- Calcium homeostasis and adrenal function

[Guest guest]

Hi , just been rereading some of the stuff I wrote a while ago, interestigly enough dysfunctional ca homeostasis affects adrenal function... No wonder our kids having adrenal problems in addition to all others

If the links to abstracts are not working copy the number and paste into pubmed (or go to http://www.autismcalciumchannelopathy.com/Hypoxia_Ischemia.html links should be ok from there)

nx

In addition, in several animal studies application of nimodipine resulted in prevention or reduction of adverse behavioural and neurochemical effects of perinatal hypoxia. In one study it was observed that nimodipine also enhanced the early postnatal development of calcium-binding proteins [8817697], while another study showed that alongside reducing negative behavioural consequences, nimodipine reduced adrenal dysfunction and abnormal corticosterone stress response in rats [8075818] (see Hormones). A study looking at energy metabolism in the developing brain damaged by aglycemic hypoxia found that calcium influx through LTCC mediated these effects. Application of diltiazem or verapamil but not nifedipine significantly improved the recovery from aglycemic hypoxia, manifested in decreased ATP energy state and increases in lactate [8897472] (see Mitochondria). Nimodipine and verapamil normalized cerebral pH following middle cerebral artery occlusion in another roden model of ischemia [3793803]. It has been suggested that the dual blockade of calcium entry using MK-801, a NMDA antagonist, alongside nimodipine may be a useful tool for protection against ischemic brain damage in clinical practice [1985301].