Vitamin K correlates with lower inflammation

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Originally published June 24 2008

Vitamin K Reduces Chronic Inflammation Throughout the Body

by Gutierrez

(NaturalNews) Higher vitamin K1 intake may decrease the incidence of the

inflammation that has been linked to a variety of diseases, according to

a new study published in the /American Journal of Epidemiology/.

" Our findings provide one potential alternative mechanism for a putative

protective effect of vitamin K in the progression of cardiovascular

disease and osteoporosis, since both diseases are characterized by

inflammation, " the researchers wrote.

Researchers analyzed data from 1,381 participants in the Framingham

Offspring study to determine blood vitamin K

<http://www.naturalnews.com/vitamin_K.html> levels and dietary intake of

vitamin K1 and vitamin D, as well as the occurrence of inflammation

<http://www.naturalnews.com/inflammation.html> biomarkers. The

participants had an average age of 59, and 52 percent were women.

The researchers found that higher blood levels and dietary intake of K1

was correlated with lower levels of 14 different inflammation biomarkers

<http://www.naturalnews.com/biomarkers.html>. After the researchers

adjusted to exclude people with heart disease, increased vitamin K1

intake still correlated with lower levels of five specific biomarkers: a

15 percent reduction in CD40 ligand, 8 percent reduction in

interleukin-6 concentration, 4 percent reduction in serum

osteoprotegerin concentration, a 4 percent reduction in tumor necrosis

factor receptor-2 and a 3 percent reduction in intracellular adhesion

molecule-1 concentration.

Increased vitamin D intake was correlated with a decrease in one

inflammation biomarker, urinary isoprostane.

The correlations held up even after the researchers adjusted for age,

sex, body mass index, use of drugs including aspirin or statins, time of

year and whether female participants were using hormone replacement

therapy after menopause.

Vitamin K occurs in three main forms: phylloquinone or phytonadione,

known as vitamin K1; and menaquinones, known as vitamin K2. Vitamin K2

can be synthesized by the human gut, and is also found in meat and

fermented food products. Vitamin K1 is found in green leafy vegetables,

including broccoli, lettuce and spinach. Vitamin K3, a synthetic form,

is not recommended for humans.