Guest guest Posted November 27, 2008 Report Share Posted November 27, 2008 Hi, Lou, <<<<<Does anyone know what Scleroderma is? Is that the only thing that goes with Nucleola pattern? For 10 years my ANA pattern has always been Homogeneous and Speckled. Why would it change to a different pattern now that I've never had? What things go with the Nucleola pattern?>>>> Typically positive ANA results go with SLE, systemic lupus erythematosis. Lupus is usually associated with a butterfly-shaped rash across the face, but it is extremely variable in its presentation. Lupus patients are usually extremely photosensitive - they sunburn in minutes, and can get 2nd and 3rd degree burns from sun exposure that would not e en tan most of us. Scleroderma, like lupus, is an autoimmune disorder. Scleroderma is the hardening of various areas of the body - hopefully only the skin (hence the -derma in its name; the hardening areas take on somwhat the feel of fingernail tissue), but there is a systemic scleroderma that includes the hardening (and loss of function) of internal organs. Kidneys seem to be most susceptible, possibly because they cannot regenerate to repair damaged areas. The ANA pattern changing means that the exact antibody that is being produced has changed. Nucleolar autoantibodies are more often seen with lupus than with scleroderma, but other symptoms are needed for a solid diagnosis. Many of us with CFS have positive ANA tests at some time - in my own case it has been highly positive (speckled pattern) on two occassions, lasting for several months each. I did not have any particular increase or decrease in symptoms during those episodes. I hope I have answer your questions without causing more confusion. Otherwise, please feel free to email me directly. Jerry Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 28, 2008 Report Share Posted November 28, 2008 > > Hi, Lou, > > <<<<<Does anyone know what Scleroderma is? Is that the only thing that goes > with Nucleola pattern? > > For 10 years my ANA pattern has always been Homogeneous and Speckled. > Why would it change to a different pattern now that I've never had? > > What things go with the Nucleola pattern?>>>> > Hi Jerry: This is great how well you explained all of this. It really helped alot. How do I e-mail you directly? I do have more questions? How do you know all this information so well? Lou Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 3, 2008 Report Share Posted December 3, 2008 Hi, Lou, Sorry, I thought my email would show up in the header in. My email is jerrycamz@... Jerry Quote Link to comment Share on other sites More sharing options...
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