Recup and Lyme disease, was: Re: Latest Dubbo results and glutathione

[Guest guest]

---Kellas (in previous post) talks about how your electrolye balance

is affected thus the need for something like Recup.

wallace

In infections , " rvankonynen "

<richvank@...> wrote:

>

> Hi, a.

>

> I realize that you've asked me about Recup several times, and I

wish I

> could give you a definitive answer for why it works for you, but

I'm

> not sure.

>

> Here is something to consider, though:

>

> Mark London noted the high citrate content of Recup, and that

citrate

> produces alkalinization, and this has gotten me thinking. I want

to

> comment on that a little, and suggest a possible mechanism for how

it

> could be helping you.

>

> First, it's true that in a person whose citric acid cycles are

> operating normally, if citrate is ingested, it will be utilized by

the

> citric acid cycle in the cells and will be burned as fuel.

Probably

> the cells of the gut will burn most of it, because they get first

> access. So long as the citric acid cycle (Krebs cycle) is

operating

> well, this should happen. Since citrate is an anion (negatively

> charged ion), it must come into the body with a cation (positively

> charged ion) to balance the charge. In Recup, the cation is

sodium.

> Being an elemental mineral, sodium survives in the body as sodium,

and

> the excess is excreted in the urine. Since sodium is a cation, in

the

> urine it must be balanced with an anion, and the body takes care of

> this by dissociating water molecules into hydrogen ions and

hydroxide

> ions, and matching up the excreted sodium with hydroxide. The

result

> is that the pH of the urine rises, i.e. becomes more alkaline. So

> that's why taking a citrate causes alkalinization of the urine, and

> that's what happens in a person who has normally operating Krebs

> cycles. I suspect that your Krebs cycles are operating more or

less

> normally, so that this is what happens in your body when you ingest

> Recup. I'll get back to your case (Lyme disease) again below, but

> first I want to talk about cases in which the citric acid cycle is

not

> operating normally.

>

> In many PWCs (I expect not in you, but I don't have a urine organic

> acids test for you, so I can't be positive in your case) it is

found

> that citrate is elevated in the urine. This means that there is a

> partial blockade in the citric acid cycle beyond the location of

> citrate. I have argued that the partial blockade is at actonitase,

> and is produced by a rise in superoxide in response to glutathione

> depletion and consequenct product inhibition of the superoxide

> dismutase reaction. If people who have this partial blockade

ingest

> citrate, I don't believe their bodies will be able to metabolize it

> well, and the excess will be excreted in the urine. To the degree

> this happens, the ingestion of citrate will probably not alkalinize

> their urine to the degree it does in a person with normally

operating

> citric acid cycles. This may explain why Recup doesn't work well

for

> some PWCs. This could be checked by urine organic acids testing

and

> correlation with response to Recup. Also, by the, way, in these

> people, the ingestion of citrate will not help to raise their

> magnesium and calcium, as Mark suggested, because citrate is a good

> chelator for the +2 ions, and will tend to take them out in the

urine.

>

> Now, back to your case, a. We know that you have tested

positive

> for Lyme disease, and we also know that your HLA typing shows that

> your immune system is not able to recognize and destroy Lyme

disease

> toxin. We know from Dr. Shoemaker's work that Borrelia produce an

> anion toxin, because he has been able to bind it with

cholestyramine,

> which is an anion exchange resin. I'm going to guess that this

anion

> toxin acts as a weak acid. What that means is that it binds

hydrogen

> ions fairly well, and doesn't give them up and become ionized as an

> anion unless the pH of the environment is fairly high. This is the

> case in bile (pH 7.5 in the liver, pH 6 in the gall bladder), and

that

> would explain why the Lyme toxin is able to be in anion form when

it

> is excreted into the duodenum in the bile, and hence, why it can be

> bound with an anion exchange resin.

>

> Now, move with me to the field of clinical toxicology. In this

field,

> one of the ways used to cause certain toxins to be excreted faster

is

> to alkalinize the urine, usually by the injection of bicarbonate.

> However, ingesting sodium citrate will also alkalinize the urine,

> provided that the Krebs cycles can burn the citrate, as I discussed

> above. The reason alkalinization is used for detox of certain

> substances is that if they behave as weak acids, the elevation of

pH

> will cause them to become ionized, and then they are more likely to

> remain in solution and be excreted in the urine than to be resorbed

in

> the kidney tubules and be retained in the body. In clinical

> toxicology, this is referred to as " ion trapping. "

>

> So I suggest that in your case what's happening is that taking

Recup

> is raising the pH of your urine to a level where the Lyme toxin is

> ionized and thus is excreted more readily.

>

> This hypothesis can be tested. One of the simplest things you

could

> do would be to get some pH paper at a drugstore and check the pH of

> your urine when you have been taking Recup. I would guess that it

> will be on the high side, say pH 6 or higher. Many people,

especially

> if their diet is high in meat and low in vegetables, have a lower

pH

> than this. If your urine pH is lower than about six and Recup is

> helping you, then I would say that this hypothesis is not valid for

> your case. If it's pH 6 or higher, I would say that this

hypothesis

> still has a chance.

>

> Another test would be to try taking a significant amount of sodium

> bicarbonate orally instead of Recup, and see if that also gives a

> benefit. Of course, this will tend to make you burp a lot if you

have

> normal stomach acid leves, but it's all for the sake of science,

and

> you do want to know why Recup helps you, right?(:-) If the bicarb

> also helps you, then I think the alkalinization-of-urine idea may

be

> valid in your case.

>

> Rich

>

>

> >

> > Rich,

> > Have you read Mark London's article on Recuperation and why it

may

> > work? So far Recuperation along with antibiotics has worked the

best

> > of anything I have tried. My diagnosis is cfs, Lyme, and

quinolone

> > tendon damage.

> >

> > Here is a link to his article. I would be interested in your

> > perspective on it.

> > http://web.mit.edu/london/www/RRR.htm

> >

> > a Carnes

>