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http://www.congre.co.jp/icfs2008/

International Conference

on Fatigue Science 2008

Okiniawa

Dates 3 (Wed) - 5 (Fri), 2008

````````

Greetings

Dear Colleagues:

Fatigue is an indispensable bio-alarm to avoid the

exhaustive state caused by severe stresses and

overwork, which may also induce a variety of

diseases. However, still not so much are known

about the molecular and neural mechanisms of

fatigue. The world-wide efforts to explore the

mechanisms of fatigue and to develop better ways to

recover from fatigue have increased markedly in the

past five years, concomitant with new enthusiasm for

exploring the molecular/neural mechanisms and

epidemiology of Chronic Fatigue Syndrome (CFS) and

related diseases.

The International Conference on Fatigue Science

2008 will be held as a part of activities of The 21st

Century COE Program, " Base to Overcome Fatigue " in

Japan, and therefore will be sponsored mainly by the

Ministry of Education, Culture, Sports, Science and

Technology, Japanese Government (MEXT). The

International Association on CFS/ME and the

Japanese Society of Fatigue Science will support the

Conference.

In our discussion of ways to merge research on

fatigue with that on CFS/ME, we planned our

upcoming conference to be in " Bankoku Shinryokan, "

Okinawa. " Bankoku Shinryo " meaning " Bridge

between Nations, " is named after a phrase carved on

the large bell at Shuri Castle. Bankoku Shinryokan

stands on the scenic Busena Point overlooking the

East China Sea. It was established as the main

Convention Center for the 2000 Kyushu-Okinawa G-8

Summit and has hosted many successful conventions

since the Summit. Okinawa is an idyllic holiday

destination with its coral reefs, limestone carves,

and its sub-tropical climate.

We look forward to seeing you in Okinawa to discuss

a lot about and corporately rescue the people

suffering from " fatigue. "

Chair: Yasuyoshi Watanabe (Kobe/Osaka, Japan)

International Conference on Fatigue Science 2008

```````````

Organizing Committee

Chair: Yasuyoshi Watanabe (Kobe/Osaka, Japan)

Vice-chair: G. Klimas (Miami, USA; President

of IACFS/ME)

Hirohiko Kuratsune (Osaka, Japan)

Birgitta M. EvengDrd (Stockholm/UmeD, Sweden)

Honorary Presidents: Teruo Kitani (Osaka, Japan)

Nobuya Hashimoto (Tokyo, Japan; President of Japan

Society of Fatigue Science)

Satoru Kaneko (Osaka, Japan; President, Osaka City

University)

Akira Shimizu (Osaka, Japan; President, Kansai

University of Welfare Science)

Organizing Committee: Yasuyoshi Watanabe

(Kobe/Osaka, Japan)

G. Klimas (Miami, USA)

Hirohiko Kuratsune (Osaka, Japan)

Birgitta M. EvengDrd (Stockholm/UmeD, Sweden)

Suzanne D. Vernon (Bethesda, USA)

Leonard A. (Chicago, USA)

H. Natelson (New Jersey, USA)

S. Rowe (Melbourne, Australia)

Kenny L. De Meirleir (Brussel, Belgium)

S. Bell (USA)

Yoshiki Nishizawa (Osaka, Japan)

Teruhisa Miike (Kobe, Japan)

Nobutaro Ban (Nagoya, Japan)

Chiharu Kubo (Fukuoka, Japan)

Kazuhiro Kondo (Tokyo, Japan)

Teruichi Shimomitsu (Tokyo, Japan)

Osami Kajimoto (Osaka, Japan)

Yoshinobu Hirayama (Osaka, Japan)

Kiyoshi Matsumura (Osaka, Japan)

Hirotaka Onoe (Kobe, Japan)

Local Organizing Committee: Yosky Kataoka,

Masaaki Tanaka, Kouzi Yamaguti, Sanae Fukuda,

Hidenori Koyama, Tokuzo Matsui, Kei Mizuno, Emi

Yamano, Yoko Nagatomo

`````````````````

Conference Information

Meeting Period

Wednesday, September 3 - Friday, September 5 ,

2008

Venue

Bankoku Shinryokan

1792 Kise, Nago-city, Okinawa 905-0026, Japan

Language

The official language of the conference is English.

Simultaneous interpretation will not be provided.

``````````

Program

Wednesday, September 3, 2008

Opening Session

9:00 Opening Remarks Yoshiki Nishizawa

9:10 Greeting Nobuya Hashimoto

9:20 Greeting G. Klimas

9:30 Greeting Suzanne D. Vernon

Keynote Lectures

Chairs: Yasuyoshi Watanabe/ H. Natelson

9:40 KL-01 Immune and neuoendocrine networking,

and novel approaches to biomarker discovery in

CFS/ME and related illnesses

G. Klimas

University of Miami and the Miami Veteran

Healthcare System, USA

10:10 KL-02 The epidemiology of fatigue and Chronic

Fatigue Syndrome

D. White

Barts and the London Medical School, London, UK

10:40 Coffeee Break

Chairs: Yoshiki Nishizawa/Birgitta M. Evengard

11:00 KL-03 A genomic approach to understand the

biology of fatigue and fatiguing illness to improve

objective diagnosis and treatment

Suzanne D. Vernon

CFIDS Association of America, USA

11:30 KL-04 Fatigue science for human health

Yasuyoshi Watanabe

The 21st Century COE Program, 'Base to Overcome

Fatigue', MEXT,

Molecular Imaging Research Program, RIKEN,

Department of Physiology, Osaka City University

Graduate School of Medicine, JST/RISTEX, Japan

12:10-13:00 Luncheon Seminar [sanofi-aventis K.K.,

Astellas Pharma Inc.]

Chair: Yoshiki Nishizawa

Association between metabolic syndrome and

insomnia

Naohisa Uchimura

Department of Neuropsychiatry, Kurume University

School of Medicine, Fukuoka, Japan

[symposium 1] Chronic Fatigue Syndrome (CFS) and

Related Diseases(I)

Chairs: Kenny L. De Meirleir/Hirohiko Kuratsune

13:10 S1-01 Biomarkers in CFS

Birgitta M. Evengard

13:35 S1-02 Chronic Fatigue Syndrome &

Fibromyalgia: An exploration of differences

H. Natelson

14:00 S1-03 Dynamics of brain structure in CFS

Floris P. de Lange

14:25 S1-04 Neural mechanisms underlying chronic

fatigue (P-07)

Masaaki Tanaka

14:50 S1-05 Ventricular CSF lactate is elevated in

Chronic Fatigue Syndrome compared to generalized

anxiety disorder: An in vivo 1H magnetic resonance

spectroscopic imaging study

Dikoma C. Shungu

15:15 Coffee Break

Chairs: Leonard A. /Kazuhiro Kondo

15:35 S1-06 ish centre for the study of fatigue

science: DNA microarray analysis of gene expression

in Chronic Fatigue Syndrome

W. Gow

16:00 S1-07 Dipeptidyl peptidase IV (DDPIV/CD26)

and neuropeptide Y (NPY): Biomarkers for Chronic

Fatigue Syndrome

A. Fletcher

16:25 S1-08 A population-based twin study of

functional somatic syndromes

Kenji Kato

16:50 S1-09 A new Japanese guideline for Chronic

Fatigue Syndrome

Tokuzo Matsui

17:30-18:30 Poster Discussion

19:00-21:00 Buffet Dinner

Thursday, September 4, 2008

[symposium 2] Chronic Fatigue Syndrome (CFS)

and Related Diseases(II)

Chairs: Suzanne D. Vernon/Hidenori Koyama

8:30 S2-01 Viral DNA in the gastric and intestinal

mucosa of patients with Chronic Fatigue Syndrome

Kenny L. De Meirleir

8:50 S2-02 Increased D-lactic acid intestinal

bacteria in patients with Chronic Fatigue Syndrome

Kenny L. De Meirleir

9:10 S2-03 Identification of novel HHV-6 latent

protein associated with mood disorders and

molecular mechanism of fatigue due to overwork

Kazuhiro Kondo

9:35 S2-04 Immunologic and virologic profiling of

individuals with Myalgic Encephaolomyelitis/Chronic

Fatigue Syndrome (ME/CFS) reveals distinct pathogen

associated signatures within a well characterized

cohort.

Judy A. Mikovits

10:00 S2-05 Chronic Fatigue Syndrome and major

depressive disorder

Nobuo Kiriike

10:25 Coffee Break

[symposium 3] Measure/Scale of Fatigue

Chairs: G. Klimas/Kazuhiro Iwai

10:40 S3-01 Evaluation of fatigue by acceleration

plethysmography (Part.I)

(From the viewpoint of autonomic nervous system)

Kouzi Yamaguti

11:00 S3-02 The CardioPulmonary Exercise Test

(CPET) for the differential diagnosis of chronic

fatigue

Ruud C. Vermeulen

11:20 S3-03 Heart rate variability can have an

insight into working-quality of white-collar jobs

Jun-ichi Koizumi

11:40 S3-04 Non-arbitrary detection of flicker fusion

threshold with pupil diameter and visual evoked

magnetic field

Nobuyoshi Harada

12:00 S3-05 Alternans lowers the scaling exponent of

heartbeat fluctuation dynamics: A detrended

fluctuation analysis in animal models and humans for

a health check up

Toru Yazawa

12:30-13:20 Luncheon Seminar [soiken Holdings Inc.

Japan Preventive Medicine Inc.]

Chair: Yosky Kataoka

Anti-fatigue effects of imidazole dipeptides

Masaaki Tanaka

Department of Biomarker and Molecular Biophysics,

Osaka City University Graduate School of Medicine,

Osaka, Japan

[symposium 4] Mechanisms of Fatigue and

Fibromyalgia

Chairs: D. White/Kiyoshi Matsumura

13:35 S4-01 Fatigue signalings in the brain

Yosky Kataoka

14:00 S4-02 Disorders of homeostasis centers in

fatigued rat

Hiroshi Kiyama

14:25 S4-03 Disturbed heme metabolism in the liver

of fatigue model rats and its involvement of fatigue

Kazuhiro Iwai

14:50 S4-04 Brain mechanisms of immunologically

induced fatigue in the rat

Toshihiko Katafuchi

15:15 Coffee Break

Chairs: Floris P. de Lange/Hiroshi Kiyama

15:35 S4-05 Sex difference in the stress response to

fasting

Mika Jikumaru

16:00 S4-06 Imaging of lactate utilization in the

brain in vitro and in vivo

Kiyoshi Matsumura

16:25 S4-07 Intermittent cold stress causes a

long-term allodynia and hyperalgesia in mice, a

model for generalized chronic pain syndrome or

Fibromyalgia

Hiroshi Ueda

16:50-18:00 Poster Discussion

19:00-21:30 Reception

Friday, September 5, 2008

[symposium 5] Childhood/Adolescent Fatigue and

Learning Motivation

Chairs: S. Rowe/Teruhisa Miike

8:30 S5-01 Sleep problems and Chronic Fatigue

Syndrome in childhood

Teruhisa Miike

8:55 S5-02 Autoantibodies generating fatigue long

before the onset of the diseases in children

Yasuhiko Itoh

9:20 S5-03 Natural history of Chronic Fatigue

Syndrome in adolescents in Australia

S. Rowe

9:45 S5-04 Motivation for learning, fatigue and

sleep; from the results of the cohort study

Sanae Fukuda

10:10 S5-05 Neural substrates of academic

achievement motivation related to neural mechanism

of fatigue

Kei Mizuno

10:35 Coffee Break

[symposium 6] Treatment and Fatigue

Chairs: W. Gow/Masaaki Tanaka

10:55 S6-01 Relationship between fatigue and the

daily diet in Japan (P-22)

Hirohiko Kuratsune

11:20 S6-02 Behavioural treatments for Chronic

Fatigue Syndrome

D. White

11:45 S6-03 Biological predictors of change following

participation in non-pharmacologic interventions

Leonard A.

12:10-13:10 Lunch

Chairs: W. Gow/Masaaki Tanaka

13:20 S6-04 Psychosomatic treatment and

management of Chronic Fatigue Syndrome

Chiharu Kubo

13:45 S6-05 Fatigue in patients with end-stage renal

diseases

Hidenori Koyama

14:10 S6-06 Development of anti-fatigue food:

Results from human studies

Yoshitaka Kajimoto

Closing Remark

14:35 Hirohiko Kuratsune

Wednesday, September 3 - Friday, September 5,

2008

````````

Poster Session

P-01 A two-year follow-up study of psychiatric

disorders comorbid with Chronic Fatigue Syndrome

(CFS)

Yasunori Matsuda

P-02 Summary of patients with chronic fatigue

visiting to medical experts in fatigue

Yukiko H. Kato

P-03 Cognitive Behavioral Therapy (CBT) for patients

with Chronic Fatigue Syndrome: Comparing CBT in

group and individual therapy

Nahoko Kusaka

P-04 No difference of parvovirus B19 prevalence

between Chronic Fatigue Syndrome patients and

healthy individuals in Japan

Yukiko H. Kato

P-05 Evaluation of fatigue by acceleration

plethysmography (Part.II)

(From the view point of complexity system)

Kouzi Yamaguti

P-06 Experimental therapeutic approach with

polymyxin B column Kazuki Miura absorption to

Chronic Fatigue Syndrome

P-07 Neural mechanisms underlying chronic fatigue

Masaaki Tanaka

P-08 Job-related stress, job satisfaction, and

working conditions among doctors in the regional

core hospitals

Sayuri Kaneko

P-09 Physical performance tests are useful for the

evaluation of fatigue induced by physical load in

healthy people

Tomohiro Sugino

P-10 Therapeutic effects of thalassotherapy on

fatigue in healthy young women

Kuniaki Takagi

P-11 Increase in serotonin release in human brain

induced by exercise: A PET study

Toshihiko Fujimoto

P-12 Investigation of Okinawa-spa effect from the

view point of EEG power value

Toshiharu Kurita

P-13 The relationship between fatigue and visual

evoked cortical magnetic response

Yoshihito Shigihara

P-14 A preliminary trial of physiological fatigue

evaluation using heart rate variability analysis

Seiki Tajima

P-15 Salivary cortisol and self-reports of

pleasure-displeasure of unmarried young people in

contact with infant

Kyoko Imai-Matsumura

P-16 Fatigue is associated with eating habits and

intake of nutrients in general population

Hisako Fujii

P-17 Infant-directed behavior and speech of

university students: A basic study aiming at

preventing childcare stress.

Ai Nakagawa

P-18 Fatigue and metabolic syndrome among

Japanese men and women

Tetsuya Ohira

P-19 The evaluation of fatigue by using

plethysmograph and self-organizing map

Tetsuya Sasabe

P-20 Effect of acupressure points stimulation on

ocular fatigue causes by VDT work

FengHao XU

P-21 Which aroma is the most effective for

anti-fatigue? A preliminary study

Sanae Fukuda

P-22 Relationship between fatigue and the daily diet

in Japan

Hirohiko Kuratsune

P-23 Imidazole dipeptides attenuate fatigue induced

by physical load in human

Sayaka Aoyagi

P-24 Examination of the high bright light therapy for

the Childhood Chronic Fatigue Syndrome

Takako Jodoi

P-25 Metabolic dysfunction and circadian rhythm

abnormalities in children and adolescents with sleep

disturbance

Akemi Tomoda

P-26 The actigraphic evaluation of sleep-awake

rhythm and daily activity level among with Child

Chronic Fatigue Syndrome

Junko Kawatani

P-27 Feedback from young people with Chronic

Fatigue Syndrome on the perceived usefulness of

various management strategies including alternative

therapies

S. Rowe

P-28 Aspects of intellectual ability in Childhood

Chronic Fatigue Syndrome (CCFS)

Miyuki Takano

P-29 The association between effort-reward

imbalance for learning and fatigue in school children

Sanae Fukuda

P-30 Learning motivation among early elementary

school aged children - What would make them

intrinsically motivated?

Rika Okamura

P-31 Psychosocial predictors of fatigue among

school children in Japan: The one-year follow-up

study

Emi Yamano

P-32 Children's feeling transformation and health

care in summer seaside camp

Tadashi Yano

P-33 Examination of Hb/Alb as the simple screening

of Sleep Apnea syndrome (SAS) for psychiatric

patients

Tatsuyo Suzuki

P-34 Moxibustion improved pain in patients with

Fibromyalgia

Takeo Madarame

P-35 Activation of microglia and reduction of

cerebral glucose metabolism in a mouse model of

fatigue caused by sleep disturbance

Miho Shukuri

P-36 Alterations of inflammatory responses to LPS in

rat fatigue model

Nobue Shishioh-Ikejima

P-37 Prolonged fatigue exhibits the opposed

proliferation regulations in the anterior and

intermediate pituitary cells

Tokiko Ogawa

P-38 Aged garlic extract as an anti-fatigue agent

Takeshi Nishihama

P-39 Genotype dependent antidepressant-like effect

of green odor in mice

Yasuhito Nakatomi

P-40 Inflammatory cytokines expression in the brain

is involved in poly I:C-induced immunological

fatigue-like behavior in rats

Masanori Yamato

P-41 Mechanisms of decreased [18F]

2-fluoro-2-deoxy-D-glucose accumulation in the brain

of fatigued rats

Ko-hei Akazawa

P-42 Effects of (-)-epigallocatechin gallate on an

animal model of combined (physical and mental)

fatigue

Yoshitake Baba

P-43 A novel method of PET imaging for

neuropsychiatric disorders in mice

Hiroshi Mizuma

P-44 Non-REM sleep induction after excessive brain

excitation: A possible pathway for central fatigue

recovery

Yilong Cui

P-45 The role of laminin-332 and -511 in the

regulation of stress-induced alopecia

Daisuke Tsuruta

P-46 Regulation of gastric emptying by reciprocal

alteration between plasma catecholamine and ghrelin

levels in a rat model of fatigue

Masahiro Ochi

P-47 Expression of c-Fos in the central nervous

system in a rat model for immunological fatigue

induced by poly I:C administration

GuangHua Jin

P-48 Changes in behavior and brain GABAergic

activity by mental fatigue: PET study with macaque

monkeys

Hirotaka Onoe

P-49 Decrease of hepatic delta-aminolevulinate

dehydratase activity in an animal model of fatigue

Tsuyoshi Tahara

P-50 Up-regulation of aromatase in the fatigued

model rats

Makoto Ozawa

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Fatigue Shmatigue, as some one once famously said (can’t remember who) – I

can see that there are a few good presenters here, but I am so, so fed up

with all the connection & confusion with ME and “Fatigue”. I’m at the point

where I want to remove that word from the English language! Aylwin xox

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>

> Fatigue Shmatigue, as some one once famously said (can't remember

who) – I

> can see that there are a few good presenters here, but I am so, so

fed up

> with all the connection & confusion with ME and " Fatigue " . I'm at the

point

> where I want to remove that word from the English language! Aylwin xox

>

Couldn't have said it better myself. Maybe we should invent our own

word!!! Something that means a cross between excruciating pain,

enormous frustration and " oh my god I feel sooooooo bloody awful I wish

I were dead!! " Any ideas???

And I know Jodi has a section titled 'Fatigue Shmatigue' (?spelling?)

on her hummingbirds website.

take care, ness.

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Oh that’s right, it was from Jodi’s site! Now when I do talk about it, I

talk about muscle failure or extremely low stamina – and that’s just the

so-called “fatigue” pert, never mind the feeling bloody awful of all the

rest of it <sigh>. Aylwin xox

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