Re: Q: Celiac,C.Diff, allergies,and more

[Guest guest]

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In terms of the glutamine issue, this came up for me with Daignostech's as well. A patient of mine who is fanatically gluten free and takes (and does extremely well with) glutamine for her Chron's came up positive for her gliadin test. I was told the same thing you were and it didn't make sense to me either. I did a lot of research on the issue, especially with doctors and researchers involved with autism research. What I found out was that the gliadin test is most likely looking for certain sequences of amino acids, rather than the entire protein sequence, which would be too expensive to test for. Because glutamine is present in large amounts in gliadin, that is one of the major portions of that test. However, that doesn't mean that glutamine itself is the issue- it's the major fuel for the enterocytes, which wouldn't make a lot of biological sense to have a toxic reaction to the major energy source. What I and the autism docs think is happening is that large amounts of glutamine may be causing a false positive on the gliadin test if the test is designed to look for a certain amount of that particular amino acid. If your patient has been doing well with the glutamine and has been compliant with truly being gluten-free, then I would suspect you may be in the same situation with a false positive on the test.

Hindman, ND, LAc

Portland, OR

family practice (when back from maternity leave!)

Hello all-

This is a patient I've written about before; 15 yo female who presented at 13 with severe eczema, multiple food allergies, poor energy, failure to thrive and GI issues (gas, dumping, diarrhea). She is doing very well, for the past year she has had no GI symptoms and the eczema has cleared except from the knees down. She is on a very restricted diet due to her many sensitivites (IgG and IgE). Repeated IgG testing after a 6 month elimination of all the food culprits showed NO CHANGE at all in her reactivity. She has tested negative for celiac dz.(done by her MD) but avoids gluten due to the severe reactivity shown via IgG and IgE testing. She has been on an elemental amino acid formula for the past 8 months which has allowed her to gain more weight and grow.

A GI health panel was run in 8/06 that showed +2 candida, moderate overgrowth of strep, low sIgA, colonic inflammation, low pancreatic enzyme output.

We re-ran the GI health panel last month, expecting many parameters to have improved and the results were as follows: No yeast (hooray) but the strep persists and NEW pathogens are present including moderate pseudomonas, rare cornybacterium and positive C.Diff !!? Inflammatory markers and SIgA are virtually unchanged. How is this possible when she has been on serious doses of probiotics for almost 3 years now, along with gut healing formulas, antioxidants, enzymes, rotating botanical antifungals and antimicrobials, EFAs and homeopathic drainage? Granted, as a teen there have been power struggles with her folks and periods of non-compliance. She has not been hospitalized or on any pharmaceuticals. She recently fractured the growth plate in her wrist and did have one episode of gastroenteritis last winter that was treated with homeopathy.

I am perplexed. Tech support at Diagnostechs suggested that her body is not responding to the probiotic, and that glutamine is contraindicated in celiac disease because it shares an amino acid sequence with gliadin...? I asked him how that can be when glutamine is just one amino acid, not a sequence. I lost faith in his logic after that statement but I did find some references that say in a small percentage of folks with celiac, they will respond poorly to glutamine (which she has had in her gut repair formulas).

Diagnostechs has offered to re-run the stool portion of the test, and that is pending. They do not do sensitivity testing, and Drs.Data won't work with me because I'm in Rhode Island.

So... I'm going to order Celiac DNA testing, change her probiotic, take her off glutamine, add colostrum and amla-plex, and am considering concentrated allicin extract (which we've done in the past).

She has no GI symptoms and feels very well except for the itchiness of her eczema.

Any thoughts about this....? What am I missing?

If you've made it this far, thanks.

N.D.

N.field, RI

401*597*0477

[Guest guest]

Hi ,

2 things:

(1) I'm not sure if your GI repair formulas addressed acidifcation the GI tract or if you are doing ACV for that. It seems if the testing is saying she's not utilizing the probiotics this could be part of the problem. I really like SP's Lactic Acid Yeast wafers to acidify, thus allowing the probiotics to populate.

(2) Definately AlliMed or AlliUltra caps daily to provide a stabilized allicin that will address the C.Diff. and other bacteria. The stabilized allicin has also been shown to help up-regulate the good digestive flora.

Hope you are well!

Dr. McCool, N.D.

Sunnyside Natural Medicine

13110 SE Sunnyside/Suite B

Clackamas, Oregon 97015

www.sunnysidenm.com

Hello all-

This is a patient I've written about before; 15 yo female who presented at 13 with severe eczema, multiple food allergies, poor energy, failure to thrive and GI issues (gas, dumping, diarrhea). She is doing very well, for the past year she has had no GI symptoms and the eczema has cleared except from the knees down. She is on a very restricted diet due to her many sensitivites (IgG and IgE). Repeated IgG testing after a 6 month elimination of all the food culprits showed NO CHANGE at all in her reactivity. She has tested negative for celiac dz.(done by her MD) but avoids gluten due to the severe reactivity shown via IgG and IgE testing. She has been on an elemental amino acid formula for the past 8 months which has allowed her to gain more weight and grow.

A GI health panel was run in 8/06 that showed +2 candida, moderate overgrowth of strep, low sIgA, colonic inflammation, low pancreatic enzyme output.

We re-ran the GI health panel last month, expecting many parameters to have improved and the results were as follows: No yeast (hooray) but the strep persists and NEW pathogens are present including moderate pseudomonas, rare cornybacterium and positive C.Diff !!? Inflammatory markers and SIgA are virtually unchanged. How is this possible when she has been on serious doses of probiotics for almost 3 years now, along with gut healing formulas, antioxidants, enzymes, rotating botanical antifungals and antimicrobials, EFAs and homeopathic drainage? Granted, as a teen there have been power struggles with her folks and periods of non-compliance. She has not been hospitalized or on any pharmaceuticals. She recently fractured the growth plate in her wrist and did have one episode of gastroenteritis last winter that was treated with homeopathy.

I am perplexed. Tech support at Diagnostechs suggested that her body is not responding to the probiotic, and that glutamine is contraindicated in celiac disease because it shares an amino acid sequence with gliadin...? I asked him how that can be when glutamine is just one amino acid, not a sequence. I lost faith in his logic after that statement but I did find some references that say in a small percentage of folks with celiac, they will respond poorly to glutamine (which she has had in her gut repair formulas).

Diagnostechs has offered to re-run the stool portion of the test, and that is pending. They do not do sensitivity testing, and Drs.Data won't work with me because I'm in Rhode Island.

So... I'm going to order Celiac DNA testing, change her probiotic, take her off glutamine, add colostrum and amla-plex, and am considering concentrated allicin extract (which we've done in the past).

She has no GI symptoms and feels very well except for the itchiness of her eczema.

Any thoughts about this....? What am I missing?

If you've made it this far, thanks.

N.D.

N.field, RI

401*597*0477