Eye Tox Tests, Was Re: AAAAI - Fungi Stake a Claim in Allergic Sinusitis Patholo

[Guest guest]

:

1. There are at least 8 studies on Styrene exposure causing color or

contrast sensitivity issues.

Gobba and Cavalleri,1993

Campagna 1995

Eguchi 1995

Mergler at al., 1996

Gobba and Cavalleri, 2000

Kishi et al, 2001

Triebig et al, 2001

Castillo et al., 2001

Evidence indicates that loss will occur below the OSHA PEL.

2. There are 3 studies on 5 different groups for perc.

Cavalleri et al, 1994

Schreiber et al. 2002

Gobba et al, 1998

3. In essence, there are studies on:

Mixed solvent exposures

Carbon disulfide

Perchloroethylene

Styrene

Toluene

Trichloroethylene

1,2-dichlorobenzene

Methyl mercury

Acrylamides

Chloropyrifos (marginal at best)

Carbon Monoxide (negative)

n-Hexane

2-t-Butylazo-2-hydroxy-5-methylxane

Metals (Pb,Zn,Mn)

3. There are confounding factors to consider:

Clinical Retinopathies

Diabetic retinopathy

Age-related macular degeneration

Parkinson's Disease

Multiple Sclerosis

4. There is data that suggests reversibility of effects:

B. Lomax, et al.: Does Occupational Exposure to Organic Solvents

Affect Colour Discrimination? Toxicological Reviews 23, 2, 91-121, 2004.

5. Key Refs:

Anger, Neurobehavioral Test Methods For Environmental Health Studies of

Adults, Neurotox Terat, 16, 5, 489-497, 1994.

Geller, Critical Issues in the Use and Analysis of the Lanthony Desaturate

Color Vision Test, Neuortox Tetra, 19, 6, 455-465, 1997.

Geller, A Table of Color Distance Scores for Quantitative scoring of the

Lanthony Desaturate color vision test, Neuortox Tetra, 23, 265-267, 2001

Gobba, Occupational Exposure to Chemicals and Sensory Organs, A Neglected

Research Field, NeuroTox, 24, 675-691, 2003.

Iregren, Color Vision and Occupational Chemical Exposures I, An Overview of

Tests and Effects, NeuroTox, 23, 719-733, 2002.

6. Benefits:

Pretty objective

Eye to use

Quick

As before:

Test everything, hold on to what is good.

Tony

.......................................................................

" Tony " Havics, CHMM, CIH, PE

pH2, LLC

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[Guest guest]

Tony, With these studies about styrene exposure would that make use of foam insulation problematic. Please correct me if I'm wrong, but isn't styrene a component in most foam insulations? I'm asking as we are considering it's use for our home. Thanks, Sam Tony Havics wrote:1. There are at least 8 studies on Styrene exposure causing color orcontrast sensitivity issues.

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