Guest guest Posted May 25, 2002 Report Share Posted May 25, 2002 Haven't looked into it too far as yet, but to get me started does anyone know of a way of stabilising vitamin C in a lotion. Or is there a supplier of a stabilised version of vitamin C out there? I seem to remember coming across this a while ago. Thanks Dave E Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 25, 2002 Report Share Posted May 25, 2002 >Haven't looked into it too far as yet, but to get me started does >anyone know of a way of stabilising vitamin C in a lotion. Or is >there a supplier of a stabilised version of vitamin C out there? I >seem to remember coming across this a while ago. I've used Nikkol VC-PMG (Magnesium Ascorbyl Phosphate). There is a lot of good support literature available. Maurice. ------------------------ Maurice O. Hevey Convergent Cosmetics, Inc. http://www.ConvergentCosmetics.com Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 25, 2002 Report Share Posted May 25, 2002 >I've used Nikkol VC-PMG (Magnesium Ascorbyl Phosphate).ÿ There is a lot >of good support literature available. ------------------------- Postadministration protective effect of magnesium-L-ascorbyl-phosphate on the development of UVB-induced cutaneous damage in mice. Kobayashi S, Takehana M, Kanke M, Itoh S, Ogata E. Photochem Photobiol. 1998 Jun;67(6):669-75. Kyoritsu College of Pharmacy, Tokyo, Japan. kobayashi-sz@... The effects of stable vitamin C, magnesium-L-ascorbyl-2-phosphate (MAP), administered after acute and chronic exposure to UVB irradiation were investigated using hairless mice. Intraperitoneal administration of 100 mg/kg of MAP immediately after acute exposure to 15 kJ/m2 of UVB significantly prevented increases of UVB-induced lipid peroxidation in skin and sialic acid in serum, an inflammation marker. Administration of 50 mg/kg of MAP immediately after each exposure significantly delayed skin tumor formation and hyperplasia induced by chronic exposure to 2 kJ/m2 of UVB. Intraperitoneal administration of 200 mg/kg of MAP produced an increase in ascorbic acid (As) levels in the serum, liver and skin within 15 min. Serum As levels quickly returned to normal, but hepatic and cutaneous levels remained elevated before returning to normal after 24 h, suggesting that MAP was converted to As in the serum and in those tissues. Ultraviolet B-induced hydroxyl radical generation in murine skin homogenates was scavenged by As-Na addition, which was directly detected by electron spin resonance (ESR). These results suggest that postadministration of MAP delays progression of skin damage induced by UVB irradiation. It is presumed that MAP, once converted to As, exhibits such inhibitory effects by scavenging hydroxyl and lipid radicals generated as a direct or indirect result of UVB exposure. ------------------------- Stability of vitamin C derivatives in solution and topical formulations. Austria R, Semenzato A, Bettero A. J Pharm Biomed Anal. 1997 Mar;15(6):795-801. Universita di Padova, Dipartimento di Scienze Farmaceutiche, Italy. The stability of ascorbic acid, ascorbyl palmitate and magnesium ascorbyl phosphate (VC-PMG) in both standard solutions and topical formulations was investigated by direct RP-HPLC analysis after sample dilution with a suitable aqueous-organic solvent mixture. The results showed that, whereas the two vitamin C derivatives were more stable than ascorbic acid, the ascorbyl esters showed significant differences. Esterification with palmitic acid in 6 position did not prevent hydrolysis of the molecule, either in solution or in emulsion; only the special preparation of products with high viscoelastic properties was able to reduce the typical behaviour of this compound. Conversely, the introduction of the phosphoric group in 2 position protected the molecule from break-up of the enediol system, confirming VC-PMG as a very stable derivative of vitamin C that may be easily used in various types of cosmetic products. ------------------------- Protective effect of magnesium-L-ascorbyl-2 phosphate against skin damage induced by UVB irradiation. Kobayashi S, Takehana M, Itoh S, Ogata E. Photochem Photobiol. 1996 Jul;64(1):224-8. Kyoritsu College of Pharmacy, Tokyo, Japan. The protective effect of magnesium-L-ascorbyl-2-phosphate (MAP) on cutaneous photodamage such as lipid peroxidation and inflammation induced by ultraviolet B (UVB) exposure (290-320 nm, max. 312 nm) was investigated using hairless mice. When MAP was administered intraperitoneally to mice at a dose of 100 mg of ascorbic acid (AS) per kg body weight base immediately before irradiation (15 kj/m2), the expected increases in thiobarbituric acid reactive substance (TBARS) formation in skin and serum sialic acid, indices of lipid peroxidation and inflammatory reaction, respectively, were significantly reduced. However, the expected decrease in the level of cutaneous AS was unchanged. Similar results were observed for animals given 100 mg of AS-Na per kg body weight before UVB irradiation. When MAP was administered intracutaneously immediately before irradiation, the expected UVB-induced increases in TBARS and sialic acid were again significantly prevented. Ascorbic acid-Na had a less protective effect than intracutaneous MAP administration. The cutaneous AS level was significantly higher in the MAP-treated mice than in the controls, and the UVB-induced decrease in tissue AS was prevented by intracutaneous MAP administration. These results suggest that MAP protects against UVB irradiation-induced lipid peroxidation and inflammation in cutaneous tissue, regardless of the drug administration route. We found, in an in vitro experiment, that MAP was converted to AS as it crossed the epidermis, but that AS-Na did not pass through the epidermis. Furthermore, MAP was also converted to AS in serum. These results suggest that the protective effect of MAP on UVB-induced cutaneous damage is due to conversion of MAP to AS. ------------------------- Inhibitory effect of magnesium L-ascorbyl-2-phosphate (VC-PMG) on melanogenesis in vitro and in vivo. Kameyama K, Sakai C, Kondoh S, Yonemoto K, Nishiyama S, Tagawa M, Murata T, Ohnuma T, Quigley J, Dorsky A, Bucks D, Blanock K. J Am Acad Dermatol. 1996 Jan;34(1):29-33. Department of Dermatology, Kitasato University School of Medicine, Sagamihara, Japan. BACKGROUND: An inhibitory effect of ascorbic acid (AsA) on melanogenesis has been described. However, AsA is quickly oxidized and decomposed in aqueous solution and thus is not generally useful as a depigmenting agent. OBJECTIVE: Our purpose was to examine the effect on pigmentation of magnesium-L-ascorbyl-2-phosphate (VC-PMG), a stable derivative of AsA. METHODS: Percutaneous absorption of VC-PMG was examined in dermatomed human skin, and its effect on melanin production by mammalian tyrosinase and human melanoma cells in culture was also measured. A 10% VC-PMG cream was applied to the patients. RESULTS: VC-PMG suppressed melanin formation by tyrosinase and melanoma cells. In situ experiments demonstrated that VC-PMG cream was absorbed into the epidermis and that 1.6% remained 48 hours after application. The lightening effect was significant in 19 of 34 patients with chloasma or senile freckles and in 3 of 25 patients with normal skin. CONCLUSION: VC-PMG is effective in reducing skin hyperpigmentation in some patients. ------------------------- Regulation of collagen synthesis in human dermal fibroblasts by the sodium and magnesium salts of ascorbyl-2-phosphate. Geesin JC, Gordon JS, Berg RA. Skin Pharmacol. 1993;6(1):65-71. Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Wood Medical School, Piscataway 08854. Ascorbic acid has been shown to stimulate collagen synthesis in dermal fibroblasts by increasing the rate of transcription of collagen genes. Experiments involving the use of ascorbic acid require daily supplementation due to the instability of the molecule in aqueous solutions. In order to provide a more stable alternative to ascorbic acid, two salts of ascorbyl-2-phosphate, having a greater chemical stability than ascorbic acid, were tested for their ability to stimulate collagen synthesis in monolayer fibroblast cultures. The concentration and time dependence of their activities were compared with ascorbic acid. The magnesium salt of ascorbyl-2-phosphate was found to be equivalent to ascorbic acid in stimulating collagen synthesis in these assays, while the sodium salt required at least a tenfold greater concentration to produce the same effect as ascorbic acid. Solutions of either ascorbic acid or the ascorbyl-2-phosphate analogs (at 10 mM) in phosphate-buffered saline (PBS) were relatively stable as shown by their decay rates and their ability to stimulate collagen synthesis even after nine days in solution prior to testing their effects on cultured cells. Ascorbic acid was unstable at neutral pH compared to solutions of either sodium or magnesium ascorbyl-2-phosphate. These data support the use of magnesium ascorbyl-2-phosphate in experiments where stability of ascorbic acid is a concern, e.g. in long-term cultures or in in vivo studies. ------------------------- ------------------------ Maurice O. Hevey Convergent Cosmetics, Inc. http://www.ConvergentCosmetics.com Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 25, 2002 Report Share Posted May 25, 2002 >I've used Nikkol VC-PMG (Magnesium Ascorbyl Phosphate). Nikkol VC-PMG is sold by Nikko Chemicals. According to the Nikko website <http://www.nikkol.co.jp/english/index_e.html>, their products are distributed by JAN DEKKER (UK) Ltd. Suite 3, Hillbrow House, Linden Dirve Liss. Hampshire GU33 7RJ United Kingdom Tel: 44 1730 89 55 11 / Fax: 44 1730 89 51 11 E-mail: sales@... Maurice ------------------------ Maurice O. Hevey Convergent Cosmetics, Inc. http://www.ConvergentCosmetics.com Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 25, 2002 Report Share Posted May 25, 2002 > >I've used Nikkol VC-PMG (Magnesium Ascorbyl Phosphate). > > Nikkol VC-PMG is sold by Nikko Chemicals. According to the Nikko website <http://www.nikkol.co.jp/english/index_e.html>, their > products are distributed by > > JAN DEKKER (UK) Ltd. > Suite 3, Hillbrow House, Linden Dirve > Liss. Hampshire GU33 7RJ United Kingdom > Tel: 44 1730 89 55 11 / Fax: 44 1730 89 51 11 > E-mail: sales@j... > Superb. I'll be on to Leanne at Jan Dekker on Monday. Just been the shops and seen Garnier use ascorbyl glucoside; was going to look into this but Jan Dekker is now the preferred option. I just didn't want to use vit c in liposome form. Cheers Maurice. Dave E Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 25, 2002 Report Share Posted May 25, 2002 , You should also note that EM Industries also sells Mag Ascorbyl Phosphate. I have that EM's price is less than Nikkol in the USA. Perhaps it is that Nikkol distributor wants more $$ than EM for the same product. Young KY Labs Innovators of Fine Personal Care Products www.kylabs.com Re: Vitamin C > >I've used Nikkol VC-PMG (Magnesium Ascorbyl Phosphate). > > Nikkol VC-PMG is sold by Nikko Chemicals. According to the Nikko website <http://www.nikkol.co.jp/english/index_e.html>, their > products are distributed by > > JAN DEKKER (UK) Ltd. > Suite 3, Hillbrow House, Linden Dirve > Liss. Hampshire GU33 7RJ United Kingdom > Tel: 44 1730 89 55 11 / Fax: 44 1730 89 51 11 > E-mail: sales@j... > Superb. I'll be on to Leanne at Jan Dekker on Monday. Just been the shops and seen Garnier use ascorbyl glucoside; was going to look into this but Jan Dekker is now the preferred option. I just didn't want to use vit c in liposome form. Cheers Maurice. Dave E Post message: Cosmeticinfo Subscribe: Cosmeticinfo-subscribe Unsubscribe: Cosmeticinfo-unsubscribe List owner: Cosmeticinfo-owner URL to this page: http://groups.yahoo.com/group/Cosmeticinfo Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 26, 2002 Report Share Posted May 26, 2002 In a message dated 5/25/02 3:32:56 AM Pacific Daylight Time, david@... writes: > Haven't looked into it too far as yet, but to get me started does > anyone know of a way of stabilising vitamin C in a lotion. Or is > there a supplier of a stabilised version of vitamin C out there? I > seem to remember coming across this a while ago. > > Thanks > > Dave E > > Hi Dave, A chemist at Roche mentioned a product that I think is called StaC-----not sure if this is the correct spelling. But it is supposted to be stable for use in formulations. He is sending me some samples and literature. Angie The Herbarie...Visit us at: http://www.theherbarie.com for Body Care Products and Bulk Ingredients...Botanical Extracts and Proteins, Ultra-Mild Surfactant Blends, Conditioning Emulsifiers. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 26, 2002 Report Share Posted May 26, 2002 >A chemist at Roche mentioned a product that I think is called StaC-----not >sure if this is the correct spelling.ÿ But it is supposted to be stable for >use in formulations.ÿ He is sending me some samples and literature. STAY-C 50 (INCI = Sodium Ascorbyl Phosphate) CAS NO.: 66170-10-3 Other names: L-Ascorbic Acid, 2-(Dihydrogen Phosphate), Trisodium Salt Sodium L-Ascorbyl-2-Phosphate Empirical Formula: C6H6O9P - 3Na ------------ Stability of ascorbyl palmitate in topical microemulsions. Spiclin P, Gasperlin M, Kmetec V. Int J Pharm. 2001 Jul 17;222(2):271-9. Faculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000, Ljubljana, Slovenia. Ascorbyl palmitate and sodium ascorbyl phosphate are derivatives of ascorbic acid, which differ in stability and hydro-lipophilic properties. They are widely used in cosmetic and pharmaceutical preparations. In the present work the stability of both derivatives was studied in microemulsions for topical use as carrier systems. The microemulsions were of both o/w and w/o types and composed of the same ingredients. The stability of the less stable derivative ascorbyl palmitate was tested under different conditions to evaluate the influence of initial concentration, location in microemulsion, dissolved oxygen and storage conditions. High concentrations of ascorbyl palmitate reduced the extent of its degradation. The location of ascorbyl palmitate in the microemulsion and oxygen dissolved in the system together significantly influence the stability of the compound. Light accelerated the degradation of ascorbyl palmitate. In contrast, sodium ascorbyl phosphate was stable in both types of microemulsions. Sodium ascorbyl phosphate is shown to be convenient as an active ingredient in topical preparations. In the case of ascorbyl palmitate, long-term stability in selected microemulsions was not adequate. To formulate an optimal carrier system for this ingredient other factors influencing the stability have to be considered. ------------ Protective effects of sodium-L-ascorbyl-2 phosphate on the development of UVB-induced damage in cultured mouse skin. Nayama S, Takehana M, Kanke M, Itoh S, Ogata E, Kobayashi S. Biol Pharm Bull. 1999 Dec;22(12):1301-5. Kyoritsu College of Pharmacy, Tokyo, Japan. The protective effect of sodium-L-ascorbyl-2 phosphate (As-2P), a stable form of ascorbic acid (AsA), against photodamage induced by a single dose of UVB exposure (290-320 nm, Max 312 nm) was investigated using cultured mouse skin. When the cultured skin was treated with various As-2P concentrations, the cutaneous AsA level increased in proportion to the As-2P concentration. After 3 h of incubation, the AsA level in the cultured skin treated with 2, 20 and 100 mM As-2P increased 1.03-, 2.17- and 6.27-fold, respectively, compared with that of the control skin. These results suggest that As-2P was transported into the cultured mouse skin where it was converted to AsA. After 3 h, the cutaneous AsA level in irradiated (20 kJ/m2) skin was depleted to a half of that in the control skin. However, the level in skin pretreated with 20 mM As-2P was maintained within normal limits, even after 24 h. Pretreatment with 20 mM As-2P significantly prevented such photodamage as sunburn cell formation, DNA fragmentation and lipid peroxidation, which were caused by a single dose of UVB irradiation. These results suggest that the protective effect of 20 mM As-2P on UVB-induced cutaneous damage is due to the maintenance of a normal As level by conversion of As-2P to As in skin tissue. ------------ Protective effects of sodium-L-ascorbyl-2 phosphate on the development of UVB-induced damage in cultured mouse skin. Nayama S, Takehana M, Kanke M, Itoh S, Ogata E, Kobayashi S. Biol Pharm Bull. 1999 Dec;22(12):1301-5. Kyoritsu College of Pharmacy, Tokyo, Japan. The protective effect of sodium-L-ascorbyl-2 phosphate (As-2P), a stable form of ascorbic acid (AsA), against photodamage induced by a single dose of UVB exposure (290-320 nm, Max 312 nm) was investigated using cultured mouse skin. When the cultured skin was treated with various As-2P concentrations, the cutaneous AsA level increased in proportion to the As-2P concentration. After 3 h of incubation, the AsA level in the cultured skin treated with 2, 20 and 100 mM As-2P increased 1.03-, 2.17- and 6.27-fold, respectively, compared with that of the control skin. These results suggest that As-2P was transported into the cultured mouse skin where it was converted to AsA. After 3 h, the cutaneous AsA level in irradiated (20 kJ/m2) skin was depleted to a half of that in the control skin. However, the level in skin pretreated with 20 mM As-2P was maintained within normal limits, even after 24 h. Pretreatment with 20 mM As-2P significantly prevented such photodamage as sunburn cell formation, DNA fragmentation and lipid peroxidation, which were caused by a single dose of UVB irradiation. These results suggest that the protective effect of 20 mM As-2P on UVB-induced cutaneous damage is due to the maintenance of a normal As level by conversion of As-2P to As in skin tissue. ------------ ------------------------ Maurice O. Hevey Convergent Cosmetics, Inc. http://www.ConvergentCosmetics.com Quote Link to comment Share on other sites More sharing options...
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