Guest guest Posted October 11, 2002 Report Share Posted October 11, 2002 or a, Have you heard what this drug is going to cost when it is brought to market next year? Just curious. Love and hugs, Carol Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 13, 2002 Report Share Posted October 13, 2002 Carol, I haven't heard anything about the price of D2E7. Usually the manufacturer keeps that information very quiet until it looks quite certain that the product will actually be sold and the moment to release the news is just right. Such a big game! I would guess that, unfortunately, it will be very expensive. It's not an easy product to make and they will be going head to head with Remicade (infliximab) and Enbrel (etanercept). It's hard to imagine that it will be a bargain. [ ] D2E7 > or a, > > Have you heard what this drug is going to cost when it is brought to market > next year? > > Just curious. > > Love and hugs, > Carol Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 13, 2002 Report Share Posted October 13, 2002 Hi , Since I wrote that, I found one business source that estimated the price to consumers to be about $600 per month, or 40% less than Enbrel. Hopefully that will be the case. It's still expensive, but it's a step in the right direction. Love, Carol Re: [ ] D2E7 Carol, I haven't heard anything about the price of D2E7. Usually the manufacturer keeps that information very quiet until it looks quite certain that the product will actually be sold and the moment to release the news is just right. Such a big game! I would guess that, unfortunately, it will be very expensive. It's not an easy product to make and they will be going head to head with Remicade (infliximab) and Enbrel (etanercept). It's hard to imagine that it will be a bargain. [ ] D2E7 > or a, > > Have you heard what this drug is going to cost when it is brought to market > next year? > > Just curious. > > Love and hugs, > Carol Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 13, 2002 Report Share Posted October 13, 2002 Carol, I saw that same figure at one site, but it didn't look as if the document were for public consumption. It would be nice if there were a less costly but equally effective anti-TNF product out there. Time will tell. Interesting, too, that there are no trials comparing D2E7 (adalimumab) directly to either of the other TNF inhibitors. If Immunex/Amgen/Wyeth group doesn't get its act together and get the Enbrel supply going strong, Abbott may be able to charge more than that. I hope not though! Even $300 per dose is a budget-buster. Re: [ ] D2E7 > > Carol, I haven't heard anything about the price of D2E7. Usually the > manufacturer keeps that information very quiet until it looks quite > certain that the product will actually be sold and the moment to release > the news is just right. Such a big game! > > I would guess that, unfortunately, it will be very expensive. It's not > an easy product to make and they will be going head to head with > Remicade (infliximab) and Enbrel (etanercept). It's hard to imagine that > it will be a bargain. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 13, 2002 Report Share Posted October 13, 2002 It's amazing that I'm to the point I consider a $600 per month price tag a bargain! Love and hugs, Carol Re: [ ] D2E7 Carol, I saw that same figure at one site, but it didn't look as if the document were for public consumption. It would be nice if there were a less costly but equally effective anti-TNF product out there. Time will tell. Interesting, too, that there are no trials comparing D2E7 (adalimumab) directly to either of the other TNF inhibitors. If Immunex/Amgen/Wyeth group doesn't get its act together and get the Enbrel supply going strong, Abbott may be able to charge more than that. I hope not though! Even $300 per dose is a budget-buster. Re: [ ] D2E7 > > Carol, I haven't heard anything about the price of D2E7. Usually the > manufacturer keeps that information very quiet until it looks quite > certain that the product will actually be sold and the moment to release > the news is just right. Such a big game! > > I would guess that, unfortunately, it will be very expensive. It's not > an easy product to make and they will be going head to head with > Remicade (infliximab) and Enbrel (etanercept). It's hard to imagine that > it will be a bargain. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 15, 2002 Report Share Posted October 15, 2002 I didn't see any mention of side effects either. Did anyone else? Hugs Stacey in PA Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 20, 2002 Report Share Posted October 20, 2002 Oh great, getting herpes as a side effect? Gheeeeeeeeeeeesh... Is it just me, or are some of these biologics just not " quite ready for prime time " ? Suzanne [ ] D2E7 - Stacey > Stacey, the side-effect profile of D2E7 will probably be similar to those of > Enbrel and Remicade since all three are TNF-alpha inhibitors. They are expecting > fewer side-effects with D2E7 (adalimumab) than Remicade since it is " fully human " > (no mouse parts). We'll see. > > Check this out: > > " The most frequent side effects were injection site reactions, which > were three- to five-fold more common with adalimumab, at 15 percent, > compared to 3 percent for placebo. Infection complications were similar > in both groups except for a two- to three-fold increase in herpes > simplex. Three patients on placebo and six on adalimumab withdrew from > the treatment. " > > http://www.docguide.com/dg.nsf/PrintPrint/E5C244FDA6FD0F0E85256A6C0052E3C3 > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 20, 2002 Report Share Posted October 20, 2002 Suzanne, it's not that the biologics " give " you herpes simplex, it's that certain medications such as these interfere with your immune system in such a way that you are more susceptible to a new infection or reactivation of a latent virus or bacterium you have already previously acquired. Herpes simplex includes both HSV-1 and HSV-2; HSV-1 is the one responsible for cold sores, and HSV-2 causes genital herpes. Both are contracted from contact with an infected person, but HSV-2 only through sexual contact. http://www.aad.org/pamphlets/herpes.html I do agree that there is still much to be learned about how exactly these drugs will affect us, especially long-term, but it is important to keep in mind that even old standbys like MTX and prednisone also increase the chance for opportunistic infections or recurrence of latent ones. [ ] D2E7 - Stacey > > > > Stacey, the side-effect profile of D2E7 will probably be similar to those > of > > Enbrel and Remicade since all three are TNF-alpha inhibitors. They are > expecting > > fewer side-effects with D2E7 (adalimumab) than Remicade since it is " fully > human " > > (no mouse parts). We'll see. > > > > Check this out: > > > > " The most frequent side effects were injection site reactions, which > > were three- to five-fold more common with adalimumab, at 15 percent, > > compared to 3 percent for placebo. Infection complications were similar > > in both groups except for a two- to three-fold increase in herpes > > simplex. Three patients on placebo and six on adalimumab withdrew from > > the treatment. " > > > > http://www.docguide.com/dg.nsf/PrintPrint/E5C244FDA6FD0F0E85256A6C0052E3 C3 > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 20, 2002 Report Share Posted October 20, 2002 Many years ago I managed to acquire warts in my genital area from taking birth control pills.....My soon to be husband managed to get one too...so we had to abstain, I couldn't take the pill any more, and I had to go about getting mine removed by burning them off by freezing them(ouch!!!!)and then his went away ....the Gyn said we were lucky to not have managed to get them on the inside of me as that was a much harder thing to deal with....but it is amazing some of the ways our bodies react to certain things.....it is now manyyrs later (30!) and I take HRT(which is essentially BC pills again) and no big deal now.Judy in AZ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 21, 2002 Report Share Posted October 21, 2002 , aaahhhh, thanks. Still, it is interesting that the biologics " activate " certain infections or bacteriums that would be best left " unactiviated " . Suzanne Re: [ ] D2E7 > Suzanne, it's not that the biologics " give " you herpes simplex, it's > that certain medications such as these interfere with your immune > system in such a way that you are more susceptible to a new infection or > reactivation of a latent virus or bacterium you have already previously > acquired. Herpes simplex includes both HSV-1 and HSV-2; HSV-1 is the one > responsible for cold sores, and HSV-2 causes genital herpes. Both are > contracted from contact with an infected person, but HSV-2 only through > sexual contact. > > http://www.aad.org/pamphlets/herpes.html > > I do agree that there is still much to be learned about how exactly > these drugs will affect us, especially long-term, but it is important to > keep in mind that even old standbys like MTX and prednisone also > increase the chance for opportunistic infections or recurrence of latent > ones. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 21, 2002 Report Share Posted October 21, 2002 In my eyes, the biologicals are not only ready for prime time, they should have an award. Enbrel is the first drug to really give me any relief. I¹m in my 4th year on it and so far so good. But of course 4 years isn¹t considered long term. All meds have their problems. It¹s up to us to weigh the pros and cons and decide if we can live with the cons. a > Suzanne, it's not that the biologics " give " you herpes simplex, it's > that certain medications such as these interfere with your immune > system in such a way that you are more susceptible to a new infection or > reactivation of a latent virus or bacterium you have already previously > acquired. Herpes simplex includes both HSV-1 and HSV-2; HSV-1 is the one > responsible for cold sores, and HSV-2 causes genital herpes. Both are > contracted from contact with an infected person, but HSV-2 only through > sexual contact. > > http://www.aad.org/pamphlets/herpes.html > > I do agree that there is still much to be learned about how exactly > these drugs will affect us, especially long-term, but it is important to > keep in mind that even old standbys like MTX and prednisone also > increase the chance for opportunistic infections or recurrence of latent > ones. > > > > > [ ] D2E7 - Stacey >> > >> > >>> > > Stacey, the side-effect profile of D2E7 will probably be similar to > those >> > of >>> > > Enbrel and Remicade since all three are TNF-alpha inhibitors. They > are >> > expecting >>> > > fewer side-effects with D2E7 (adalimumab) than Remicade since it is > " fully >> > human " >>> > > (no mouse parts). We'll see. >>> > > >>> > > Check this out: >>> > > >>> > > " The most frequent side effects were injection site reactions, which >>> > > were three- to five-fold more common with adalimumab, at 15 percent, >>> > > compared to 3 percent for placebo. Infection complications were > similar >>> > > in both groups except for a two- to three-fold increase in herpes >>> > > simplex. Three patients on placebo and six on adalimumab withdrew > from >>> > > the treatment. " >>> > > >>> > > > http://www.docguide.com/dg.nsf/PrintPrint/E5C244FDA6FD0F0E85256A6C0052E3 > C3 >>> > > >>> > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 22, 2002 Report Share Posted October 22, 2002 a, You've been on Embrel for 4 years? That's a long time. Wonderful that you are having continue long term success with it. I guess it is all in the eye of the beholder. I was terrified to take mtx. The reality has been okay. Probably no different with the biologics. The fear of the unknown vs the reality. You're right, any opportunity for relief is worth the attempt. Still, the side affects sound alarming, I know, I know, just read the sides for mtx. It's a crummy disease and the treatments seem scary too. Suzanne [ ] D2E7 - Stacey >> > >> > >>> > > Stacey, the side-effect profile of D2E7 will probably be similar to > those >> > of >>> > > Enbrel and Remicade since all three are TNF-alpha inhibitors. They > are >> > expecting >>> > > fewer side-effects with D2E7 (adalimumab) than Remicade since it is > " fully >> > human " >>> > > (no mouse parts). We'll see. >>> > > >>> > > Check this out: >>> > > >>> > > " The most frequent side effects were injection site reactions, which >>> > > were three- to five-fold more common with adalimumab, at 15 percent, >>> > > compared to 3 percent for placebo. Infection complications were > similar >>> > > in both groups except for a two- to three-fold increase in herpes >>> > > simplex. Three patients on placebo and six on adalimumab withdrew > from >>> > > the treatment. " >>> > > >>> > > > http://www.docguide.com/dg.nsf/PrintPrint/E5C244FDA6FD0F0E85256A6C0052E3 > C3 >>> > > >>> > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 22, 2002 Report Share Posted October 22, 2002 Suzanne, Enbrel was approved in September of 1998 and I started very soon after it was approved. I had immediate results. There have been times over the years that I swore I was injecting water, but all in all it has been the first drug that has really helped me since being diagnosed over 25 years ago. Sometimes I think I can see my joints deflating. I was also terrified to take mtx especially after reading so many stories about liver toxicity and lung complications. But like most meds, serious side effects are rare. Because drug manufacturers are required to list all known side effects, sometimes that list is pretty long and scary. It goes to show you that these meds affect everyone differently and that is one reason that the list is so long. Some people read that list and expect to experience all the side effects. If I didn¹t already have such severe damage to my joints, I probably wouldn¹t be so eager to try new meds. Yeah, it¹s a crummy disease alright. a > a, > > You've been on Embrel for 4 years? That's a long time. Wonderful that you > are having continue long term success with it. I guess it is all in the eye > of the beholder. I was terrified to take mtx. The reality has been okay. > Probably no different with the biologics. The fear of the unknown vs the > reality. You're right, any opportunity for relief is worth the attempt. > Still, the side affects sound alarming, I know, I know, just read the sides > for mtx. It's a crummy disease and the treatments seem scary too. > > Suzanne > > [ ] D2E7 - Stacey >>>> >> > >>>> >> > >>>>>> >>> > > Stacey, the side-effect profile of D2E7 will probably be similar to >> > those >>>> >> > of >>>>>> >>> > > Enbrel and Remicade since all three are TNF-alpha inhibitors. They >> > are >>>> >> > expecting >>>>>> >>> > > fewer side-effects with D2E7 (adalimumab) than Remicade since it is >> > " fully >>>> >> > human " >>>>>> >>> > > (no mouse parts). We'll see. >>>>>> >>> > > >>>>>> >>> > > Check this out: >>>>>> >>> > > >>>>>> >>> > > " The most frequent side effects were injection site reactions, which >>>>>> >>> > > were three- to five-fold more common with adalimumab, at 15 >>>>>> percent, >>>>>> >>> > > compared to 3 percent for placebo. Infection complications were >> > similar >>>>>> >>> > > in both groups except for a two- to three-fold increase in herpes >>>>>> >>> > > simplex. Three patients on placebo and six on adalimumab withdrew >> > from >>>>>> >>> > > the treatment. " >>>>>> >>> > > >>>>>> >>> > > >> > http://www.docguide.com/dg.nsf/PrintPrint/E5C244FDA6FD0F0E85256A6C0052E3 >> > C3 >>>>>> >>> > > >>>>>> >>> > > >> > >> > Quote Link to comment Share on other sites More sharing options...
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