Re: Fwd: Emailing: RE_ miralax

[Guest guest]

"MiraLax is made of polyethylene glycol, which is poorly absorbed from the intestine. This pulls water into the intestinal tract, and hence helps with hard stools or constipation. It is different then ethylene glycol, which is readily absorbed and metabolized in to oxalate in the liver. Polyethylene glycol is not broken down into ethylene glycol. The only connection between polyethylene glycol and crystals in the urine would be if a person took enough of the polyethylene glycol to have diarrhea and then get dehydrated, leading to the urine becoming very concentrated."

Isn't that interesting,

Note: So there IS a causation between them!!!

The only connection between polyethylene glycol and crystals in the urine would be if a person took enough of the polyethylene glycol to have diarrhea and then get dehydrated, leading to the urine becoming very concentrated."

Isn't this exactly how the medication works??? then they wonder why they are complaining of oxalate crystals, not to mention the overdoses they are prescribing, thank you Marg, this is very important information. Also, "It's Poorly absorbed" means some is absorbed, this is really simply here. I believe it goes in fine, because they changed the chemical make up, but somewhere inside it's breaking down and when it comes back out it's stining and burning, almost as if it converted to it's origianl state, if it didn't we all wouldn't have been here for 6 years and we wouldn't have even ONE case.

Jeanie

--------- miralax

can miralax contribute to oxalate crystals in the urine

[Guest guest]

Ok not only is this reply from the RN/MD no where near technical -- it's also "technically" incorrect.

http://www.calpoison.org/hcp/2002/callusvol1no1.html

Hello Marg and Doug,

I am the Study Coordinator for the Mayo Clinic Hyperoxaluria Center, I forwarded you questions to one of our Center's Nephrologists, Dr. Lieske. The answer to your questions is no, MiraLax (taken as recommended) would not contribute to oxalate crystals in your urine.

I am including Dr. Lieske's comments below, but they are quite technical!

"MiraLax is made of polyethylene glycol, which is poorly absorbed from the intestine. This pulls water into the intestinal tract, and hence helps with hard stools or constipation. It is different then ethylene glycol, which is readily absorbed and metabolized in to oxalate in the liver. Polyethylene glycol is not broken down into ethylene glycol. The only connection between polyethylene glycol and crystals in the urine would be if a person took enough of the polyethylene glycol to have diarrhea and then get dehydrated, leading to the urine becoming very concentrated."

I hope this helps, let me know if you have further questions,

Regards,

B. Olson, RN

Mayo Clinic Hyperoxaluria Center

Nephrology Research

Mayo Clinic - Ei S 33L, Rochester, MN 55905

Phone:

800#:

hyperoxaluriacenter@...

________________________________

From: Marg & Doug

Sent: Sunday, February 03, 2008 4:14 AM

To: Mayo Hyperoxaluria Center

Subject: miralax

can miralax contribute to oxalate crystals in the urine

[Guest guest]

Wow LeeAnn, all's I can say is Wow! This would explain why blood tests come up normal and it would be extremely hard to prove. I wonder if it ever gets out of the system? Do you have anything on that?

thank you for all your time and effort

--------- miralax

can miralax contribute to oxalate crystals in the urine

[Guest guest]

I think we also need to consider that this group is focused on Miralax and children...the info here seems to be focused on adults. Children are going to metabolize and react differently to EG/PEG due to body weight and gender. It's not the same as adults.

Re: Fwd: Emailing: RE_ miralax

"MiraLax is made of polyethylene glycol, which is poorly absorbed from the intestine. This pulls water into the intestinal tract, and hence helps with hard stools or constipation. It is different then ethylene glycol, which is readily absorbed and metabolized in to oxalate in the liver. Polyethylene glycol is not broken down into ethylene glycol. The only connection between polyethylene glycol and crystals in the urine would be if a person took enough of the polyethylene glycol to have diarrhea and then get dehydrated, leading to the urine becoming very concentrated."

Isn't that interesting,

Note: So there IS a causation between them!!!

The only connection between polyethylene glycol and crystals in the urine would be if a person took enough of the polyethylene glycol to have diarrhea and then get dehydrated, leading to the urine becoming very concentrated."

Isn't this exactly how the medication works??? then they wonder why they are complaining of oxalate crystals, not to mention the overdoses they are prescribing, thank you Marg, this is very important information. Also, "It's Poorly absorbed" means some is absorbed, this is really simply here. I believe it goes in fine, because they changed the chemical make up, but somewhere inside it's breaking down and when it comes back out it's stining and burning, almost as if it converted to it's origianl state, if it didn't we all wouldn't have been here for 6 years and we wouldn't have even ONE case.

Jeanie

-------------- Original message -------------- From: Marg Messick <margmessick>

Note: forwarded message attached.

Be a better friend, newshound, and know-it-all with Yahoo! Mobile. Try it now.

[Guest guest]

AMEN to that! It ticks me off to no end when i hear a ped say

that " children are not tiny adults " but yet will readily prescribe an

adult dosage of Miralax cause it is considered " safe " even though it

is not recomended or even FDA approved (I'm assuming it is still not

anyway) for usage in kids. My old ped that i have recently fired

seemed to think becusae " I have several children a day with this

excact issue and i always use miralax. It is compeletly safe, non

habit forming and can be used for years without dangers even at twice

the adult dosage " but then sits there and says that " kids arent'

adults in little bodie " So which is it then!!!??? And why even think

to prescribe an adult dosage of miralax on a 30 lbs child!!!????

>

> I think we also need to consider that this group is focused on

Miralax and children...the info here seems to be focused on adults.

Children are going to metabolize and react differently to EG/PEG due

to body weight and gender. It's not the same as adults.

> Re: Fwd: Emailing: RE_ miralax

>

>

>

> " MiraLax is made of polyethylene glycol, which is poorly absorbed

from the intestine. This pulls water into the intestinal tract, and

hence helps with hard stools or constipation. It is different then

ethylene glycol, which is readily absorbed and metabolized in to

oxalate in the liver. Polyethylene glycol is not broken down into

ethylene glycol. The only connection between polyethylene glycol and

crystals in the urine would be if a person took enough of the

polyethylene glycol to have diarrhea and then get dehydrated, leading

to the urine becoming very concentrated. "

>

> Isn't that interesting,

> Note: So there IS a causation between them!!!

> The only connection between polyethylene glycol and crystals in

the urine would be if a person took enough of the polyethylene glycol

to have diarrhea and then get dehydrated, leading to the urine

becoming very concentrated. "

> Isn't this exactly how the medication works??? then they wonder

why they are complaining of oxalate crystals, not to mention the

overdoses they are prescribing, thank you Marg, this is very

important information. Also, " It's Poorly absorbed " means some is

absorbed, this is really simply here. I believe it goes in fine,

because they changed the chemical make up, but somewhere inside it's

breaking down and when it comes back out it's stining and burning,

almost as if it converted to it's origianl state, if it didn't we all

wouldn't have been here for 6 years and we wouldn't have even ONE

case.

> Jeanie

>

>

>

>

>

> -------------- Original message --------------

>

>

>

>

> Note: forwarded message attached.

>

>

>

> --------------------------------------------------------------------

--------

> Be a better friend, newshound, and know-it-all with Yahoo!

Mobile. Try it now.

>

[Guest guest]

We created this group for anyone that's had a reaction to, or are inquiring any information regarding the safety and effectiveness to polyethylene glycol 3350. Anyone sharing their reactions or inquiries are welcome here.................

--------- Re: Fwd: Emailing: RE_ miralax

"MiraLax is made of polyethylene glycol, which is poorly absorbed from the intestine. This pulls water into the intestinal tract, and hence helps with hard stools or constipation. It is different then ethylene glycol, which is readily absorbed and metabolized in to oxalate in the liver. Polyethylene glycol is not broken down into ethylene glycol. The only connection between polyethylene glycol and crystals in the urine would be if a person took enough of the polyethylene glycol to have diarrhea and then get dehydrated, leading to the urine becoming very concentrated."

Isn't that interesting,

Note: So there IS a causation between them!!!

The only connection between polyethylene glycol and crystals in the urine would be if a person took enough of the polyethylene glycol to have diarrhea and then get dehydrated, leading to the urine becoming very concentrated."

Isn't this exactly how the medication works??? then they wonder why they are complaining of oxalate crystals, not to mention the overdoses they are prescribing, thank you Marg, this is very important information. Also, "It's Poorly absorbed" means some is absorbed, this is really simply here. I believe it goes in fine, because they changed the chemical make up, but somewhere inside it's breaking down and when it comes back out it's stining and burning, almost as if it converted to it's origianl state, if it didn't we all wouldn't have been here for 6 years and we wouldn't have even ONE case.

Jeanie

-------------- Original message -------------- From: Marg Messick <margmessick>

Note: forwarded message attached.

Be a better friend, newshound, and know-it-all with Yahoo! Mobile. Try it now.

[Guest guest]

My mistake. You are right - sorry. I still maintain that when looking at research, most of it is done on adults. Children will have stronger reactions on adult dosages. That was my point, sorry.

Re: Fwd: Emailing: RE_ miralax

"MiraLax is made of polyethylene glycol, which is poorly absorbed from the intestine. This pulls water into the intestinal tract, and hence helps with hard stools or constipation. It is different then ethylene glycol, which is readily absorbed and metabolized in to oxalate in the liver. Polyethylene glycol is not broken down into ethylene glycol. The only connection between polyethylene glycol and crystals in the urine would be if a person took enough of the polyethylene glycol to have diarrhea and then get dehydrated, leading to the urine becoming very concentrated."

Isn't that interesting,

Note: So there IS a causation between them!!!

The only connection between polyethylene glycol and crystals in the urine would be if a person took enough of the polyethylene glycol to have diarrhea and then get dehydrated, leading to the urine becoming very concentrated."

Isn't this exactly how the medication works??? then they wonder why they are complaining of oxalate crystals, not to mention the overdoses they are prescribing, thank you Marg, this is very important information. Also, "It's Poorly absorbed" means some is absorbed, this is really simply here. I believe it goes in fine, because they changed the chemical make up, but somewhere inside it's breaking down and when it comes back out it's stining and burning, almost as if it converted to it's origianl state, if it didn't we all wouldn't have been here for 6 years and we wouldn't have even ONE case.

Jeanie

-------------- Original message -------------- From: Marg Messick <margmessick>

Note: forwarded message attached.

Be a better friend, newshound, and know-it-all with Yahoo! Mobile. Try it now.