Kate - Mtb and metronidazole

[Guest guest]

I'm pretty sure Wayne was the first to publish on the metronidazole

sensitivity of hypoxic Mtb. Others have repeated the same work.

However metro was near inactive in the TB mouse model. [O2] is low-ish

inside activated macrophages (and resting ones?). But maybe not low

enough.

I dont know whether O2 deactivates the metronidazole-derived radical

by reacting with it, or instead stops Mtb from expressing the

nitroreductase enzyme that produces the radical. Same question goes

for the Cpn situation.