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Re: Update on Dianne

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Dianne,

The Synvisc has helped to delay replacements, so I hope you are one that

benefits from it. I had the debridment done before getting mine replaced

and it gave me a few additional years.

It¹s good that you have options to hopefully delay replacements until you

have no choice.

a

> Hi, Everyone,

>

> My MRI report was presented to me today. The news is " mixed " .

>

> The immediate observation was that both knees were loaded with scar

> tissue, but not all of it was due to the earlier surgeries. Arthritis

> inflammation in the joints has caused a lot of scarring. What to do? There

> were some suggestions. I could have the joints " debrided " , which would be

> done with an arthroscope, which would involve removing the inflamed tissue

> and the scarring. I have had that procedure twice before and it does

> provide some relief. For how long? That is something that no one can

> predict and with the problems that I already have, there could be no

> improvement at all.

>

> The results of the MRI were reviewed by two orthopedic surgeons at

> my request.

>

> The opinion that I was most interested in is that of my former

> orthopedic surgeon -- the one who did all of the previous surgeries on the

> knees. His first response was that he was surprised that my knees had held

> up as long as they did. When he wrote his P & S statement for Federal Work

> Compensation he stated that a TJR would be required within five to eight

> years. He also noted that there had been no indications of RA or Lupus SLE

> the entire time that he was treating me, a period of four years. His

> treatment recommendations were that no surgery be performed right away, but

> that Synvisc or similar injections be tried first. If I get good results

> from those injections, then the TJR can be postponed. He noted that the

> damage from the lack of cartilage is surprisingly low and that the knees

> appear to have been damaged more by the inflammation processes that have

> occurred since he last saw me. He stated that there is really nothing more

> that could be tried after the Synvisc other than implanting an artificial

> cartilage in each knee, but also noted the various problems that a foreign

> body would pose for me in light of a compromised immune system.

>

> The second orthopedic surgeon is the one to whom I will be referred

> if the Synvisc injections do not bring relief. He noted that the cartilage

> in the left knee has been repaired, but that the blood source had been

> removed through the waxing and waning of the inflammatory disease process,

> both degenerative arthritis and Rheumatoid Arthritis could have brought that

> about. He also recommended that Synvisc be tried in hopes of delaying

> further invasive treatment; however, he does not feel that a failure with

> Synvisc should be followed with the implantation of artificial cartilage

> because my immune system attacks healthy parts of the body and the presence

> of a foreign material could trigger a larger problem that could involve more

> than just the knees. If the Synvisc does not work, he recommends

> debridement of the two knees on an inpatient basis in order to monitor my

> response afterward -- any sign of infection would have to be aggressively

> attacked with both antibiotics and other medications to slow down the immune

> system (i.e.. chemotherapy such as is used for cancer treatment). He

> recommends that both an immunologist and an oncologist begin assessing

> tissue samples to find the drugs and other agents best suited to combat

> possible side affects, or infection, or massive immune system response.

>

> My PCP started the process today with my primary and secondary

> insurance carriers to gain approval to use the Synvisc; however, he went

> further and indicated that he wanted " Direct Admission Authority " in the

> event of reaction to the hospital in Lake Havasu City, where my orthopedic

> surgeon is on staff. The hospital also has a immunologist, Rheumatologist,

> and oncologist on staff, all of whom might be needed if my immune system

> decides to go haywire in response to the injections. The literature does

> not make mention of the responses in patients who have immune system

> problems, but when he contacted the manufacturer, the doctors on staff

> stated that there had only been two cases of " immediate medical risk

> situation " to the injections, both of which required hospitalization. Both

> of those cases were treated, the injections curtailed, and the patients had

> no further adverse affects. He was not aware of what occurred in follow-up

> with regard to subsequent treatment of their knees.

>

> As my doctor put it, " This is really a report about what a mess your

> knees are! " . So, I will try the Synvisc. If it is successful, then I " wait

> and see " how long the relief lasts. It could be a matter of weeks,

> months -- no one really knows. The next step after that would be to either

> redo the Synvisc or proceed directly to the debridement procedures. If the

> debridement is not successful in relieving the pain and instability, then I

> proceed to replacement of the knees.

>

> While it isn't all good news, it isn't all bad either. In the end,

> the knees will be replaced, but it is hoped that the surgery can be delayed

> long enough for me to do three things: get relief from the interim

> procedures, lose enough weight to make the rehab easier on me, and get in

> good enough physical shape to be able to deal with the surgeries when they

> are done.

>

> I have some work ahead of me. I am determined to do what I can to

> delay the TJRs, so I had better get busy!

>

> Dianne

>

>

>

>

>

>

>

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----- Original Message -----

From: " a " <paula54@...>

Dianne,

The Synvisc has helped to delay replacements, so I hope you are one that

benefits from it. I had the debridment done before getting mine replaced

and it gave me a few additional years.

It¹s good that you have options to hopefully delay replacements until you

have no choice.

a

> Hi, Everyone,

>

> My MRI report was presented to me today. The news is " mixed " .

>

> The immediate observation was that both knees were loaded with

scar

> tissue, but not all of it was due to the earlier surgeries. Arthritis

> inflammation in the joints has caused a lot of scarring. What to do?

There

> were some suggestions. I could have the joints " debrided " , which would be

> done with an arthroscope, which would involve removing the inflamed tissue

> and the scarring. I have had that procedure twice before and it does

> provide some relief. For how long? That is something that no one can

> predict and with the problems that I already have, there could be no

> improvement at all.

>

> The results of the MRI were reviewed by two orthopedic surgeons at

> my request.

>

> The opinion that I was most interested in is that of my former

> orthopedic surgeon -- the one who did all of the previous surgeries on the

> knees. His first response was that he was surprised that my knees had

held

> up as long as they did. When he wrote his P & S statement for Federal Work

> Compensation he stated that a TJR would be required within five to eight

> years. He also noted that there had been no indications of RA or Lupus

SLE

> the entire time that he was treating me, a period of four years. His

> treatment recommendations were that no surgery be performed right away,

but

> that Synvisc or similar injections be tried first. If I get good results

> from those injections, then the TJR can be postponed. He noted that the

> damage from the lack of cartilage is surprisingly low and that the knees

> appear to have been damaged more by the inflammation processes that have

> occurred since he last saw me. He stated that there is really nothing

more

> that could be tried after the Synvisc other than implanting an artificial

> cartilage in each knee, but also noted the various problems that a foreign

> body would pose for me in light of a compromised immune system.

>

> The second orthopedic surgeon is the one to whom I will be

referred

> if the Synvisc injections do not bring relief. He noted that the

cartilage

> in the left knee has been repaired, but that the blood source had been

> removed through the waxing and waning of the inflammatory disease process,

> both degenerative arthritis and Rheumatoid Arthritis could have brought

that

> about. He also recommended that Synvisc be tried in hopes of delaying

> further invasive treatment; however, he does not feel that a failure with

> Synvisc should be followed with the implantation of artificial cartilage

> because my immune system attacks healthy parts of the body and the

presence

> of a foreign material could trigger a larger problem that could involve

more

> than just the knees. If the Synvisc does not work, he recommends

> debridement of the two knees on an inpatient basis in order to monitor my

> response afterward -- any sign of infection would have to be aggressively

> attacked with both antibiotics and other medications to slow down the

immune

> system (i.e.. chemotherapy such as is used for cancer treatment). He

> recommends that both an immunologist and an oncologist begin assessing

> tissue samples to find the drugs and other agents best suited to combat

> possible side affects, or infection, or massive immune system response.

>

> My PCP started the process today with my primary and secondary

> insurance carriers to gain approval to use the Synvisc; however, he went

> further and indicated that he wanted " Direct Admission Authority " in the

> event of reaction to the hospital in Lake Havasu City, where my orthopedic

> surgeon is on staff. The hospital also has a immunologist,

Rheumatologist,

> and oncologist on staff, all of whom might be needed if my immune system

> decides to go haywire in response to the injections. The literature does

> not make mention of the responses in patients who have immune system

> problems, but when he contacted the manufacturer, the doctors on staff

> stated that there had only been two cases of " immediate medical risk

> situation " to the injections, both of which required hospitalization.

Both

> of those cases were treated, the injections curtailed, and the patients

had

> no further adverse affects. He was not aware of what occurred in

follow-up

> with regard to subsequent treatment of their knees.

>

> As my doctor put it, " This is really a report about what a mess

your

> knees are! " . So, I will try the Synvisc. If it is successful, then I

" wait

> and see " how long the relief lasts. It could be a matter of weeks,

> months -- no one really knows. The next step after that would be to

either

> redo the Synvisc or proceed directly to the debridement procedures. If

the

> debridement is not successful in relieving the pain and instability, then

I

> proceed to replacement of the knees.

>

> While it isn't all good news, it isn't all bad either. In the

end,

> the knees will be replaced, but it is hoped that the surgery can be

delayed

> long enough for me to do three things: get relief from the interim

> procedures, lose enough weight to make the rehab easier on me, and get in

> good enough physical shape to be able to deal with the surgeries when they

> are done.

>

> I have some work ahead of me. I am determined to do what I can to

> delay the TJRs, so I had better get busy!

>

> Dianne

>

>

>

>

>

>

>

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