Re:Dr. O: Lecture 1: Lets try to decrease autoantibodies...

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Hi Dr. O, I agree with the selenium studies and have read this many times and take a minimum of 200 mcg of selenium daily and also give it to my children who also have antibodies and HAIT or AIT. My children and I also take Thyrostim a supplement by Biotics Research. My daughter has both Graves and Hashi antibodies. She also has soy and gluten intolerances. Her TSI, TBII, TPO, and TG have improved. I have had quite a bit of fun with her puzzle (not –the first six doctors would only see her if she has RAI ablation –they all insisted she had Graves, but symptoms were Hashi. Her TSH (I know a child’s TSH range is slightly higher than adults) was suppressed, low FT4 and high normal FT3. Now the TSH with supplements and diet change has come up to .99 and FT4/FT3 are both mid range. If I listened to them I would have a 6 year old with no thyroid and probably multi other diseases from the RAI alone. I was told a couple years back that thyroxine (T4) is the ideal drug (that was by a Naturopathic Doctor) The ND refused to prescribe Armour and said it was foreign and the human body couldn't use it properly. She even said all her patients did badly on it so she quit using it –you can only get optimal treatment on synthetics. I had severe reactions prior to seeing her from both Synthroid and Levoxyl -binders, fillers, dye -not

sure, but had rash, swelling and breathing problems. When I started seeing her I had just been released from the hospital with Myxedema. (Another doc -Endo took my meds away and I crashed fast -was treating by TSH levels alone -another story another time) She took me off of 4 grains of Armour and gave me 100 mcg of Levothroid and I went down hill, within two weeks (I am sure the first reason was 4 grain of Armour is not equivalent to 100mcg of Levothroid -way too low) I couldn't get out of bed or walk and was freezing and couldn't carry on a rational conversation from the brain fog. (Thought I would end up back in the hospital) She then upped me to 150 mcg and in three weeks changed it to Unithroid, and added 10 mcg SRT3 (compounded triiodothyronine) every 12 hours; still with little improvement in four weeks upped it again to 200 mcg of Unithroid and 15 mcg SRT3 every 12

hrs; four weeks later to 250 mcg of Unithroid and 20 mcg of SRT3. My FT4 levels went up, but my FT3 levels only made it up to the arbitrary low range of 7%, but the FT4 was a the 80%. My TSH came up from <.0001 to 1.02 during this time. My FT3 finally came up to 30% for maybe three months, but then it went back down and stayed there, but she wouldn't up the SRT3 past 30 mcg every twelve hrs. However, my FT3 level. eventually within nine months, went back down to 10% of range. And I felt so bad that I self medicated and went back to Armour and when it ran out found a doctor who would prescribe it, and have stayed on Armour. Since, June I have went from 4 grains down to 2.5 after eliminating gluten, soy, dairy, sugar from my diet. So, what the solution for a patient that does NOT convert T4 into T3? I have had numerous tests that reveal I do NOT have elevated levels of RT3. So is it a correct assumption the T4 does not turn into RT3? RT3 levels are all at the 50% in stated ranges. I have tried synthetic T4 with Cytomel, too –similar response. I have even taken Cytomel alone for six months. Could the food intolerances cause all this? Perhaps I need to re-try some of the failure of the past. Not persuaded

yet. I also realize how important good or optimal iron and Vitamin B12 levels are. I take 5000 mcg of sub-lingual Vit B12 daily, plus get a shot weekly as mine is pathetic. My serum ferritin, iron, hemoglobin, and hematocrit only seem to come up to the lowest numbers in the range and then only sometimes. I have been diagnosed with both Vit B12 (sure you recognize it as Pernicious) and iron deficient anemia. I am hoping the levels and symptoms will improve now that the gluten, soy and dairy are no longer an issue -We will retest after December. Thanks for your contribution. Bj Dr. O: Lecture 1:

Lets try to decrease autoantibodies... Posted by: "dr_035" dr_035@... dr_035 Wed Nov 15, 2006 2:42 am (PST) Hi happy people! Would you like to learn more about your disease? So webegin..."Hashimoto's thyroiditis, atrophic thyroiditis (the late course of thedisease) and postpartum thyroiditis (an other form which usually beginsafter delivery)".. . They are all called as "autoimmune thyroiditis"(AIT).Infact the triggering mechanisms are similar...

Our immune cells (CD4etc) are educated during the intrauterine life. So they can recognizetheir own cells and the enemies (like bacterias, viruses, or abnormalcells like cancer cells). Now, smoking (active or passive), additives,pollutants or what ever they are... Many inciting agents change thefaces of our cells. They became abnormal... Your soldiers love you.Inorder to defense you, they begin an attack to what ever does not seemfamiliar. This war is mediated by many immune cells or the mediators ofthem (antibodies) ... Do you hate your immune cells still? Do not please.They love you...Many authors think that killing of these abnormal cells may save us manybigger problems like cancer. Because, prolonged period of change indegenerated cells may cause generation of cancer cells. Most importantautoantibody is TPOAb. It is against to a cellular component of thyroidcell.Recent studies suggest that, many

therapies suppress this autoimmunewar. One of them is "selenium". It's an element similar to sulphur.Selenium is essential for an optimal function of immune system and wehave more than 30 kind of selenoproteins (GPX, TR, H, I, K, ... V). Wedon't know the function of most of them. But you have to use 200microgram/d L-Selenomethionine for at least 6 mo. Doses less than 200microgram/d fail. You can use 2 tablets of 100 microgramL-Selenomethionine) (eg: 2 tablets of seleno-6 (solgar)). Rarely it maycause gastric discomfort (less than 1% of patients) but you can take itwithin meal to reduce it. There are intersting datas about the use ofselenium in pregnant AIT patients, AIT patients with vitiligo etc...(Ref: http://joe.endocrin ology-journals. org/cgi/content/ short/190/ 1/151<http://joe.endocrin ology-journals. org/cgi/content/ short/190/ 1/151>Second important pearl is to keep your FT3, FT4, TSH balanced. Animportant fault of thyroidologs is to monitor only the level of TSH. Infact, TSH responses the alterations of FT3, FT4 within months. You seemany patients who say "my TSH is normal but I feel not well". So, youhave to check your TSH, FT3, FT4 for each 3 mo. I suggest you to addTPOAb and TgAb to this list. They are effected from the seasons, changesin body weight etc. So you cant guess the titers. If your TPOAbincrease, it points the increasing velocity of the autoimmune war.Decrease of it is accepted as the messenger of remission (peace).You have to use thyroxine (T4) pills if you are hypothyroid. But studiessuggest that using of T4 in euthyroid state

cause resting of yourthyrocytes. So it causes decrease in antigenic stimulus. So please uselow dose T4 if your TSH, FT3 and FT4 levels let it. Ideal TSH level is 1(if normal range of the assay is 0 - 4).Which T4 pill is the best? The most identical and purified one ofcourse. Only recombinant pills can prove it. Are you pig? So why do youneed to use the extract of pig thyroid? I see the disaster in USA. MDsare classified as ones who prescribe Armour or the OTHERS. Me and mypatients are very glad cause I'm one of the OTHERS. I prescribe thepurest, safest, cheapest, recombinant pills. (Sorry Miss Piggy). Eachforeign protein can trigger an immune response to your own hormones.Years and years ago, many genius colleagues prescribed fish calcitoninin the treatment of osteoporosis? But your soldiers hate foreigners.Furthermore, it may cause antibody response to your own calcitonin too.So, now it is exactly rejected in the

treatment of osteoporosis. Manypeople try to manipulate you and try to use your known symptoms to selltheir products. There are many sponsors of them in the yahoo groupsalso. I think I missed the opportunity to be within the top 10 doctorsin USA. Cause I do not serve Armour. But king is naked... Sorry piggy.You have to take thyroxin (T4) pills once before the breakfast. And youhave to be fast for one hour. Because content of meal may interact withpills or decrease the absorption rate. Addition of T3 is usuallyunnecessary and dangerous. Because T3 is really more potent than T4 andit's half live is within hours. It means it reaches peak activity fastthen the effect of it ends quickly. So it increases the amplitude ofalterations. So combined pills (T3 + T4) have a disadvantage.I know many investigators (my friends) study on a more potentimmunomodulator than selenium (although the success rate of seleniumreaches

to 50%). But the studies go on. I hope the success rate of thisnatural agent will exceed the selenium's.Love your immune cells... They are not your enemies...Be happy... Go on to open your window and smell the flowers. They loveyou too..Dr. O (not within top 10 docs).

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