Vitamin C is an important cofactor for both adrenal cortex and,adrenal medulla.

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Vitamin C is an important cofactor for both adrenal cortex and

adrenal medulla.

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> *: *Endocr Res. <javascript:AL_get(this, 'jour', 'Endocr Res.');> 2004

> Nov;30(4):871-5. Links <javascript:PopUpMenu2_Set(Menu15666839);>

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>

>

> *Patak P*

>

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> *Willenberg HS*

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> *Bornstein SR*

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>

> Department of Endocrinology, Diabetes, Rheumatology, Heinrich-Heine

> University, Duesseldorf, Germany.

>

> The adrenal gland is among the organs with the highest concentration

> of vitamin C in the body. Interestingly, both the adrenal cortex and

> the medulla accumulate such high levels of ascorbate. Ascorbic acid

> is a cofactor required both in catecholamine biosynthesis and in

> adrenal steroidogenesis. Here we provide an overview on the role of

> vitamin C in the adrenal cortex and medulla derived from in vitro

> and in vivo studies. In addition, recent insights gained from an

> animal model with a deletion in the gene for the ascorbic acid

> transporter will be summarized. Mutant mice lacking the plasma

> membrane ascorbic acid transporter (SVCT2) have severely reduced

> tissue levels of ascorbic acid and die soon after birth. There is a

> significant decrease of tissue catecholamine levels in the adrenals.

> On the ultrastructural level, adrenal chromaffin cells in SVCT2 null

> mice show depletion of catecholamine storage vesicles, signs of

> apoptosis, and increased glycogen storage. Decreased plasma levels

> of corticosterone and altered morphology of mitochondrial membranes

> indicate additional effects of the deficiency on adrenal cortical

> function. The data derived from these animal models and various cell

> culture studies confirm a crucial role for vitamin C for both the

> adrenal cortex as well as the adrenal medulla further underlining

> the interdependence of the two endocrine systems united in one gland.

>

> PMID: 15666839 [PubMed - indexed for MEDLINE

>

>

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