Guest guest Posted October 24, 2002 Report Share Posted October 24, 2002 Dear Helen, Here is an Rx from my notes on a Materia Medica Lecture by Chevallier: General travel mix: Hydrastis 20 Echinacea 25 Glycyrrhiza 15 (1:1) Artemisa abs 15 (1:4) Zingiber 10 Thymus 20 Sig: 2.5ml tds increasing if any infection develops. Re Art.annua says need to take 160ml / Week for distinc antimalarial action. Hope this proves useful.... Hannah. > >Reply-To: ukherbal-list >To: <ukherbal-list > >Subject: malaria >Date: Thu, 24 Oct 2002 17:01:31 +0100 > >Apart from Artemisia annua, has anyone any good ideas for travelling to >malaria-affected countries? >Patient going away soon so early suggestions appreciated. >Many thanks >Helen > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 24, 2002 Report Share Posted October 24, 2002 > > >Re Art.annua says need to take 160ml / Week for distinc antimalarial >action. actually its best to use straight artemsinin - you can obtain it pretty easily from Vietnamese and Chinese grown sources where as quinghaosu it has been much studied and used for a long time for drug resistant malaria. it is used in acute dose of around 1gm up to 3x for a day. this single shot clears 100% schizonts within 48 hours. In acute doses, minimal toxicity. The most reliable company IMO is Allergy Research, out of California, with HPLC and bio assay QC. We are also using artemisinin as an anti-cancer agent - with some very interesting results. -- Treasure, MNIMH, AHG Partners For Health, 525 East Main Street, Ashland, OR 97520 tel fax http://www.partnersforhealth.net Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 25, 2002 Report Share Posted October 25, 2002 Hannah, Do you rember if recommends using the Artemisia annua as a fresh (or 'specific' ) tincture? That seems to be the more effective. We usually use a 1:2 fresh tincture, which produces a higher fresh plant juice to menstrum ratio. Best wishes, Chenery Rutland Biodynamics Ltd malaria > >Date: Thu, 24 Oct 2002 17:01:31 +0100 > > > >Apart from Artemisia annua, has anyone any good ideas for travelling to > >malaria-affected countries? > >Patient going away soon so early suggestions appreciated. > >Many thanks > >Helen > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 24, 2003 Report Share Posted September 24, 2003 Yes Artemsia annua can be used but I would not rely on it since malaria is a potentiallly life threatening illness. Only good in slowing down illness, not a cure. If you need any I do supply it.Offlist though. Lorraine. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 24, 2003 Report Share Posted September 24, 2003 On 9/24/03 05:46 AM, " Lorraine Hodgkinson MNIMH MRCHM " wrote: > Yes Artemsia annua can be used but I would not rely on it since malaria is a > potentiallly life threatening illness. Only good in slowing down illness, > not a cure. If you need any I do supply it.Offlist though. > > Lorraine. > Actually there is no evidence that A annua is effective as a prophylactic. As far as tx of simple malaria is concerned, artemesinin, the sesquiterpene lactone is very effective po and taken alone will cure 90% plus cases if used over 7 days ( more than one asexual cycle of the parasite). Taken with mefloquine it will clear 100% cases. It is not recommended as a prophylactic either, neither according to WHO or by the literature. Artemsinin is easily available in 100mg capsules. Most Plasmodium is now chloroquine resistant. Falciform malaria, if untreated can develop into " complex " disease with multiple life threatening sequela but it is a little dramatic to suggest that a western traveler with access to medication is in serious danger from a simple exposure. Unfortunately indigenous populations all over the world are exposed to infection daily and millions are are almost completely lacking in medical care or treatment resources. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 24, 2003 Report Share Posted September 24, 2003 It has been shown that Artemsia annua can slow down the rate of replication of the parasites and also Artemesin has been shown to have an anti cancer action and is regularly used by one of my patients to good effect, Lorraine. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 24, 2003 Report Share Posted September 24, 2003 Ann is doing her dissertation on this I think, so may have lots of info. Don't know whether she is on this chat list, but could prop. be contacted through college. Regards Alix malaria Colleagues, I am going to a malarial area (S. India). Has anyone experience using Artemesia annua or any herb as a preventative? or is it only used in the treatment thereof. Any other advice, greatfully received. Vicki Pitman Somerset Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 24, 2003 Report Share Posted September 24, 2003 On 9/24/03 08:13 AM, " Lorraine Hodgkinson MNIMH MRCHM " wrote: > It has been shown that Artemsia annua can slow down the rate of replication > of the parasites and also Artemesin has been shown to have an anti cancer > action and is regularly used by one of my patients to good effect, > > Lorraine. > Lorraine , there are no data as far as I know on A annua " slowing down rate of plasmodium replication " There are no clinical trial data on the whole herb as an antimalarial either. There is one rodent study on whole herb (Klayman , 1985)with the rat form of malaria. During the original screening of Chinese herbs for antimalarial activity in the 6O's, A annua was almost overlooked because traditional hot water extracts were inneffective. Artemisinin (and derivatives) however can clear parasitemia within a matter of hours/a few days and are in extensive use in malaria zones. Also, TCM use of A annua , as you know, depends on polypharmaceutical formulations such as Qing Hao Bie Jia Tang, in which A annua is but one component. I think it is not appropriate to recommend use of the whole herb alone either for treatment or prophylaxis of malaria. The pharmacological basis of the antimalarial action is fairly well understood these days, and since it kills mature trophozoites within RBC's, it cannot work as a prophylactic against the sporozoites from an infected vector bite. In addition the pharmacokinetics has been well studied, at least in acute doses, and it is rapidly cleared from the body. ( one reason for recrudescene rates being high in remote areas where compliance with a 5-7 day treatment schedule is low) Interestingly, it is true that a couple of the methoxyflavones in the plant synergize with artemsinin in antimalarial activity tests, although they have no effect on their own. The same compounds also act as MDR pump inhibitors.(see below) For this reason one might consider combining small quantities of whole herb with artemsinin in an anti-cancer protocol especially when co-administered with chemotherapies susceptible to development of drug resistance. Stermitz, F. R., L. N. Scriven, et al. (2002). " Two Flavonols from Artemisa annua which Potentiate the Activity of Berberine and Norfloxacin Against a Resistant Strain of Staphylococcus aureus. " Planta Med 68(12): 1140-1. Bioassay-guided fractionation of an extract of Artemisia annua L. (Asteraceae) was conducted in order to assess the possible presence in the plant material of inhibitors of bacterial multidrug resistance pumps. Fractions were tested for Staphylococcus aureus growth inhibition in the presence of a subinhibitory dose of the weak antibacterial alkaloid berberine. Active fractions yielded the flavones chrysosplenol-D and chrysoplenetin, which themselves had very weak growth inhibitory action, but which made a potent combination with berberine. In comparison with work on other flavonols, it is likely that potentiation is due to the inhibition of an S. aureus multidrug resistance (MDR) pump. These same two flavonols were earlier reported to potentiate the activity of artemisinin against Plasmodium falciparum. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 25, 2003 Report Share Posted September 25, 2003 > vicki pitman wrote: >> O.k. thanks all. This has sparked a good discussion. But I'm wondering >> now about cinchona and quinine water, didn't the colonials use this as a >> preventative? Any thoughts? > > Yes. And it works. And it's still in use, but it has _severe_ side > effects... just check the fine print on " Lariam " and other fine > Cinchona-derived anti-malarial meds. Sensitive folk can die from " cinchonism " . (hemolytic reaction) Normal doses are neurotoxic to 8th nerve and vision > That's one of the reasons why people are looking for alternatives. > (Also, I've heard there's med-resistant malaria, but have forgotten all the > details. Was that Lariam, another cinchona-derived med, or some malaria med > that had't ever even seen cinchona?) The quinine derivative mefloquine is the commonest drug these days and resistance is now widespread. There is no cross resistance between artemsinin and mefloquine. j Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 25, 2003 Report Share Posted September 25, 2003 jonathan treasure wrote: > > Yes. And it works. And it's still in use, but it has _severe_ side > > effects... just check the fine print on " Lariam " and other fine > > Cinchona-derived anti-malarial meds. > > Sensitive folk can die from " cinchonism " . (hemolytic reaction) > Normal doses are neurotoxic to 8th nerve and vision Also among the side effects are suicidal depression and change of personality; really, gastric upset is among the lesser evils in the fine print. It's not a benign medicine. Which is why I haven't scanned + OCR'd King's 30 page entry on Cinchona (+ more the alkaloids) - it's not a herb, it's a med. Henriette -- Henriette Kress, AHG Helsinki, Finland Henriette's herbal homepage: http://www.ibiblio.org/herbmed Quote Link to comment Share on other sites More sharing options...
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