Re: Finally cured after 2 years of hell

April 20, 2011

He said he didnt start feeling a lot until like week 5 or 7.

> > > > > > > > > > > >

> > > > > > > > > > > > Background about me: I'm a 27 year old male. I was put

> > >onPaxil for social anxiety disorder. After a few months, I found it really

hard

> > >to orgasm. I was having marathon sex sessions with my wife. I went off the

Paxil

> > >in March of 2009 (after a total of 8 months on it) and since then I've

noticed

> > >that it takes me forever to get aroused. I've also been hit with extreme

> > >premature ejaculation, loss of libido and interest in sex.

> > > > > > > > > > > >

> > > > > > > > > > > > After trying a few products mentioned by people here

that

> > >didn't work, I decided to look at the matter scientifically. PSSD is most

likely

> > >caused by persistent desensitization of 5-HT1A receptors. After doing some

> > >research on substances that reverse desensitization of these receptors I

> > >stumbled across inositol, a naturally occuring sugar in our bodies.

> > > > > > > > > > > >

> > > > > > > > > > > > I've been on 18 grams of inositol once daily at bedtime

for

> > >the past 7 weeks and few days (Jan 24/2011 to March 16/2011) and I am happy

to

> > >say that my interest in sex has returned, my erections are back to normal,

and

> > >my premature ejaculation has returned to how it was before I went on Paxil.

> > >Never will I touch an SSRI again.

> > > > > > > > > > > >

> > > > > > > > > > > > I hope this will help anyone who is still trying to get

rid

> > >of this horrible peoplem.

> > > > > > > > > > > >

> > > > > > > > > > > > Greg

> > > > > > > > > > > >

> > > > > > > > > > >

> > > > > > > > > >

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>

April 21, 2011

so now thats three different people having a wet dream on inositol ? thats

really interesting since wet dreams are really hard to come by even if

everything was fine.

> > > > > > > > > > > > >

> > > > > > > > > > > > > Background about me: I'm a 27 year old male. I was put

> > > >onPaxil for social anxiety disorder. After a few months, I found it

really hard

> > > >to orgasm. I was having marathon sex sessions with my wife. I went off

the Paxil

> > > >in March of 2009 (after a total of 8 months on it) and since then I've

noticed

> > > >that it takes me forever to get aroused. I've also been hit with extreme

> > > >premature ejaculation, loss of libido and interest in sex.

> > > > > > > > > > > > >

> > > > > > > > > > > > > After trying a few products mentioned by people here

that

> > > >didn't work, I decided to look at the matter scientifically. PSSD is most

likely

> > > >caused by persistent desensitization of 5-HT1A receptors. After doing

some

> > > >research on substances that reverse desensitization of these receptors I

> > > >stumbled across inositol, a naturally occuring sugar in our bodies.

> > > > > > > > > > > > >

> > > > > > > > > > > > > I've been on 18 grams of inositol once daily at

bedtime for

> > > >the past 7 weeks and few days (Jan 24/2011 to March 16/2011) and I am

happy to

> > > >say that my interest in sex has returned, my erections are back to

normal, and

> > > >my premature ejaculation has returned to how it was before I went on

Paxil.

> > > >Never will I touch an SSRI again.

> > > > > > > > > > > > >

> > > > > > > > > > > > > I hope this will help anyone who is still trying to

get rid

> > > >of this horrible peoplem.

> > > > > > > > > > > > >

> > > > > > > > > > > > > Greg

> > > > > > > > > > > > >

> > > > > > > > > > > >

> > > > > > > > > > >

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> > > >

> > >

> >

>

April 21, 2011

I've been putting a heaped tablesppon in oatmeal (porridge oats) once or twice a

day with no problems. It's a simple sugar so it goes nice with the oats. The

oats means that the body digests the inosital slowly. I haven't noticed any

improvement yet, though, but I have only been taking it for a week or so.

Kaivey

> > > > > > > > > > > >

> > > > > > > > > > > > Background about me: I'm a 27 year old male. I was put

> > >onPaxil for social anxiety disorder. After a few months, I found it really

hard

> > >to orgasm. I was having marathon sex sessions with my wife. I went off the

Paxil

> > >in March of 2009 (after a total of 8 months on it) and since then I've

noticed

> > >that it takes me forever to get aroused. I've also been hit with extreme

> > >premature ejaculation, loss of libido and interest in sex.

> > > > > > > > > > > >

> > > > > > > > > > > > After trying a few products mentioned by people here

that

> > >didn't work, I decided to look at the matter scientifically. PSSD is most

likely

> > >caused by persistent desensitization of 5-HT1A receptors. After doing some

> > >research on substances that reverse desensitization of these receptors I

> > >stumbled across inositol, a naturally occuring sugar in our bodies.

> > > > > > > > > > > >

> > > > > > > > > > > > I've been on 18 grams of inositol once daily at bedtime

for

> > >the past 7 weeks and few days (Jan 24/2011 to March 16/2011) and I am happy

to

> > >say that my interest in sex has returned, my erections are back to normal,

and

> > >my premature ejaculation has returned to how it was before I went on Paxil.

> > >Never will I touch an SSRI again.

> > > > > > > > > > > >

> > > > > > > > > > > > I hope this will help anyone who is still trying to get

rid

> > >of this horrible peoplem.

> > > > > > > > > > > >

> > > > > > > > > > > > Greg

> > > > > > > > > > > >

> > > > > > > > > > >

> > > > > > > > > >

> > > > > > > > >

> > > > > > > >

> > > > > > >

> > > > > >

> > > > >

> > > >

> > >

> >

>

April 21, 2011

Now that you mention it I didn't have digestive problems with it the first few

days because I took it with food. I'm gonna keep doing that then. Also, this is

finals week at my university so the stress I'm in might be the reason for the

negative feelings I've been having lately.. so maybe it's not the inositol.

Yesterday I was able to have an erection consistently with just thought which is

also unheard of for me... so maybe this stuff really is working it just takes

time.

> > > > > > > > > > > > >

> > > > > > > > > > > > > Background about me: I'm a 27 year old male. I was put

> > > >onPaxil for social anxiety disorder. After a few months, I found it

really hard

> > > >to orgasm. I was having marathon sex sessions with my wife. I went off

the Paxil

> > > >in March of 2009 (after a total of 8 months on it) and since then I've

noticed

> > > >that it takes me forever to get aroused. I've also been hit with extreme

> > > >premature ejaculation, loss of libido and interest in sex.

> > > > > > > > > > > > >

> > > > > > > > > > > > > After trying a few products mentioned by people here

that

> > > >didn't work, I decided to look at the matter scientifically. PSSD is most

likely

> > > >caused by persistent desensitization of 5-HT1A receptors. After doing

some

> > > >research on substances that reverse desensitization of these receptors I

> > > >stumbled across inositol, a naturally occuring sugar in our bodies.

> > > > > > > > > > > > >

> > > > > > > > > > > > > I've been on 18 grams of inositol once daily at

bedtime for

> > > >the past 7 weeks and few days (Jan 24/2011 to March 16/2011) and I am

happy to

> > > >say that my interest in sex has returned, my erections are back to

normal, and

> > > >my premature ejaculation has returned to how it was before I went on

Paxil.

> > > >Never will I touch an SSRI again.

> > > > > > > > > > > > >

> > > > > > > > > > > > > I hope this will help anyone who is still trying to

get rid

> > > >of this horrible peoplem.

> > > > > > > > > > > > >

> > > > > > > > > > > > > Greg

> > > > > > > > > > > > >

> > > > > > > > > > > >

> > > > > > > > > > >

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> > > >

> > >

> >

>

April 26, 2011

How are you taking 18 grams of inositol? I just bought the powder, and it says

the dosage is 1/4 teaspoon which is 600mg. Are you taking like 20x that?

> > > > > > > > > > > > > > > > > > >

> > > > > > > > > > > > > > > > > > > Background about me: I'm a 27 year old

male. I was put

> > > > > > > > > >onPaxil for social anxiety disorder. After a few months, I

found it really hard

> > > > > > > > > >to orgasm. I was having marathon sex sessions with my wife. I

went off the Paxil

> > > > > > > > > >in March of 2009 (after a total of 8 months on it) and since

then I've noticed

> > > > > > > > > >that it takes me forever to get aroused. I've also been hit

with extreme

> > > > > > > > > >premature ejaculation, loss of libido and interest in sex.

> > > > > > > > > > > > > > > > > > >

> > > > > > > > > > > > > > > > > > > After trying a few products mentioned by

people here that

> > > > > > > > > >didn't work, I decided to look at the matter scientifically.

PSSD is most likely

> > > > > > > > > >caused by persistent desensitization of 5-HT1A receptors.

After doing some

> > > > > > > > > >research on substances that reverse desensitization of these

receptors I

> > > > > > > > > >stumbled across inositol, a naturally occuring sugar in our

bodies.

> > > > > > > > > > > > > > > > > > >

> > > > > > > > > > > > > > > > > > > I've been on 18 grams of inositol once

daily at bedtime for

> > > > > > > > > >the past 7 weeks and few days (Jan 24/2011 to March 16/2011)

and I am happy to

> > > > > > > > > >say that my interest in sex has returned, my erections are

back to normal, and

> > > > > > > > > >my premature ejaculation has returned to how it was before I

went on Paxil.

> > > > > > > > > >Never will I touch an SSRI again.

> > > > > > > > > > > > > > > > > > >

> > > > > > > > > > > > > > > > > > > I hope this will help anyone who is still

trying to get rid

> > > > > > > > > >of this horrible peoplem.

> > > > > > > > > > > > > > > > > > >

> > > > > > > > > > > > > > > > > > > Greg

> > > > > > > > > > > > > > > > > > >

> > > > > > > > > > > > > > > > > >

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> > > > > > > > > > > > > > > >

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>

April 26, 2011

I'm considering trying inositol and was doing some research - there was a thread

that said coffee will cancel the inositol effects if taken with coffee. I

assume they mean within couple hours of coffee. It was a website on natural

remedies for bipolar but was specifically addressing inositol since it has

proven positive results on OCD. It also said you want to start gradually

increasing doses to get most results while limiting side effects (if any).

> > > > > > > > > > > > > > > > > > > >

> > > > > > > > > > > > > > > > > > > > Background about me: I'm a 27 year old

male. I was put

> > > > > > > > > > >onPaxil for social anxiety disorder. After a few months, I

found it really hard

> > > > > > > > > > >to orgasm. I was having marathon sex sessions with my wife.

I went off the Paxil

> > > > > > > > > > >in March of 2009 (after a total of 8 months on it) and

since then I've noticed

> > > > > > > > > > >that it takes me forever to get aroused. I've also been hit

with extreme

> > > > > > > > > > >premature ejaculation, loss of libido and interest in sex.

> > > > > > > > > > > > > > > > > > > >

> > > > > > > > > > > > > > > > > > > > After trying a few products mentioned by

people here that

> > > > > > > > > > >didn't work, I decided to look at the matter

scientifically. PSSD is most likely

> > > > > > > > > > >caused by persistent desensitization of 5-HT1A receptors.

After doing some

> > > > > > > > > > >research on substances that reverse desensitization of

these receptors I

> > > > > > > > > > >stumbled across inositol, a naturally occuring sugar in our

bodies.

> > > > > > > > > > > > > > > > > > > >

> > > > > > > > > > > > > > > > > > > > I've been on 18 grams of inositol once

daily at bedtime for

> > > > > > > > > > >the past 7 weeks and few days (Jan 24/2011 to March

16/2011) and I am happy to

> > > > > > > > > > >say that my interest in sex has returned, my erections are

back to normal, and

> > > > > > > > > > >my premature ejaculation has returned to how it was before

I went on Paxil.

> > > > > > > > > > >Never will I touch an SSRI again.

> > > > > > > > > > > > > > > > > > > >

> > > > > > > > > > > > > > > > > > > > I hope this will help anyone who is

still trying to get rid

> > > > > > > > > > >of this horrible peoplem.

> > > > > > > > > > > > > > > > > > > >

> > > > > > > > > > > > > > > > > > > > Greg

> > > > > > > > > > > > > > > > > > > >

> > > > > > > > > > > > > > > > > > >

> > > > > > > > > > > > > > > > > >

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>

April 28, 2011

What kind of gains do you still have? Can you orgasm completely normal and have

normal erection? And also, just out of curiosity was there any positive change

in your life you could attribute your gains to or do you feel sure it was the

inositol?

thanks

> > > > > > >

> > > > > > > Background about me: I'm a 27 year old male. I was put onPaxil for

social anxiety disorder. After a few months, I found it really hard to orgasm. I

was having marathon sex sessions with my wife. I went off the Paxil in March of

2009 (after a total of 8 months on it) and since then I've noticed that it takes

me forever to get aroused. I've also been hit with extreme premature

ejaculation, loss of libido and interest in sex.

> > > > > > >

> > > > > > > After trying a few products mentioned by people here that didn't

work, I decided to look at the matter scientifically. PSSD is most likely caused

by persistent desensitization of 5-HT1A receptors. After doing some research on

substances that reverse desensitization of these receptors I stumbled across

inositol, a naturally occuring sugar in our bodies.

> > > > > > >

> > > > > > > I've been on 18 grams of inositol once daily at bedtime for the

past 7 weeks and few days (Jan 24/2011 to March 16/2011) and I am happy to say

that my interest in sex has returned, my erections are back to normal, and my

premature ejaculation has returned to how it was before I went on Paxil. Never

will I touch an SSRI again.

> > > > > > >

> > > > > > > I hope this will help anyone who is still trying to get rid of

this horrible peoplem.

> > > > > > >

> > > > > > > Greg

> > > > > > >

> > > > > >

> > > > >

> > > >

> > >

> >

>

May 1, 2011

I still have all my gains. I can orgasm normally, genital numbness has resolved.

The only things that arent totally gone is the premature ejaculation. I

definately think it was the inositol,because right before I started taking it, I

couldn't even get a hard on at all regardless of what the stimulus was.

Greg

> > > > > > > >

> > > > > > > > Background about me: I'm a 27 year old male. I was put onPaxil

for social anxiety disorder. After a few months, I found it really hard to

orgasm. I was having marathon sex sessions with my wife. I went off the Paxil in

March of 2009 (after a total of 8 months on it) and since then I've noticed that

it takes me forever to get aroused. I've also been hit with extreme premature

ejaculation, loss of libido and interest in sex.

> > > > > > > >

> > > > > > > > After trying a few products mentioned by people here that didn't

work, I decided to look at the matter scientifically. PSSD is most likely caused

by persistent desensitization of 5-HT1A receptors. After doing some research on

substances that reverse desensitization of these receptors I stumbled across

inositol, a naturally occuring sugar in our bodies.

> > > > > > > >

> > > > > > > > I've been on 18 grams of inositol once daily at bedtime for the

past 7 weeks and few days (Jan 24/2011 to March 16/2011) and I am happy to say

that my interest in sex has returned, my erections are back to normal, and my

premature ejaculation has returned to how it was before I went on Paxil. Never

will I touch an SSRI again.

> > > > > > > >

> > > > > > > > I hope this will help anyone who is still trying to get rid of

this horrible peoplem.

> > > > > > > >

> > > > > > > > Greg

> > > > > > > >

> > > > > > >

> > > > > >

> > > > >

> > > >

> > >

> >

>

June 14, 2011

May I ask: can you point to a study or source of the information where you

found that Inositol reverses desensitization of 5-HT1A receptors?

This stuff is cheap enough I'm going to try it out, regardless. But since I am

curious about all things biochemical I wanted to read the source. Thanks !

> > > > > > > > >

> > > > > > > > > Background about me: I'm a 27 year old male. I was put onPaxil

for social anxiety disorder. After a few months, I found it really hard to

orgasm. I was having marathon sex sessions with my wife. I went off the Paxil in

March of 2009 (after a total of 8 months on it) and since then I've noticed that

it takes me forever to get aroused. I've also been hit with extreme premature

ejaculation, loss of libido and interest in sex.

> > > > > > > > >

> > > > > > > > > After trying a few products mentioned by people here that

didn't work, I decided to look at the matter scientifically. PSSD is most likely

caused by persistent desensitization of 5-HT1A receptors. After doing some

research on substances that reverse desensitization of these receptors I

stumbled across inositol, a naturally occuring sugar in our bodies.

> > > > > > > > >

> > > > > > > > > I've been on 18 grams of inositol once daily at bedtime for

the past 7 weeks and few days (Jan 24/2011 to March 16/2011) and I am happy to

say that my interest in sex has returned, my erections are back to normal, and

my premature ejaculation has returned to how it was before I went on Paxil.

Never will I touch an SSRI again.

> > > > > > > > >

> > > > > > > > > I hope this will help anyone who is still trying to get rid of

this horrible peoplem.

> > > > > > > > >

> > > > > > > > > Greg

> > > > > > > > >

> > > > > > > >

> > > > > > >

> > > > > >

> > > > >

> > > >

> > >

> >

>

June 14, 2011

I have taken inositol (50g/daily for about a week), and have noted significant

improvements in cognition, emotional and sexual functioning.

This is consistent with the fact that SSRIs desensitize the 5HT-2 (5HT =

serotonin) receptor (http://www.ncbi.nlm.nih.gov/pubmed/2550988), and inositol

helps to elimination desensitization of the 5HT-2 receptors

(http://www.ncbi.nlm.nih.gov/pubmed/8131066), amongst other things such as

sensitizing alpha adrenergic receptors.

I have noted that after you take inositol, your sexual functioning becomes

incredibly weak, but afterwards it gets much better (therefore, it should be

taken at night, after any sexual actvivity).However, in consideration to members

who have suffered from intolerable amounts of social/other forms of anxiety, it

will most certainly increase anxiety, however sexual desire/arousal at least in

my opinion, is a type of excitable energy (both use noadrenaline and

adrenaline), and thus one cannot feel sexual excitement, if one's ability to

feel anxiety is impaired. The side effects are diarrhea, and nausea, however

these side effects are worth it my opinion.

BUT..

What I think may also be a factor is that SSRIS downregulate (eliminated)

certain beta adrenoreceptors (http://www.ncbi.nlm.nih.gov/pubmed/2825912), as

well as the fact that inositol does not seem to play any part in desensitizing

5HT1A receptors, but I believe the former point is more important. Beta

adrenorecptors are important for sympathetic responses (increase heart rate, and

are targets of noadrenaline, and adrenaline, key towards healthy sexual and

emotional functioning. Increasing them will most certainly help with sexual

functioning.

I am currently in the process to find another supplement to help reverse the

5HT1A desensitization in addition towards finding a medication that will

increase the beta adrenoreceptors. Possible candidates include beta blockers (I

have yet to find one that increases BOTH beta 1, and beta 2 receptors), and

other medication. This is the part where I need YOUR help. If you guys could

help me find medical studies that show which substances have preferably:

a) Beta Adrenoreceptor Upregulation (must be increase in number, as the previous

study showed that SSRIS do not affect affinity)

5HT1A Sensitzation

may not be as important as A) as I have recently found that there may be some

interplay between the 5HT-1, and 5HT-2 receptors (there is a reasonable

possibility that if you sensitize one, the other will sensitize as well, as the

reverse is true. (http://www.ncbi.nlm.nih.gov/pubmed/15064330).

There are many beta antagonists that double as 5HT1A antagonists (will increase

the receptor count), but they need to ultimately increase both beta 1 and beta 2

receptors. A good site is http://www.ncbi.nlm.nih.gov/pubmed (US National

Insitute of Health website) , and wikipedia is useful for obtaining information

regarding what general type the drug is, but any information should be

crosschecked with the the US government health site. Anyways, best of luck, and

rest assured, that I will not rest until I find a solution, and hope you do the

same.

June 14, 2011

It reverses the desensitization of the 5HT-2 receptors

(http://www.ncbi.nlm.nih.gov/pubmed/8131066). Have not seen any studies

indicating that eliminates 5HT-1A.

> > > > > > > > > >

> > > > > > > > > > Background about me: I'm a 27 year old male. I was put

onPaxil for social anxiety disorder. After a few months, I found it really hard

to orgasm. I was having marathon sex sessions with my wife. I went off the Paxil

in March of 2009 (after a total of 8 months on it) and since then I've noticed

that it takes me forever to get aroused. I've also been hit with extreme

premature ejaculation, loss of libido and interest in sex.

> > > > > > > > > >

> > > > > > > > > > After trying a few products mentioned by people here that

didn't work, I decided to look at the matter scientifically. PSSD is most likely

caused by persistent desensitization of 5-HT1A receptors. After doing some

research on substances that reverse desensitization of these receptors I

stumbled across inositol, a naturally occuring sugar in our bodies.

> > > > > > > > > >

> > > > > > > > > > I've been on 18 grams of inositol once daily at bedtime for

the past 7 weeks and few days (Jan 24/2011 to March 16/2011) and I am happy to

say that my interest in sex has returned, my erections are back to normal, and

my premature ejaculation has returned to how it was before I went on Paxil.

Never will I touch an SSRI again.

> > > > > > > > > >

> > > > > > > > > > I hope this will help anyone who is still trying to get rid

of this horrible peoplem.

> > > > > > > > > >

> > > > > > > > > > Greg

> > > > > > > > > >

> > > > > > > > >

> > > > > > > >

> > > > > > >

> > > > > >

> > > > >

> > > >

> > >

> >

>

June 15, 2011

You've been taking 50grams daily?! Most of the reports and things say to take a maximum of 20 grams. What made you try that high of a dose. I've been doing 18 grams for a month and haven't had much of a response. Just want to be sure of the dose you're taking cuz my stomach has been messed up at 18, feel like I'd blow myself out of my ass with 50g Been trying a lot of supplements that people recommend here and hoping for the best. It's interesting to hear how differently people respond. Hope I find something that works for me. I'm wishing the best for all of us here cuz this F'in SUCKS!! I don't know any of you but I find comfort in coming back here and hearing from all of you. You guys are the only ones that understand. It's so abstract for everyone else. I'm tired of everyone thinking

that it's all in my head....Shit sorry for the rant, we're all in this together. We will get thru it!! To: SSRIsex Sent: Tue, June 14, 2011 7:43:51 PMSubject: Re: Finally cured after 2 years of hell

I have taken inositol (50g/daily for about a week), and have noted significant improvements in cognition, emotional and sexual functioning.

This is consistent with the fact that SSRIs desensitize the 5HT-2 (5HT = serotonin) receptor (http://www.ncbi.nlm.nih.gov/pubmed/2550988), and inositol helps to elimination desensitization of the 5HT-2 receptors (http://www.ncbi.nlm.nih.gov/pubmed/8131066), amongst other things such as sensitizing alpha adrenergic receptors.

I have noted that after you take inositol, your sexual functioning becomes incredibly weak, but afterwards it gets much better (therefore, it should be taken at night, after any sexual actvivity).However, in consideration to members who have suffered from intolerable amounts of social/other forms of anxiety, it will most certainly increase anxiety, however sexual desire/arousal at least in my opinion, is a type of excitable energy (both use noadrenaline and adrenaline), and thus one cannot feel sexual excitement, if one's ability to feel anxiety is impaired. The side effects are diarrhea, and nausea, however these side effects are worth it my opinion.

BUT..

What I think may also be a factor is that SSRIS downregulate (eliminated) certain beta adrenoreceptors (http://www.ncbi.nlm.nih.gov/pubmed/2825912), as well as the fact that inositol does not seem to play any part in desensitizing 5HT1A receptors, but I believe the former point is more important. Beta adrenorecptors are important for sympathetic responses (increase heart rate, and are targets of noadrenaline, and adrenaline, key towards healthy sexual and emotional functioning. Increasing them will most certainly help with sexual functioning.

I am currently in the process to find another supplement to help reverse the 5HT1A desensitization in addition towards finding a medication that will increase the beta adrenoreceptors. Possible candidates include beta blockers (I have yet to find one that increases BOTH beta 1, and beta 2 receptors), and other medication. This is the part where I need YOUR help. If you guys could help me find medical studies that show which substances have preferably:

a) Beta Adrenoreceptor Upregulation (must be increase in number, as the previous study showed that SSRIS do not affect affinity)

5HT1A Sensitzation

may not be as important as A) as I have recently found that there may be some interplay between the 5HT-1, and 5HT-2 receptors (there is a reasonable possibility that if you sensitize one, the other will sensitize as well, as the reverse is true. (http://www.ncbi.nlm.nih.gov/pubmed/15064330).

There are many beta antagonists that double as 5HT1A antagonists (will increase the receptor count), but they need to ultimately increase both beta 1 and beta 2 receptors. A good site is http://www.ncbi.nlm.nih.gov/pubmed (US National Insitute of Health website) , and wikipedia is useful for obtaining information regarding what general type the drug is, but any information should be crosschecked with the the US government health site. Anyways, best of luck, and rest assured, that I will not rest until I find a solution, and hope you do the same.

June 15, 2011

Very interesting. I have been taking inositol and choline at low doses for a few months. I plan to increase, but I came across something interesting in some research. It was stated in a few studies that stimulation of the 5-ht2 receptors inhibits sexual reactions. This would be the opposite of what I want. Or is this only a temporary stimulation and that in the future this resensization will help our sexual performance? I read many things and at times get very, very confused with what I read. Please let me know what you think. Good luck in your reseach. I will help you if I come across anything helpful. Thank you. Mike

Subject: Re: Finally cured after 2 years of hellTo: SSRIsex Date: Tuesday, June 14, 2011, 11:43 PM

I have taken inositol (50g/daily for about a week), and have noted significant improvements in cognition, emotional and sexual functioning. This is consistent with the fact that SSRIs desensitize the 5HT-2 (5HT = serotonin) receptor (http://www.ncbi.nlm.nih.gov/pubmed/2550988), and inositol helps to elimination desensitization of the 5HT-2 receptors (http://www.ncbi.nlm.nih.gov/pubmed/8131066), amongst other things such as sensitizing alpha adrenergic receptors. I have noted that after you take inositol, your sexual functioning becomes incredibly weak, but afterwards it gets much better (therefore, it should be taken at night, after any sexual actvivity).However, in consideration to members who have suffered from intolerable amounts of social/other forms of anxiety, it

will most certainly increase anxiety, however sexual desire/arousal at least in my opinion, is a type of excitable energy (both use noadrenaline and adrenaline), and thus one cannot feel sexual excitement, if one's ability to feel anxiety is impaired. The side effects are diarrhea, and nausea, however these side effects are worth it my opinion. BUT..What I think may also be a factor is that SSRIS downregulate (eliminated) certain beta adrenoreceptors (http://www.ncbi.nlm.nih.gov/pubmed/2825912), as well as the fact that inositol does not seem to play any part in desensitizing 5HT1A receptors, but I believe the former point is more important. Beta adrenorecptors are important for sympathetic responses (increase heart rate, and are targets of noadrenaline, and adrenaline, key towards healthy sexual and emotional functioning. Increasing them will most

certainly help with sexual functioning. I am currently in the process to find another supplement to help reverse the 5HT1A desensitization in addition towards finding a medication that will increase the beta adrenoreceptors. Possible candidates include beta blockers (I have yet to find one that increases BOTH beta 1, and beta 2 receptors), and other medication. This is the part where I need YOUR help. If you guys could help me find medical studies that show which substances have preferably:a) Beta Adrenoreceptor Upregulation (must be increase in number, as the previous study showed that SSRIS do not affect affinity) 5HT1A SensitzationB) may not be as important as A) as I have recently found that there may be some interplay between the 5HT-1, and 5HT-2 receptors (there is a reasonable possibility that if you sensitize one, the other will sensitize as well, as the reverse is true. (http://www.ncbi.nlm.nih.gov/pubmed/15064330).There are many beta antagonists that double as 5HT1A antagonists (will increase the receptor count), but they need to ultimately increase both beta 1 and beta 2 receptors. A good site is http://www.ncbi.nlm.nih.gov/pubmed (US National Insitute of Health website) , and wikipedia is useful for obtaining information regarding what general type the drug is, but any information should be crosschecked with the the US government health site. Anyways, best of luck, and rest assured, that I will not rest until I find a solution, and hope you do the same.

June 15, 2011

Hello,

I don't would try beta blockers if you don`t really need them.

It is postulated that antagonists in generelly a able to damage the receptors

they block. Look at some long therm side effects of neuroleptics. The dopamine

line sometimes is so damaged after years that it response in a kind of parkinson

even if the drug is discontinued.

Somewhere I read also a strange thing: 5-ht2 agonists AND antagonists should be

downregulate them. but I don't know where I read this.

5-HT1a Antagonists exist but the most have also a lot of side effects. a NOT

strong antagonist seems to be quetiapine. it's also a strong 5-ht2a and 5-ht2c

antagonist and many more too.

I think maybe it could possible to desensitize some receptors with antagonists

by a timely limited course. (is that the german word for " Kur " ?)

if I will able to stop my quetiapine I will see. now I already have reduce it

and i can say that my brain fog for example isn't so bad as before i start it.

>

> Subject: Re: Finally cured after 2 years of hell

> To: SSRIsex

> Date: Tuesday, June 14, 2011, 11:43 PM

>

> Â

>

> I have taken inositol (50g/daily for about a week), and have noted significant

improvements in cognition, emotional and sexual functioning.

>

> This is consistent with the fact that SSRIs desensitize the 5HT-2 (5HT =

serotonin) receptor (http://www.ncbi.nlm.nih.gov/pubmed/2550988), and inositol

helps to elimination desensitization of the 5HT-2 receptors

(http://www.ncbi.nlm.nih.gov/pubmed/8131066), amongst other things such as

sensitizing alpha adrenergic receptors.

>

> I have noted that after you take inositol, your sexual functioning becomes

incredibly weak, but afterwards it gets much better (therefore, it should be

taken at night, after any sexual actvivity).However, in consideration to members

who have suffered from intolerable amounts of social/other forms of anxiety, it

will most certainly increase anxiety, however sexual desire/arousal at least in

my opinion, is a type of excitable energy (both use noadrenaline and

adrenaline), and thus one cannot feel sexual excitement, if one's ability to

feel anxiety is impaired. The side effects are diarrhea, and nausea, however

these side effects are worth it my opinion.

>

> BUT..

>

> What I think may also be a factor is that SSRIS downregulate (eliminated)

certain beta adrenoreceptors (http://www.ncbi.nlm.nih.gov/pubmed/2825912), as

well as the fact that inositol does not seem to play any part in desensitizing

5HT1A receptors, but I believe the former point is more important. Beta

adrenorecptors are important for sympathetic responses (increase heart rate, and

are targets of noadrenaline, and adrenaline, key towards healthy sexual and

emotional functioning. Increasing them will most certainly help with sexual

functioning.

>

> I am currently in the process to find another supplement to help reverse the

5HT1A desensitization in addition towards finding a medication that will

increase the beta adrenoreceptors. Possible candidates include beta blockers (I

have yet to find one that increases BOTH beta 1, and beta 2 receptors), and

other medication. This is the part where I need YOUR help. If you guys could

help me find medical studies that show which substances have preferably:

>

> a) Beta Adrenoreceptor Upregulation (must be increase in number, as the

previous study showed that SSRIS do not affect affinity)

> 5HT1A Sensitzation

>

> may not be as important as A) as I have recently found that there may be

some interplay between the 5HT-1, and 5HT-2 receptors (there is a reasonable

possibility that if you sensitize one, the other will sensitize as well, as the

reverse is true. (http://www.ncbi.nlm.nih.gov/pubmed/15064330).

>

> There are many beta antagonists that double as 5HT1A antagonists (will

increase the receptor count), but they need to ultimately increase both beta 1

and beta 2 receptors. A good site is http://www.ncbi.nlm.nih.gov/pubmed (US

National Insitute of Health website) , and wikipedia is useful for obtaining

information regarding what general type the drug is, but any information should

be crosschecked with the the US government health site. Anyways, best of luck,

and rest assured, that I will not rest until I find a solution, and hope you do

the same.

>

June 15, 2011

Do you use the powder form of inositol? If so, how are you exactly measuring

your 50mg? I just take a heaping spoonful, but I have no idea how much it

actually is!