A Look at Vaccinations and Autism Theories - Revisited

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November 10, 2000

A Look at Vaccinations and Autism Theories - Revisited

Part 1

[This is part of series of summaries of Theories of Autism written

and maintained by Mehl-Madrona, M.D., Ph.D., Medical Director of The

Center for Complementary Medicine. Email coyotemd@.... It

appeared only 11 days ago in this newsletter, prior to the announcement of

this Sunday's CBS 60 Minutes report (7 pm) on the subject. For those who

may have missed it, and for a number of new recent subscribers, we are

reprinting here again in two parts. Other theory of autism summaries are

also available at the website below. References have been deleted but are

available at the website. This material contains technical language.]

http://www.healing-arts.org/children/

Dr. Wakefield, a Gastroenterologist at the Royal Free Hospital

in London, England, discovered a possible connection between autism and

viral infection associated with the MMR vaccination. The damage from autism

is thought to be provoked by the an allergic type reaction initiated by the

body’s reaction to the vaccine. This auto-immine response could also affect

DPP-IV, reducing its levels, thereby connecting vaccines to the opioid

theory of autism.

For more information, please see The Mechanism of Encephalitic Damage

from Vaccines by Val Valerian.

Myelination is an essential part of human brain development. Nerves

can only conduct pulses of energy efficiently if it is covered with myelin.

Like insulation on an electric wire, the fatty coating of myelin helps keep

the pulses confined and maintains the integrity of the electrical signal so

that it has a high signal-to-noise ratio. When the insulation on a wire is

damaged or destroyed, the flow of electrical current may be interrupted and

a short-circuit occurs. See Colorado Health Net's MS Definitions, Facts, and

Statistics for more information.

Oligodendrocyte cells give white matter its color by manufacturing

myelin. If myelin falls into disrepair, nerve axons cease to function, even

though they themselves aren't damaged. Protecting oligodendrocytes after

brain or spinal cord injury might keep nerve cells intact. " See Washington

University in St. Louis School of Medicine's article on new findings on

nervous system damage for more information.

At birth, relatively few pathways have myelin insulation. Myelination

in the human brain continues from before birth until at least 20 years of

age. Up until the age of 10 or so, vast areas of the cortex are not yet

myelinated, and up to the age of 20, large areas of the frontal lobes are

not yet myelinated 21.

Myelination begins in the developmentally oldest parts of the brain,

like the brain stem, moving to the areas of the nervous system that have

developed more recently, like the prefrontal lobe and cortex. Myelin spreads

throughout the nervous system in stages which vary slightly in each

individual. Impairment of myelination can alter neural communication without

necessarily causing severe CNS damage.

The prefrontal portions of the cerebrum have a profound influence on

human behavior. If an individual is injected with vaccines, most of which

have adjuvants like mercury and aluminum compounds, as well as foreign

proteins (some from other species in which the vaccines were grown) and

biological organisms, unprotected nerves may be impacted. The argument for a

role of vaccines in the development of autistic disorders hinges on these

biological effects upon nerves, damaging them in a way that influences

behavior and learning patterns.

The history of studies on vaccines began in 1922 when a smallpox

vaccination program caused an outbreak of encephalitis, with a secondary

result of Guillain-Barre Syndrome, an ascending paralysis ending in death.

The polio virus produces a breakdown of the myelin shealth, called

poliomyelitis, which results in paralysis. Encephalitis, whether caused

through disease or as a result of vaccination, can cause demyelination of

the nerves. For more information, see again The Mechanism of Encephalitic

Damage from Vaccines. " In regions in which there is no organized vaccination

of the population, general paralysis is rare. It is impossible to deny a

connection between vaccination and the encephalitis which follows it. 23 "

In 1935, Rivers discovered " experimental allergic

encephalomyelitis, " or (EAE). Until then, it was assumed that encephalitis

was caused by a viral or bacterial infection of the nervous system. Rivers

was able to produce brain inflammation in laboratory monkeys by injecting

them repeatedly with extracts of sterile normal rabbit brain and spinal cord

material, which made it apparent that encephalitis was an allergic reaction.

EAE can explain the association of allergies and autoimmune states with

encephalitis.

In 1947, Isaac Karlin suggested that stuttering was caused by " delay

in the myelinization of the cortical areas in the brain concerned with

speech. " In 1988, research by Dietrich and others using MRI imaging of the

brains of infants and children from four days old to 36 months of age have

found that those who were developmentally delayed had immature patterns of

myelination.

In 1953 it was realized that some children's diseases, measles in

particular, showed an increased propensity to attack the central nervous

system. This indicated a growing allergic reaction in the population to both

the diseases and the vaccinations for the diseases.

In 1978, British researcher, Bannister, observed that the

demyelinating diseases were getting more serious " because of some abnormal

process of sensitization of the nervous system. "

Some investigators believe that this increased sensitization of the

population is being enhanced by vaccination programs.

DPT and Brain Damage:

In 1948, Randolph Byers and Frederick Moll of Harvard Medical School

and the Federal Drug Administration carried out tests on DPT vaccines at

Children's Hospital in Boston and concluded that severe neurological

problems could follow the administration of DPT vaccines. The results of the

tests were published in Pediatrics.

In 1976, Dr. Manclark, an FDA scientist, remarked that " the

DPT vaccine had one of the worst failure rates of any product submitted to

the Division of Biologics for testing. "

According to the testimony of the Assistant Secretary of Health,

Grant, Jr., before a U.S. Senate Committee on May 3rd, 1985, every

year, 35,000 children suffer neurological damage related to the DTP vaccine.

See " Vaccinations " , by Logia, for more information.

In 1992, the Institute of Medicine concluded that " the evidence is

consistent with a causal relation between DPT vaccine and acute

encephalopathy, defined in the studies reviewed as encephalopathy,

encephalitis, or encephalomyelitis, and the evidence indicates a causal

relation between DPT vaccine and anaphylaxis, between the pertussis

component of DPT vaccine and protracted, inconsolable crying. " For more

information, see the Leading Edge Master Analysis of the Vaccination

Paradigm.

Like the material used to produce experimental allergic encephalitis,

vaccines contain substances which qualify as " adjuvants. " These substances

initiate reactionary antibody formation. Common adjuvants used in vaccines

are aluminum hydroxide and aluminum potassium sulfate. In the body, formalin

coating around the injected material dissolves, releasing all bacterial and

viral particles from animal culture sources. Substances such as thimerosal

[mercury] and these adjuvant chemicals irritate body tissues and increase

the action of accompanying bacteria and viruses, as well as the reaction of

the immune system to the foreign protein antigens, potentially damaging

neurological membranes where the myelin sheath has only partially protected

the nervous system. This can result in mild to severe neurological damage,

leading to learning disabilities and other nervous system disorders, or

death, especially upon subsequent injections, since body has already been

sensitized, promoting allergic reactions of increasingly severe nature. For

more information, see again the Leading Edge Master Analysis of the

Vaccination Paradigm.

Dr. M Poser has drawn the link between the vaccines and

demyelination: " Almost any... vaccine can lead to a non infectious

inflammatory reaction involving the nervous system 24. The common

denominator consists of a vasculopathy that is often... associated with

demyelination. " For more information, see the Society For The Autistically

Handicapped (S.F.T.A.H.)'s Vaccines: Fact Sheet.

Jonas Salk, the developer of the vaccine, wrote in 1975, " Live virus

vaccines against influenza or poliomyelitis may in each instance produce the

disease it intended to prevent . . . . the live virus against measles and

mumps may produce such side effects as encephalitis 25. "

Post-vaccinal pathology of the central nervous system (CNS) is a topic

deserving further investigation (An Italian Study Finding Biochemical

Markers of Vaccine Damage, © 1996, L. Coulter, Ph.D.). Observation of

30 patients of Italian nationality, observed between April, 1994, and

October, 1995, showed that clinical signs of CNS pathology, along with

associated dermatitis, food allergies, constipation, and leaking from the

anus, emerged concomitantly or immediately after vaccination with the Salk

or Sabin polio vaccine, DT, measles, DPT, anti-tuberculosis, or Hepatitis-B

vaccines 26.

These 30 patients from various regions of Italy, all presented with a

clinical history of convulsions concomitant with, or immediately after,

vaccinations. Patients whose clinical history was not referable to a

vaccination were excluded from the study. Accepted patients received tissue

typing for HLA (A, B, C) and HLA DR-DQ. Various immune functions: were also

studied, including lymphocyte subpopulations, serum immunoglobulin content,

and presence of antibodies to specific viruses (CMV, EBV, HSV-1 and HSV-2,

VZV).

Patients had earlier been diagnosed with epilepsy, myoclonic epilepsy,

evoving epilepsy, epileptigenic encephalopathy, autism, West Syndrome, and

Angelman's Syndrome. All the patients had presented with the first symptoms

shortly after receiving a vaccination.

The first symptoms were convulsions, high fever, or diarrhea

immediately following vaccination. The parents had told their physicians

about this; then, after taking EEGs and visiting neuropsychiatric

specialists or pediatricians without conclusion, the physicians had

administered the recall shots of the vaccines leading to stabilization of

the condition with progressive clinical deterioration.

Children were 3 to 9 months old. All patients were studied for the

presence of metabolic diseases with negative results; then chromosomal

mapping was done, also with negative results; encephalic TAC and RMN were

performed at first appearance of the symptomatology, also with negative

results.

The EEG performed at first appearance of the symptomatology gave a

negative result in 92% of the patients. Serologic investigations for

herpetic virus (IgG and IgM) were positive in all for IgG and negative for

all for IgM, leading to an estimate of seropositivity (IgG) for Epstein-Barr

virus of 73.8%; for cytomegalovirus, of 71.4%; for Herpes Simplex virus, of

47.6%; and for Varicella-Zoster Virus of 21.4%. In all the patients they

observed diminished sideremia and a deficit of IgA and IgG with a slight

increase of SGOT and SGPT. None of the patients had maternally transmitted

viral encephalopathy, and in all the patients the vegetative and relational

life was quite normal prior to administration of the first dose of vaccine.

Again, see An Italian Study Finding Biochemical Markers of Vaccine Damage,

for more information.

Tomorrow Part 2: MMR Vaccine and Autism

Take Some Mystery out of Autism

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