Miralax / hyponatremia

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Overuse may cause diarrhea, excess loss of body water (dehydration), and mineral imbalance (e.g., low sodium).

http://www.webmd.com/drugs/drug-17118-Polyethylene+Glycol+3350+Oral.aspx?drugid=17118 & drugname=Polyethylene+Glycol+3350+Oral

Before 1990, bowel prep products required patients to ingest isotonic saline, but a large group of patients were unable to process the solution and could not excrete large salt and water loads. GoLytely was designed to decrease salt and water absorption. The Nulytely solution was created without sodium sulfate and included increased amounts of polyethylene glycol (PEG).

http://www.endonurse.com/articles/bowel_preps/586_281feat1.html

Use with caution in patients using concomitant medications (such as diuretics) that increase the risk of electrolyte abnormality, patients with known or suspected hyponatremia, patients with severe ulcerative colitis, ileus or gastric retention. There have been reports of ischemic colitis in patients with use of HalfLytely and 20 mg Bisacodyl Tablets Bowel Prep Kit. However, a causal relationship has not been established. If patients develop severe abdominal pain or rectal bleeding, patients should be evaluated as soon as possible. Patients with impaired water handling who experience severe vomiting should be closely monitored including measurement of electrolytes. Hives and skin rashes have been reported with PEG-based products which are suggestive of an allergic reaction.

http://www.halflytely.com/prof/faqs/faqs.html

I guess once you've PEGylated something, this is where the PEG Protein comes in and you can have an allergic reaction.....................

Here's the SCARY PART..........look what's inside the parenthasis

PEGylation is the process of covalent attachment of poly(ethylene glycol) polymer chains to another molecule, normally a drug or therapeutic protein. PEGylation is routinely achieved by incubation of a reactive derivative of PEG with the target macromolecule. The covalent attachment of PEG to a drug or therapeutic protein can "mask" the agent from the host's immune system (reduced immunogenicity and antigenicity), increase the hydrodynamic size (size in solution) of the agent which prolongs its circulatory time by reducing renal clearance.

PEGylation can also provide water solubility to hydrophobic drugs and proteins.

http://en.wikipedia.org/wiki/PEGylation

From: Jennie <mykidshisgift@ yahoo.com>Subject: Re: Fluid Intake DecreasedTo: miralax@yahoogroups .comDate: Sunday, September 28, 2008, 9:25 AM

I dont think this is possibly connected with our son, but YES, infact he completely quit all forms of drinking. We have to manually do ourselves for him. All his doctors just pressumed this was his ACC disablity, ACCers are known for feeding/drinking issues! Even with that knowledge, I did think it was odd for him to start later with the drinking issues(has feeding issues from birth but not the drinking until around 6yrs of age). Im not saying the miralax caused this with our son, but your post sure caught my attention. Can you explain in better detail your issue/fluid intake decrease? Jennie<><>> Did any of your children considerably cut back on their daily fluid intake when they began taking Miralax?> >

Remembering Our Little Boy...> Every Second of Every Day> Baker> October 19, 2004~October 30, 2005>