AW: Re: [M-T] EN>DE follow-up (masked) investigator in a clinical trial

[Guest guest]

I agree with Sue on the fact that masked means blinded in this context.

The term follow-up investigator is fairly unusual. It could simply be a

convoluted expression for investigator or may suggest that several

investigators are involved at different stages of the clinical study.

As for the " is blinded to /masked from the results of the previous

examinations " I would like to point out that investigators are usually not

blinded to results but to the treatments producing the results. In this

case, the same physician is obviously also performing the initial exams (eye

exams) and I would not know how to blind a physician from the results he is

obtaining in such exams. The only thing he could be blinded to is the

treatment patients receive during the clinical trial and which may have an

impact on the outcome of eye examinations. This would be important for

preventing physician-induced bias in the evaluation of follow-up exams.

Last but not least, I would like to suggest that when submitting such

questions more context be provided on the type of study, design, treatments

etc.

My two cents.

A.

_____

Von: medical_translation

[mailto:medical_translation ] Im Auftrag von Sue Levy

Gesendet: Donnerstag, 5. Oktober 2006 21:35

An: medical_translation

Betreff: Re: [M-T] EN>DE " follow-up (masked) investigator " in a

clinical trial

Hello Charlotte,

Masked is the same as blinded. In this case, I presume it means that

the follow-up investigator - who performs the examination during

and/or after treatment (in any case, sometime after the screening

and baseline exams) - is blinded to/masked from the results of the

previous examinations.

regards

Sue

>

> Hi everybody,

>

> Does anyone know what a " follow-up (masked) investigator " is in a

clinical

> trial (translation of a CRF)? I neither know what a " follow-up

investigator "

> is nor what " masked " means (maybe the same as " blinded " ?)

>

> Strangely, the " follow-up investigator " has to perform an eye

examination

> even at screening and baseline visits.

>

> Any idea for an explanation or even translation into German?

>

> Thanks.

>

> Charlotte Kauczor

>