > months of> > > age, babies with Down syndrome have ONLY HALF of the number of > neurons> > in the brain as a typical child. In the lab, when Prozac was > > > given to> > > mice their neuron count DOUBLED in 24 days (this article is > also > > > postedin the Research section on changingmindsfoundation.com > ). > > > So basically,> > > by increasing the neuron count AND "releasing the parking > brake" > > > on the> > > inhibitory pathway - the kids in the film made tremendous progress.> > > > > > I was able to meet with Dr. Garner and discuss his current > > > research for> > > over an hour after the film. He truly has a passion to find an> > > effective treatment to improve cognition in individuals with Down> > > syndrome. I'm sure that many of you have the same questions I > > > did, but> > > here is the main one - WHAT IS IT GOING TO TAKE TO GET THIS > NEW DRUG> > > THROUGH CLINICAL TRIAL AND TO MARKET? The answer is very > simple > > > - Money> > > - approximately $3 - $5 million. This may sound like a lot, > but > > > really- it's not! There are 350,000 people with Ds living in > > > the US. If each> > > family of each person with Ds gave just $15 DIRECTLY to Dr. > > > Garner's Ds> > > Lab fund that would be over $5 million!! He could go forward > > > with the> > > process of conducting a proper clinical trial without having > to jump> > > through time consuming hoops to raise the money through alternate> > > sources.> > > > > > The Changing Minds Foundation is also raising money to go > > > toward Dr.> > > Garner's research. Don't take my word for how impressive this > > > researchis - I'm not a scientist, I'm just a mom like you. > Read > > > all of the> > > information for yourself at http://garnerlab.stanford.edu/> > > . Watch the 3 minute > > > preview on> > > www.changingmindsfoundation.org> > > . Read the research posted> > > on www.changingmindsfoundation.com> > > . Buy the DVD > > > directly from> > > their website for $35. Host a showing of the DVD at a local > > > church or> > > school as a fund raiser for this vital research!> > > > > > I would like to encourage each of you to do your part right > now and> > > write a check for at least $15 and send it to: Attn: Deborah> > > Stinchfield, Stanford University, Office of Medical > Development, 2700> > > Sand Hill Road, Menlo Park, CA 94025. Make your check payable to> > > Stanford University and BE SURE TO INCLUDE THE FOLLOWING CODE > > > in the> > > memo section (DHAYQ) - this designates your gift for the > Garner Down> > > Syndrome Fund.> > > > > > "Studies in the Garner lab have confirmed that in this mouse model> > > of Down syndrome communication between two types of brain> > > cells—excitatory and inhibitory neurons—is out of balance. There> > > is too much inhibitory communication, which prevents learning from> > > properly taking place. It's as if somebody forgot to release the> > > parking break—the car just won't go.> > > The Garner lab further investigated whether inhibitory communication> > > between neurons could somehow be reduced in this mouse model. > > > For this> > > purpose, Down syndrome mice and normal mice were tested on two tasks> > > that were designed to assess learning and memory. As expected, > > > the Down> > > syndrome mice performed significantly worse than the normal mice.> > > > > > > > > The Down syndrome mice were then treated for several weeks with> > > different drugs, which are known to reduce inhibitory communication.> > > These drugs work by partially blocking a receptor located on > the > > > neuronscalled GABA A receptor. Blocking these receptors should > reduce> > inhibitory communication, thereby increasing excitatory > communication.> > When tested on the learning and memory tasks, the Down > syndrome > > > mice now> > > performed almost as well as the normal mice. Even several > weeks after> > > drug treatment had been terminated, these mice still performed > better.> > > > > > > > These results confirm that too much inhibitory communication between> > > neurons indeed prevents learning from taking place in this > mouse model> > > of Down syndrome. Reducing this inhibition with specific drugs > > > restoresthe balance between inhibitory and excitatory neurons > so > > > that learning> > > can take place."> > > > > > > > > > > > > > > > > > > > > > > > >

September 28, 2008

That is so great of you! Thank you so much! I want to have all of Olivia's specialists and ped read it over. She has so many health issues.

Thanks again,

Carolyn

http://stores.ebay.com/ck-antiques_W0QQsspagenameZL2222QQtZkm

We've gone co-op! Come and see our newest location at Black Diamond Antiques in the Schuylkill Mall, Frackville, PA!

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-- Re: [DownSyndromeInfoExchange] Stanford Ds Research Supports Possible Treatment to Improve Cognition

Not sure yet. I am waiting to hear from Dr. Cody bythe end of the week or beginning of next. As soon as I know I will let EVERYONE know.

[DownSyndromeInfoExchange] Stanford Ds Research > Supports Possible> Treatment to Improve Cognition> > To: DownSyndromeInfoExchange > > > > > > > > My name is Christy and I have a 12 month old son with Ds. I > > > want to> > > share the following information with your group. Last weekend > I > > > flew to> > > New York City and watched the premiere of the documentary, > > > "Changing a> > > Mind." Let me say, my reaction to the film was "WOW!" The > > > potential of> > > the research being done at Garner Lab at Stanford is > absolutely > > > amazing.If you have not looked at Garner Lab's website lately -> > > > you need to! > > > Dr. Garner just posted A LOT of new information last week. Be > > > sure to> > > read through every page, every link - it is quite interesting.> > > > > > Please read the excerpt (from Garner Lab's website) I've > pasted > > > at the> > > end of this email. It discusses how learning is impaired for > > > individualswith Ds. In a nutshell, he has demonstrated in the > Ds > > > mouse model that> > > the inhibitory communication in the brains of Ds mice is > acting > > > like a> > > "parking brake" by being overactive and inhibiting learning. > By > > > turningit down (they are using a drug called PTZ in the lab - > > > currently not> > > available in the US) learning can better occur. It is based on this> > > research that people are now giving their kids Ginkgo Biloba. > > > It is the> > > Bilobalide in the Ginkgo Biloba that works to "release the parking> > > brake" ever so slightly. Dr. Garner is hopeful that the PTZ > > > will have a> > > much BETTER effect than the Ginkgo Biloba on the inhibitory > > > pathways. > > > Dr. Cody Cashion formulated the CMP treatment featured > in the> > > documentary. It is important to note that the BEST RESULTS > > > occurred in> > > the film when the Ginkgo Biloba was used IN CONJUNCTION with > > > Prozac. > > > According to the research referenced on the > > > changingmindsfoundation.comResearch section, Prozac has been > > > proven to have a neurogenesis effect> > > on the brain (produce new neurons). This is an important > > > component of> > > the Protocol since it has been shown by autopsy that by six > > > months of> > > age, babies with Down syndrome have ONLY HALF of the number of > neurons> > in the brain as a typical child. In the lab, when Prozac was > > > given to> > > mice their neuron count DOUBLED in 24 days (this article is > also > > > postedin the Research section on changingmindsfoundation.com > ). > > > So basically,> > > by increasing the neuron count AND "releasing the parking > brake" > > > on the> > > inhibitory pathway - the kids in the film made tremendous progress.> > > > > > I was able to meet with Dr. Garner and discuss his current > > > research for> > > over an hour after the film. He truly has a passion to find an> > > effective treatment to improve cognition in individuals with Down> > > syndrome. I'm sure that many of you have the same questions I > > > did, but> > > here is the main one - WHAT IS IT GOING TO TAKE TO GET THIS > NEW DRUG> > > THROUGH CLINICAL TRIAL AND TO MARKET? The answer is very > simple > > > - Money> > > - approximately $3 - $5 million. This may sound like a lot, > but > > > really- it's not! There are 350,000 people with Ds living in > > > the US. If each> > > family of each person with Ds gave just $15 DIRECTLY to Dr. > > > Garner's Ds> > > Lab fund that would be over $5 million!! He could go forward > > > with the> > > process of conducting a proper clinical trial without having > to jump> > > through time consuming hoops to raise the money through alternate> > > sources.> > > > > > The Changing Minds Foundation is also raising money to go > > > toward Dr.> > > Garner's research. Don't take my word for how impressive this > > > researchis - I'm not a scientist, I'm just a mom like you. > Read > > > all of the> > > information for yourself at http://garnerlab.stanford.edu/> > > . Watch the 3 minute > > > preview on> > > www.changingmindsfoundation.org> > > . Read the research posted> > > on www.changingmindsfoundation.com> > > . Buy the DVD > > > directly from> > > their website for $35. Host a showing of the DVD at a local > > > church or> > > school as a fund raiser for this vital research!> > > > > > I would like to encourage each of you to do your part right > now and> > > write a check for at least $15 and send it to: Attn: Deborah> > > Stinchfield, Stanford University, Office of Medical > Development, 2700> > > Sand Hill Road, Menlo Park, CA 94025. Make your check payable to> > > Stanford University and BE SURE TO INCLUDE THE FOLLOWING CODE > > > in the> > > memo section (DHAYQ) - this designates your gift for the > Garner Down> > > Syndrome Fund.> > > > > > "Studies in the Garner lab have confirmed that in this mouse model> > > of Down syndrome communication between two types of brain> > > cells—excitatory and inhibitory neurons—is out of balance. There> > > is too much inhibitory communication, which prevents learning from> > > properly taking place. It's as if somebody forgot to release the> > > parking break—the car just won't go.> > > The Garner lab further investigated whether inhibitory communication> > > between neurons could somehow be reduced in this mouse model. > > > For this> > > purpose, Down syndrome mice and normal mice were tested on two tasks> > > that were designed to assess learning and memory. As expected, > > > the Down> > > syndrome mice performed significantly worse than the normal mice.> > > > > > > > > The Down syndrome mice were then treated for several weeks with> > > different drugs, which are known to reduce inhibitory communication.> > > These drugs work by partially blocking a receptor located on > the > > > neuronscalled GABA A receptor. Blocking these receptors should > reduce> > inhibitory communication, thereby increasing excitatory > communication.> > When tested on the learning and memory tasks, the Down > syndrome > > > mice now> > > performed almost as well as the normal mice. Even several > weeks after> > > drug treatment had been terminated, these mice still performed > better.> > > > > > > > These results confirm that too much inhibitory communication between> > > neurons indeed prevents learning from taking place in this > mouse model> > > of Down syndrome. Reducing this inhibition with specific drugs > > > restoresthe balance between inhibitory and excitatory neurons > so > > > that learning> > > can take place."> > > > > > > > > > > > > > > > > > > > > > > > >

September 28, 2008

I am wondering what about Piracetam? Didn't that use to be the reccomended protocol not that long ago? I thought it was supposed to "wake up the brain" and that it was proven safe. Anyone's child still taking Piracetam? Have you seen results?

Subject: Re: [DownSyndromeInfoExchange] Re: Stanford Ds Research Supports Possible Treatment to Improve CognitionTo: DownSyndromeInfoExchange Date: Sunday, September 28, 2008, 11:21 AM

This has been a great thread, enjoy reading it and will be anxiously awaiting the results of the trials and the resulting recommendations. I like to listen to the medical podcasts and they all say the same thing regarding the suicide risk of prozac- the stats are because of the population that typicaly takes it, not a side effect of the drug it's self.Also wanted to point out the SCD helps guts to work efficiently and there by improves immunity and serotonin levels. One of the big surprises of the diet was her huge increase in skills across the board. Exercise has been shown to increase serotonin and exposing your child to as many new experiences as possible, also helps to build neuronal connections. That's the route I have been taking and it's working very well. If this proves safe, we would use if for , but until

then I will send money and wait. :-)

Carol in ILMom to , 8 DS My problem is not how I look. It's how you see me.VOTE NOBAMA '08Join our Down Syndrome information group - http://health. groups.yahoo. com/group/ DownSyndromeInfo Exchange/Listen to oldest dd's music http://www.myspace. com/vennamusic

[DownSyndromeInfoEx change] Re: Stanford Ds Research Supports Possible Treatment to Improve Cognition

Judy,I'm glad that your doctor is willing to work closely with you on this! How exciting. I know that just seeing the word Prozac listed assomething to give our kids scares a lot of parents. But I think thatyou and I have the right idea by taking it straight to our doctorsfirst. And may I suggest to others that if your own doctor isn'tfamiliar with or willing to work with you on this protocol to seek asecond (or third) opinion. I didn't realize until investigating thisrecently that Prozac is sometimes prescribed for constipation! It seemsthat not only is most of our immune system in our gut, but it also hasserotonin which when brought back into balance can help regulate bowelmovements. I would also like to say that I was quite concerned aboutthe "increased suicidal thoughts" side effect listed for Prozac. Iasked a doctor about that also and he said that you have to keep in mindthat this

side effect was noticed in persons who already had suicidal ordepression tendencies. My child doesn't have a depressed bone in hisbody right now. . . so I believe that the risk of this incidence wouldbe minutely small. Good luck and let us how this works for your son.Christy--

September 28, 2008

I am wondering what about Piracetam? Didn't that use to be the reccomended protocol not that long ago? I thought it was supposed to "wake up the brain" and that it was proven safe. Anyone's child still taking Piracetam? Have you seen results?

Subject: Re: [DownSyndromeInfoExchange] Re: Stanford Ds Research Supports Possible Treatment to Improve CognitionTo: DownSyndromeInfoExchange Date: Sunday, September 28, 2008, 11:21 AM

This has been a great thread, enjoy reading it and will be anxiously awaiting the results of the trials and the resulting recommendations. I like to listen to the medical podcasts and they all say the same thing regarding the suicide risk of prozac- the stats are because of the population that typicaly takes it, not a side effect of the drug it's self.Also wanted to point out the SCD helps guts to work efficiently and there by improves immunity and serotonin levels. One of the big surprises of the diet was her huge increase in skills across the board. Exercise has been shown to increase serotonin and exposing your child to as many new experiences as possible, also helps to build neuronal connections. That's the route I have been taking and it's working very well. If this proves safe, we would use if for , but until

then I will send money and wait. :-)

Carol in ILMom to , 8 DS My problem is not how I look. It's how you see me.VOTE NOBAMA '08Join our Down Syndrome information group - http://health. groups.yahoo. com/group/ DownSyndromeInfo Exchange/Listen to oldest dd's music http://www.myspace. com/vennamusic

[DownSyndromeInfoEx change] Re: Stanford Ds Research Supports Possible Treatment to Improve Cognition

Judy,I'm glad that your doctor is willing to work closely with you on this! How exciting. I know that just seeing the word Prozac listed assomething to give our kids scares a lot of parents. But I think thatyou and I have the right idea by taking it straight to our doctorsfirst. And may I suggest to others that if your own doctor isn'tfamiliar with or willing to work with you on this protocol to seek asecond (or third) opinion. I didn't realize until investigating thisrecently that Prozac is sometimes prescribed for constipation! It seemsthat not only is most of our immune system in our gut, but it also hasserotonin which when brought back into balance can help regulate bowelmovements. I would also like to say that I was quite concerned aboutthe "increased suicidal thoughts" side effect listed for Prozac. Iasked a doctor about that also and he said that you have to keep in mindthat this

side effect was noticed in persons who already had suicidal ordepression tendencies. My child doesn't have a depressed bone in hisbody right now. . . so I believe that the risk of this incidence wouldbe minutely small. Good luck and let us how this works for your son.Christy--

September 28, 2008

Piracetam is still recommended (along with Ginkgo Biloba) in the

Trisomy 21 Research Foundation Protocol with Nutrivene. We do not give my

brother Piracetam or Prozac through .

Qadoshyah

From:

DownSyndromeInfoExchange

[mailto:DownSyndromeInfoExchange ] On Behalf Of

Keener

Sent: Sunday, September 28, 2008 10:45 PM

To: DownSyndromeInfoExchange

Subject: [DownSyndromeInfoExchange] Re: Stanford Ds Research Supports

Possible Treatment to Improve Cognition

I am wondering what about

Piracetam? Didn't that use to be the reccomended protocol not that long

ago? I thought it was supposed to " wake up the brain " and

that it was proven safe. Anyone's child still taking Piracetam?

Have you seen results?

From: Carol in IL

Subject: Re: [DownSyndromeInfoExchange] Re: Stanford Ds Research Supports

Possible Treatment to Improve Cognition

To: DownSyndromeInfoExchange

Date: Sunday, September 28, 2008, 11:21 AM

This

has been a great thread, enjoy reading it and will be anxiously awaiting the

results of the trials and the resulting recommendations. I like to

listen to the medical podcasts and they all say the same thing regarding the

suicide risk of prozac- the stats are because of the population

that typicaly takes it, not a side effect of the drug it's self.

Also wanted to point out the SCD helps guts to work efficiently and there by

improves immunity and serotonin levels. One of the big surprises of the diet

was her huge increase in skills across the board. Exercise has been shown

to increase serotonin and exposing your child to as many new

experiences as possible, also helps to build neuronal connections.

That's the route I have been taking and it's working very well.

If this proves safe, we would use if for , but until then I

will send money and wait. :-)

Carol

in IL

Mom to , 8 DS

My problem is not how I look. It's how you see me.

VOTE NOBAMA '08

Join our Down Syndrome information group -

http://health. groups.yahoo. com/group/ DownSyndromeInfo Exchange/

Listen to oldest dd's music http://www.myspace. com/vennamusic

[DownSyndromeInfoEx change] Re: Stanford Ds Research Supports

Possible Treatment to Improve Cognition

Judy,

I'm glad that your doctor is willing to work closely with you on this!

How exciting. I know that just seeing the word Prozac listed as

something to give our kids scares a lot of parents. But I think that

you and I have the right idea by taking it straight to our doctors

first. And may I suggest to others that if your own doctor isn't

familiar with or willing to work with you on this protocol to seek a

second (or third) opinion. I didn't realize until investigating this

recently that Prozac is sometimes prescribed for constipation! It seems

that not only is most of our immune system in our gut, but it also has

serotonin which when brought back into balance can help regulate bowel

movements. I would also like to say that I was quite concerned about

the " increased suicidal thoughts " side effect listed for Prozac. I

asked a doctor about that also and he said that you have to keep in mind

that this side effect was noticed in persons who already had suicidal or

depression tendencies. My child doesn't have a depressed bone in his

body right now. . . so I believe that the risk of this incidence would

be minutely small. Good luck and let us how this works for your son.

Christy

--

September 28, 2008