TNF-α production in fibrosing alveolitis is macrophage subset specific

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Research article:

" Tumour necrosis factor-α production in fibrosing alveolitis is

macrophage subset specific " :

http://respiratory-research.com/content/pdf/rr87.pdf

" Background: Previous studies have revealed that tumour necrosis factor

(TNF)-α is upregulated in fibrosing alveolitis (FA) in humans. The aim

of this study was to compare the TNF-α secretory profile of alveolar

macrophages (AMs) and peripheral blood monocytes (Mos) of patients with

cryptogenic FA and systemic sclerosis (SSc), a rheumatological disorder

in which lung fibrosis can occur. In particular, we wished to assess

whether TNF-α levels differ between SSc patients

with FA (FASSc) and a nonfibrotic group. "