Re: And Isn't This Interesting....

[Guest guest]

,

Thanks for this reference - very, very interesting! I might just

ask to have my TRH tested.

I did know about the 100ug for T4 and I think that's why so many

doctors are fixated on that number when Rxing T4. Of course, that's

based on the theory of organ failure and totally excludes any other

complication.

B.

>

> ........A way to determine if your own gland is outputting it's

own hormone, all this while taking thyroid hormone orally. Hmmmmm---

-hadn't known that thyroglobulin measurement (not the antibodies to

it, but the thyroglobulin itself, the raw material produced by the

gland itself) was ever used for this purpose, other than maybe

science researchers.

>

> http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?

book=endocrin & part=A290#A249

>

> From same book: Endocrinology---An Integrated Approach----S.S.

Nussey and S.A. Whitehead

>

>

> "

> Approximately 100 ?g of thyroid hormones are secreted from the

gland each day, mostly in the form of T4 with about 10% as T3.

Eighty percent of the T4 undergoes peripheral conversion to the more

active T3 in the liver and kidney (T3 is ten times more active than

T4) or to reverse T3 (rT3) that has little or no biological activity

(Box 3.1). Very small quantities of other iodinated molecules, such

as MIT and DIT as well as thyroglobulin, are also measurable in the

circulation. As this thyroglobulin originates from the normal

secretory process, its measurement in the serum is used, for

example, to detect endogenous thyroid secretion when patients are

taking oral T4 replacement (an important clinical use). "

>

> I find it quite interesting, also, that it says that a normal

thyroid gland only secretes around 100 ug a day. Hmmm.

>

>

>

>

>

[Guest guest]

can somene explain what this means in layman's terms???

thanks

steph

Re: And Isn't This Interesting....

, Thanks for this reference - very, very interesting! I might just ask to have my TRH tested. I did know about the 100ug for T4 and I think that's why so many doctors are fixated on that number when Rxing T4. Of course, that's based on the theory of organ failure and totally excludes any other complication.

B.

>

> ........A way to determine if your own gland is outputting it's own hormone, all this while taking thyroid hormone orally. Hmmmmm---

-hadn't known that thyroglobulin measurement (not the antibodies to it, but the thyroglobulin itself, the raw material produced by the gland itself) was ever used for this purpose, other than maybe science researchers.

> > http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?

book=endocrin & part=A290#A249

> > From same book: Endocrinology---An Integrated Approach----S.S. Nussey and S.A. Whitehead

> > > "

> Approximately 100 ?g of thyroid hormones are secreted from the gland each day, mostly in the form of T4 with about 10% as T3. Eighty percent of the T4 undergoes peripheral conversion to the more active T3 in the liver and kidney (T3 is ten times more active than T4) or to reverse T3 (rT3) that has little or no biological activity (Box 3.1). Very small quantities of other iodinated molecules, such as MIT and DIT as well as thyroglobulin, are also measurable in the circulation. As this thyroglobulin originates from the normal secretory process, its measurement in the serum is used, for example, to detect endogenous thyroid secretion when patients are taking oral T4 replacement (an important clinical use)."

> > I find it quite interesting, also, that it says that a normal thyroid gland only secretes around 100 ug a day. Hmmm.

> > > >

>

------------------------------------

[Guest guest]

I had the TRH stimulation test done by the endo that said to come back when my thyroid "crapped out." The test was abnormal, and I tested postive for antibodies, and he still told me that nothing was wrong. I can dig up my results if you'd like. I remember it making me feel nauseated and clammy. I had a headache for 3 days afterwards and the nurse told me that was not normal but nobody did anything about it.

http://www.mythyroid.com/TRHtest.html

http://thyroid.about.com/b/a/256646.htm

http://thyroid.about.com/od/gettestedanddiagnosed/a/trhtest.htm

-

> To: Texas_Thyroid_Groups > Date: Tue, 19 Aug 2008 14:52:28 +0000> Subject: Re: And Isn't This Interesting....> > , > > Thanks for this reference - very, very interesting! I might just > ask to have my TRH tested. > > I did know about the 100ug for T4 and I think that's why so many > doctors are fixated on that number when Rxing T4. Of course, that's > based on the theory of organ failure and totally excludes any other > complication.> > B. > > > >> > ........A way to determine if your own gland is outputting it's > own hormone, all this while taking thyroid hormone orally. Hmmmmm---> -hadn't known that thyroglobulin measurement (not the antibodies to > it, but the thyroglobulin itself, the raw material produced by the > gland itself) was ever used for this purpose, other than maybe > science researchers.> > > > http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?> book=endocrin & part=A290#A249> > > > From same book: Endocrinology---An Integrated Approach----S.S. > Nussey and S.A. Whitehead> > > > > > "> > Approximately 100 ?g of thyroid hormones are secreted from the > gland each day, mostly in the form of T4 with about 10% as T3. > Eighty percent of the T4 undergoes peripheral conversion to the more > active T3 in the liver and kidney (T3 is ten times more active than > T4) or to reverse T3 (rT3) that has little or no biological activity > (Box 3.1). Very small quantities of other iodinated molecules, such > as MIT and DIT as well as thyroglobulin, are also measurable in the > circulation. As this thyroglobulin originates from the normal > secretory process, its measurement in the serum is used, for > example, to detect endogenous thyroid secretion when patients are > taking oral T4 replacement (an important clinical use)."> > > > I find it quite interesting, also, that it says that a normal > thyroid gland only secretes around 100 ug a day. Hmmm.> > > > > > > > > >> > > > ------------------------------------> >

[Guest guest]

Measuring the thyroglobulin is a way to see if your own gland is outuptting it's OWN hormone, and this is while adjusting or taking thyroid hormone, when you already have thyroid disease. I didn't know that this could be used as a measure of how to treat, suppress, or whatever is in your treatment plan. Seems like it would be great for Hashi's patients. Yes, we know some of this by a suppressed TSH, but could there be an "escape" of some thyroid hormone from the gland itself. This is the way I'm interpreting what they are saying here in this link. The TRH is the Thyroid Releasing Hormone, I believe from what? The hypothalamus? But that's just one angle of the picture. The thyroglobulin is put out only by the thyroid gland itself.

Re: And Isn't This Interesting....

, Thanks for this reference - very, very interesting! I might just ask to have my TRH tested. I did know about the 100ug for T4 and I think that's why so many doctors are fixated on that number when Rxing T4. Of course, that's based on the theory of organ failure and totally excludes any other complication.

B.

>

> ........A way to determine if your own gland is outputting it's own hormone, all this while taking thyroid hormone orally. Hmmmmm---

-hadn't known that thyroglobulin measurement (not the antibodies to it, but the thyroglobulin itself, the raw material produced by the gland itself) was ever used for this purpose, other than maybe science researchers.

> > http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?

book=endocrin & part=A290#A249

[Guest guest]

,

Yes, as I understand it, the TRH is released by the hypothalamus,

thus if you have damage to the hypothalamus, the right amount might

not be released, thus you can have a normal TSH and still be

severely hypo. What I find most interesting about this is this Dr.

Shoemaker I mention believes that the biotoxins damage the

hypothalamus and thus all the other hormones are impacted. BUT, the

confusing thing is that he only measures TSH. So, I have yet another

thing on my list to bug him about. It would seem that if he would

do this TRH test on his patients, then that would be more supporting

evidence for his biotoxin theory.

My only concern about tetsing this TRH is that the Shomon

article (thanks for posting that!) mentions that few doctors

know how to do that test properly. I will ask Dr. H. about this when

I see her with my son next week. He might really be a good guinea

pig for this test since he has such " normal " labs but we know he's

Hashi's.

B.

> >

> > ........A way to determine if your own gland is outputting it's

> own hormone, all this while taking thyroid hormone orally. Hmmmmm-

--

> -hadn't known that thyroglobulin measurement (not the antibodies

to

> it, but the thyroglobulin itself, the raw material produced by the

> gland itself) was ever used for this purpose, other than maybe

> science researchers.

> >

> > http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?

> book=endocrin & part=A290#A249

>