Re: transthermal medication

[Guest guest]

,

I came across a very recent paper that addresses this issue (abstract

below). It concludes it is not a viable route. (Not sure about T3 -

but I would guess a similar result.)

However, many people report noticing absorption of thyroid hormones

from levothyroxine, liothyronine and natural thyroid products when

taking sublingually. Maybe the lining of the mouth and tongue is

sufficiently different to ordinary skin to allow it to happen? But

would this be helpful as, inevitably, a proportion of the medication

would go into her stomach when taken this way?

The other option I can think of, though expensive, unpleasant and

inconvenient, is injection. Suitably prepared, both levothyroxine and

liothyronine can be injected.

Int J Pharm. 2008 Feb 12;349(1-2):161-5.

In vitro permeation of levothyroxine across the skin.

Padula C, Pappani A, Santi P.

Dipartimento Farmaceutico, Università degli Studi di Parma, Viale G.P.

Usberti 27/A, 43100 Parma, Italy.

The aim of this work was to investigate the in vitro transdermal

permeation characteristics of sodium levothyroxine, in view of its

topical application. Permeation experiments were performed in vitro,

using rabbit ear skin as barrier. At the end of the experiments

levothyroxine retained in the skin was extracted and quantified by

HPLC. The formulations tested were solutions and a commercial cream.

The use of dimethyl beta-cyclodextrin as solubilizing agent increased

to a significant extent levothyroxine solubility, but reduced its skin

accumulation. Skin stripping before drug application produced a

considerable increase in the amount retained and levothyroxine was

found also in the receptor compartment. The application of the

commercial cream in occlusive conditions increased to a significant

extent drug retention in the skin. In conclusion, levothyroxine skin

administration is promising in view of a localized effect, because it

was retained in the skin. On the contrary, transdermal administration

in view of systemic effect does not represent a concrete possibility.

PMID: 17931806

<http://www.ncbi.nlm.nih.gov/pubmed/17931806>

All the best

Rod

>

> hi,

> Would anyone know how well transthermal medication would work well

> for thyroid medication.?

> The pharmacist that specially compounds dd's thyroid meds.(additive

> free) told me this was possible. Poor dd is no longer tolerating her

> thyroid meds.,It took me a long time to figure this out; with 2

> adjustments in meds this summer, a couple virisus and carefully

> eliminating all possible food and supplement causes... I dont think

> her gut will tolerate anything synthetic ... any drug well...

> thanks,

>

> cathy..mom to rachel(8)

>

[Guest guest]

Hi,

This is how I take my Armour, sublingually, and have done this for

about five years now. It sure works for me expecially since I still

take probiotics and digestive enzymes trying to deal my gut from the

years of abusing it with gluten etc.

At first the smell and taste wasa bit much, but soon got used to it

and never give it a second thought.

Bj

> >

> > hi,

> > Would anyone know how well transthermal medication would work

well

> > for thyroid medication.?

> > The pharmacist that specially compounds dd's thyroid meds.

(additive

> > free) told me this was possible. Poor dd is no longer tolerating

her

> > thyroid meds.,It took me a long time to figure this out; with 2

> > adjustments in meds this summer, a couple virisus and carefully

> > eliminating all possible food and supplement causes... I dont

think

> > her gut will tolerate anything synthetic ... any drug well...

> > thanks,

> >

> > cathy..mom to rachel(8)

> >

>

[Guest guest]

Rod wrote:

> However, many people report noticing absorption of thyroid hormones

> from levothyroxine, liothyronine and natural thyroid products when

> taking sublingually......... But

> would this be helpful as, inevitably, a proportion of the medication

> would go into her stomach when taken this way?

>

I found that when taking my thyroid (T3) sublingually, it did increase

saliva production and at least some was inevitably swallowed. So I early

on switched to taking it buccally (between cheek and gum). This produces

virtually no increase in saliva production for me, thus I feel I swallow

very little of the T3. The T3 does not dissolve as quickly, which may

bother some people. But I just tuck it back by my molars and forget it.

For me it is an advantage to have it dissolve and absorb more slowly, as

I feel it gives me a more gradual dose, which is less stressful to my

adrenals.

I have been told that sublingual produces better absorption than buccal,

but I've been fine with buccal.

sol